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California Polytechnic State University at San Luis Obispo
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Papers by zafar ibragimov
Physiology
Introduction: Type 2 Diabetes Mellitus (DM2) viewed as a major cause for neurodegenerative and co... more Introduction: Type 2 Diabetes Mellitus (DM2) viewed as a major cause for neurodegenerative and cognitive abnormalities. One of the possible reason for that should be insulin resistance and hyperinsulinemia two main clinical future of DM2. The mechanism relationship between insulin and development of diabetic neuropathy and encephalopathy not clear yet. Material and methods: In 51 DM2 patients in age between 42 and 64 years old, without neurologic complications or with presence of different stages of neuropathy/encephalopathy were observed clinically and diagnosis confirmed by neurologist. Patients divided into two groups according to presence of mild and severe neuropathy or encephalopathy. For lab study cubital venous blood plasma taken for measure of plasma insulin level by ELISA. Results: Neuropathy/encephalopathy were registered in 71% of DM2 patients. HbA1c level were higher than healthy subjects and were comparable in both groups with severe neuropathy/encephalopathy and witho...
American Journal of Medicine and Medical Sciences, 2021
Bulletin of Pirogov National Medical & Surgical Center, 2021
Endocrine Abstracts, 2016
Over the last few years, roles of cytokines in the pathogenesis of human diseases are being studi... more Over the last few years, roles of cytokines in the pathogenesis of human diseases are being studied intensively.1,2 The Tumour necrosis factor-alpha (TNF-α), a pro-inflammatory cytokine, is a highly active polyfunctional cytokine playing a key role in the pathogenesis of diseases such as Rheumatoid arthritis, Parkinson Disease, Obesity, Diabetes Mellitus (DM) and making an impact on the regulation of metabolism in a human organism.3 Under physiological conditions, TNF-α plays a critical role in the regulation of normal differentiation, growth and metabolism of various cells involved in mechanisms of cell death and apoptosis. On the other hand, TNF-α acts as a mediator of inflammation in various human diseases.1,2 Findings from multiple studies demonstrated interrelation between increase in TNF-α levels and the initiation of inflammation and cancer, as well as of some metabolic, autoimmune and neurodegenerative diseases.2,5-7 There is convincing evidence of TNF-α as a key pro-inflamm...
International Journal of Current Research and Review
Introduction: Tumour necrosis factor-alpha (TNF-α), a pro-inflammation cytokine, plays a critical... more Introduction: Tumour necrosis factor-alpha (TNF-α), a pro-inflammation cytokine, plays a critical role in the pathogenesis of type 2 diabetes mellitus due to involving into the regulation of insulin signalling. Overproduction of this cytokine in metabolic syndrome is linked to TNF-α promoter gene G-308A polymorphism. Objective: The work was initiated to measure the serum TNF-α concentrations and to determine the frequency of the Tumour necrosis factor-alpha (TNF-α) gene G308A polymorphism in Uzbek patients with type 2 diabetes mellitus. Methods: Healthy and type 2 diabetes mellitus Uzbek patients were observed. Results: In the group with diabetes fasting blood glucose and the glycated haemoglobin (HbA1c) levels were 2.7 and 1.6 times higher respectively (both p<0.01). HDL cholesterol was reduced, while LDL cholesterol, total cholesterol and triglycerides were higher in diabetic group. There was a significant difference between the serum TNF-α concentration in people with and without DM. As to TNF-α gene G308A polymorphism in the sample under study, it was represented mostly by GG homozygous genotype to be registered among persons without diabetes (90.2%) and patients with type 2 DM (83.3%). GA heterozygous genotype occurred in 9.8% and 16.7% of non-diabetics and diabetics, respectively. In our study, pathological AA homozygous genotype was found neither among the diabetics nor in the controls. There were no significant differences in frequencies of alleles and genotypes of TNFα gene G308A polymorphism. In the diabetics, frequencies of A allele and GA genotype is insignificantly higher than those in the controls. Conclusion: In compare to non-diabetic controls, patients with type 2 diabetes mellitus had higher serum concentrations of TNF-α. However, in that small group association of A allele and GA genotype of TNF-α gene with a higher risk of DM2 were insignificant.
Journal of biomedicine and practice
Physiology
Introduction: Type 2 Diabetes Mellitus (DM2) viewed as a major cause for neurodegenerative and co... more Introduction: Type 2 Diabetes Mellitus (DM2) viewed as a major cause for neurodegenerative and cognitive abnormalities. One of the possible reason for that should be insulin resistance and hyperinsulinemia two main clinical future of DM2. The mechanism relationship between insulin and development of diabetic neuropathy and encephalopathy not clear yet. Material and methods: In 51 DM2 patients in age between 42 and 64 years old, without neurologic complications or with presence of different stages of neuropathy/encephalopathy were observed clinically and diagnosis confirmed by neurologist. Patients divided into two groups according to presence of mild and severe neuropathy or encephalopathy. For lab study cubital venous blood plasma taken for measure of plasma insulin level by ELISA. Results: Neuropathy/encephalopathy were registered in 71% of DM2 patients. HbA1c level were higher than healthy subjects and were comparable in both groups with severe neuropathy/encephalopathy and witho...
American Journal of Medicine and Medical Sciences, 2021
Bulletin of Pirogov National Medical & Surgical Center, 2021
Endocrine Abstracts, 2016
Over the last few years, roles of cytokines in the pathogenesis of human diseases are being studi... more Over the last few years, roles of cytokines in the pathogenesis of human diseases are being studied intensively.1,2 The Tumour necrosis factor-alpha (TNF-α), a pro-inflammatory cytokine, is a highly active polyfunctional cytokine playing a key role in the pathogenesis of diseases such as Rheumatoid arthritis, Parkinson Disease, Obesity, Diabetes Mellitus (DM) and making an impact on the regulation of metabolism in a human organism.3 Under physiological conditions, TNF-α plays a critical role in the regulation of normal differentiation, growth and metabolism of various cells involved in mechanisms of cell death and apoptosis. On the other hand, TNF-α acts as a mediator of inflammation in various human diseases.1,2 Findings from multiple studies demonstrated interrelation between increase in TNF-α levels and the initiation of inflammation and cancer, as well as of some metabolic, autoimmune and neurodegenerative diseases.2,5-7 There is convincing evidence of TNF-α as a key pro-inflamm...
International Journal of Current Research and Review
Introduction: Tumour necrosis factor-alpha (TNF-α), a pro-inflammation cytokine, plays a critical... more Introduction: Tumour necrosis factor-alpha (TNF-α), a pro-inflammation cytokine, plays a critical role in the pathogenesis of type 2 diabetes mellitus due to involving into the regulation of insulin signalling. Overproduction of this cytokine in metabolic syndrome is linked to TNF-α promoter gene G-308A polymorphism. Objective: The work was initiated to measure the serum TNF-α concentrations and to determine the frequency of the Tumour necrosis factor-alpha (TNF-α) gene G308A polymorphism in Uzbek patients with type 2 diabetes mellitus. Methods: Healthy and type 2 diabetes mellitus Uzbek patients were observed. Results: In the group with diabetes fasting blood glucose and the glycated haemoglobin (HbA1c) levels were 2.7 and 1.6 times higher respectively (both p<0.01). HDL cholesterol was reduced, while LDL cholesterol, total cholesterol and triglycerides were higher in diabetic group. There was a significant difference between the serum TNF-α concentration in people with and without DM. As to TNF-α gene G308A polymorphism in the sample under study, it was represented mostly by GG homozygous genotype to be registered among persons without diabetes (90.2%) and patients with type 2 DM (83.3%). GA heterozygous genotype occurred in 9.8% and 16.7% of non-diabetics and diabetics, respectively. In our study, pathological AA homozygous genotype was found neither among the diabetics nor in the controls. There were no significant differences in frequencies of alleles and genotypes of TNFα gene G308A polymorphism. In the diabetics, frequencies of A allele and GA genotype is insignificantly higher than those in the controls. Conclusion: In compare to non-diabetic controls, patients with type 2 diabetes mellitus had higher serum concentrations of TNF-α. However, in that small group association of A allele and GA genotype of TNF-α gene with a higher risk of DM2 were insignificant.
Journal of biomedicine and practice