Mehmet Baris Baslo | Istanbul University (original) (raw)

Papers by Mehmet Baris Baslo

Research paper thumbnail of 63. Decline of compound muscle action potentials and estimated motor unit numbers during wallerian degeneration

Research paper thumbnail of Abnormal Neuromuscular Transmission in Cluster Headache

Headache: The Journal of Head and Face Pain, 2003

To identify and investigate any dysfunction of neuromuscular transmission in episodic cluster hea... more To identify and investigate any dysfunction of neuromuscular transmission in episodic cluster headache. Abnormal neuromuscular transmission has been shown in migraine with aura and in migraine without aura by using single fiber electromyography. Especially for migraine with aura, a genetic cause has been postulated. Episodic cluster headache is a primary headache disorder in which genetic factors may, at times, play a strong role. Single fiber electromyography during voluntary contraction of the extensor digitorum communis muscle, nerve conduction studies of upper and lower extremities, and concentric needle electromyography of the extensor digitorum communis were performed on 6 patients with episodic cluster headache and 6 age-matched normal controls. Twenty potential pairs were recorded from each subject. Twenty individual jitter values and a mean jitter value were calculated for each subject. Both mean individual jitter values and numbers of abnormal individual jitter values were compared in patients with cluster headache versus normal controls. Three of 6 patients with episodic cluster headache showed pronounced neuromuscular transmission abnormalities by single fiber electromyography. None of the controls had any neuromuscular transmission abnormality. Another patient with episodic cluster headache had borderline dysfunction of neuromuscular transmission. Transmission was clearly normal in only 2 of 6 patients with cluster headache. These results suggest that episodic cluster headache may share the same abnormality of neuromuscular transmission observed in migraine.

Research paper thumbnail of 63. Decline of compound muscle action potentials and estimated motor unit numbers during wallerian degeneration

Clinical Neurophysiology, 2008

Research paper thumbnail of Reference voluntary jitter values using disposable monopolar needle electrodes in the extensor digitorum communis muscle

Clinical Neurophysiology, 2010

To measure normal variability in neuromuscular transmission in the extensor digitorum communis (E... more To measure normal variability in neuromuscular transmission in the extensor digitorum communis (EDC) muscle voluntarily activated using a disposable monopolar needle electrode (MNPE). We examined the EDC muscle using MNPE in 50 healthy volunteers (12 male and 38 female, mean age: 41.5+/-12.9 years, age range: 18-74 years). The high-pass filter setting was 3 kHz. Jitter values are expressed as the mean consecutive difference (MCD) of 20 potential pairs. Mean MCD (n=50) was 21.3+/-3 micros (upper 95% confidence limit (CL): 27.3 micros). Mean MCD in all potential pairs (n=1000) was 21.3+/-6.6 micros (upper 95% CL: 34 micros). Mean MCD for the 18th highest value was 28+/-4.7 micros (upper 95% CL: 37.5 micros). The suggested practical upper limit for mean MCD was set to 28 micros; for outliers it was 38 micros. The present study defines the normative value for jitter recorded with disposable MNPE, which is a low-cost alternative for the evaluation of neuromuscular transmission, although certain precautions must be taken.

Research paper thumbnail of Investigation of neuromuscular transmission in some rare types of migraine

Research paper thumbnail of Evaluation of neuromuscular transmission by using monopolar needle electrode

Acta Neurologica Scandinavica, 2006

Objective: To evaluate the value of single-fibre electromyography (SFEMG) with monopolar electrod... more Objective: To evaluate the value of single-fibre electromyography (SFEMG) with monopolar electrode (MNPE) in revealing neuromuscular transmission dysfunction. Material and methods: We examined the extensor digitorum communis muscle by using singlefibre electrode (SFE) and MNPE sequentially, in randomly assigned 20 healthy volunteers and in 17 patients with known myasthenia gravis (MG). The high-pass filter setting was 3 kHz for MNPE. Ten individual jitter values were calculated for each electrode in every muscle. Repetitive nerve stimulation (RNS) test on trapezius muscle was performed on 15 patients. Results: In controls, the mean jitter values were 27 AE 9 (10-59) ls with SFE, and 21 AE 7.2 (9-56) ls with MNPE (P ¼ 0.001). In the MG group, the mean jitter values were 52.4 AE 38 (12-221) ls with SFE, and 51.8 AE 34.7 (12-179) ls with MNPE. Both electrodes identified junction dysfunction in 14 patients. RNS revealed decrement in four patients but 11. Conclusion: SFEMG with SFE is still the gold standard; however, SFEMG with MNPE is superior to RNS like SFEMG with SFE.

Research paper thumbnail of Surface stimulation single-fiber electromyography in myasthenia gravis

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2002

Surface stimulation for single-fiber electromyography has been proposed previously as a novel tec... more Surface stimulation for single-fiber electromyography has been proposed previously as a novel technique based on a study performed on healthy subjects. The current study was designed to determine the diagnostic value of surface stimulation single-fiber electromyography in patients with myasthenia gravis. Ten patients with myasthenia gravis were recruited for the study. Surface stimulation of the facial nerve trunk, as well as extramuscular needle stimulation of its zygomatic branch was performed. Twenty single-fiber potentials were recorded from the orbicularis oculi muscle for each stimulation type in each patient. For both stimulation techniques, mean jitter values and the total number of abnormal individual junctions were found to be abnormally high. Jitter values obtained by surface stimulation were comparable with those obtained by needle stimulation.

Research paper thumbnail of 63. Decline of compound muscle action potentials and estimated motor unit numbers during wallerian degeneration

Research paper thumbnail of Abnormal Neuromuscular Transmission in Cluster Headache

Headache: The Journal of Head and Face Pain, 2003

To identify and investigate any dysfunction of neuromuscular transmission in episodic cluster hea... more To identify and investigate any dysfunction of neuromuscular transmission in episodic cluster headache. Abnormal neuromuscular transmission has been shown in migraine with aura and in migraine without aura by using single fiber electromyography. Especially for migraine with aura, a genetic cause has been postulated. Episodic cluster headache is a primary headache disorder in which genetic factors may, at times, play a strong role. Single fiber electromyography during voluntary contraction of the extensor digitorum communis muscle, nerve conduction studies of upper and lower extremities, and concentric needle electromyography of the extensor digitorum communis were performed on 6 patients with episodic cluster headache and 6 age-matched normal controls. Twenty potential pairs were recorded from each subject. Twenty individual jitter values and a mean jitter value were calculated for each subject. Both mean individual jitter values and numbers of abnormal individual jitter values were compared in patients with cluster headache versus normal controls. Three of 6 patients with episodic cluster headache showed pronounced neuromuscular transmission abnormalities by single fiber electromyography. None of the controls had any neuromuscular transmission abnormality. Another patient with episodic cluster headache had borderline dysfunction of neuromuscular transmission. Transmission was clearly normal in only 2 of 6 patients with cluster headache. These results suggest that episodic cluster headache may share the same abnormality of neuromuscular transmission observed in migraine.

Research paper thumbnail of 63. Decline of compound muscle action potentials and estimated motor unit numbers during wallerian degeneration

Clinical Neurophysiology, 2008

Research paper thumbnail of Reference voluntary jitter values using disposable monopolar needle electrodes in the extensor digitorum communis muscle

Clinical Neurophysiology, 2010

To measure normal variability in neuromuscular transmission in the extensor digitorum communis (E... more To measure normal variability in neuromuscular transmission in the extensor digitorum communis (EDC) muscle voluntarily activated using a disposable monopolar needle electrode (MNPE). We examined the EDC muscle using MNPE in 50 healthy volunteers (12 male and 38 female, mean age: 41.5+/-12.9 years, age range: 18-74 years). The high-pass filter setting was 3 kHz. Jitter values are expressed as the mean consecutive difference (MCD) of 20 potential pairs. Mean MCD (n=50) was 21.3+/-3 micros (upper 95% confidence limit (CL): 27.3 micros). Mean MCD in all potential pairs (n=1000) was 21.3+/-6.6 micros (upper 95% CL: 34 micros). Mean MCD for the 18th highest value was 28+/-4.7 micros (upper 95% CL: 37.5 micros). The suggested practical upper limit for mean MCD was set to 28 micros; for outliers it was 38 micros. The present study defines the normative value for jitter recorded with disposable MNPE, which is a low-cost alternative for the evaluation of neuromuscular transmission, although certain precautions must be taken.

Research paper thumbnail of Investigation of neuromuscular transmission in some rare types of migraine

Research paper thumbnail of Evaluation of neuromuscular transmission by using monopolar needle electrode

Acta Neurologica Scandinavica, 2006

Objective: To evaluate the value of single-fibre electromyography (SFEMG) with monopolar electrod... more Objective: To evaluate the value of single-fibre electromyography (SFEMG) with monopolar electrode (MNPE) in revealing neuromuscular transmission dysfunction. Material and methods: We examined the extensor digitorum communis muscle by using singlefibre electrode (SFE) and MNPE sequentially, in randomly assigned 20 healthy volunteers and in 17 patients with known myasthenia gravis (MG). The high-pass filter setting was 3 kHz for MNPE. Ten individual jitter values were calculated for each electrode in every muscle. Repetitive nerve stimulation (RNS) test on trapezius muscle was performed on 15 patients. Results: In controls, the mean jitter values were 27 AE 9 (10-59) ls with SFE, and 21 AE 7.2 (9-56) ls with MNPE (P ¼ 0.001). In the MG group, the mean jitter values were 52.4 AE 38 (12-221) ls with SFE, and 51.8 AE 34.7 (12-179) ls with MNPE. Both electrodes identified junction dysfunction in 14 patients. RNS revealed decrement in four patients but 11. Conclusion: SFEMG with SFE is still the gold standard; however, SFEMG with MNPE is superior to RNS like SFEMG with SFE.

Research paper thumbnail of Surface stimulation single-fiber electromyography in myasthenia gravis

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2002

Surface stimulation for single-fiber electromyography has been proposed previously as a novel tec... more Surface stimulation for single-fiber electromyography has been proposed previously as a novel technique based on a study performed on healthy subjects. The current study was designed to determine the diagnostic value of surface stimulation single-fiber electromyography in patients with myasthenia gravis. Ten patients with myasthenia gravis were recruited for the study. Surface stimulation of the facial nerve trunk, as well as extramuscular needle stimulation of its zygomatic branch was performed. Twenty single-fiber potentials were recorded from the orbicularis oculi muscle for each stimulation type in each patient. For both stimulation techniques, mean jitter values and the total number of abnormal individual junctions were found to be abnormally high. Jitter values obtained by surface stimulation were comparable with those obtained by needle stimulation.