yaron naveh - Academia.edu (original) (raw)
Papers by yaron naveh
American Journal of Medical Genetics, Apr 6, 2017
Journal of Pediatric Surgery, 2006
Journal of Pediatric Gastroenterology and Nutrition, 2004
American journal of medical genetics, Aug 26, 2002
European Journal of Immunology, 2004
The fat soluble vitamin D3 metabolite 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D(3)], and its nuclear... more The fat soluble vitamin D3 metabolite 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D(3)], and its nuclear receptor play an important role in regulating immune responses. While 1,25(OH)(2)D(3 )is known to inhibit transcription of cytokine genes that are required for Th1 differentiation or are products of differentiated Th1 cells, its role in regulating differentiation of Th2 cells is less clear. In this study, we show that 1,25(OH)(2)D(3) has anti-inflammatory effects in an in vivo Th2-dependent asthma model. In addition, we demonstrate that 1,25(OH)(2)D(3 )down-regulates the cytoskeleton rearrangement required for promoting integrin-mediated adhesion of naive and effector CD4(+) T cells. Finally, 1,25(OH)(2)D(3 )inhibits chemokine-induced migration of naive cells and their homing to the lymph nodes. Thus, in addition to its regulation of cytokine transcription, 1,25(OH)(2)D(3 )regulates migration of cells and thus controls the skewing of various Th subsets in the secondary lymphoid organs and inhibits Th function at sites of inflammation.
The Israel Medical Association journal : IMAJ, 2007
BACKGROUND Babies born with extreme prematurity and low birth weight (< 1000 g) present a uniq... more BACKGROUND Babies born with extreme prematurity and low birth weight (< 1000 g) present a unique treatment challenge. In addition to the complexity of achieving survival, they may require surgical interventions for abdominal emergencies. Usually, these infants are transferred to a referral center for surgical treatment. Since 2000 our approach is bedside abdominal surgery at the referring center. OBJECTIVES To evaluate whether the approach of bedside abdominal surgery at the referring center is safe and perhaps even beneficial for the baby. METHODS We retrospectively reviewed our data since 2000 and included only babies weighing < 1000 g who were ventilated, suffered from hemodynamic instability, and underwent surgery for perforated bowel at the referring neonatal unit. Results were analyzed according to survival from the acute event (> 1 week), survival from the abdominal disease (> 30 days), and survival to discharge. RESULTS Twelve babies met the inclusion criteria. M...
American Journal of Medical Genetics, 2002
The Israel Medical Association journal : IMAJ, 2007
Babies born with extreme prematurity and low birth weight (< 1000 g) present a unique treatmen... more Babies born with extreme prematurity and low birth weight (< 1000 g) present a unique treatment challenge. In addition to the complexity of achieving survival, they may require surgical interventions for abdominal emergencies. Usually, these infants are transferred to a referral center for surgical treatment. Since 2000 our approach is bedside abdominal surgery at the referring center. To evaluate whether the approach of bedside abdominal surgery at the referring center is safe and perhaps even beneficial for the baby. We retrospectively reviewed our data since 2000 and included only babies weighing < 1000 g who were ventilated, suffered from hemodynamic instability, and underwent surgery for perforated bowel at the referring neonatal unit. Results were analyzed according to survival from the acute event (> 1 week), survival from the abdominal disease (> 30 days), and survival to discharge. Twelve babies met the inclusion criteria. Median weight at operation was 850 g (r...
Journal of Pediatric Gastroenterology and Nutrition, 2004
American Journal of Medical Genetics, 2002
American Journal of Medical Genetics, Apr 6, 2017
Journal of Pediatric Surgery, 2006
Journal of Pediatric Gastroenterology and Nutrition, 2004
American journal of medical genetics, Aug 26, 2002
European Journal of Immunology, 2004
The fat soluble vitamin D3 metabolite 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D(3)], and its nuclear... more The fat soluble vitamin D3 metabolite 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D(3)], and its nuclear receptor play an important role in regulating immune responses. While 1,25(OH)(2)D(3 )is known to inhibit transcription of cytokine genes that are required for Th1 differentiation or are products of differentiated Th1 cells, its role in regulating differentiation of Th2 cells is less clear. In this study, we show that 1,25(OH)(2)D(3) has anti-inflammatory effects in an in vivo Th2-dependent asthma model. In addition, we demonstrate that 1,25(OH)(2)D(3 )down-regulates the cytoskeleton rearrangement required for promoting integrin-mediated adhesion of naive and effector CD4(+) T cells. Finally, 1,25(OH)(2)D(3 )inhibits chemokine-induced migration of naive cells and their homing to the lymph nodes. Thus, in addition to its regulation of cytokine transcription, 1,25(OH)(2)D(3 )regulates migration of cells and thus controls the skewing of various Th subsets in the secondary lymphoid organs and inhibits Th function at sites of inflammation.
The Israel Medical Association journal : IMAJ, 2007
BACKGROUND Babies born with extreme prematurity and low birth weight (< 1000 g) present a uniq... more BACKGROUND Babies born with extreme prematurity and low birth weight (< 1000 g) present a unique treatment challenge. In addition to the complexity of achieving survival, they may require surgical interventions for abdominal emergencies. Usually, these infants are transferred to a referral center for surgical treatment. Since 2000 our approach is bedside abdominal surgery at the referring center. OBJECTIVES To evaluate whether the approach of bedside abdominal surgery at the referring center is safe and perhaps even beneficial for the baby. METHODS We retrospectively reviewed our data since 2000 and included only babies weighing < 1000 g who were ventilated, suffered from hemodynamic instability, and underwent surgery for perforated bowel at the referring neonatal unit. Results were analyzed according to survival from the acute event (> 1 week), survival from the abdominal disease (> 30 days), and survival to discharge. RESULTS Twelve babies met the inclusion criteria. M...
American Journal of Medical Genetics, 2002
The Israel Medical Association journal : IMAJ, 2007
Babies born with extreme prematurity and low birth weight (< 1000 g) present a unique treatmen... more Babies born with extreme prematurity and low birth weight (< 1000 g) present a unique treatment challenge. In addition to the complexity of achieving survival, they may require surgical interventions for abdominal emergencies. Usually, these infants are transferred to a referral center for surgical treatment. Since 2000 our approach is bedside abdominal surgery at the referring center. To evaluate whether the approach of bedside abdominal surgery at the referring center is safe and perhaps even beneficial for the baby. We retrospectively reviewed our data since 2000 and included only babies weighing < 1000 g who were ventilated, suffered from hemodynamic instability, and underwent surgery for perforated bowel at the referring neonatal unit. Results were analyzed according to survival from the acute event (> 1 week), survival from the abdominal disease (> 30 days), and survival to discharge. Twelve babies met the inclusion criteria. Median weight at operation was 850 g (r...
Journal of Pediatric Gastroenterology and Nutrition, 2004
American Journal of Medical Genetics, 2002