Putri Eyanoer | Universitas Sumatera Utara (original) (raw)

Papers by Putri Eyanoer

Research paper thumbnail of Testosterone and sexual function in menopausal women based on the Female Sexual Function Index (FSFI) score

Majalah Obstetri & Ginekologi

HIGHLIGHTS Testosterone level correlates with FSFI score, showing that sexual function correlates... more HIGHLIGHTS Testosterone level correlates with FSFI score, showing that sexual function correlates with hormonal physiology. FSFI is a valid and useful tool in measuring sexual function. ABSTRACT Objective: This research aimed to analyze the correlation between testosterone levels and sexual function in postmenopausal women. Materials and Methods: This research was a descriptive observational study with a case series approach conducted at Aras Kabu Health Center Outpatient Polyclinic from May to August 2022. The normality test was carried out using the Shapiro-Wilk test. If the data were not normally distributed, data would be analyzed using the Spearman correlation test. If the data were normally distributed, the data analysis would use the Pearson correlation test. Results: There was a significant relationship between Female Sexual Function Index (FSFI) score with testosterone levels and duration of menopause with p<0.05. The degree of correlation found was 0.619 between testo...

Research paper thumbnail of Effect of intra-arterial heparin flushing (IAHF) to prestin and vascular endothelial growth factor (VEGF) level in hearing loss patients

Pharmacia

Background: According to the World Health Organization (WHO), hearing loss is the fourth largest ... more Background: According to the World Health Organization (WHO), hearing loss is the fourth largest disability globally, affecting an estimated 466 million people in 2018. In Indonesia, the prevalence of hearing loss was estimated at 16.8% in 2016. Intra-Arterial Heparin Flushing (IAHF) is an endovascular technique that uses heparin to promote reperfusion and increases Vascular Endothelial Growth Factor (VEGF) expression. VEGF is a polypeptide angiogenesis factor present in the nervous system, which functions as a neurotrophic and neuroprotective. Meanwhile, prestin is a protein of outer ear hair cells that shows early signs of hearing loss through increased levels in cases of ear hair cell damage. Objective: This study aims to evaluate the effect of IAHF on prestin and VEGF levels in hearing-impaired patients. Methods: The design is experimental with Pre-Post Test One-Group Only. A total of 22 patients with hearing loss were measured for prestin and VEGF before and 4 hours after the I...

Research paper thumbnail of Association Between Serum Cytotoxic T Lymphocyte Antigen (CTLA)-4 Level and Disease Progression in Patients With Chronic Hepatitis B

Research paper thumbnail of Respiratory Emergency in Hospitalized patient with Intrathoracic Malignancy at H. Adam Malik General Hospital

Jurnal Respirologi Indonesia

Background: Increased number of intrathoracic malignancy cases (Lung tumor, Mediastinum tumor, Se... more Background: Increased number of intrathoracic malignancy cases (Lung tumor, Mediastinum tumor, Secondary lung cancer and Chest wall tumor) contribute in increased complications of respiratory emergencies such as superior cava vein yyndrome (scvs), massive malignant pleura effusion (mpe), central airway obstruction (cao), massive hemoptysis, lung thromboembolism and pneumothorax. This study aims to look at the proportions, outcomes, and factors that influence respiratory emergency in intrathoracic malignancy cases.Methods: This was a retrospective case series of inpatient respiratory emergencies in patients intrathoracic malignancy at H. Adam Malik Central General Hospital - Medan from 1 May 2011 to 30 April 2016.Results: From 690 subjects intrathoracic malignancy, there were 137 (19.8%) patients with respiratory emergencies and mostly caused by lung tumors (83.9%). Massive MPE was is the most common emergency of 45 cases (6.5%) and massive haemoptysis of at least 4 cases (0.6%). The...

Research paper thumbnail of Factors affecting HBV DNA suppression in chronic hepatitis B patients treated with tenofovir disoproxil fumarate

F1000Research

Background: This study aims to determine the factors affecting HBV DNA suppression in chronic hep... more Background: This study aims to determine the factors affecting HBV DNA suppression in chronic hepatitis B patients with tenofovir disoproxil fumarate (TDF). Methods: A case-control was carried out from October 2021 to August 2022 on 182 chronic hepatitis B patients who had TDF therapy regularly for 24 weeks at H. Adam Malik and USU Hospitals in Medan, Indonesia. The history of the samples was obtained, followed by physical examination, and blood collection. CTLA-4 polymorphism examination was carried out using real-time PCR, while the serum CTLA-4 levels were assessed with ELISA. Results: The results showed that CTLA-4, HBV DNA, ALT, and CTLA-4 -1661G>A polymorphisms have a relationship with HBV DNA suppression in chronic hepatitis B patients with TDF. Conclusions: The levels of CTLA-4, HBV DNA, ALT, and CTLA-4 -1661G>A polymorphism have a potential relationship with the suppression of HBV DNA in chronic hepatitis B patients with TDF.

Research paper thumbnail of Olive Polyphenol as Neuroprotective in Chronic Cervical Myelopathy Rabbit Model

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Olive polyphenols are known to be an anti-oxidants and anti-inflammatory agents. AIM:... more BACKGROUND: Olive polyphenols are known to be an anti-oxidants and anti-inflammatory agents. AIM: The purpose of this study was to determine the potential neuroprotective effect on chronic cervical myelopathy rabbit model. METHODS: This study was divided into six groups; control negative (Sham-Operated) group, control positive 1 and 2, treatment groups 1, 2, and 3. Olive leaf extract (OLE) gives 350 mg/kg BW and spinal cord sample was taken at the compression level C5. Histopathological assessment and immunohistochemistry of neurofilaments (NF), S-100, brain derived neurotrophic factor (BDNF), and evaluation of functional motoric outcome were done before animals were terminated. RESULTS: Chronic cervical myelopathy in rabbit model causes decreased expression of NF, S-100, BDNF, and decreased motor function. Oral administration of OLE increased the expression of these biomarkers and improved motor function outcomes. DISCUSSION: These findings indicate that OLE may be effective in pro...

Research paper thumbnail of Association of CYP2A6 Genetic Polymorphism and Lung Cancer in Female Never Smokers

Molecular and Cellular Biomedical Sciences

Background: The major significant factor that affected lung cancer development among female passi... more Background: The major significant factor that affected lung cancer development among female passive smokers is environmental tobacco smoke. Nicotine can be found in a never smoker population, such as a child whose father is a smoker. Lung carcinogenesis in never smoker populations is affected by nicotine metabolism by CYP2A6 gene, which encodes the main nicotine metabolizing-enzyme. The aim of this study was to assess the genetic polymorphism of CYP2A6 and its association with secondhand smokers among females who have suffered from lung cancer in North Sumatra population.Materials and methods: This study was a case-control study, composed of 53 case subjects and 46 control subjects that were involved through a purposive sampling technique from two hospitals in Medan. PCR-RFLP was used for the examination of CYP2A6 gene to determine the genotype. The data were analyzed with conditional logistic regression test using Epi Info 7.0 software.Results: The most common genotype of CYP2A6 de...

Research paper thumbnail of Premedikasi Atropin Tidak Mengurangi Sekret Dahak Selama Tindakan Bronkoskopi

Research paper thumbnail of Renal survival analysis of CAKUT and outcomes in chronic kidney disease

Current Pediatric Research, 2017

Background: The prevalence of ESRD has risen rapidly worldwide due to congenital anomalies of the... more Background: The prevalence of ESRD has risen rapidly worldwide due to congenital anomalies of the kidney and urinary tract (CAKUT). In the developing countries, these abnormalities could be delay in diagnosed, and treatment. The aim of this study was to analyzed renal survival patients of CAKUT and outcomes in chronic kidney disease. Methods: In this cohort study, 53 CAKUT patients were followed up. Clinical end points were censored on 31st September, 2017. ESRD or death was assigned as a dependent variable. Renal survival was measured from the date of patient chronological ages to the date of initiation of renal dialysis or to the date of ?rst eGFR <15 ml/min per 1.73 m2 (stage 5) or death secondary to renal causes. Results: The frequency of renal diagnosis based on CAKUT abnormalities are 38 in obstructive type and 15 in non obstructive type. Mean age for obstructive type was 8.9 ± 4.42 years and for non obstructive type 9.92 ± 2.42 years. Mean basal glomerular filtration rate ...

Research paper thumbnail of Hubungan rinitis alergi dan disfungsi tuba Eustachius dengan menggunakan timpanometri

Oto Rhino Laryngologica Indonesiana, 2013

Latar belakang: Rinitis alergi merupakan masalah kesehatan global dengan prevalensi yang terusmen... more Latar belakang: Rinitis alergi merupakan masalah kesehatan global dengan prevalensi yang terusmeningkat serta dapat berdampak pada penurunan kualitas hidup penderitanya. Ko-morbiditas rinitis alergi salahsatunya adalah otitis media yang sangat erat hubungannya dengan gangguan fungsi tuba Eustachius yangberkaitan dengan tekanan telinga tengah. Tujuan: Mengetahui hubungan rinitis alergi dengan disfungsi tubaEustachius dengan menggunakan timpanometri. Metode: Satu studi kasus-kontrol. Disfungsi tuba ditentukandengan pemeriksaan timpanometri (MEP negatif/

Research paper thumbnail of Korelasi ekspresi Cyclooxygenase-2 (COX-2) dan TNF-α sebagai mediator cancer-related inflammation pada karsinoma nasofaring

Oto Rhino Laryngologica Indonesiana, 2014

Latar belakang: Karsinoma nasofaring (KNF) adalah suatu karsinoma sel skuamosa yang berasal dari ... more Latar belakang: Karsinoma nasofaring (KNF) adalah suatu karsinoma sel skuamosa yang berasal dari sel epitel nasofaring. Cyclooxygenase (COX) merupakan enzim pada jalur biosintetik dari prostaglandin, tromboksan dan prostasiklin dari asam arakhidonat. Ekspresi seluler COX-2 meningkat di atas normal pada stadium awal karsinogenesis dan selama perkembangan serta pertumbuhan invasif tumor. TNF-α diperlukan untuk proliferasi dan fungsi yang normal dari NK cells, sel T, sel B, makrofag dan sel dendrit. Akan tetapi bukti yang terbarumenunjukkan bahwa TNF-α merupakan suatu mediator utama pada cancer-related inflammation dan juga berperan sebagai tumour-promoting factor.Tujuan: Untuk mengetahui ekspresi COX-2 dan TNF-α sebagai mediator cancer-related inflammation pada KNF. Metode: Penelitian ini bersifat deskriptif secara cross sectional design dengan 30 sampel dilakukan di RSUP. H. Adam Malik Medan. Ekspresi COX-2 dan TNF-α pada KNF diperiksa dengan immunohistokimia. Hasil: Dengan menggunak...

Research paper thumbnail of Prevalence of recurrent urinary tract infection in children with congenital anomalies of the kidney and urinary tract (CAKUT)

IOP Conference Series: Earth and Environmental Science, 2018

View the article online for updates and enhancements. Content from this work may be used under th... more View the article online for updates and enhancements. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.

Research paper thumbnail of Positive correlation between retinol binding protein 4 (RBP4) and triglyceride level in central obesity

IOP Conference Series: Earth and Environmental Science, 2018

Obesity has become an epidemic in both developed and developing countries. Central obesity consid... more Obesity has become an epidemic in both developed and developing countries. Central obesity considered a risk factor that is closely related to several chronic diseases. Central obesity is associated with elevated triglyceride levels and associated with RBP4 which can lead to insulin resistance. Increased level of RBP4 can cause lipid metabolism disorders and can become a marker for insulin resistance and metabolic syndrome. This study aims to find the correlation of RBP4 with triglycerides and Apo B100 in central obesity. It was a crosssectional study on 46 subjects with central obesity, aged 20-50 years old. Blood samples were taken in cubital vein and examined for RBP4 and triglyceride levels. Data analysis was performed using Spearman correlation test. The results showed that gender frequency distribution showed little difference between men and women, i.e., men 43.5% and women 56.5%. RBP4 level was positively correlated with triglyceride (r = 0.48) and statistically significant (p = 0.001). The rbp4 level was positively correlated with triglyceride, indicating the role of RBP4 on high triglyceride level in central obesity.

Research paper thumbnail of Cellulitis as complication of nephrotic syndrome in a pediatric patient

IOP Conference Series: Earth and Environmental Science, 2018

Nephrotic syndrome is a chronic disease that may act as a risk for other major infection in skin,... more Nephrotic syndrome is a chronic disease that may act as a risk for other major infection in skin, respiratory and urinary tract, while also increasingthe chance for other diseases, like peritonitis, meningitis, and cellulitis. Cellulitis is often caused by Streptococcus β-hemolytic, Staphylococcus aureus, and Escherichia coli. The clinical features of cellulitis marked with redness rash and well-defined borders, pain pressure and swelling. Hypoalbuminemia which occurs due to proteinuria occurred in this patient acts as a risk factor for cellulitis. It has been reported the case of cellulitis as one of the complications of the nephrotic syndrome in the pediatric patient. The treatment has been given to the patient such as antibiotics and supportive therapy and also planned albumin substitution.

Research paper thumbnail of Talenta

Journal of Physics: Conference Series, 2018

Talenta is not the talent, but it has been declared the abbreviation of: Tropical science and med... more Talenta is not the talent, but it has been declared the abbreviation of: Tropical science and medicine, Agroindustry, Local wisdom, Energy, Natural resources, Technology and Arts. They directly involve science, technology and arts, and so it becomes a talent. However, there is no specific explanation so that science, technology and art to focus on the content of Talenta. This paper defines Talenta in order for the study to be focused in accordance with the interests of the development of appropriate knowledge, i.e. a clearly articulated definition.

Research paper thumbnail of Correlation of Ceramic Dust Content in Workplace with Lung Function in Ceramics Industry Workers of X Company, Mabar, Medan

Jurnal Respirologi Indonesia

Background: Workers in the ceramics industry are often exposed to silica content which is unwitti... more Background: Workers in the ceramics industry are often exposed to silica content which is unwittingly inhaled and deposited in the lungs. Macrophages will release Interleukin 8 (IL-8), a chemoattractant that causes neutrophil recruitment to the alveoli and releases proteolytic enzymes that damage the lung parenchyma and cause a decrease in lung function. This study aimed to determine whether dust level correlate with IL-8 serum in ceramic industry workers. Method: This research is an analytic study with a cross-sectional design conducted in March–June 2019 in the X Ceramic Industry in Mabar, Medan. Personal Dust Sampler was used to measure dust level of the study subjects at work sites. Lung function was measured by spirometry. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) software. Results: A total of 35 male workers were divided into 3 working sections, 11 (31.4%) in the pre-compression section, 13 (37.1%) in the compression section an...

Research paper thumbnail of The Effect of Long-Acting Beta-2 Agonist Monotherapy and Long-Acting Anticholinergic Monotherapy to Quality-of-Life in Group B Stable COPD Patients

Jurnal Respirologi Indonesia

Background: Based on the 2019 Global Initiative for Chronic Obstructive Lung Disease (GOLD), trea... more Background: Based on the 2019 Global Initiative for Chronic Obstructive Lung Disease (GOLD), treatment for group B stable COPD patients is a long-acting beta-2 agonist (LABA) or long-acting anticholinergic (LAMA). Some studies experienced that LAMA was better than LABA but the opposite was also found in several studies. COPD patients often experience a decline in physical activity which causes a decrease in quality of life. We aimed to compare the effect of LABA or LAMA on quality of life in group B stable COPD patients.Methods: This was a study with case series design conducted on 50 COPD patients divided into two groups. The first group consisted of patients who used LABA for at least 3 months. The second group used LAMA for at least 3 months. All subjects filled in the SGRQ. The calculation of SGRQ was carried out using Microsoft Excel Calculator SGRQ.Results: A total 41 men and 9 women were enrolled in this study. There was no significant difference between the use of indacatero...

Research paper thumbnail of A-DROP Scoring System in Predicting Mortality within 30 Days of Hospitalization in Community-acquired Pneumonia Patients at H. Adam Malik General Hospital Medan

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Community-acquired pneumonia (CAP) is the leading cause of death among infectious dis... more BACKGROUND: Community-acquired pneumonia (CAP) is the leading cause of death among infectious diseases, contributing significantly to patient morbidity and mortality. Therefore, an accurate initial assessment of CAP severity should be performed immediately to determine the prognosis before starting the management. A-DROP scoring system is one of the initial assessments. AIM: This study aimed to determine the accuracy of the A-DROP scoring system in predicting mortality within 30 days of hospitalization at H. Adam Malik General Hospital Medan. METHODS: This is an observational study with a retrospective and cohort study. Data were obtained from the medical records of 76 CAP patients hospitalized from January 2018 to December 2018. Each patient was assessed with an A-DROP scoring system and the presence or absence of mortality within 30 days of hospitalization. The data were processed using statistical analysis to calculate the area under curve (AUC) on the receiver operating characte...

Research paper thumbnail of Effectiveness of Upper Limb Exercises and Breathing Exercises in COPD Stable Patients During COVID-19 Pandemic Era

Advances in Respiratory Medicine

Introduction: The objectives of study are to study and to evaluate the benefits and effectiveness... more Introduction: The objectives of study are to study and to evaluate the benefits and effectiveness of home-based pulmonary rehabilitation in compliance with Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2020 nonpharmacological initiative for Chronic Obstructive Pulmonary Disease (COPD). Material and Methods: This study was a quasi-experiment conducted from August to November 2020 involving 10 COPD stable patients. In the first meeting at the hospital, patients were taught breathing techniques and upper-limb exercise movements which subsequently had to be done and recorded at home. Patients then sent the videos to the research team via whatsapp to be evaluated. Prior to starting the 4-week with twice-a-week frequency home-based rehabilitation, and again at the end of it, patients’ conditions were evaluated based on the following factors: lung functional capacity was measured by 6MWD (6 Minutes Walking Distance), Perceived Exertion Scale by mMRC (modified Medical Resear...

Research paper thumbnail of CT Guided TTNA and Core Biopsy in Suspected Lung Cancer, Review of Cases in Adam Malik General Hospital, Medan

Respiratory Science, 2021

ounds: The cytological and histopathological findings establish the type of lung cancer cells as ... more ounds: The cytological and histopathological findings establish the type of lung cancer cells as the definitive diagnosis of lung cancer. This study aimed to determine the characteristics of lung cancer patients in terms of age, mean age, gender, staging, the proportion of lung cancer cells by cytologic examination of Transthoracic Needle Aspiration (TTNA) and histopathologic evaluation from CT-guided core biopsy. Method: This is a descriptive study involving 42 subjects diagnosed with lung cancer at H. Adam Malik Hospital Medan in 2016-2020 that met the inclusion criteria through consecutive sampling. Data was analysed using descriptive statistics for categorical variables. Results: Of 42 study subjects, the 60–71-year age group had the highest percentage of lung cancer (42.9%). Male (71.4%) was higher than female, the most common lung cancer staging was IVA (57.1%), and adenocarcinoma was found to be the most frequent type of lung cancer in both cytology (33.3%) and histopathology...

Research paper thumbnail of Testosterone and sexual function in menopausal women based on the Female Sexual Function Index (FSFI) score

Majalah Obstetri & Ginekologi

HIGHLIGHTS Testosterone level correlates with FSFI score, showing that sexual function correlates... more HIGHLIGHTS Testosterone level correlates with FSFI score, showing that sexual function correlates with hormonal physiology. FSFI is a valid and useful tool in measuring sexual function. ABSTRACT Objective: This research aimed to analyze the correlation between testosterone levels and sexual function in postmenopausal women. Materials and Methods: This research was a descriptive observational study with a case series approach conducted at Aras Kabu Health Center Outpatient Polyclinic from May to August 2022. The normality test was carried out using the Shapiro-Wilk test. If the data were not normally distributed, data would be analyzed using the Spearman correlation test. If the data were normally distributed, the data analysis would use the Pearson correlation test. Results: There was a significant relationship between Female Sexual Function Index (FSFI) score with testosterone levels and duration of menopause with p<0.05. The degree of correlation found was 0.619 between testo...

Research paper thumbnail of Effect of intra-arterial heparin flushing (IAHF) to prestin and vascular endothelial growth factor (VEGF) level in hearing loss patients

Pharmacia

Background: According to the World Health Organization (WHO), hearing loss is the fourth largest ... more Background: According to the World Health Organization (WHO), hearing loss is the fourth largest disability globally, affecting an estimated 466 million people in 2018. In Indonesia, the prevalence of hearing loss was estimated at 16.8% in 2016. Intra-Arterial Heparin Flushing (IAHF) is an endovascular technique that uses heparin to promote reperfusion and increases Vascular Endothelial Growth Factor (VEGF) expression. VEGF is a polypeptide angiogenesis factor present in the nervous system, which functions as a neurotrophic and neuroprotective. Meanwhile, prestin is a protein of outer ear hair cells that shows early signs of hearing loss through increased levels in cases of ear hair cell damage. Objective: This study aims to evaluate the effect of IAHF on prestin and VEGF levels in hearing-impaired patients. Methods: The design is experimental with Pre-Post Test One-Group Only. A total of 22 patients with hearing loss were measured for prestin and VEGF before and 4 hours after the I...

Research paper thumbnail of Association Between Serum Cytotoxic T Lymphocyte Antigen (CTLA)-4 Level and Disease Progression in Patients With Chronic Hepatitis B

Research paper thumbnail of Respiratory Emergency in Hospitalized patient with Intrathoracic Malignancy at H. Adam Malik General Hospital

Jurnal Respirologi Indonesia

Background: Increased number of intrathoracic malignancy cases (Lung tumor, Mediastinum tumor, Se... more Background: Increased number of intrathoracic malignancy cases (Lung tumor, Mediastinum tumor, Secondary lung cancer and Chest wall tumor) contribute in increased complications of respiratory emergencies such as superior cava vein yyndrome (scvs), massive malignant pleura effusion (mpe), central airway obstruction (cao), massive hemoptysis, lung thromboembolism and pneumothorax. This study aims to look at the proportions, outcomes, and factors that influence respiratory emergency in intrathoracic malignancy cases.Methods: This was a retrospective case series of inpatient respiratory emergencies in patients intrathoracic malignancy at H. Adam Malik Central General Hospital - Medan from 1 May 2011 to 30 April 2016.Results: From 690 subjects intrathoracic malignancy, there were 137 (19.8%) patients with respiratory emergencies and mostly caused by lung tumors (83.9%). Massive MPE was is the most common emergency of 45 cases (6.5%) and massive haemoptysis of at least 4 cases (0.6%). The...

Research paper thumbnail of Factors affecting HBV DNA suppression in chronic hepatitis B patients treated with tenofovir disoproxil fumarate

F1000Research

Background: This study aims to determine the factors affecting HBV DNA suppression in chronic hep... more Background: This study aims to determine the factors affecting HBV DNA suppression in chronic hepatitis B patients with tenofovir disoproxil fumarate (TDF). Methods: A case-control was carried out from October 2021 to August 2022 on 182 chronic hepatitis B patients who had TDF therapy regularly for 24 weeks at H. Adam Malik and USU Hospitals in Medan, Indonesia. The history of the samples was obtained, followed by physical examination, and blood collection. CTLA-4 polymorphism examination was carried out using real-time PCR, while the serum CTLA-4 levels were assessed with ELISA. Results: The results showed that CTLA-4, HBV DNA, ALT, and CTLA-4 -1661G>A polymorphisms have a relationship with HBV DNA suppression in chronic hepatitis B patients with TDF. Conclusions: The levels of CTLA-4, HBV DNA, ALT, and CTLA-4 -1661G>A polymorphism have a potential relationship with the suppression of HBV DNA in chronic hepatitis B patients with TDF.

Research paper thumbnail of Olive Polyphenol as Neuroprotective in Chronic Cervical Myelopathy Rabbit Model

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Olive polyphenols are known to be an anti-oxidants and anti-inflammatory agents. AIM:... more BACKGROUND: Olive polyphenols are known to be an anti-oxidants and anti-inflammatory agents. AIM: The purpose of this study was to determine the potential neuroprotective effect on chronic cervical myelopathy rabbit model. METHODS: This study was divided into six groups; control negative (Sham-Operated) group, control positive 1 and 2, treatment groups 1, 2, and 3. Olive leaf extract (OLE) gives 350 mg/kg BW and spinal cord sample was taken at the compression level C5. Histopathological assessment and immunohistochemistry of neurofilaments (NF), S-100, brain derived neurotrophic factor (BDNF), and evaluation of functional motoric outcome were done before animals were terminated. RESULTS: Chronic cervical myelopathy in rabbit model causes decreased expression of NF, S-100, BDNF, and decreased motor function. Oral administration of OLE increased the expression of these biomarkers and improved motor function outcomes. DISCUSSION: These findings indicate that OLE may be effective in pro...

Research paper thumbnail of Association of CYP2A6 Genetic Polymorphism and Lung Cancer in Female Never Smokers

Molecular and Cellular Biomedical Sciences

Background: The major significant factor that affected lung cancer development among female passi... more Background: The major significant factor that affected lung cancer development among female passive smokers is environmental tobacco smoke. Nicotine can be found in a never smoker population, such as a child whose father is a smoker. Lung carcinogenesis in never smoker populations is affected by nicotine metabolism by CYP2A6 gene, which encodes the main nicotine metabolizing-enzyme. The aim of this study was to assess the genetic polymorphism of CYP2A6 and its association with secondhand smokers among females who have suffered from lung cancer in North Sumatra population.Materials and methods: This study was a case-control study, composed of 53 case subjects and 46 control subjects that were involved through a purposive sampling technique from two hospitals in Medan. PCR-RFLP was used for the examination of CYP2A6 gene to determine the genotype. The data were analyzed with conditional logistic regression test using Epi Info 7.0 software.Results: The most common genotype of CYP2A6 de...

Research paper thumbnail of Premedikasi Atropin Tidak Mengurangi Sekret Dahak Selama Tindakan Bronkoskopi

Research paper thumbnail of Renal survival analysis of CAKUT and outcomes in chronic kidney disease

Current Pediatric Research, 2017

Background: The prevalence of ESRD has risen rapidly worldwide due to congenital anomalies of the... more Background: The prevalence of ESRD has risen rapidly worldwide due to congenital anomalies of the kidney and urinary tract (CAKUT). In the developing countries, these abnormalities could be delay in diagnosed, and treatment. The aim of this study was to analyzed renal survival patients of CAKUT and outcomes in chronic kidney disease. Methods: In this cohort study, 53 CAKUT patients were followed up. Clinical end points were censored on 31st September, 2017. ESRD or death was assigned as a dependent variable. Renal survival was measured from the date of patient chronological ages to the date of initiation of renal dialysis or to the date of ?rst eGFR <15 ml/min per 1.73 m2 (stage 5) or death secondary to renal causes. Results: The frequency of renal diagnosis based on CAKUT abnormalities are 38 in obstructive type and 15 in non obstructive type. Mean age for obstructive type was 8.9 ± 4.42 years and for non obstructive type 9.92 ± 2.42 years. Mean basal glomerular filtration rate ...

Research paper thumbnail of Hubungan rinitis alergi dan disfungsi tuba Eustachius dengan menggunakan timpanometri

Oto Rhino Laryngologica Indonesiana, 2013

Latar belakang: Rinitis alergi merupakan masalah kesehatan global dengan prevalensi yang terusmen... more Latar belakang: Rinitis alergi merupakan masalah kesehatan global dengan prevalensi yang terusmeningkat serta dapat berdampak pada penurunan kualitas hidup penderitanya. Ko-morbiditas rinitis alergi salahsatunya adalah otitis media yang sangat erat hubungannya dengan gangguan fungsi tuba Eustachius yangberkaitan dengan tekanan telinga tengah. Tujuan: Mengetahui hubungan rinitis alergi dengan disfungsi tubaEustachius dengan menggunakan timpanometri. Metode: Satu studi kasus-kontrol. Disfungsi tuba ditentukandengan pemeriksaan timpanometri (MEP negatif/

Research paper thumbnail of Korelasi ekspresi Cyclooxygenase-2 (COX-2) dan TNF-α sebagai mediator cancer-related inflammation pada karsinoma nasofaring

Oto Rhino Laryngologica Indonesiana, 2014

Latar belakang: Karsinoma nasofaring (KNF) adalah suatu karsinoma sel skuamosa yang berasal dari ... more Latar belakang: Karsinoma nasofaring (KNF) adalah suatu karsinoma sel skuamosa yang berasal dari sel epitel nasofaring. Cyclooxygenase (COX) merupakan enzim pada jalur biosintetik dari prostaglandin, tromboksan dan prostasiklin dari asam arakhidonat. Ekspresi seluler COX-2 meningkat di atas normal pada stadium awal karsinogenesis dan selama perkembangan serta pertumbuhan invasif tumor. TNF-α diperlukan untuk proliferasi dan fungsi yang normal dari NK cells, sel T, sel B, makrofag dan sel dendrit. Akan tetapi bukti yang terbarumenunjukkan bahwa TNF-α merupakan suatu mediator utama pada cancer-related inflammation dan juga berperan sebagai tumour-promoting factor.Tujuan: Untuk mengetahui ekspresi COX-2 dan TNF-α sebagai mediator cancer-related inflammation pada KNF. Metode: Penelitian ini bersifat deskriptif secara cross sectional design dengan 30 sampel dilakukan di RSUP. H. Adam Malik Medan. Ekspresi COX-2 dan TNF-α pada KNF diperiksa dengan immunohistokimia. Hasil: Dengan menggunak...

Research paper thumbnail of Prevalence of recurrent urinary tract infection in children with congenital anomalies of the kidney and urinary tract (CAKUT)

IOP Conference Series: Earth and Environmental Science, 2018

View the article online for updates and enhancements. Content from this work may be used under th... more View the article online for updates and enhancements. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.

Research paper thumbnail of Positive correlation between retinol binding protein 4 (RBP4) and triglyceride level in central obesity

IOP Conference Series: Earth and Environmental Science, 2018

Obesity has become an epidemic in both developed and developing countries. Central obesity consid... more Obesity has become an epidemic in both developed and developing countries. Central obesity considered a risk factor that is closely related to several chronic diseases. Central obesity is associated with elevated triglyceride levels and associated with RBP4 which can lead to insulin resistance. Increased level of RBP4 can cause lipid metabolism disorders and can become a marker for insulin resistance and metabolic syndrome. This study aims to find the correlation of RBP4 with triglycerides and Apo B100 in central obesity. It was a crosssectional study on 46 subjects with central obesity, aged 20-50 years old. Blood samples were taken in cubital vein and examined for RBP4 and triglyceride levels. Data analysis was performed using Spearman correlation test. The results showed that gender frequency distribution showed little difference between men and women, i.e., men 43.5% and women 56.5%. RBP4 level was positively correlated with triglyceride (r = 0.48) and statistically significant (p = 0.001). The rbp4 level was positively correlated with triglyceride, indicating the role of RBP4 on high triglyceride level in central obesity.

Research paper thumbnail of Cellulitis as complication of nephrotic syndrome in a pediatric patient

IOP Conference Series: Earth and Environmental Science, 2018

Nephrotic syndrome is a chronic disease that may act as a risk for other major infection in skin,... more Nephrotic syndrome is a chronic disease that may act as a risk for other major infection in skin, respiratory and urinary tract, while also increasingthe chance for other diseases, like peritonitis, meningitis, and cellulitis. Cellulitis is often caused by Streptococcus β-hemolytic, Staphylococcus aureus, and Escherichia coli. The clinical features of cellulitis marked with redness rash and well-defined borders, pain pressure and swelling. Hypoalbuminemia which occurs due to proteinuria occurred in this patient acts as a risk factor for cellulitis. It has been reported the case of cellulitis as one of the complications of the nephrotic syndrome in the pediatric patient. The treatment has been given to the patient such as antibiotics and supportive therapy and also planned albumin substitution.

Research paper thumbnail of Talenta

Journal of Physics: Conference Series, 2018

Talenta is not the talent, but it has been declared the abbreviation of: Tropical science and med... more Talenta is not the talent, but it has been declared the abbreviation of: Tropical science and medicine, Agroindustry, Local wisdom, Energy, Natural resources, Technology and Arts. They directly involve science, technology and arts, and so it becomes a talent. However, there is no specific explanation so that science, technology and art to focus on the content of Talenta. This paper defines Talenta in order for the study to be focused in accordance with the interests of the development of appropriate knowledge, i.e. a clearly articulated definition.

Research paper thumbnail of Correlation of Ceramic Dust Content in Workplace with Lung Function in Ceramics Industry Workers of X Company, Mabar, Medan

Jurnal Respirologi Indonesia

Background: Workers in the ceramics industry are often exposed to silica content which is unwitti... more Background: Workers in the ceramics industry are often exposed to silica content which is unwittingly inhaled and deposited in the lungs. Macrophages will release Interleukin 8 (IL-8), a chemoattractant that causes neutrophil recruitment to the alveoli and releases proteolytic enzymes that damage the lung parenchyma and cause a decrease in lung function. This study aimed to determine whether dust level correlate with IL-8 serum in ceramic industry workers. Method: This research is an analytic study with a cross-sectional design conducted in March–June 2019 in the X Ceramic Industry in Mabar, Medan. Personal Dust Sampler was used to measure dust level of the study subjects at work sites. Lung function was measured by spirometry. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) software. Results: A total of 35 male workers were divided into 3 working sections, 11 (31.4%) in the pre-compression section, 13 (37.1%) in the compression section an...

Research paper thumbnail of The Effect of Long-Acting Beta-2 Agonist Monotherapy and Long-Acting Anticholinergic Monotherapy to Quality-of-Life in Group B Stable COPD Patients

Jurnal Respirologi Indonesia

Background: Based on the 2019 Global Initiative for Chronic Obstructive Lung Disease (GOLD), trea... more Background: Based on the 2019 Global Initiative for Chronic Obstructive Lung Disease (GOLD), treatment for group B stable COPD patients is a long-acting beta-2 agonist (LABA) or long-acting anticholinergic (LAMA). Some studies experienced that LAMA was better than LABA but the opposite was also found in several studies. COPD patients often experience a decline in physical activity which causes a decrease in quality of life. We aimed to compare the effect of LABA or LAMA on quality of life in group B stable COPD patients.Methods: This was a study with case series design conducted on 50 COPD patients divided into two groups. The first group consisted of patients who used LABA for at least 3 months. The second group used LAMA for at least 3 months. All subjects filled in the SGRQ. The calculation of SGRQ was carried out using Microsoft Excel Calculator SGRQ.Results: A total 41 men and 9 women were enrolled in this study. There was no significant difference between the use of indacatero...

Research paper thumbnail of A-DROP Scoring System in Predicting Mortality within 30 Days of Hospitalization in Community-acquired Pneumonia Patients at H. Adam Malik General Hospital Medan

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Community-acquired pneumonia (CAP) is the leading cause of death among infectious dis... more BACKGROUND: Community-acquired pneumonia (CAP) is the leading cause of death among infectious diseases, contributing significantly to patient morbidity and mortality. Therefore, an accurate initial assessment of CAP severity should be performed immediately to determine the prognosis before starting the management. A-DROP scoring system is one of the initial assessments. AIM: This study aimed to determine the accuracy of the A-DROP scoring system in predicting mortality within 30 days of hospitalization at H. Adam Malik General Hospital Medan. METHODS: This is an observational study with a retrospective and cohort study. Data were obtained from the medical records of 76 CAP patients hospitalized from January 2018 to December 2018. Each patient was assessed with an A-DROP scoring system and the presence or absence of mortality within 30 days of hospitalization. The data were processed using statistical analysis to calculate the area under curve (AUC) on the receiver operating characte...

Research paper thumbnail of Effectiveness of Upper Limb Exercises and Breathing Exercises in COPD Stable Patients During COVID-19 Pandemic Era

Advances in Respiratory Medicine

Introduction: The objectives of study are to study and to evaluate the benefits and effectiveness... more Introduction: The objectives of study are to study and to evaluate the benefits and effectiveness of home-based pulmonary rehabilitation in compliance with Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2020 nonpharmacological initiative for Chronic Obstructive Pulmonary Disease (COPD). Material and Methods: This study was a quasi-experiment conducted from August to November 2020 involving 10 COPD stable patients. In the first meeting at the hospital, patients were taught breathing techniques and upper-limb exercise movements which subsequently had to be done and recorded at home. Patients then sent the videos to the research team via whatsapp to be evaluated. Prior to starting the 4-week with twice-a-week frequency home-based rehabilitation, and again at the end of it, patients’ conditions were evaluated based on the following factors: lung functional capacity was measured by 6MWD (6 Minutes Walking Distance), Perceived Exertion Scale by mMRC (modified Medical Resear...

Research paper thumbnail of CT Guided TTNA and Core Biopsy in Suspected Lung Cancer, Review of Cases in Adam Malik General Hospital, Medan

Respiratory Science, 2021

ounds: The cytological and histopathological findings establish the type of lung cancer cells as ... more ounds: The cytological and histopathological findings establish the type of lung cancer cells as the definitive diagnosis of lung cancer. This study aimed to determine the characteristics of lung cancer patients in terms of age, mean age, gender, staging, the proportion of lung cancer cells by cytologic examination of Transthoracic Needle Aspiration (TTNA) and histopathologic evaluation from CT-guided core biopsy. Method: This is a descriptive study involving 42 subjects diagnosed with lung cancer at H. Adam Malik Hospital Medan in 2016-2020 that met the inclusion criteria through consecutive sampling. Data was analysed using descriptive statistics for categorical variables. Results: Of 42 study subjects, the 60–71-year age group had the highest percentage of lung cancer (42.9%). Male (71.4%) was higher than female, the most common lung cancer staging was IVA (57.1%), and adenocarcinoma was found to be the most frequent type of lung cancer in both cytology (33.3%) and histopathology...