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Research paper thumbnail of The Prevalence of HIV and its Associated Factors among Prisoners of Central Prison, Larkana, Pakistan

Zenodo (CERN European Organization for Nuclear Research), Jan 11, 2023

Introduction: HIV/AIDS is one of the major worldwide health problems affecting inmates and a sign... more Introduction: HIV/AIDS is one of the major worldwide health problems affecting inmates and a significant concern for government, public health services and prison administration services. The aim of our study was to determine the prevalence of HIV infection among prisoners and its associated factors. Material and Methods: A descriptive cross-sectional study was carried out among prisoners of Central Prison, Larkana, Pakistan from August 2019 to December 2019. A total number of Seven hundred and eighty-three (N = 783) prisoners were invited to participate. Data were collected by means of the pre-designed and pilot tested study questionnaire and were entered in SPSS version 21 for analysis. Results: Out of 783 participants initially invited to the study, six hundred (N = 600) of whom fulfilled the criteria. The screening and questionnaire response rate was 81%. During screening three prisoners were found to be HIV positive. Among prisoners, 220 (36.7%) were drug users, 19 (8.6%) used an injectable form of drug, while 506 (84.3%) had never used condoms during the sex. The prevalence of this study was 1.00% Conclusion: The study revealed the need to educate prisoners for prevention and care measures in prisons. Further studies are needed to observe the situation in other part of the country.

Research paper thumbnail of Needle Stick Injuries: Awareness and Practices of Precautionary Measures Among Health Care Workers of Public and Private Hospitals in Pakistan

Introduction: Needle stick injuries (NSIs) is the most frequently occurring accidental injuries i... more Introduction: Needle stick injuries (NSIs) is the most frequently occurring accidental injuries in the health care settings resulting from the penetration of contaminated syringes or sharps that may expose health care workers (HCWs) to serious life threatening illnesses. NSIs are amongst the most common occupational hazards and potential source of transmission of to more than 20 fatal blood borne infections including Hepatitis B&C and HIV etc. Objectives: To ascertain the awareness of HCWs regarding needle stick injuries in public and private sector hospitals as well as to compare this awareness in both public and private sector healthcare facilities. Material and Methods: The study was a cross sectional survey conducted in public and private sector hospitals in Hyderabad, Pakistan from October 2018 to March 2019. HCWs include; nursing staff, midwives, Operation Theater and Intensive care unit technicians were invited. Data was collected using written questionnaire designed specifically for this study. Questions related to the participant's knowledge of NSIs and its precautionary measures as well as their routine practices during their routine duties were included. Results: Two hundred HCWs participated in this study. Most (53%) of them were from private sector hospital while majority (36%) of them belongs to age group 28 to 37 years. Half of them (53%) were aware of NSIs while almost two third of them knew about the diseases spread by NSIs. Moreover, 53% of them were aware of the precautionary measures of NSIs. Majority (27%) of HCWs from public hospitals believe that during medication, most of NSIs occur in comparison with private hospital participants where majority (23%) thinks that breaking and discarding needles with bare hands most frequently cause NSIs. Majority (53%) of them not use tray to keep syringes while majority (58%) do not use needle cutter for disposing used needles. There was a statistically significant difference p value < 0.05 in awareness level of HCWs in public and private sector hospitals. Conclusion: Prevalence of NSI was high among the nursing staff in both health sectors. Low awareness level was demonstrated among the HCWs of public sector hospital. There was a significant difference in awareness related to knowledge and precautionary measures of NSIs between public and private sector hospitals.

Research paper thumbnail of The Status Epilepticus in Adults: Results from a Tertiary Care Teaching Hospital in Karachi, Pakistan

Bangladesh Journal of Medical Science

Background: Status epilepticus is one of the common neurological emergencies associated healthcar... more Background: Status epilepticus is one of the common neurological emergencies associated healthcare costs, morbidity and mortality worldwide. The prevalence is more in extreme ages, in adults as well as in children. However, it can occur at any age. Aim: The aim of this study was to determine the possible causes and outcomes of status epilepticus in adults. Method: Across-sectional study was conducted in the department of Neurology, at Jinnah Postgraduate Medical College, Karachi during January 2015 to March 2016. All patients of either gender between 18-60 years of age diagnosed for status epilepticus, presented within 24 hours of their first episode of status epilepticus were included in the study. Patients were examined for the assessment of nature, type and presence or absence of precipitating factors (noncompliance, systemic infection, head trauma and central nervous system infections). Data was entered and analyzed by using SPSS version 19.0. Results: A total number of 241 pati...

Research paper thumbnail of Internet Use and Its Addiction Among Medical Students in Hyderabad, Pakistan

Journal of Islamabad Medical & Dental College

Background: With the advances in information and technology, internet addiction appears as a seri... more Background: With the advances in information and technology, internet addiction appears as a serious obsessive condition that has numerous dreadful effects on human physical and mental health. The objective of the study was to determine the level of internet addiction among medical undergraduate students of Isra University, Hyderabad. Methods: A cross-sectional survey was conducted at the Isra University, Hyderabad from August to December 2019. All medical (MBBS) undergraduate students of either sex were included. A stratified sampling technique was used for the selection of participants. A structured 5-point Likert scale questionnaire for the internet addiction test was adopted from Dr. Kimberly Young and used for the collection of participant’s information and measurement of their level of addiction. Results: A total of 263 undergraduate medical students participated in the study. The majority (56.65%) were males while 51.71% were from the age group 21-22 years. Over two-thirds (8...

Research paper thumbnail of Nephroprotective Effects of L-Arginine against Chemotherapy Induced Acute Kidney Injury in Wistar Rats

Background: L-arginine is a nitric oxide precursor that decreases oxidative stress and regulates ... more Background: L-arginine is a nitric oxide precursor that decreases oxidative stress and regulates the blood flow by modifying the tone of vessels and also prevent ischemic renal tissue injuries. The objective of this study was to evaluate the protective role of L-arginine in cisplatin-induced acute renal injury through assessment of renal, oxidative stress, and inflammatory markers in albino Wistar rats. Material and Methods: A quasi-experimental study was conducted at the Department of Physiology and Postgraduate Research Laboratory, Isra University, Hyderabad, Pakistan from April to September 2019. Thirty male Albino Wistar rats were selected through non-random purposive sampling and divided equally into three different groups: Group A (control group), Group B (cisplatin group), and Group C (cisplatin plus arginine group). Blood samples from rats were collected through cardiac puncture, followed by renal histopathological analysis under light microscope. The severity of tissue dama...

Research paper thumbnail of Socio-demographic risk factors for hemorrhagic and ischemic stroke: a study in tertiary care hospital of hyderabad

Pakistan Journal of Neurological Sciences, 2016

Background: Stroke is a common neurological disorder and major cause of death and disability worl... more Background: Stroke is a common neurological disorder and major cause of death and disability worldwide. Stroke is a second leading cause of death after cancer and ischemic heart disease. Incidence of stroke has not been well studied in Pakistan but it is estimated that 350,000 cases of stroke occur per year. Objective: To determine the frequencies and Socio-demographic features of Hemorrhagic and Ischemic strokes among stroke patients in tertiary care hospital.Material & method:This cross-sectional study was carried out at department of medicine Liaquat university hospital Hyderabad from June to September 2010, Patients were included in study according to inclusion and exclusion criteria. A data was collected on pre-designed proforma and data was analyzed according to study design.Results: Out of 261 included stroke patients, 54% were males and 46% were female patients. The mean age of patients was 54.7 years. In 172 patients (66%) had Ischemic stroke whereas 89 (34%) patients had hemorrhagic stroke noted in this study. The high proportion of patients (36.4%) were between i.e., 55-64 years, Most of them (79%) were married, only 8% were unmarried and 13% were widowed, divorced or separated. In this study (67.0%) patients of both sexes were illiterate, Positive family history of stroke was noted in 24.5% patients. Regarding Stroke types 66% had Ischemic and 34% had hemorrhagic stroke. Incidence of Ischemic stroke was more in females (70.8%) and hemorrhagic stroke was more in males (38.3%).CONCLUSION: This study on socio demographic factors of stroke patients is the effort by which we would be able to take appropriate preventive measures to create awareness about stroke. In future more extensive surveys should be conducted to get knowledge about the effects of demographic and other factors on the onset of stroke.

Research paper thumbnail of Clinical, hormonal and metabolic factors associated with polycystic ovary syndrome among Pakistani women

Rawal Medical Journal, 2020

Objective: To evaluate the clinical, hormonal and metabolic factors associated with polycystic ov... more Objective: To evaluate the clinical, hormonal and metabolic factors associated with polycystic ovary syndrome (PCOS) among women in tertiary care hospital in Hyderabad, Pakistan. Methodology: This cross-sectional study was carried out at the Nazeer Hussain Medical Complex, Hyderabad from December 2018 to May 2019. Participants were selected using non-probability purposive sampling technique. Females between 16-40 years with or without history of PCOS and menstrual irregularities like Oligomenorrhea, Polymenorrhea, Amenorrhea, etc. were included in the study. Females on oral-contraceptives >4 weeks, insulin-sensitizing agents or hormonal therapy >2 weeks, history of other disorders (gynecological, thyroid etc.) were excluded. Anthropometric, clinical, hormonal and biochemical parameters were measured for all participants. Chi-square and student t-tests were used to analyze the data using SPSS version 23. Results: Study has 200 patients with mean age of 29.23±4.12 years. The pre...

Research paper thumbnail of The novel role of resveratrol in attenuating cisplatin induced testicular toxicity in rats

To evaluate the anti-oxidative role of Resveratrol in Cisplatin-induced testicular toxicity in Al... more To evaluate the anti-oxidative role of Resveratrol in Cisplatin-induced testicular toxicity in Albino Wistar rats.

Research paper thumbnail of Socio-Demographic Differences in Distribution of Risk Factors for Hemorrhagic and Ischemic Stroke in a Tertiary Care Hospital

Research paper thumbnail of The Prevalence of HIV and its Associated Factors among Prisoners of Central Prison, Larkana, Pakistan

Zenodo (CERN European Organization for Nuclear Research), Jan 11, 2023

Introduction: HIV/AIDS is one of the major worldwide health problems affecting inmates and a sign... more Introduction: HIV/AIDS is one of the major worldwide health problems affecting inmates and a significant concern for government, public health services and prison administration services. The aim of our study was to determine the prevalence of HIV infection among prisoners and its associated factors. Material and Methods: A descriptive cross-sectional study was carried out among prisoners of Central Prison, Larkana, Pakistan from August 2019 to December 2019. A total number of Seven hundred and eighty-three (N = 783) prisoners were invited to participate. Data were collected by means of the pre-designed and pilot tested study questionnaire and were entered in SPSS version 21 for analysis. Results: Out of 783 participants initially invited to the study, six hundred (N = 600) of whom fulfilled the criteria. The screening and questionnaire response rate was 81%. During screening three prisoners were found to be HIV positive. Among prisoners, 220 (36.7%) were drug users, 19 (8.6%) used an injectable form of drug, while 506 (84.3%) had never used condoms during the sex. The prevalence of this study was 1.00% Conclusion: The study revealed the need to educate prisoners for prevention and care measures in prisons. Further studies are needed to observe the situation in other part of the country.

Research paper thumbnail of Needle Stick Injuries: Awareness and Practices of Precautionary Measures Among Health Care Workers of Public and Private Hospitals in Pakistan

Introduction: Needle stick injuries (NSIs) is the most frequently occurring accidental injuries i... more Introduction: Needle stick injuries (NSIs) is the most frequently occurring accidental injuries in the health care settings resulting from the penetration of contaminated syringes or sharps that may expose health care workers (HCWs) to serious life threatening illnesses. NSIs are amongst the most common occupational hazards and potential source of transmission of to more than 20 fatal blood borne infections including Hepatitis B&C and HIV etc. Objectives: To ascertain the awareness of HCWs regarding needle stick injuries in public and private sector hospitals as well as to compare this awareness in both public and private sector healthcare facilities. Material and Methods: The study was a cross sectional survey conducted in public and private sector hospitals in Hyderabad, Pakistan from October 2018 to March 2019. HCWs include; nursing staff, midwives, Operation Theater and Intensive care unit technicians were invited. Data was collected using written questionnaire designed specifically for this study. Questions related to the participant's knowledge of NSIs and its precautionary measures as well as their routine practices during their routine duties were included. Results: Two hundred HCWs participated in this study. Most (53%) of them were from private sector hospital while majority (36%) of them belongs to age group 28 to 37 years. Half of them (53%) were aware of NSIs while almost two third of them knew about the diseases spread by NSIs. Moreover, 53% of them were aware of the precautionary measures of NSIs. Majority (27%) of HCWs from public hospitals believe that during medication, most of NSIs occur in comparison with private hospital participants where majority (23%) thinks that breaking and discarding needles with bare hands most frequently cause NSIs. Majority (53%) of them not use tray to keep syringes while majority (58%) do not use needle cutter for disposing used needles. There was a statistically significant difference p value < 0.05 in awareness level of HCWs in public and private sector hospitals. Conclusion: Prevalence of NSI was high among the nursing staff in both health sectors. Low awareness level was demonstrated among the HCWs of public sector hospital. There was a significant difference in awareness related to knowledge and precautionary measures of NSIs between public and private sector hospitals.

Research paper thumbnail of The Status Epilepticus in Adults: Results from a Tertiary Care Teaching Hospital in Karachi, Pakistan

Bangladesh Journal of Medical Science

Background: Status epilepticus is one of the common neurological emergencies associated healthcar... more Background: Status epilepticus is one of the common neurological emergencies associated healthcare costs, morbidity and mortality worldwide. The prevalence is more in extreme ages, in adults as well as in children. However, it can occur at any age. Aim: The aim of this study was to determine the possible causes and outcomes of status epilepticus in adults. Method: Across-sectional study was conducted in the department of Neurology, at Jinnah Postgraduate Medical College, Karachi during January 2015 to March 2016. All patients of either gender between 18-60 years of age diagnosed for status epilepticus, presented within 24 hours of their first episode of status epilepticus were included in the study. Patients were examined for the assessment of nature, type and presence or absence of precipitating factors (noncompliance, systemic infection, head trauma and central nervous system infections). Data was entered and analyzed by using SPSS version 19.0. Results: A total number of 241 pati...

Research paper thumbnail of Internet Use and Its Addiction Among Medical Students in Hyderabad, Pakistan

Journal of Islamabad Medical & Dental College

Background: With the advances in information and technology, internet addiction appears as a seri... more Background: With the advances in information and technology, internet addiction appears as a serious obsessive condition that has numerous dreadful effects on human physical and mental health. The objective of the study was to determine the level of internet addiction among medical undergraduate students of Isra University, Hyderabad. Methods: A cross-sectional survey was conducted at the Isra University, Hyderabad from August to December 2019. All medical (MBBS) undergraduate students of either sex were included. A stratified sampling technique was used for the selection of participants. A structured 5-point Likert scale questionnaire for the internet addiction test was adopted from Dr. Kimberly Young and used for the collection of participant’s information and measurement of their level of addiction. Results: A total of 263 undergraduate medical students participated in the study. The majority (56.65%) were males while 51.71% were from the age group 21-22 years. Over two-thirds (8...

Research paper thumbnail of Nephroprotective Effects of L-Arginine against Chemotherapy Induced Acute Kidney Injury in Wistar Rats

Background: L-arginine is a nitric oxide precursor that decreases oxidative stress and regulates ... more Background: L-arginine is a nitric oxide precursor that decreases oxidative stress and regulates the blood flow by modifying the tone of vessels and also prevent ischemic renal tissue injuries. The objective of this study was to evaluate the protective role of L-arginine in cisplatin-induced acute renal injury through assessment of renal, oxidative stress, and inflammatory markers in albino Wistar rats. Material and Methods: A quasi-experimental study was conducted at the Department of Physiology and Postgraduate Research Laboratory, Isra University, Hyderabad, Pakistan from April to September 2019. Thirty male Albino Wistar rats were selected through non-random purposive sampling and divided equally into three different groups: Group A (control group), Group B (cisplatin group), and Group C (cisplatin plus arginine group). Blood samples from rats were collected through cardiac puncture, followed by renal histopathological analysis under light microscope. The severity of tissue dama...

Research paper thumbnail of Socio-demographic risk factors for hemorrhagic and ischemic stroke: a study in tertiary care hospital of hyderabad

Pakistan Journal of Neurological Sciences, 2016

Background: Stroke is a common neurological disorder and major cause of death and disability worl... more Background: Stroke is a common neurological disorder and major cause of death and disability worldwide. Stroke is a second leading cause of death after cancer and ischemic heart disease. Incidence of stroke has not been well studied in Pakistan but it is estimated that 350,000 cases of stroke occur per year. Objective: To determine the frequencies and Socio-demographic features of Hemorrhagic and Ischemic strokes among stroke patients in tertiary care hospital.Material & method:This cross-sectional study was carried out at department of medicine Liaquat university hospital Hyderabad from June to September 2010, Patients were included in study according to inclusion and exclusion criteria. A data was collected on pre-designed proforma and data was analyzed according to study design.Results: Out of 261 included stroke patients, 54% were males and 46% were female patients. The mean age of patients was 54.7 years. In 172 patients (66%) had Ischemic stroke whereas 89 (34%) patients had hemorrhagic stroke noted in this study. The high proportion of patients (36.4%) were between i.e., 55-64 years, Most of them (79%) were married, only 8% were unmarried and 13% were widowed, divorced or separated. In this study (67.0%) patients of both sexes were illiterate, Positive family history of stroke was noted in 24.5% patients. Regarding Stroke types 66% had Ischemic and 34% had hemorrhagic stroke. Incidence of Ischemic stroke was more in females (70.8%) and hemorrhagic stroke was more in males (38.3%).CONCLUSION: This study on socio demographic factors of stroke patients is the effort by which we would be able to take appropriate preventive measures to create awareness about stroke. In future more extensive surveys should be conducted to get knowledge about the effects of demographic and other factors on the onset of stroke.

Research paper thumbnail of Clinical, hormonal and metabolic factors associated with polycystic ovary syndrome among Pakistani women

Rawal Medical Journal, 2020

Objective: To evaluate the clinical, hormonal and metabolic factors associated with polycystic ov... more Objective: To evaluate the clinical, hormonal and metabolic factors associated with polycystic ovary syndrome (PCOS) among women in tertiary care hospital in Hyderabad, Pakistan. Methodology: This cross-sectional study was carried out at the Nazeer Hussain Medical Complex, Hyderabad from December 2018 to May 2019. Participants were selected using non-probability purposive sampling technique. Females between 16-40 years with or without history of PCOS and menstrual irregularities like Oligomenorrhea, Polymenorrhea, Amenorrhea, etc. were included in the study. Females on oral-contraceptives >4 weeks, insulin-sensitizing agents or hormonal therapy >2 weeks, history of other disorders (gynecological, thyroid etc.) were excluded. Anthropometric, clinical, hormonal and biochemical parameters were measured for all participants. Chi-square and student t-tests were used to analyze the data using SPSS version 23. Results: Study has 200 patients with mean age of 29.23±4.12 years. The pre...

Research paper thumbnail of The novel role of resveratrol in attenuating cisplatin induced testicular toxicity in rats

To evaluate the anti-oxidative role of Resveratrol in Cisplatin-induced testicular toxicity in Al... more To evaluate the anti-oxidative role of Resveratrol in Cisplatin-induced testicular toxicity in Albino Wistar rats.

Research paper thumbnail of Socio-Demographic Differences in Distribution of Risk Factors for Hemorrhagic and Ischemic Stroke in a Tertiary Care Hospital