RUMEYSA TUTAR | Istanbul University (original) (raw)

Papers by RUMEYSA TUTAR

Journal of Materials Chemistry B, 2022

Herein, we developed a photocurable silk fibroin-based ocular tissue adhesive with enhanced adhes... more Herein, we developed a photocurable silk fibroin-based ocular tissue adhesive with enhanced adhesive features.

Journal of Biomedical Materials Research Part A, Jan 31, 2022

The desired organ in micro‐tissue models of organ‐on‐a‐chip (OoC) devices dictates the optimum bi... more The desired organ in micro‐tissue models of organ‐on‐a‐chip (OoC) devices dictates the optimum biomaterials, divided into natural and synthetic biomaterials. They can resemble biological tissues' biological functions and architectures by constructing bioactivity of macromolecules, cells, nanoparticles, and other biological agents. The inclusion of such components in OoCs allows them having biological processes, such as basic biorecognition, enzymatic cleavage, and regulated drug release. In this report, we review natural‐based biomaterials that are used in OoCs and their main characteristics. We address the preparation, modification, and characterization methods of natural‐based biomaterials and summarize recent reports on their applications in the design and fabrication of micro‐tissue models. This article will help bioengineers select the proper biomaterials based on developing new technologies to meet clinical expectations and improve patient outcomes fusing disease modeling.

New Journal of Chemistry, 2023

Keratin, a biological polymer with high sulfur content, is the main component of hair, feathers a... more Keratin, a biological polymer with high sulfur content, is the main component of hair, feathers and wool.

Advanced Functional Materials, Aug 27, 2019

An emerging approach to improve the physicobiochemical properties and the multifunctionality of b... more An emerging approach to improve the physicobiochemical properties and the multifunctionality of biomaterials is to incorporate functional nanomaterials (NMs) onto 2D surfaces and into 3D hydrogel networks. This approach is starting to generate promising advanced functional materials such as selfassembled monolayers (SAMs) and nanocomposite (NC) hydrogels of NMs with remarkable properties and tailored functionalities that are beneficial for a variety of biomedical applications, including tissue engineering, drug delivery, and developing biosensors. A wide range of NMs, such as carbon-, metal-, and silica-based NMs, can be integrated into 2D and 3D biomaterial formulations due to their unique characteristics, such as magnetic properties, electrical properties, stimuli responsiveness, hydrophobicity/hydrophilicity, and chemical composition. The highly ordered nano-or microscale assemblies of NMs on surfaces alter the original properties of the NMs and add enhanced and/or synergetic and novel features to the final SAMs of the NM constructs. Furthermore, the incorporation of NMs into polymeric hydrogel networks reinforces the (soft) polymer matrix such that the formed NC hydrogels show extraordinary mechanical properties with superior biological properties.

Tissue Engineering Part B-reviews, Jun 1, 2022

The field of tissue engineering continues to advance, sometimes in exponential leaps forward, but... more The field of tissue engineering continues to advance, sometimes in exponential leaps forward, but also sometimes at a rate that does not fulfill the promise that the field imagined a few decades ago. This review is in part a catalog of success in an effort to inform the process of innovation. Tissue engineering has recruited new technologies and developed new methods for engineering tissue constructs that can be used to mitigate or model disease states for study. Key to this antecedent statement is that the scientific effort must be anchored in the needs of a disease state and be working toward a functional product in regenerative medicine. It is this focus on the wildly important ideas coupled with partnered research efforts within both academia and industry that have shown most translational potential. The field continues to thrive and among the most important recent developments are the use of three-dimensional bioprinting, organ-on-a-chip, and induced pluripotent stem cell technologies that warrant special attention. Developments in the aforementioned areas as well as future directions are highlighted in this article. Although several early efforts have not come to fruition, there are good examples of commercial profitability that merit continued investment in tissue engineering.

Journal of Polymers and the Environment

Kornea yaralari cerrahi, enfeksiyonlardan ve travmatik yaralanmalardan kaynaklanmaktadir. Bu yara... more Kornea yaralari cerrahi, enfeksiyonlardan ve travmatik yaralanmalardan kaynaklanmaktadir. Bu yaralar geleneksel olarak naylon suturler kullanilarak onarilmaktadir. Kornea bolgesindeki yaralanmanin sekline ve derecesine bagli olarak, korneanin y apisal butun lugunu geri kazanmasi icin genellikle birden fazla suture ihtiyac vardir. Doku yapistiricilari, oftalmik cerrahide suturlerin yerine kullanilabilmektedir. Doku yapistiricilari, sutur yardimci maddeleri ve yarali dokularin sizdirmazligi icin alternatif olar ak gelistirilmistir. Doku yapistiricilari, capraz baglandiktan sonra bir dokuya yapisabilen ve dunya capinda hemen hemen tum ameliyatlarda onemli bir element olan polimer temelli hidrojel sistemleridir. Uygulama kosullarina gore dahili ve harici olar ak sin iflandirilirlar. Harici doku yapistiriclari genellikle yara kapatma ve epidermal asilama gibi topikal uygulamalarda uygulanir . Dahili doku yapistiriclari ise dokular, organlar ve kronik organ sizintisi onarimi ve kanama komplikasyonlarinin azaltilmasi gibi vucut sivilari dahil olmak uzere ic ortama dogrudan temas ile intrakorporal kosullarda kullanilmaktadir. Bu derleme calismasinda, o kuler uygulamalara yonelik literaturde gelistirilen doku yapistiriclari, ticari uygulamalari ve uygulama teknikleri uzerine odaklanilmistir. Kornea insizyonlari icin kullanilan mevcut doku yapistiricilari tartisilmis, komplikasyonlari, guvenlik profilleri ve etkinli kleri, sentez yontemleri ve icerikleri birlikte degerlendirilmistir.

New Journal of Chemistry

Keratin, a biological polymer with high sulfur content, is the main component of hair, feathers a... more Keratin, a biological polymer with high sulfur content, is the main component of hair, feathers and wool.

Design, Fabrication, and Characterization of Multifunctional Nanomaterials, 2022

Kornea yaralari cerrahi, enfeksiyonlardan ve travmatik yaralanmalardan kaynaklanmaktadir. Bu yara... more Kornea yaralari cerrahi, enfeksiyonlardan ve travmatik yaralanmalardan kaynaklanmaktadir. Bu yaralar geleneksel olarak naylon suturler kullanilarak onarilmaktadir. Kornea bolgesindeki yaralanmanin sekline ve derecesine bagli olarak, korneanin y apisal butun lugunu geri kazanmasi icin genellikle birden fazla suture ihtiyac vardir. Doku yapistiricilari, oftalmik cerrahide suturlerin yerine kullanilabilmektedir. Doku yapistiricilari, sutur yardimci maddeleri ve yarali dokularin sizdirmazligi icin alternatif olar ak gelistirilmistir. Doku yapistiricilari, capraz baglandiktan sonra bir dokuya yapisabilen ve dunya capinda hemen hemen tum ameliyatlarda onemli bir element olan polimer temelli hidrojel sistemleridir. Uygulama kosullarina gore dahili ve harici olar ak sin iflandirilirlar. Harici doku yapistiriclari genellikle yara kapatma ve epidermal asilama gibi topikal uygulamalarda uygulanir . Dahili doku yapistiriclari ise dokular, organlar ve kronik organ sizintisi onarimi ve kanama kom...

Galvanostatic electrodeposition of copper foil was performed in the presence of 2-Acrylamido-2met... more Galvanostatic electrodeposition of copper foil was performed in the presence of 2-Acrylamido-2methylpropanesulfonic acid (AMPS) to obtain an electrochemical sensor for sensitive and selective glucose detection. Electrochemical performances of as-prepared enzyme-free electrodes were evaluated using chronoamperometry, cyclic voltammetry and impedance spectroscopy in 0.1 M NaOH solution. The results revealed that a detection limit of 0.98 μM is obtained along with a linearity of 7-48 μM for glucose sensing. The interference studies show that good selectivity was obtained in the presence of fructose, sucrose, lactic acid, ascorbic acid, urea etc.

Emergent Materials, 2021

Recently emerged novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resul... more Recently emerged novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting corona virus disease 2019 (COVID-19) led to urgent search for methods to prevent and treat COVID-19. Among important disciplines that were mobilized is the biomaterials science and engineering. Biomaterials offer a range of possibilities to develop disease models, protective, diagnostic, therapeutic, monitoring measures, and vaccines. Among the most important contributions made so far from this field are tissue engineering, organoids, and organ-on-a-chip systems, which have been the important frontiers in developing tissue models for viral infection studies. Also, due to low bioavailability and limited circulation time of conventional antiviral drugs, controlled and targeted drug delivery could be applied alternatively. Fortunately, at the time of writing this paper, we have two successful vaccines and new at-home detection platforms. In this paper, we aim to review recent advances of biomaterial-based platforms for protection, diagnosis, vaccination, therapeutics, and monitoring of SARS-CoV-2 and discuss challenges and possible future research directions in this field.

Advanced Healthcare Materials, 2020

Engineering mechanically-robust bioadhesive hydrogels that can withstand large strains may open n... more Engineering mechanically-robust bioadhesive hydrogels that can withstand large strains may open new opportunities for the sutureless sealing of highly stretchable tissues. While typical chemical modifications of hydrogels, such as increasing the functional group density of crosslinkable moieties and blending them with other polymers or nanomaterials have resulted in improved mechanical stiffness, the modified hydrogels have often exhibited increased brittleness resulting in deteriorated sealing capabilities under large strains. Furthermore, highly elastic hydrogels, such as tropoelastin derivatives are highly expensive. Here, gelatin methacryloyl (GelMA) is hybridized with methacrylate-modified alginate (AlgMA) to impart ion-induced reversible crosslinking that can dissipate energy under strain. The hybrid hydrogels provide a photocrosslinkable, injectable, and bioadhesive platform with an excellent toughness that can be tailored using divalent cations, such as calcium. This class of hybrid biopolymers with more than 600% improved toughness compared to GelMA may set the stage for durable, mechanically-resilient, and cost-effective tissue sealants. This strategy to increase the toughness of hydrogels may be extended to other crosslinkable polymers with similarly-reactive moieties.

Small Methods, 2019

Microphysiological systems, also known as organ-on-a-chip platforms, show promise for the develop... more Microphysiological systems, also known as organ-on-a-chip platforms, show promise for the development of new testing methods that can be more accurate than both conventional twodimensional cultures and costly animal studies. The development of more intricate microphysiological systems can help to better mimic the human physiology and highlight the systemic effects of different drugs and materials. Nanomaterials are among a technologically important class of materials used for diagnostic, therapeutic, and monitoring purposes; all of which and can be tested using new organ-on-a-chip systems. In addition, the toxicity of nanomaterials which have entered the body from ambient air or diet can have deleterious effects on various body systems. This in turn can be studied in newly developed microphysiological systems. While organ-on-a-chip models can be useful, they cannot pick up secondary and systemic

Nuclear Medicine Communications, 2013

Background Somatostatin receptor (Sstr) scintigraphy with radiolabelled somatostatin analogues ha... more Background Somatostatin receptor (Sstr) scintigraphy with radiolabelled somatostatin analogues has been used extensively for the diagnosis and therapy of Sstr-expressing tumours. It has been shown that well-differentiated thyroid cancer (WDTC) cells have a high expression of Sstr2, Sstr3 and Sstr5. Hence, WDTC cells could be an ideal target for the evaluation of lesion uptake of Ga-68 DOTA-1-NaI3-octreotide (DOTA-NOC), which has a high affinity not only to Sstr2 but also to Sstr3 and Sstr5. The aim of the present study was to evaluate the value of Ga-68 DOTA-NOC as a target for Sstr2-expressing, Sstr3-expressing and Sstr5-expressing tumours in WDTC patients and to compare the results with those of Ga-68 DOTA-TATE in the same patient population. Method Thirteen patients with WDTC were included in our study: nine with papillary thyroid cancer, three with Hurthle cell carcinoma and one with follicular thyroid carcinoma. All patients had elevated serum thyroglobulin levels and negative post-therapeutic I-131 whole-body scans, which were obtained after the last radioiodine treatment. All patients had undergone two consecutive PET imaging studies with Ga-68 DOTA-D-Phe1-Tyr3-octreotate (DOTA-TATE) and Ga-68 DOTA-NOC, respectively. All images were evaluated visually, and maximum standardized uptake values were calculated. Results Both Ga-68 DOTA-TATE and Ga-68 DOTA-NOC PET images gave comparable results. Among the 13 patients, imaging with both Ga-68 DOTA-TATE and Ga-68 DOTA-NOC gave negative results in five (38%) patients and positive results in eight (62%) patients. A total of 45 lesions were identified on Ga-68 DOTA-TATE images and 42 on Ga-68 DOTA-NOC images; three lesions were missed. Lesion uptake was significantly higher on Ga-68 DOTA-TATE images. Maximum standardized uptake values of Ga-68 DOTA-TATE and Ga-68 DOTA-NOC were 12.9±9.1 and 6.3±4.1 (n = 54, P < 0.001), respectively. Conclusion Our study suggested that Ga-68 DOTA-TATE has a higher lesion uptake even in WDTC patients and may have potential advantage over Ga-68 DOTA-NOC. Nucl Med

Journal of Biomedical Materials Research Part A

Journal of Materials Chemistry B, 2022

Herein, we developed a photocurable silk fibroin-based ocular tissue adhesive with enhanced adhes... more Herein, we developed a photocurable silk fibroin-based ocular tissue adhesive with enhanced adhesive features.

Journal of Materials Chemistry B, 2022

Herein, we developed a photocurable silk fibroin-based ocular tissue adhesive with enhanced adhes... more Herein, we developed a photocurable silk fibroin-based ocular tissue adhesive with enhanced adhesive features.

Journal of Biomedical Materials Research Part A, Jan 31, 2022

The desired organ in micro‐tissue models of organ‐on‐a‐chip (OoC) devices dictates the optimum bi... more The desired organ in micro‐tissue models of organ‐on‐a‐chip (OoC) devices dictates the optimum biomaterials, divided into natural and synthetic biomaterials. They can resemble biological tissues' biological functions and architectures by constructing bioactivity of macromolecules, cells, nanoparticles, and other biological agents. The inclusion of such components in OoCs allows them having biological processes, such as basic biorecognition, enzymatic cleavage, and regulated drug release. In this report, we review natural‐based biomaterials that are used in OoCs and their main characteristics. We address the preparation, modification, and characterization methods of natural‐based biomaterials and summarize recent reports on their applications in the design and fabrication of micro‐tissue models. This article will help bioengineers select the proper biomaterials based on developing new technologies to meet clinical expectations and improve patient outcomes fusing disease modeling.

New Journal of Chemistry, 2023

Keratin, a biological polymer with high sulfur content, is the main component of hair, feathers a... more Keratin, a biological polymer with high sulfur content, is the main component of hair, feathers and wool.

Advanced Functional Materials, Aug 27, 2019

An emerging approach to improve the physicobiochemical properties and the multifunctionality of b... more An emerging approach to improve the physicobiochemical properties and the multifunctionality of biomaterials is to incorporate functional nanomaterials (NMs) onto 2D surfaces and into 3D hydrogel networks. This approach is starting to generate promising advanced functional materials such as selfassembled monolayers (SAMs) and nanocomposite (NC) hydrogels of NMs with remarkable properties and tailored functionalities that are beneficial for a variety of biomedical applications, including tissue engineering, drug delivery, and developing biosensors. A wide range of NMs, such as carbon-, metal-, and silica-based NMs, can be integrated into 2D and 3D biomaterial formulations due to their unique characteristics, such as magnetic properties, electrical properties, stimuli responsiveness, hydrophobicity/hydrophilicity, and chemical composition. The highly ordered nano-or microscale assemblies of NMs on surfaces alter the original properties of the NMs and add enhanced and/or synergetic and novel features to the final SAMs of the NM constructs. Furthermore, the incorporation of NMs into polymeric hydrogel networks reinforces the (soft) polymer matrix such that the formed NC hydrogels show extraordinary mechanical properties with superior biological properties.

Tissue Engineering Part B-reviews, Jun 1, 2022

The field of tissue engineering continues to advance, sometimes in exponential leaps forward, but... more The field of tissue engineering continues to advance, sometimes in exponential leaps forward, but also sometimes at a rate that does not fulfill the promise that the field imagined a few decades ago. This review is in part a catalog of success in an effort to inform the process of innovation. Tissue engineering has recruited new technologies and developed new methods for engineering tissue constructs that can be used to mitigate or model disease states for study. Key to this antecedent statement is that the scientific effort must be anchored in the needs of a disease state and be working toward a functional product in regenerative medicine. It is this focus on the wildly important ideas coupled with partnered research efforts within both academia and industry that have shown most translational potential. The field continues to thrive and among the most important recent developments are the use of three-dimensional bioprinting, organ-on-a-chip, and induced pluripotent stem cell technologies that warrant special attention. Developments in the aforementioned areas as well as future directions are highlighted in this article. Although several early efforts have not come to fruition, there are good examples of commercial profitability that merit continued investment in tissue engineering.

Journal of Polymers and the Environment

Kornea yaralari cerrahi, enfeksiyonlardan ve travmatik yaralanmalardan kaynaklanmaktadir. Bu yara... more Kornea yaralari cerrahi, enfeksiyonlardan ve travmatik yaralanmalardan kaynaklanmaktadir. Bu yaralar geleneksel olarak naylon suturler kullanilarak onarilmaktadir. Kornea bolgesindeki yaralanmanin sekline ve derecesine bagli olarak, korneanin y apisal butun lugunu geri kazanmasi icin genellikle birden fazla suture ihtiyac vardir. Doku yapistiricilari, oftalmik cerrahide suturlerin yerine kullanilabilmektedir. Doku yapistiricilari, sutur yardimci maddeleri ve yarali dokularin sizdirmazligi icin alternatif olar ak gelistirilmistir. Doku yapistiricilari, capraz baglandiktan sonra bir dokuya yapisabilen ve dunya capinda hemen hemen tum ameliyatlarda onemli bir element olan polimer temelli hidrojel sistemleridir. Uygulama kosullarina gore dahili ve harici olar ak sin iflandirilirlar. Harici doku yapistiriclari genellikle yara kapatma ve epidermal asilama gibi topikal uygulamalarda uygulanir . Dahili doku yapistiriclari ise dokular, organlar ve kronik organ sizintisi onarimi ve kanama komplikasyonlarinin azaltilmasi gibi vucut sivilari dahil olmak uzere ic ortama dogrudan temas ile intrakorporal kosullarda kullanilmaktadir. Bu derleme calismasinda, o kuler uygulamalara yonelik literaturde gelistirilen doku yapistiriclari, ticari uygulamalari ve uygulama teknikleri uzerine odaklanilmistir. Kornea insizyonlari icin kullanilan mevcut doku yapistiricilari tartisilmis, komplikasyonlari, guvenlik profilleri ve etkinli kleri, sentez yontemleri ve icerikleri birlikte degerlendirilmistir.

New Journal of Chemistry

Keratin, a biological polymer with high sulfur content, is the main component of hair, feathers a... more Keratin, a biological polymer with high sulfur content, is the main component of hair, feathers and wool.

Design, Fabrication, and Characterization of Multifunctional Nanomaterials, 2022

Kornea yaralari cerrahi, enfeksiyonlardan ve travmatik yaralanmalardan kaynaklanmaktadir. Bu yara... more Kornea yaralari cerrahi, enfeksiyonlardan ve travmatik yaralanmalardan kaynaklanmaktadir. Bu yaralar geleneksel olarak naylon suturler kullanilarak onarilmaktadir. Kornea bolgesindeki yaralanmanin sekline ve derecesine bagli olarak, korneanin y apisal butun lugunu geri kazanmasi icin genellikle birden fazla suture ihtiyac vardir. Doku yapistiricilari, oftalmik cerrahide suturlerin yerine kullanilabilmektedir. Doku yapistiricilari, sutur yardimci maddeleri ve yarali dokularin sizdirmazligi icin alternatif olar ak gelistirilmistir. Doku yapistiricilari, capraz baglandiktan sonra bir dokuya yapisabilen ve dunya capinda hemen hemen tum ameliyatlarda onemli bir element olan polimer temelli hidrojel sistemleridir. Uygulama kosullarina gore dahili ve harici olar ak sin iflandirilirlar. Harici doku yapistiriclari genellikle yara kapatma ve epidermal asilama gibi topikal uygulamalarda uygulanir . Dahili doku yapistiriclari ise dokular, organlar ve kronik organ sizintisi onarimi ve kanama kom...

Galvanostatic electrodeposition of copper foil was performed in the presence of 2-Acrylamido-2met... more Galvanostatic electrodeposition of copper foil was performed in the presence of 2-Acrylamido-2methylpropanesulfonic acid (AMPS) to obtain an electrochemical sensor for sensitive and selective glucose detection. Electrochemical performances of as-prepared enzyme-free electrodes were evaluated using chronoamperometry, cyclic voltammetry and impedance spectroscopy in 0.1 M NaOH solution. The results revealed that a detection limit of 0.98 μM is obtained along with a linearity of 7-48 μM for glucose sensing. The interference studies show that good selectivity was obtained in the presence of fructose, sucrose, lactic acid, ascorbic acid, urea etc.

Emergent Materials, 2021

Recently emerged novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resul... more Recently emerged novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting corona virus disease 2019 (COVID-19) led to urgent search for methods to prevent and treat COVID-19. Among important disciplines that were mobilized is the biomaterials science and engineering. Biomaterials offer a range of possibilities to develop disease models, protective, diagnostic, therapeutic, monitoring measures, and vaccines. Among the most important contributions made so far from this field are tissue engineering, organoids, and organ-on-a-chip systems, which have been the important frontiers in developing tissue models for viral infection studies. Also, due to low bioavailability and limited circulation time of conventional antiviral drugs, controlled and targeted drug delivery could be applied alternatively. Fortunately, at the time of writing this paper, we have two successful vaccines and new at-home detection platforms. In this paper, we aim to review recent advances of biomaterial-based platforms for protection, diagnosis, vaccination, therapeutics, and monitoring of SARS-CoV-2 and discuss challenges and possible future research directions in this field.

Advanced Healthcare Materials, 2020

Engineering mechanically-robust bioadhesive hydrogels that can withstand large strains may open n... more Engineering mechanically-robust bioadhesive hydrogels that can withstand large strains may open new opportunities for the sutureless sealing of highly stretchable tissues. While typical chemical modifications of hydrogels, such as increasing the functional group density of crosslinkable moieties and blending them with other polymers or nanomaterials have resulted in improved mechanical stiffness, the modified hydrogels have often exhibited increased brittleness resulting in deteriorated sealing capabilities under large strains. Furthermore, highly elastic hydrogels, such as tropoelastin derivatives are highly expensive. Here, gelatin methacryloyl (GelMA) is hybridized with methacrylate-modified alginate (AlgMA) to impart ion-induced reversible crosslinking that can dissipate energy under strain. The hybrid hydrogels provide a photocrosslinkable, injectable, and bioadhesive platform with an excellent toughness that can be tailored using divalent cations, such as calcium. This class of hybrid biopolymers with more than 600% improved toughness compared to GelMA may set the stage for durable, mechanically-resilient, and cost-effective tissue sealants. This strategy to increase the toughness of hydrogels may be extended to other crosslinkable polymers with similarly-reactive moieties.

Small Methods, 2019

Microphysiological systems, also known as organ-on-a-chip platforms, show promise for the develop... more Microphysiological systems, also known as organ-on-a-chip platforms, show promise for the development of new testing methods that can be more accurate than both conventional twodimensional cultures and costly animal studies. The development of more intricate microphysiological systems can help to better mimic the human physiology and highlight the systemic effects of different drugs and materials. Nanomaterials are among a technologically important class of materials used for diagnostic, therapeutic, and monitoring purposes; all of which and can be tested using new organ-on-a-chip systems. In addition, the toxicity of nanomaterials which have entered the body from ambient air or diet can have deleterious effects on various body systems. This in turn can be studied in newly developed microphysiological systems. While organ-on-a-chip models can be useful, they cannot pick up secondary and systemic

Nuclear Medicine Communications, 2013

Background Somatostatin receptor (Sstr) scintigraphy with radiolabelled somatostatin analogues ha... more Background Somatostatin receptor (Sstr) scintigraphy with radiolabelled somatostatin analogues has been used extensively for the diagnosis and therapy of Sstr-expressing tumours. It has been shown that well-differentiated thyroid cancer (WDTC) cells have a high expression of Sstr2, Sstr3 and Sstr5. Hence, WDTC cells could be an ideal target for the evaluation of lesion uptake of Ga-68 DOTA-1-NaI3-octreotide (DOTA-NOC), which has a high affinity not only to Sstr2 but also to Sstr3 and Sstr5. The aim of the present study was to evaluate the value of Ga-68 DOTA-NOC as a target for Sstr2-expressing, Sstr3-expressing and Sstr5-expressing tumours in WDTC patients and to compare the results with those of Ga-68 DOTA-TATE in the same patient population. Method Thirteen patients with WDTC were included in our study: nine with papillary thyroid cancer, three with Hurthle cell carcinoma and one with follicular thyroid carcinoma. All patients had elevated serum thyroglobulin levels and negative post-therapeutic I-131 whole-body scans, which were obtained after the last radioiodine treatment. All patients had undergone two consecutive PET imaging studies with Ga-68 DOTA-D-Phe1-Tyr3-octreotate (DOTA-TATE) and Ga-68 DOTA-NOC, respectively. All images were evaluated visually, and maximum standardized uptake values were calculated. Results Both Ga-68 DOTA-TATE and Ga-68 DOTA-NOC PET images gave comparable results. Among the 13 patients, imaging with both Ga-68 DOTA-TATE and Ga-68 DOTA-NOC gave negative results in five (38%) patients and positive results in eight (62%) patients. A total of 45 lesions were identified on Ga-68 DOTA-TATE images and 42 on Ga-68 DOTA-NOC images; three lesions were missed. Lesion uptake was significantly higher on Ga-68 DOTA-TATE images. Maximum standardized uptake values of Ga-68 DOTA-TATE and Ga-68 DOTA-NOC were 12.9±9.1 and 6.3±4.1 (n = 54, P < 0.001), respectively. Conclusion Our study suggested that Ga-68 DOTA-TATE has a higher lesion uptake even in WDTC patients and may have potential advantage over Ga-68 DOTA-NOC. Nucl Med

Journal of Biomedical Materials Research Part A

Journal of Materials Chemistry B, 2022

Herein, we developed a photocurable silk fibroin-based ocular tissue adhesive with enhanced adhes... more Herein, we developed a photocurable silk fibroin-based ocular tissue adhesive with enhanced adhesive features.