waseem raja - Academia.edu (original) (raw)
Related Authors
Universidade Federal de Santa Catarina - UFSC (Federal University of Santa Catarina)
Universidade Federal de Santa Catarina - UFSC (Federal University of Santa Catarina)
Uploads
Papers by waseem raja
International Journal of Advanced Research, 2019
Inroduction : Hepatic encephalopathy is one of the most common cause of hospitalization for cirrh... more Inroduction : Hepatic encephalopathy is one of the most common cause of hospitalization for cirrhotic patients.. Lactulose has long been used as the standard therapy for the treatment of acute HE. This study evaluated the efficacy of PEG as compared with lactulose for the initial treatment of HE. Aims & Objective: (1) To compare efficacy of PEG 3350 electrolyte solution over lactulose in patients admitted for hepatic encephalopathy. (2) To determine whether treatment with PEG will reduce duration of hospital stay ,and whether PEG can be an effective additional treatment option for HE. Material & Methods:This Prospective , randomized , Comparative study was conducted in the Department of Gastroenterology Medical Trust hospital , Kochi-Kerala India , over a period of two year from May 2015-April 2017 following its approval by the Institutional ethical committee. 50 patients with cirrhosis and altered mental status attributed to HE were randomized to a standard lactulose protocol or a PEG protocol (25 in each group). Interventions : Patients in the PEG group (n =25) received 2 L of PEG orally or via NG tube as a single dose over 4 hours. Patients in the lactulose group (n=25) received 20-30 g lactulose orally or via NG tube for 3 or more doses over 24 hours, or a single dose of 200 g lactulose via rectal tube. Grade of HE was determined prior to treatment and again at 24 hours using the hepatic encephalopathy scoring algorithm (HESA). After 24 hours, all patients received lactulose per the standard of care. Main Outcomes And Measures : The primary end point was an improvement of 1 or more in HE grade at 24 hours, determined using the hepatic encephalopathy scoring algorithm (HESA), ranging from 0 (normal clinical and neuropsychological assessments) to 4 (coma). Secondary outcomes included time to HE resolution and overall length of stay. Results : In our study , the gender distribution among two study groups showed a male predominant. Majority of HE patients were found in age group of 55-64 years. The most common underlying etiology of Liver Cirrhosis was Alcoholic
Background: Acute Upper Gastrointestinal Bleeding is a common medical emergency with a hospital m... more Background: Acute Upper Gastrointestinal Bleeding is a common medical emergency with a hospital mortality of approximately 10 percent. The presentation of bleeding depends on the amount and location of hemorrhage and the endoscopic profile varies according to different etiology. Despite advancements in medical intervention UGIB still carries considerable morbidity, mortality and economic burden on health care system. Aims: The aim was to study the clinical and endoscopic profile of patients presenting with acute UGIB admitted, at our Gastroenterology center. Methods: A hospital based, prospective study was conducted in Gastroenterology unit of Medical Trust Hospital Kochi –Kerala, one of the tertiary care referral centre in South India over a period of one year, from march 2016 to march 2017. During this study period, 120 patients were identified who came to Emergency Department with UGIB and were subjected to endoscopy to identify the etiology. The clinical and endoscopic profile w...
International Journal of Advanced Research, 2019
Inroduction : Hepatic encephalopathy is one of the most common cause of hospitalization for cirrh... more Inroduction : Hepatic encephalopathy is one of the most common cause of hospitalization for cirrhotic patients.. Lactulose has long been used as the standard therapy for the treatment of acute HE. This study evaluated the efficacy of PEG as compared with lactulose for the initial treatment of HE. Aims & Objective: (1) To compare efficacy of PEG 3350 electrolyte solution over lactulose in patients admitted for hepatic encephalopathy. (2) To determine whether treatment with PEG will reduce duration of hospital stay ,and whether PEG can be an effective additional treatment option for HE. Material & Methods:This Prospective , randomized , Comparative study was conducted in the Department of Gastroenterology Medical Trust hospital , Kochi-Kerala India , over a period of two year from May 2015-April 2017 following its approval by the Institutional ethical committee. 50 patients with cirrhosis and altered mental status attributed to HE were randomized to a standard lactulose protocol or a PEG protocol (25 in each group). Interventions : Patients in the PEG group (n =25) received 2 L of PEG orally or via NG tube as a single dose over 4 hours. Patients in the lactulose group (n=25) received 20-30 g lactulose orally or via NG tube for 3 or more doses over 24 hours, or a single dose of 200 g lactulose via rectal tube. Grade of HE was determined prior to treatment and again at 24 hours using the hepatic encephalopathy scoring algorithm (HESA). After 24 hours, all patients received lactulose per the standard of care. Main Outcomes And Measures : The primary end point was an improvement of 1 or more in HE grade at 24 hours, determined using the hepatic encephalopathy scoring algorithm (HESA), ranging from 0 (normal clinical and neuropsychological assessments) to 4 (coma). Secondary outcomes included time to HE resolution and overall length of stay. Results : In our study , the gender distribution among two study groups showed a male predominant. Majority of HE patients were found in age group of 55-64 years. The most common underlying etiology of Liver Cirrhosis was Alcoholic
Background: Acute Upper Gastrointestinal Bleeding is a common medical emergency with a hospital m... more Background: Acute Upper Gastrointestinal Bleeding is a common medical emergency with a hospital mortality of approximately 10 percent. The presentation of bleeding depends on the amount and location of hemorrhage and the endoscopic profile varies according to different etiology. Despite advancements in medical intervention UGIB still carries considerable morbidity, mortality and economic burden on health care system. Aims: The aim was to study the clinical and endoscopic profile of patients presenting with acute UGIB admitted, at our Gastroenterology center. Methods: A hospital based, prospective study was conducted in Gastroenterology unit of Medical Trust Hospital Kochi –Kerala, one of the tertiary care referral centre in South India over a period of one year, from march 2016 to march 2017. During this study period, 120 patients were identified who came to Emergency Department with UGIB and were subjected to endoscopy to identify the etiology. The clinical and endoscopic profile w...