Aurelian Bidulescu | Indiana University (original) (raw)

Papers by Aurelian Bidulescu

Carolina Digital Repository (University of North Carolina at Chapel Hill), 2012

American Heart Journal, Jul 1, 2016

Hypertension, Mar 1, 2010

Annals of Epidemiology, May 1, 2023

Diabetic Medicine, Dec 25, 2020

Aim:To evaluate the association between plasma biomarkers including leptin, adiponectin, adiponec... more Aim:To evaluate the association between plasma biomarkers including leptin, adiponectin, adiponectin-to-leptin ratio and high-sensitivity C-reactive protein (hsCRP) with risk of glycaemic progression and incident dysglycaemia (pre-diabetes or diabetes) in a community-based sample of African American (AAs).Methods:We analysed data from 3223 participants without type 2 diabetes at baseline (2000–2004) who attended ≥1 follow-up visit. Poisson regression was used to generate risk ratios (RRs) for glycaemic progression and incident dysglycaemia.Results:Over a median of 7 years, 46.4% developed glycaemic progression (n=1495). After adjusting for demographic and lifestyle variables, the RRs (95% CI) for glycaemic progression comparing highest (Q4) to lowest (Q1) quartiles were 1.30 (1.10–1.54), 0.74 (0.65–0.84), 0.70 (0.62–0.80) and 1.22 (1.07–1.38) for leptin, adiponectin, adiponectin–leptin ratio and hsCRP, respectively. Upon additional adjustment for BMI, the corresponding RRs (95% CIs) were 1.15 (0.94–1.42), 0.76 (0.67–0.86), 0.72 (0.62–0.84) and 1.14 (0.99–1.31) respectively. Among participants with normal glycaemia, the RRs (95% CIs) for incident pre-diabetes in Q4 vs Q1 were 1.37 (1.13–1.67), 0.73 (0.63–0.85), 0.70 (0.59–0.82) and 1.28 (1.10–1.48) for leptin, adiponectin, adiponectin–leptin ratio and hsCRP, respectively; equivalent RRs for incident diabetes were 5.15 (2.63–10.10), 0.36 (0.20–0.68), 0.21 (0.12–0.38) and 3.04 (1.70–5.44), respectively.Conclusions:In this large community-based cohort of AAs, our results suggest that high plasma leptin and hsCRP, as well as low adiponectin and adiponectin-to-leptin ratio, are associated with higher risks of glycaemic progression. The findings point to the potential utility of these biomarkers in predicting and preventing glycaemic progression in this high-risk population.

American Journal of Hypertension, Jun 24, 2021

Addiction, Dec 9, 2021

AimsTo measure the prospective relationship between smoking trajectories from adolescence to youn... more AimsTo measure the prospective relationship between smoking trajectories from adolescence to young adulthood and mental health in later adulthood and test whether this relationship was mediated by concurrent co‐use of alcohol and marijuana.DesignLongitudinal study using data drawn from rounds 1 to 18 of the National Longitudinal Survey of Youth 1997 (NLSY97), a nationally representative cohort study spanning 21 years.SettingUnited States.ParticipantsThe analytical sample included those who completed survey items about smoking behaviors on at least half the data collection opportunities in adolescence and young adulthood (n = 8570, 48.9% female, 66.2% white).MeasurementsMental health in adulthood was measured using the five‐item Mental Health Inventory (MHI‐5; range = 0–100) at round 18. Seven trajectories of smoking from adolescence to young adulthood were identified by group‐based multi‐trajectory modeling, using data over 11 years from rounds 1 to 11.FindingsLate‐onset moderate smokers [β = −1.95, 95% confidence interval (CI) = −3.61 to −0.29], late‐onset accelerated smokers (β = −2.53, 95% CI = −4.28 to −0.78), early‐onset heavy smokers (β = −3.72, 95% CI = −5.59 to −1.85) and early‐onset moderate smokers (β = −2.66, 95% CI = −4.48 to −0.84) showed poorer regression‐adjusted mean MHI‐5 scores in later adulthood than stable abstainers, even after controlling for baseline mental health and covariates. Whether or not a difference in MHI‐5 scores was present between quitters and stable abstainers was inconclusive. The concurrent co‐use of alcohol and marijuana in young adulthood significantly mediated the relationship between smoking trajectory and mental health.ConclusionsContinued smoking, especially early‐onset and heavy smoking from adolescence to young adulthood, appears to increase the risk of poor mental health later in mid‐adulthood, and quitting smoking in young adulthood may mitigate such risk even among early‐onset smokers. Mediation analyses underscore the role of using multiple substances in this pathway.

American Journal of Preventive Medicine, Mar 1, 2021

INTRODUCTION African Americans are disproportionately affected by high blood pressure, which may ... more INTRODUCTION African Americans are disproportionately affected by high blood pressure, which may be associated with exposure to air pollutants, such as fine particulate matter and ozone. METHODS Among African American Jackson Heart Study participants, this study examined associations between 1-year and 3-year mean fine particulate matter and ozone concentrations with prevalent and incident hypertension at Visits 1 (2000-2004, n=5,191) and 2 (2005-2008, n=4,105) using log binomial regression. Investigators examined associations with systolic blood pressure, diastolic blood pressure, pulse pressure, and mean arterial pressure using linear regression and hierarchical linear models, adjusting for sociodemographic, behavioral, and clinical characteristics. Analyses were conducted in 2017-2019. RESULTS No associations were observed between fine particulate matter or ozone concentration and prevalent or incident hypertension. In linear models, an IQR increase in 1-year ozone concentration was associated with 0.67 mmHg higher systolic blood pressure (95% CI=0.27, 1.06), 0.42 mmHg higher diastolic blood pressure (95% CI=0.20, 0.63), and 0.50 mmHg higher mean arterial pressure (95% CI=0.26, 0.74). In hierarchical models, fine particulate matter was inversely associated with systolic blood pressure (-0.72, 95% CI= -1.31, -0.13), diastolic blood pressure (-0.69, 95% CI= -1.02, -0.36), and mean arterial pressure (-0.71, 95% CI= -1.08, -0.33). Attenuated associations were observed with 1-year concentrations and at Visit 1. CONCLUSIONS Positive associations were observed between ozone and systolic blood pressure, diastolic blood pressure, and mean arterial pressure, and inverse associations between fine particulate matter and systolic blood pressure, diastolic blood pressure, and mean arterial pressure in an African American population with high (56%) prevalence of hypertension. Effect sizes were small and may not be clinically relevant.

Hypertension, 2013

B-type natriuretic peptide (BNP) is a peptide hormone released by the cardiac myocytes in respons... more B-type natriuretic peptide (BNP) is a peptide hormone released by the cardiac myocytes in response to myocardial stretch during pressure and volume overload states. 1,2 The peptide has known systemic effects, including vasodilatation, increase in urinary output, and sodium excretion, as well as inhibition of the sympathetic nervous system and the renin-angiotensin-aldosterone system. 3 BNP maintains hemodynamic and neurohormonal equilibrium by counterbalancing the vasoconstriction and retentive effects of sustained neurohormonal secretion. 2 Although it acts as a compensating mechanism to reduce preload and afterload, the increase in endogenous BNP is not sufficient to compensate for pressure and volume overload in disease states such as hypertension and heart failure. 1 Animal studies suggests that BNP expression antedates the development of hypertension. 4 Although circulating plasma BNP concentrations have been associated with blood pressure (BP) in cross-sectional human studies, there is limited information on the relations of BNP to longitudinal changes in BP and incident hypertension, specifically in African Americans. 5-11 The Jackson Heart Study (JHS) provides a unique opportunity to pursue this research question. We hypothesized that higher BNP concentrations will be associated positively with longitudinal changes in systolic and diastolic BPs and with a greater progression of BP stage and a higher incidence of hypertension in a community-based sample of African Americans. Methods The JHS is a longitudinal, observational cohort established in 2000 in part to prospectively investigate the role of environmental and genetic factors in the development of cardiovascular risk factors in an African American population. The base population was derived from a tricounty area that encompasses Jackson, MS (Hinds County, Madison County,

BMC Endocrine Disorders, Mar 4, 2020

Current developments in nutrition, Jul 1, 2023

BMC Public Health, Sep 28, 2010

Circulation, Mar 26, 2013

<jats:p> <jats:bold>Background:</jats:bold> In population studies leptin is dir... more <jats:p> <jats:bold>Background:</jats:bold> In population studies leptin is directly associated with coronary heart disease (CHD) and ischemic stroke, but leptin's proatherogenic properties in animal models are not clear. Opposite to leptin, adiponectin is atheroprotective in animal models but epidemiological investigations evaluating its role in cardiovascular disease (CVD) have been contradictory. Because the predictive significance of previously reported racial differences in adipokine levels remains unclear, we assessed the prospective association of the two adipokines with the risk of incident CVD events in African Americans (AA), known to have a high prevalence of cardiometabolic risk factors. </jats:p> <jats:p> <jats:bold>Methods:</jats:bold> Serum specimens from 5,108 AA Jackson Heart Study (JHS) participants without prevalent CVD at baseline examination (2000-2004) were analyzed by ELISA for adiponectin levels and by a radioimmunoassay method for leptin levels. Age-adjusted correlation coefficients and Cox proportional hazards regression models were used to estimate the associations of the two adipokines with incident CHD and incident ischemic stroke. </jats:p> <jats:p> <jats:bold>Results:</jats:bold> During 6.2 years average of follow-up, 164 incident CHD and 122 incident ischemic stroke events were documented. Among our study participants (63% women; mean age 54 ± 13 years), the mean (standard deviation, SD) was 6.14 (4.55) μg/mL in women and 4.19 (3.51) μg/mL in men for adiponectin and 37.54 (24.02) ng/mL in women and 11.30 (10.36) ng/mL in men for leptin. Adiponectin statistically significantly correlated with insulin resistance, as measured continuously by the homeostasis assessment model for insulin resistance, HOMA-IR (r = - 0.41 in women and r = - 0.30 in men) and with high-density lipoprotein cholesterol, HDL-cholesterol (r = 0.37 in women and r = 0.39 in men). Leptin significantly correlated with body mass index, BMI (r = 0.66 in women and r = 0.73 in men) and with HOMA-IR (r = 0.38 in women and r = 0.50 in men). After multivariate adjustment that included age, BMI, HDL-cholesterol, triglycerides, HOMA-IR, systolic blood pressure, hypertension medication, smoking and physical activity, adiponectin was marginally directly associated among women with incident CHD (HR = 1.27, 95% CI = 1.00 - 1.61 per 1 SD; p = 0.05), but not among men (p = 0.29). It was associated among women with incident stroke, HR = 1.36 (1.05 - 1.76) per 1 SD (p = 0.02), but not among men (p = 0.09). Leptin was not associated with incident CHD nor incident stroke. </jats:p> <jats:p> <jats:bold>Conclusion:</jats:bold> In the largest community-based cohort of African Americans, a higher adiponectin level was associated among women with a higher risk of incident stroke and marginally with a higher risk of incident coronary heart disease. Whether adiponectin harbors harmful properties, or it is produced in response to vascular inflammation to counter the atherosclerotic process, or the putative 'adiponectin resistance' phenomenon acts, should be further investigated. </jats:p>

Clinical Nutrition, Apr 1, 2021

Objective:To investigate the longitudinal association between magnesium (Mg) intake and the risk ... more Objective:To investigate the longitudinal association between magnesium (Mg) intake and the risk of metabolic syndrome (MetS).Methods:Poisson regression models with robust standard error estimation were used to examine the association between total Mg intake and the risk of MetS in 6,802 participants aged ≥45 years at baseline in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Dietary data were collected using the modified Block 98 food frequency questionnaire (FFQ) at baseline and incident MetS was diagnosed during follow-up if a participant had three or more of the five components of MetS based on the harmonized definition.Results:A total of 1,470 participants developed MetS during an average follow-up of 10 years. Comparing the highest quintile of total Mg intake (>437.9 mg/day) to the lowest group (<223.5 mg/day), total Mg intake had a significant inverse association with the risk of MetS [relative risk (RR) = 0.79 (0.63, 0.98), P trend = 0.043]. Dietary Mg intake was inversely associated with MetS [RR = 0.72 (0.56, 0.91), P trend = 0.006]. Adjusting for baseline components of MetS attenuated the associations, but the linear trends remained.Conclusion:The findings from this study indicate that dietary Mg intake was inversely associated with the risk of MetS. We recommend further studies to explain the underlying mechanisms of action.

International Journal of Cancer

BMC Public Health

Background This study aims to examine how the presence of chronic conditions or positive COVID-19... more Background This study aims to examine how the presence of chronic conditions or positive COVID-19 infection (as exposures) is related to food insecurity (as an outcome) in the older population and whether there is a dose–response relationship between the number of chronic conditions and the severity of food insecurity. Methods Cross-sectional data of 17,977 older adults (≥ 65 years) from the 2020–2021 National Health Interview Survey were analyzed. Chronic conditions included physical health conditions (i.e., arthritis, coronary heart diseases, hypertension, stroke, prediabetes, diabetes, asthma, chronic obstructive pulmonary disease, and disability) and mental health conditions (i.e., anxiety and depression disorder). COVID-19 infection status was determined by a self-reported diagnosis of COVID-19. Household food insecurity was measured using the 10-item US Department of Agriculture (USDA) Food Security Survey Module with a 30-day look-back window. Multinomial logistic regression ...

American Journal of Obstetrics and Gynecology

Journal of Affective Disorders

Repeatability and measurement error in the assessment of choline and betaine dietary intake: the ... more Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in