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Pityriasis rosea (PR) is a self-limited disease with exanthematous papulosquamous rashes mostly a... more Pityriasis rosea (PR) is a self-limited disease with exanthematous papulosquamous rashes mostly associated with reactivation of human herpesvirus (HHV)-6 or HHV-7. PR-like eruptions, which occur along with peripheral eosinophilia, interface dermatitis, and eosinophils on histopathology, may result from medications or vaccinations. Previously, PR-like eruptions had been noted following vaccination for influenza or other vaccines. During this pandemic, acute COVID-19 infection has been related to PR or PR-like eruptions in several cases. Various COVID-19 vaccines associated with PR-like eruptions were rarely reported. Herein, we report a case of cutaneous PR-like eruptions following COVID-19 mRNA-1273 vaccination.

Para-phenylenediamine (PPD), a primary intermediate in hair dye, is a potent contact allergen and... more Para-phenylenediamine (PPD), a primary intermediate in hair dye, is a potent contact allergen and a common cause of allergic contact dermatitis in hairdressers. We report the results of patch testing with PPD in National Taiwan University Hospital in the past 22years. 115(3.46%) of the total patch-tested 3322patients were positive to PPD. The commonest sites of dermatitis were the face (41.5%) and the hand (28.3%). Hands of hairdressers and face of non-hairdressers were the commonest site of allergic dermatitis of PPD. Hairdressers had an increased risk to be allergic to PPD (odds ratio=20.4). We also review the literatures about allergic contact dermatitis to PPD.

Mycobacterium kansasii infections of the skin are rarely seen and present variable clinical and h... more Mycobacterium kansasii infections of the skin are rarely seen and present variable clinical and histologic features. Most patients with M. kansasii infection have altered immunity, caused either by immunosuppressants or underlying diseases. Laboratory identification of the organism is essential for proper diagnosis and selection of appropriate antimycobacterial medication. We report cutaneous M. kansasii infection in a patient with systemic lupus erythematosus. DNA was extracted from skin biop- sy specimen and a portion of HSP65 gene was amplified by polymerase chain reaction(PCR). The DNA sequence of the amplified product was compatible with that of M. kansasii. Culture of the skin biopsy specimen also yielded M. kansasii in 8 weeks. Treatment including isoniazid, ethambutol and rifampin was insititued right after the diagnosis was established. No new lesions have been noted for three months after initiation of the three combined therapy.

We report on a 5-year-old girl with a pruritic, erythematous cutaneous eruption on the right sid... more We report on a 5-year-old girl with a pruritic, erythematous
cutaneous eruption on the right side of the face for more than 1 year.
The lesion had a linear distribution following the lines of Blaschko.
Histopathological findings and direct immunofluorescence were
compatible with cutaneous lupus erythematosus. We consider this
unusual clinical presentation of childhood facial “Blaschko-linear
cutaneous lupus erythematosus” to be a distinct subtype of lupus
erythematosus. The clinical characteristics and a review of the
literature are presented.

This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmer... more This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Ustekinumab is a human monoclonal antibody selectively targeting the shared p40 subunit of inter... more Ustekinumab is a human monoclonal antibody selectively
targeting the shared p40 subunit of interleukin-12 (IL-12) and IL-23.
Its efficacy for the treatment of psoriasis has been well documented
in previous trials. We report a rare case of a patient who developed
Squamous Cell Carcinoma (SCC) of the tongue after the commencement
of ustekinumab as the treatment of plaque type psoriasis. To our
knowledge, no link between ustekinumab and tongue SCC has been
demonstrated before. Our report suggests that ustekinumab may
induce the development of oral SCC in predisposed individuals

Palisaded and Neutrophilic Granulomatous Dermatitis (PNGD) is a rare form of neutrophilic dermat... more Palisaded and Neutrophilic Granulomatous Dermatitis (PNGD)
is a rare form of neutrophilic dermatoses with granulomatous
inflammation. It is a benign, inflammatory dermatosis with distinct
histopathological features and varied clinical presentations.
Associated systemic conditions include connective-tissue diseases
and lympho proliferative disorders. Dermatomyositis associated
PNGD was rarely reported before. Herein, a PNGD patient with
dermatomyositis and nasopharyngeal cancer was presented. The
clinical and pathological findings as well as mechanism of neutrophilic
and granulomatous infiltrates in autoimmune connective tissue
disease related skin lesions were also briefly discussed.

Journal of Clinical Research in Dermatology, 2016

A 5-year-old girl went to our clinic presented with a more than 1 year history of linear and annu... more A 5-year-old girl went to our clinic presented with a more than 1 year history of linear and annular erythematous patches and telangiectasia from right cheek to right forehead (Figure1a), which was consistent with the implemented lines of Blaschko on the head (Figure1b). Some mild atrophic center over right forehead was noted (Figure1c). She was treated with topical steroids by other dermatologists for more than 1 year but in vain. There were no oral ulcer, alopecia, muscular weakness, or arthralgia, but photosensitivity was noted. The clinical impression was Discoid Lupus Erythematosus (DLE). The initial screening laboratory examination results revealed negative Antinuclear Antibodies (ANA), and positive anti-ENA antibodies. The complement C3, C4, and complete blood count were all within normal limits. The further laboratory examination confirmed positive anti-nDNA antibodies (45.3 IU/ml, >10 IU/ml), and negative anti-Sm/RNP, anti-SSA or anti-SSB antibodies. A skin biopsy was performed on the right forehead and the sample was sent for histological and Direct Immuno fluorescent Examination (DIF). Microscopic features showed papillary dermal edema and perivascular and periappendageal infiltration in both superficial and deep dermis. There were increased dermal mucin deposition and perivascular lymphocytic infiltration (Figure 2). The higher magnification showed interface dermatitis in the epidermis characterized by presence of basal cell vacuolar change, lymphocyte exocytosis, and dyskeratotic cells (Figure 3). Pigment incontinence was present in the papillary dermis. The DIF of the skin biopsy demonstrated a thick linear-granular IgG deposition in the basement membrane zone (Figure 4). There were also granular IgA, IgM, and C3 deposition at the dermo-epidermal junction. These findings were consistent with cutaneous lupus erythematosus. The systemic workup revealed normal chest x ray, and urianalysis. The repeated laboratory workup showed complete blood count, renal profile, total protein and albumin were within normal limits. The ANA, anti-dsDNA antibody, anticardiolipin IgM antibody, C3, C4, and direct Coombs test were all negative. Oral hydroxychloroquine 100mg a day was then prescribed. The skin lesions improved after treatment. Discussion The clinical presentation of childhood DLE is similar to that of the adult form. Over 50% of patients presented with lesions before the age of 10 years. The remainder presented between the ages of 10 and 16 years [1]. Unlike adults with a female predominance, it seems that there is no sex association in children.

Annular Elastolytic Giant Cell Granuloma (AEGCG) is a rare form of granulomatous dermatoses with ... more Annular Elastolytic Giant Cell Granuloma (AEGCG) is a rare form of granulomatous dermatoses with various clinical manifestations. Herein, apityriasis versicolor-like unusual clinical presentation was presented. The pathological findings and different treatment methods were also briefly reviewed.

Journal of Clinical Research in Dermatology, 2016