w zhang - Academia.edu (original) (raw)
Papers by w zhang
Environmental Progress, 2006
An improved method was developed to rank activated carbon in removing organic water pollutants. T... more An improved method was developed to rank activated carbon in removing organic water pollutants. The simple and standardized evaluation method uses a set of four adsorptive capacity indicators: phenol, iodine, methylene blue, and tannic acid numbers; those four indicator compounds were selected because they cover the molecular size range of most organic water pollutants. An improved microcolumn rapid breakthrough (MCRB) test method was developed from the existing HPMC (high-pressure minicolumn) and RSSCT (rapid small-scale column test) methods by simplifying the experimental procedure and using readily available low-cost pump, sampler, piping, and fittings. This method can be practiced in an ordinary environmental laboratory to select the best carbon, to verify the treatment effectiveness, and to estimate the adsorption treatment cost based on the observed capacity utilization rate for carbon in the adsorber without the problems often encountered with using small and mini traditional columns. The benefits of the four-parameter carbon selection method and the MCRB method were demonstrated by adsorption isotherm and breakthrough data for several indicator compounds and organic water pollutants. These improved methods will enable efficient carbon adsorption studies necessary for more applications of carbon adsorption technology in water and wastewater treatment. Figure 13. MCRB curves for MTBE (carbon: 1.0 g; EBCT: 10 s; C 0 : 120 mg/L).
2009 International Conference on Optical Instruments and Technology: Optoelectronic Devices and Integration, 2009
The analytical expression of transmittivity and reflectivity of dual fiber Bragg grating (FBG) an... more The analytical expression of transmittivity and reflectivity of dual fiber Bragg grating (FBG) and the gain equations of the laser are obtained by the coupled mode theory. The laser gain curve is studied through the length of dual FBG and optical fiber length between two gratings under coherence collapse. The relative parameters have been optimized to get the best mode-stabilizing
Environmental Progress, 2007
A simple and cost-effective method for conducting adsorption breakthrough experiments in a micros... more A simple and cost-effective method for conducting adsorption breakthrough experiments in a microsize carbon column is proposed; it is much faster than the conventional methods. Relative to the existing microcolumn rapid breakthrough (MCRB) methods, this method employs simplified procedure, low cost and readily available pump, sampler, and piping and fittings to allow its practice in an ordinary environmental laboratory. The efficient MCRB method may be employed to identify the best granular activated carbon, to verify its treatment effectiveness, and to estimate its capacity utilization rate and the adsorption treatment cost. The effects of particle size and empty bed contact time on MCRB test results were determined. The validity and benefits of this MCRB method were demonstrated by the adsorption breakthrough data for phenol, red dye X3B, tannic acid, MTBE, 2,4-dichrophenol, and the organic pollutants in a biologically treated coking plant effluent. 2007
Environmental Progress, 2007
A series of follow-up investigations were performed to produce data for improving the four-indica... more A series of follow-up investigations were performed to produce data for improving the four-indicator carbon selection method that we developed to identify high-potential activated carbons effective for removing specific organic water pollutants. The carbon's pore structure and surface chemistry are dependent on the raw material and the activation process. Coconut carbons have relatively more small pores than large pores; coal and apricot nutshell/walnut shell fruit carbons have the desirable pore structures for removing adsorbates of all sizes. Chemical activation, excessive activation, and/or thermal reactivation enlarge small pores, resulting in reduced phenol number and higher tannic acid number. Activated carbon's phenol, iodine, methylene blue, and tannic acid numbers are convenient indicators of its surface area and pore volume of pore diameters <10, 10-15, 15-28, and >28 A˚, respectively. The phenol number of a carbon is also a good indicator of its surface acidity of oxygen-containing organic functional groups that affect the adsorptive capacity for aromatic and other small polar organics. The tannic acid number is an indicator of carbon's capacity for large, high-molecular-weight natural organic precursors of disinfection by-products in water treatment. The experimental results for removing nitrobenzene, methyl-tert-butyl ether, 4,4-bisphenol, humic acid, and the organic constituents of a biologically treated coking-plant effluent have demonstrated the effectiveness of this capacity-indicator-based method of carbon selection. A comprehensive table of iodine, phenol, methylene blue, and tannic numbers of common activated carbons is a useful database to environmental professionals for selecting few high-potential activated carbons to be evaluated in an efficient water/wastewater treatability study.
Advanced Materials Research, 2010
In order to improve the information management of the modern digital agriculture, combined severa... more In order to improve the information management of the modern digital agriculture, combined several modern digital agriculture technologies, namely wireless sensor network (WSN), global positioning system (GPS), geographic information system (GIS) and general packet radio service (GPRS), and applied them to the information collection and intelligent control process of the modern digital agriculture. Combining the advantage of the local multi-channel information collection and the low-power wireless transmission of WSN, the stable and low cost long-distance communication and data transmission ability of GPRS, the high-precision positioning technology of the DGPS positioning and the large-scale field information layer-management technology of GIS, such a hybrid technology combination is applied to the large-scale field information and intelligent management. In this study, wireless sensor network routing nodes are disposed in the sub-area of field. These nodes have GPS receiver modules...
BMC proceedings, 2007
Gene expression profiles and single-nucleotide polymorphism (SNP) profiles are modern data for ge... more Gene expression profiles and single-nucleotide polymorphism (SNP) profiles are modern data for genetic analysis. It is possible to use the two types of information to analyze the relationships among genes by some genetical genomics approaches. In this study, gene expression profiles were used as expression traits. And relationships among the genes, which were co-linked to a common SNP(s), were identified by integrating the two types of information. Further research on the co-expressions among the co-linked genes was carried out after the gene-SNP relationships were established using the Haseman-Elston sib-pair regression. The results showed that the co-expressions among the co-linked genes were significantly higher if the number of connections between the genes and a SNP(s) was more than six. Then, the genes were interconnected via one or more SNP co-linkers to construct a gene-SNP intermixed network. The genes sharing more SNPs tended to have a stronger correlation. Finally, a gene...
Medical Oncology, 2008
No biomarker has been available to detect early lung cancer so far. The aim of this study is to s... more No biomarker has been available to detect early lung cancer so far. The aim of this study is to screen biomarker patterns for early diagnosis of non-small cell lung cancer (NSCLC) using laser capture microdissection (LCM) and surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS). The 3 groups of the interested cells from 13 NSCLC tissues, 11 normal lung tissues (out of the 13 NSCLC patients), and 6 benign lung diseased tissues (BLD) were successfully separated by LCM, respectively, and the homogeneities of each type of the cell populations in the three groups were estimated to be over 95%. One-hundred-and twenty-three M/Z peaks were found in the NSCLCs and normal lungs, and between the two groups the relative intensity of 98 M/ Z peaks was significantly different (P \ 0.05) using SEL-DI-TOF-MS. The diagnostic pattern constructed using support vector machine (SVM) including three proteins, M/ Z 4282, 3201, and 4252 Da, respectively, showed maximum Youden Index (YI). The pattern was validated by leave-one-out cross validation (LOOCV) and the results showed that the sensitivity was 100.0%, specificity 90.9%, and positive predictive value (PPV) 92.9%. In the NSCLCs and BLDs 188 M/Z peaks were determined and 54 showed statistically difference (P \ 0.05). The sensitivity, specificity, and PPV of the diagnostic pattern consisting of two proteins, M/Z 3204 and 3701 Da, were all 100.0%. So, by using LCM we have successfully purified the interested cells and solved the problem of heterogeneity of lung cancer tissue. SELDI protein chip coupled with SVM could effectively screen the differentially expressional protein profiles and eventually establish biomarker patterns with high sensitivity and specificity.
Cellular & molecular immunology, 2005
Prolactin is a multifunctional hormone that exerts many separate functions and acts as an importa... more Prolactin is a multifunctional hormone that exerts many separate functions and acts as an important connection between the endocrine and immune systems. There are increasing researches implicating the role of prolactin in hematopoiesis. Enhanced erythropoiesis in pregnant women and direct erythropoietic effects in vitro of plasma either from pregnant or lactating mice have been reported. Furthermore, regression of erythroblastic leukemia has been observed in a significant number of rats after hypophysectomy. In this study, the effects of recombinant human prolactin (rhPRL) on hematopoiesis were assessed in irradiated mice. Mice were treated with rhPRL for five consecutive days after exposure to a lethal dose or a sub-dose irradiation. Prolonged survival rate and increased erythropoiesis were observed in the irradiation-induced myelosuppressive mice. It was concluded that rhPRL might act on erythropoiesis and could be a potential candidate for the treatment of irradiation-induced mye...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2011
Raman and surface-enhanced Raman scattering (SERS) technique are reliably used to compare relativ... more Raman and surface-enhanced Raman scattering (SERS) technique are reliably used to compare relative intensity shifts and to investigate the adsorption geometry of protoberberine alkaloids on Ag nanoparticles. We report joint application of fluorescence and SERS spectroscopy to study the interaction between protoberberine alkaloids and human serum albumin (HSA). We propose SERS technique to improve the quenching interaction caused by protoberberine alkaloids which are used to be applied in recognition process of fluorescent drugs with large biomolecules. The fluorescence results show that the fluorescence intensity of HSA is significantly decreased in presence of protoberberine alkaloids. The SERS technique demonstrates obvious advantages over direct measurements in discriminating and identifying pharmaceutical molecules. By means of this method, we are able to detect important information concerning the orientation of protoberberine alkaloids when interacting with HSA. We also show t...
Medical oncology (Northwood, London, England), 2011
C8orf4, thyroid cancer-1 (TC1), was first identified in papillary thyroid carcinoma and encodes a... more C8orf4, thyroid cancer-1 (TC1), was first identified in papillary thyroid carcinoma and encodes a nucleus-localized protein. A recent array-based study implicated the presence of copy-number variations (CNVs) of C8orf4 in the genomes of acute myelogenous leukemia. However, the functional impact of such regions needs to be extensively investigated in large amount of clinical samples. The purpose of this study is to confirm the relationship between C8orf4 CNVs and hematological malignancies. In our study, we collected bone marrow samples from 515 hematological malignancies and 102 healthy controls. And the CNVs of C8orf4 were detected by real-time PCR. We found significant association between the copy-number deletions of C8orf4 and the risk of these hematological malignancies including acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), multiple myeloma (MM), and myelodysplastic syndrome (MDS). W...
2005 International Conference on Machine Learning and Cybernetics, 2005
Proceedings of the Fourth International Conference on Machine Learning and Cybernetics, Guangzhou... more Proceedings of the Fourth International Conference on Machine Learning and Cybernetics, Guangzhou, 18-21 August 2005 ... LONG-MEMORY OF SHANGHAI STOCK MARKET: A WAVELET-BASED APPROACH ... WEI ZHANG1,2, XIAO-TAO ZHANG1, XIONG XIONG1, ...
Proceedings of 2004 International Conference on Machine Learning and Cybernetics (IEEE Cat. No.04EX826), 2004
Proceedings of the Third International Conference on Machine L earhg and Cybernetics, Shanghai, 2... more Proceedings of the Third International Conference on Machine L earhg and Cybernetics, Shanghai, 26-29 August 2004 ... A MODEL-BASED CLUSTERING FOR TIME-SERIES WITH IRREGULAR INTER~AL ... XIAO-TAO ZHANG', WEI ZHANG~, XIONG XIONG', QI-WEN ...
American Journal of Pathology, 2005
Signal transducer and activator of transcription 3 (STAT3) has oncogenic potential. The biologica... more Signal transducer and activator of transcription 3 (STAT3) has oncogenic potential. The biological effects of STAT3 have not been studied extensively in the pathogenesis of colon cancer, nor has the role of Janus kinase 3 (JAK3), the physiological activator of STAT3, been evaluated. Here, we demonstrate that activated STAT3 (pSTAT3) and activated JAK3 (pJAK3) are expressed constitutively in two colon cancer cell lines, SW480 and HT29. To evaluate the significance of JAK3/STAT3 signaling, we inhibited JAK3 with AG490 and STAT3 with a dominant-negative construct. Inhibition of JAK3 down-regulated pSTAT3. The blockade of JAK3/STAT3 signaling significantly decreased viability of colon cancer cells due to apoptosis and cellcycle arrest through down-regulation of Bcl-2, Bcl-X L , Mcl-1, and cyclin D2 and up-regulation of p21 waf1/cip1 and p27 kip1 . We also examined histological sections from 22 tumors from patients with stage II or stage IV colon cancer and found STAT3, JAK3, and their activated forms to be frequently expressed. Furthermore, quantitative reverse transcriptase-polymerase chain reaction identified JAK3 mRNA in colon cancer cell lines and primary tumors. Our findings illustrate the biological importance of JAK3/ STAT3 activation in the oncogenesis of colon cancer and provide novel evidence that JAK3 is expressed and contributes to STAT3 activation in this malignant neoplasm.
Chinese Optics Letters, 2013
ABSTRACT An ultra-compact variable optical attenuator based on slow light photonic crystal wavegu... more ABSTRACT An ultra-compact variable optical attenuator based on slow light photonic crystal waveguide with thermooptic effect is demonstrated. Along with power consumption of as low as 30.7 mW, a variable attenuation range of 10 dB is experimentally achieved by shifting the transmission spectrum at about 4.6 nm. The length of the proposed device is only 20 μm.
Chinese Optics Letters, 2014
ABSTRACT An optical fiber sensor for ultrathin layer sensing based on short-range surface plasmon... more ABSTRACT An optical fiber sensor for ultrathin layer sensing based on short-range surface plasmon polariton (SRSPP) is proposed, and the sensing characteristics are theoretically analyzed. Simulation results indicate that even for a detecting layer much thinner than the vacuum wavelength, a resolution as high as 3.7\times 10-6 RIU can be obtained. Moreover, an average thickness-detection sensitivity of 6.2 dB/nm is obtained, which enables the sensor to detect the thickness variation of the ultrathin layer up to tens of nanometers. The sensitive region of thickness could be adjusted by tuning the structure parameters.
2010 4th International Conference on Bioinformatics and Biomedical Engineering, 2010
Abstract The internal ring matrix distribution of many special ceramic porous medium tubes on a c... more Abstract The internal ring matrix distribution of many special ceramic porous medium tubes on a circular plate constitutes an adsorbent device, which can retain nanoparticles aerosol agglomerate by the way of collision, adsorption and diffusion in the process of mass transfer. In this paper, the behavior of industrial flue dust diffusion in the ceramic porous medium device is researched by computational fluid dynamics (CFD) simulation and experiments. Furthermore, resistance characteristic of aerosol flow, nonlinear time-dependent ...
Network Architectures, Management, and Applications, 2011
In this paper, a novel survivable algorithm with dynamic load balancing shared-path protection is... more In this paper, a novel survivable algorithm with dynamic load balancing shared-path protection is proposed, named DLBSPP algorithm, in spectrum-elastic optical path networks (SLICE). To tolerate multi-link failures in SLICE, traffic self-adaptive restoration (TSAR) mechanism is adopted to restore the traffic affected by the failures. Simulation results show that, compared with the conventional SPP algorithm, DLBSPP algorithm has lower blocking
Proteomics, 2009
To gain a better understanding of salt stress responses in plants, we used a proteomic approach t... more To gain a better understanding of salt stress responses in plants, we used a proteomic approach to investigate changes in rice (Oryza sativa) root plasma-membrane-associated proteins following treatment with 150 mmol/L NaCl. With or without a 48 h salt treatment, plasma membrane fractions from root tip cells of a salt-sensitive rice cultivar, Wuyunjing 8, were purified by PEG aqueous two-phase partitioning, and plasma-membrane-associated proteins were separated by IEF/SDS-PAGE using an optimized rehydration buffer. Comparative analysis of three independent biological replicates revealed that the expressions of 18 proteins changed by more than 1.5-fold in response to salt stress. Of these proteins, nine were up-regulated and nine were down-regulated. MS analysis indicated that most of these membrane-associated proteins are involved in important physiological processes such as membrane stabilization, ion homeostasis, and signal transduction. In addition, a new leucine-rich-repeat type...
Acta biochimica et biophysica Sinica, 2010
To understand roles of transcriptional factors and miRNAs in regulating gene expression in the ep... more To understand roles of transcriptional factors and miRNAs in regulating gene expression in the epididymis from postnatal development through aging, systematic profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides was performed by cDNA array and miRNA array analysis, respectively. The newborn human epididymis expressed the fewest mRNAs but the largest number of miRNAs, whereas the adult and aged epididymides expressed the most mRNAs but the fewest miRNAs, a negative correlation between mRNAs and miRNA during aging. By integrative analysis, a set of miRNA targets were predicted based on the miRNA and cDNA arrays. In the newborn epididymis, 127 miRNAs were exclusively or preferentially expressed but only 3 and 2 miRNAs showed an age-enriched expression pattern in the adult and aged epididymides, respectively. This study provides a basic database as well as new insights and foundations for further studies on the complex regulation of gene expre...
Environmental Progress, 2006
An improved method was developed to rank activated carbon in removing organic water pollutants. T... more An improved method was developed to rank activated carbon in removing organic water pollutants. The simple and standardized evaluation method uses a set of four adsorptive capacity indicators: phenol, iodine, methylene blue, and tannic acid numbers; those four indicator compounds were selected because they cover the molecular size range of most organic water pollutants. An improved microcolumn rapid breakthrough (MCRB) test method was developed from the existing HPMC (high-pressure minicolumn) and RSSCT (rapid small-scale column test) methods by simplifying the experimental procedure and using readily available low-cost pump, sampler, piping, and fittings. This method can be practiced in an ordinary environmental laboratory to select the best carbon, to verify the treatment effectiveness, and to estimate the adsorption treatment cost based on the observed capacity utilization rate for carbon in the adsorber without the problems often encountered with using small and mini traditional columns. The benefits of the four-parameter carbon selection method and the MCRB method were demonstrated by adsorption isotherm and breakthrough data for several indicator compounds and organic water pollutants. These improved methods will enable efficient carbon adsorption studies necessary for more applications of carbon adsorption technology in water and wastewater treatment. Figure 13. MCRB curves for MTBE (carbon: 1.0 g; EBCT: 10 s; C 0 : 120 mg/L).
2009 International Conference on Optical Instruments and Technology: Optoelectronic Devices and Integration, 2009
The analytical expression of transmittivity and reflectivity of dual fiber Bragg grating (FBG) an... more The analytical expression of transmittivity and reflectivity of dual fiber Bragg grating (FBG) and the gain equations of the laser are obtained by the coupled mode theory. The laser gain curve is studied through the length of dual FBG and optical fiber length between two gratings under coherence collapse. The relative parameters have been optimized to get the best mode-stabilizing
Environmental Progress, 2007
A simple and cost-effective method for conducting adsorption breakthrough experiments in a micros... more A simple and cost-effective method for conducting adsorption breakthrough experiments in a microsize carbon column is proposed; it is much faster than the conventional methods. Relative to the existing microcolumn rapid breakthrough (MCRB) methods, this method employs simplified procedure, low cost and readily available pump, sampler, and piping and fittings to allow its practice in an ordinary environmental laboratory. The efficient MCRB method may be employed to identify the best granular activated carbon, to verify its treatment effectiveness, and to estimate its capacity utilization rate and the adsorption treatment cost. The effects of particle size and empty bed contact time on MCRB test results were determined. The validity and benefits of this MCRB method were demonstrated by the adsorption breakthrough data for phenol, red dye X3B, tannic acid, MTBE, 2,4-dichrophenol, and the organic pollutants in a biologically treated coking plant effluent. 2007
Environmental Progress, 2007
A series of follow-up investigations were performed to produce data for improving the four-indica... more A series of follow-up investigations were performed to produce data for improving the four-indicator carbon selection method that we developed to identify high-potential activated carbons effective for removing specific organic water pollutants. The carbon's pore structure and surface chemistry are dependent on the raw material and the activation process. Coconut carbons have relatively more small pores than large pores; coal and apricot nutshell/walnut shell fruit carbons have the desirable pore structures for removing adsorbates of all sizes. Chemical activation, excessive activation, and/or thermal reactivation enlarge small pores, resulting in reduced phenol number and higher tannic acid number. Activated carbon's phenol, iodine, methylene blue, and tannic acid numbers are convenient indicators of its surface area and pore volume of pore diameters <10, 10-15, 15-28, and >28 A˚, respectively. The phenol number of a carbon is also a good indicator of its surface acidity of oxygen-containing organic functional groups that affect the adsorptive capacity for aromatic and other small polar organics. The tannic acid number is an indicator of carbon's capacity for large, high-molecular-weight natural organic precursors of disinfection by-products in water treatment. The experimental results for removing nitrobenzene, methyl-tert-butyl ether, 4,4-bisphenol, humic acid, and the organic constituents of a biologically treated coking-plant effluent have demonstrated the effectiveness of this capacity-indicator-based method of carbon selection. A comprehensive table of iodine, phenol, methylene blue, and tannic numbers of common activated carbons is a useful database to environmental professionals for selecting few high-potential activated carbons to be evaluated in an efficient water/wastewater treatability study.
Advanced Materials Research, 2010
In order to improve the information management of the modern digital agriculture, combined severa... more In order to improve the information management of the modern digital agriculture, combined several modern digital agriculture technologies, namely wireless sensor network (WSN), global positioning system (GPS), geographic information system (GIS) and general packet radio service (GPRS), and applied them to the information collection and intelligent control process of the modern digital agriculture. Combining the advantage of the local multi-channel information collection and the low-power wireless transmission of WSN, the stable and low cost long-distance communication and data transmission ability of GPRS, the high-precision positioning technology of the DGPS positioning and the large-scale field information layer-management technology of GIS, such a hybrid technology combination is applied to the large-scale field information and intelligent management. In this study, wireless sensor network routing nodes are disposed in the sub-area of field. These nodes have GPS receiver modules...
BMC proceedings, 2007
Gene expression profiles and single-nucleotide polymorphism (SNP) profiles are modern data for ge... more Gene expression profiles and single-nucleotide polymorphism (SNP) profiles are modern data for genetic analysis. It is possible to use the two types of information to analyze the relationships among genes by some genetical genomics approaches. In this study, gene expression profiles were used as expression traits. And relationships among the genes, which were co-linked to a common SNP(s), were identified by integrating the two types of information. Further research on the co-expressions among the co-linked genes was carried out after the gene-SNP relationships were established using the Haseman-Elston sib-pair regression. The results showed that the co-expressions among the co-linked genes were significantly higher if the number of connections between the genes and a SNP(s) was more than six. Then, the genes were interconnected via one or more SNP co-linkers to construct a gene-SNP intermixed network. The genes sharing more SNPs tended to have a stronger correlation. Finally, a gene...
Medical Oncology, 2008
No biomarker has been available to detect early lung cancer so far. The aim of this study is to s... more No biomarker has been available to detect early lung cancer so far. The aim of this study is to screen biomarker patterns for early diagnosis of non-small cell lung cancer (NSCLC) using laser capture microdissection (LCM) and surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS). The 3 groups of the interested cells from 13 NSCLC tissues, 11 normal lung tissues (out of the 13 NSCLC patients), and 6 benign lung diseased tissues (BLD) were successfully separated by LCM, respectively, and the homogeneities of each type of the cell populations in the three groups were estimated to be over 95%. One-hundred-and twenty-three M/Z peaks were found in the NSCLCs and normal lungs, and between the two groups the relative intensity of 98 M/ Z peaks was significantly different (P \ 0.05) using SEL-DI-TOF-MS. The diagnostic pattern constructed using support vector machine (SVM) including three proteins, M/ Z 4282, 3201, and 4252 Da, respectively, showed maximum Youden Index (YI). The pattern was validated by leave-one-out cross validation (LOOCV) and the results showed that the sensitivity was 100.0%, specificity 90.9%, and positive predictive value (PPV) 92.9%. In the NSCLCs and BLDs 188 M/Z peaks were determined and 54 showed statistically difference (P \ 0.05). The sensitivity, specificity, and PPV of the diagnostic pattern consisting of two proteins, M/Z 3204 and 3701 Da, were all 100.0%. So, by using LCM we have successfully purified the interested cells and solved the problem of heterogeneity of lung cancer tissue. SELDI protein chip coupled with SVM could effectively screen the differentially expressional protein profiles and eventually establish biomarker patterns with high sensitivity and specificity.
Cellular & molecular immunology, 2005
Prolactin is a multifunctional hormone that exerts many separate functions and acts as an importa... more Prolactin is a multifunctional hormone that exerts many separate functions and acts as an important connection between the endocrine and immune systems. There are increasing researches implicating the role of prolactin in hematopoiesis. Enhanced erythropoiesis in pregnant women and direct erythropoietic effects in vitro of plasma either from pregnant or lactating mice have been reported. Furthermore, regression of erythroblastic leukemia has been observed in a significant number of rats after hypophysectomy. In this study, the effects of recombinant human prolactin (rhPRL) on hematopoiesis were assessed in irradiated mice. Mice were treated with rhPRL for five consecutive days after exposure to a lethal dose or a sub-dose irradiation. Prolonged survival rate and increased erythropoiesis were observed in the irradiation-induced myelosuppressive mice. It was concluded that rhPRL might act on erythropoiesis and could be a potential candidate for the treatment of irradiation-induced mye...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2011
Raman and surface-enhanced Raman scattering (SERS) technique are reliably used to compare relativ... more Raman and surface-enhanced Raman scattering (SERS) technique are reliably used to compare relative intensity shifts and to investigate the adsorption geometry of protoberberine alkaloids on Ag nanoparticles. We report joint application of fluorescence and SERS spectroscopy to study the interaction between protoberberine alkaloids and human serum albumin (HSA). We propose SERS technique to improve the quenching interaction caused by protoberberine alkaloids which are used to be applied in recognition process of fluorescent drugs with large biomolecules. The fluorescence results show that the fluorescence intensity of HSA is significantly decreased in presence of protoberberine alkaloids. The SERS technique demonstrates obvious advantages over direct measurements in discriminating and identifying pharmaceutical molecules. By means of this method, we are able to detect important information concerning the orientation of protoberberine alkaloids when interacting with HSA. We also show t...
Medical oncology (Northwood, London, England), 2011
C8orf4, thyroid cancer-1 (TC1), was first identified in papillary thyroid carcinoma and encodes a... more C8orf4, thyroid cancer-1 (TC1), was first identified in papillary thyroid carcinoma and encodes a nucleus-localized protein. A recent array-based study implicated the presence of copy-number variations (CNVs) of C8orf4 in the genomes of acute myelogenous leukemia. However, the functional impact of such regions needs to be extensively investigated in large amount of clinical samples. The purpose of this study is to confirm the relationship between C8orf4 CNVs and hematological malignancies. In our study, we collected bone marrow samples from 515 hematological malignancies and 102 healthy controls. And the CNVs of C8orf4 were detected by real-time PCR. We found significant association between the copy-number deletions of C8orf4 and the risk of these hematological malignancies including acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), multiple myeloma (MM), and myelodysplastic syndrome (MDS). W...
2005 International Conference on Machine Learning and Cybernetics, 2005
Proceedings of the Fourth International Conference on Machine Learning and Cybernetics, Guangzhou... more Proceedings of the Fourth International Conference on Machine Learning and Cybernetics, Guangzhou, 18-21 August 2005 ... LONG-MEMORY OF SHANGHAI STOCK MARKET: A WAVELET-BASED APPROACH ... WEI ZHANG1,2, XIAO-TAO ZHANG1, XIONG XIONG1, ...
Proceedings of 2004 International Conference on Machine Learning and Cybernetics (IEEE Cat. No.04EX826), 2004
Proceedings of the Third International Conference on Machine L earhg and Cybernetics, Shanghai, 2... more Proceedings of the Third International Conference on Machine L earhg and Cybernetics, Shanghai, 26-29 August 2004 ... A MODEL-BASED CLUSTERING FOR TIME-SERIES WITH IRREGULAR INTER~AL ... XIAO-TAO ZHANG', WEI ZHANG~, XIONG XIONG', QI-WEN ...
American Journal of Pathology, 2005
Signal transducer and activator of transcription 3 (STAT3) has oncogenic potential. The biologica... more Signal transducer and activator of transcription 3 (STAT3) has oncogenic potential. The biological effects of STAT3 have not been studied extensively in the pathogenesis of colon cancer, nor has the role of Janus kinase 3 (JAK3), the physiological activator of STAT3, been evaluated. Here, we demonstrate that activated STAT3 (pSTAT3) and activated JAK3 (pJAK3) are expressed constitutively in two colon cancer cell lines, SW480 and HT29. To evaluate the significance of JAK3/STAT3 signaling, we inhibited JAK3 with AG490 and STAT3 with a dominant-negative construct. Inhibition of JAK3 down-regulated pSTAT3. The blockade of JAK3/STAT3 signaling significantly decreased viability of colon cancer cells due to apoptosis and cellcycle arrest through down-regulation of Bcl-2, Bcl-X L , Mcl-1, and cyclin D2 and up-regulation of p21 waf1/cip1 and p27 kip1 . We also examined histological sections from 22 tumors from patients with stage II or stage IV colon cancer and found STAT3, JAK3, and their activated forms to be frequently expressed. Furthermore, quantitative reverse transcriptase-polymerase chain reaction identified JAK3 mRNA in colon cancer cell lines and primary tumors. Our findings illustrate the biological importance of JAK3/ STAT3 activation in the oncogenesis of colon cancer and provide novel evidence that JAK3 is expressed and contributes to STAT3 activation in this malignant neoplasm.
Chinese Optics Letters, 2013
ABSTRACT An ultra-compact variable optical attenuator based on slow light photonic crystal wavegu... more ABSTRACT An ultra-compact variable optical attenuator based on slow light photonic crystal waveguide with thermooptic effect is demonstrated. Along with power consumption of as low as 30.7 mW, a variable attenuation range of 10 dB is experimentally achieved by shifting the transmission spectrum at about 4.6 nm. The length of the proposed device is only 20 μm.
Chinese Optics Letters, 2014
ABSTRACT An optical fiber sensor for ultrathin layer sensing based on short-range surface plasmon... more ABSTRACT An optical fiber sensor for ultrathin layer sensing based on short-range surface plasmon polariton (SRSPP) is proposed, and the sensing characteristics are theoretically analyzed. Simulation results indicate that even for a detecting layer much thinner than the vacuum wavelength, a resolution as high as 3.7\times 10-6 RIU can be obtained. Moreover, an average thickness-detection sensitivity of 6.2 dB/nm is obtained, which enables the sensor to detect the thickness variation of the ultrathin layer up to tens of nanometers. The sensitive region of thickness could be adjusted by tuning the structure parameters.
2010 4th International Conference on Bioinformatics and Biomedical Engineering, 2010
Abstract The internal ring matrix distribution of many special ceramic porous medium tubes on a c... more Abstract The internal ring matrix distribution of many special ceramic porous medium tubes on a circular plate constitutes an adsorbent device, which can retain nanoparticles aerosol agglomerate by the way of collision, adsorption and diffusion in the process of mass transfer. In this paper, the behavior of industrial flue dust diffusion in the ceramic porous medium device is researched by computational fluid dynamics (CFD) simulation and experiments. Furthermore, resistance characteristic of aerosol flow, nonlinear time-dependent ...
Network Architectures, Management, and Applications, 2011
In this paper, a novel survivable algorithm with dynamic load balancing shared-path protection is... more In this paper, a novel survivable algorithm with dynamic load balancing shared-path protection is proposed, named DLBSPP algorithm, in spectrum-elastic optical path networks (SLICE). To tolerate multi-link failures in SLICE, traffic self-adaptive restoration (TSAR) mechanism is adopted to restore the traffic affected by the failures. Simulation results show that, compared with the conventional SPP algorithm, DLBSPP algorithm has lower blocking
Proteomics, 2009
To gain a better understanding of salt stress responses in plants, we used a proteomic approach t... more To gain a better understanding of salt stress responses in plants, we used a proteomic approach to investigate changes in rice (Oryza sativa) root plasma-membrane-associated proteins following treatment with 150 mmol/L NaCl. With or without a 48 h salt treatment, plasma membrane fractions from root tip cells of a salt-sensitive rice cultivar, Wuyunjing 8, were purified by PEG aqueous two-phase partitioning, and plasma-membrane-associated proteins were separated by IEF/SDS-PAGE using an optimized rehydration buffer. Comparative analysis of three independent biological replicates revealed that the expressions of 18 proteins changed by more than 1.5-fold in response to salt stress. Of these proteins, nine were up-regulated and nine were down-regulated. MS analysis indicated that most of these membrane-associated proteins are involved in important physiological processes such as membrane stabilization, ion homeostasis, and signal transduction. In addition, a new leucine-rich-repeat type...
Acta biochimica et biophysica Sinica, 2010
To understand roles of transcriptional factors and miRNAs in regulating gene expression in the ep... more To understand roles of transcriptional factors and miRNAs in regulating gene expression in the epididymis from postnatal development through aging, systematic profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides was performed by cDNA array and miRNA array analysis, respectively. The newborn human epididymis expressed the fewest mRNAs but the largest number of miRNAs, whereas the adult and aged epididymides expressed the most mRNAs but the fewest miRNAs, a negative correlation between mRNAs and miRNA during aging. By integrative analysis, a set of miRNA targets were predicted based on the miRNA and cDNA arrays. In the newborn epididymis, 127 miRNAs were exclusively or preferentially expressed but only 3 and 2 miRNAs showed an age-enriched expression pattern in the adult and aged epididymides, respectively. This study provides a basic database as well as new insights and foundations for further studies on the complex regulation of gene expre...