Sergio Cortés | Instituto Politécnico Nacional (original) (raw)
Papers by Sergio Cortés
Journal of the Chemical Society, Dalton Transactions, 1992
A non-cyclic tetraazatricarboxylate ligand, tris (4-carboxy-3-methyl-3-azabutyl) amine (H 3 L), d... more A non-cyclic tetraazatricarboxylate ligand, tris (4-carboxy-3-methyl-3-azabutyl) amine (H 3 L), derived from tris (2-aminoethyl) amine, was synthesised and purified. Its macroscopic and microscopic protonation behaviour was studied using potentiometry and proton NMR ...
Journal of the Chemical Society, Dalton Transactions, 1992
A non-cyclic tetraazatricarboxylate ligand, tris (4-carboxy-3-methyl-3-azabutyl) amine (H 3 L), d... more A non-cyclic tetraazatricarboxylate ligand, tris (4-carboxy-3-methyl-3-azabutyl) amine (H 3 L), derived from tris (2-aminoethyl) amine, was synthesised and purified. Its macroscopic and microscopic protonation behaviour was studied using potentiometry and proton NMR ...
Journal of The Chemical Society-perkin Transactions 2, 1991
... Carlos FGC Geraldes, * A. Dean Sherry,b M. Paula M. Marques,a M. Carmen Alpoima and Sergio C... more ... Carlos FGC Geraldes, * A. Dean Sherry,b M. Paula M. Marques,a M. Carmen Alpoima and Sergio Cortesb a Chemistry Department, University of Coimbra, 3000 Coimbra, Portugal Chemistry Department, University of Texas at Dallas, PO Box 830688, Richardson, Texas 75083 ...
Journal of The Chemical Society-perkin Transactions 2, 1991
... Carlos FGC Geraldes, * A. Dean Sherry,b M. Paula M. Marques,a M. Carmen Alpoima and Sergio C... more ... Carlos FGC Geraldes, * A. Dean Sherry,b M. Paula M. Marques,a M. Carmen Alpoima and Sergio Cortesb a Chemistry Department, University of Coimbra, 3000 Coimbra, Portugal Chemistry Department, University of Texas at Dallas, PO Box 830688, Richardson, Texas 75083 ...
Journal of the Chemical Society, Dalton Transactions, 1992
A non-cyclic tetraazatricarboxylate ligand, tris (4-carboxy-3-methyl-3-azabutyl) amine (H 3 L), d... more A non-cyclic tetraazatricarboxylate ligand, tris (4-carboxy-3-methyl-3-azabutyl) amine (H 3 L), derived from tris (2-aminoethyl) amine, was synthesised and purified. Its macroscopic and microscopic protonation behaviour was studied using potentiometry and proton NMR ...
Journal of The Chemical Society-perkin Transactions 2, 1991
... Carlos FGC Geraldes, * A. Dean Sherry,b M. Paula M. Marques,a M. Carmen Alpoima and Sergio C... more ... Carlos FGC Geraldes, * A. Dean Sherry,b M. Paula M. Marques,a M. Carmen Alpoima and Sergio Cortesb a Chemistry Department, University of Coimbra, 3000 Coimbra, Portugal Chemistry Department, University of Texas at Dallas, PO Box 830688, Richardson, Texas 75083 ...
Journal of Organic Chemistry, 1991
... SOC. 1982,104,4037-4044. (b) Pierce, J.; Serianni, A. S.; Barker, R. J. Am. Chem. SOC. ... Co... more ... SOC. 1982,104,4037-4044. (b) Pierce, J.; Serianni, A. S.; Barker, R. J. Am. Chem. SOC. ... Conformational Effects in Cyclic and Acyclic Dilit hiated Hydrocarbons Stephanie D. Meyer, Nancy S. Mills,* Joy B. Runnels, Barbara de la Torre, C. Channing Ruud, and David K. Johnson ...
Journal of Organic Chemistry, 1990
Journal of Organic Chemistry, 1983
N3-Substituted hydantoins (1) have been shown to undergo LM 4 reduction (THF, room temperature, 2... more N3-Substituted hydantoins (1) have been shown to undergo LM 4 reduction (THF, room temperature, 2 days) to give 4-hydroxy-2-imidazolidinones (3) in good yields. Reduction of 3, Ci-disubstituted hydantoins in which an aliphatic substituent was present at nitrogen 3 ...
Journal of Medicinal Chemistry, 1985
Selectively substituted hydantoins 1 (15 examples), 4-hydroxy-2-imidazolidinones 2 (13 examples),... more Selectively substituted hydantoins 1 (15 examples), 4-hydroxy-2-imidazolidinones 2 (13 examples), 2-imidazolones 3 (10 examples), 2-imidazolidinones 4 (four examples), vicinal diamines 5 (two examples), and simple amino acid derivatives 6 (four examples) have been prepared and evaluated in the maximal electroshock seizure (MES), subcutaneous pentylenetetrazole seizure threshold (sc Met), and rotorod (Tox) tests. The medium effective doses (ED50) and the medium toxic dose (TD50) for the most active compounds are reported. In general, the most pronounced activity was observed for hydantoins 1 and protected amino acids 6. Within each series of compounds, enhanced anticonvulsant activity was often noted for compounds containing an aromatic group one carbon removed from a nitrogen atom. Among the most active compounds observed were the amino acid derivative N-acetyl-D,L-alanine benzylamide (6d) and the two 2-imidazolones 4-methyl-1-(phenylmethyl)-1,3-dihydro-2H-imidazol-2-one (3e) and 1-phenyl-1,3-dihydro-2H-imidazol-2-one (3g). Compound 6d proved to be slightly more potent in the MES test than phenacemide.
The Journal of Organic Chemistry, 1983
Journal of the Chemical Society, Dalton Transactions, 1992
A non-cyclic tetraazatricarboxylate ligand, tris (4-carboxy-3-methyl-3-azabutyl) amine (H 3 L), d... more A non-cyclic tetraazatricarboxylate ligand, tris (4-carboxy-3-methyl-3-azabutyl) amine (H 3 L), derived from tris (2-aminoethyl) amine, was synthesised and purified. Its macroscopic and microscopic protonation behaviour was studied using potentiometry and proton NMR ...
Journal of the Chemical Society, Dalton Transactions, 1992
A non-cyclic tetraazatricarboxylate ligand, tris (4-carboxy-3-methyl-3-azabutyl) amine (H 3 L), d... more A non-cyclic tetraazatricarboxylate ligand, tris (4-carboxy-3-methyl-3-azabutyl) amine (H 3 L), derived from tris (2-aminoethyl) amine, was synthesised and purified. Its macroscopic and microscopic protonation behaviour was studied using potentiometry and proton NMR ...
Journal of The Chemical Society-perkin Transactions 2, 1991
... Carlos FGC Geraldes, * A. Dean Sherry,b M. Paula M. Marques,a M. Carmen Alpoima and Sergio C... more ... Carlos FGC Geraldes, * A. Dean Sherry,b M. Paula M. Marques,a M. Carmen Alpoima and Sergio Cortesb a Chemistry Department, University of Coimbra, 3000 Coimbra, Portugal Chemistry Department, University of Texas at Dallas, PO Box 830688, Richardson, Texas 75083 ...
Journal of The Chemical Society-perkin Transactions 2, 1991
... Carlos FGC Geraldes, * A. Dean Sherry,b M. Paula M. Marques,a M. Carmen Alpoima and Sergio C... more ... Carlos FGC Geraldes, * A. Dean Sherry,b M. Paula M. Marques,a M. Carmen Alpoima and Sergio Cortesb a Chemistry Department, University of Coimbra, 3000 Coimbra, Portugal Chemistry Department, University of Texas at Dallas, PO Box 830688, Richardson, Texas 75083 ...
Journal of the Chemical Society, Dalton Transactions, 1992
A non-cyclic tetraazatricarboxylate ligand, tris (4-carboxy-3-methyl-3-azabutyl) amine (H 3 L), d... more A non-cyclic tetraazatricarboxylate ligand, tris (4-carboxy-3-methyl-3-azabutyl) amine (H 3 L), derived from tris (2-aminoethyl) amine, was synthesised and purified. Its macroscopic and microscopic protonation behaviour was studied using potentiometry and proton NMR ...
Journal of The Chemical Society-perkin Transactions 2, 1991
... Carlos FGC Geraldes, * A. Dean Sherry,b M. Paula M. Marques,a M. Carmen Alpoima and Sergio C... more ... Carlos FGC Geraldes, * A. Dean Sherry,b M. Paula M. Marques,a M. Carmen Alpoima and Sergio Cortesb a Chemistry Department, University of Coimbra, 3000 Coimbra, Portugal Chemistry Department, University of Texas at Dallas, PO Box 830688, Richardson, Texas 75083 ...
Journal of Organic Chemistry, 1991
... SOC. 1982,104,4037-4044. (b) Pierce, J.; Serianni, A. S.; Barker, R. J. Am. Chem. SOC. ... Co... more ... SOC. 1982,104,4037-4044. (b) Pierce, J.; Serianni, A. S.; Barker, R. J. Am. Chem. SOC. ... Conformational Effects in Cyclic and Acyclic Dilit hiated Hydrocarbons Stephanie D. Meyer, Nancy S. Mills,* Joy B. Runnels, Barbara de la Torre, C. Channing Ruud, and David K. Johnson ...
Journal of Organic Chemistry, 1990
Journal of Organic Chemistry, 1983
N3-Substituted hydantoins (1) have been shown to undergo LM 4 reduction (THF, room temperature, 2... more N3-Substituted hydantoins (1) have been shown to undergo LM 4 reduction (THF, room temperature, 2 days) to give 4-hydroxy-2-imidazolidinones (3) in good yields. Reduction of 3, Ci-disubstituted hydantoins in which an aliphatic substituent was present at nitrogen 3 ...
Journal of Medicinal Chemistry, 1985
Selectively substituted hydantoins 1 (15 examples), 4-hydroxy-2-imidazolidinones 2 (13 examples),... more Selectively substituted hydantoins 1 (15 examples), 4-hydroxy-2-imidazolidinones 2 (13 examples), 2-imidazolones 3 (10 examples), 2-imidazolidinones 4 (four examples), vicinal diamines 5 (two examples), and simple amino acid derivatives 6 (four examples) have been prepared and evaluated in the maximal electroshock seizure (MES), subcutaneous pentylenetetrazole seizure threshold (sc Met), and rotorod (Tox) tests. The medium effective doses (ED50) and the medium toxic dose (TD50) for the most active compounds are reported. In general, the most pronounced activity was observed for hydantoins 1 and protected amino acids 6. Within each series of compounds, enhanced anticonvulsant activity was often noted for compounds containing an aromatic group one carbon removed from a nitrogen atom. Among the most active compounds observed were the amino acid derivative N-acetyl-D,L-alanine benzylamide (6d) and the two 2-imidazolones 4-methyl-1-(phenylmethyl)-1,3-dihydro-2H-imidazol-2-one (3e) and 1-phenyl-1,3-dihydro-2H-imidazol-2-one (3g). Compound 6d proved to be slightly more potent in the MES test than phenacemide.
The Journal of Organic Chemistry, 1983