Ali parsaeimehr | Tecnológico de Monterrey (original) (raw)

Papers by Ali parsaeimehr

Elsevier eBooks, 2014

ABSTRACT Medicinal plants are priceless source of bioactive compounds and despite the contemporar... more ABSTRACT Medicinal plants are priceless source of bioactive compounds and despite the contemporary progresses in pharmaceuticals and drug developments; they still remain as a major source of medicine for a large percentage of our world. Novel antibacterial quinolone compounds derived from Evodia rutaecarpa against Helico bacterpylori or plant based anticancer agents including vincristine, vinblastine, irinotecan, or novel maloyl glucans derived from Aloe vera with wound healing effects and 4-hydroxypanduratin A as an antimutagenic agent isolated from fresh rhizomes of Boesenbergia pandurata against mutagenic heterocyclic amines are a few sample of thousands valuable discoveries in this area of science which help us to maintain our lives in this world. This chapter has been focused on presentation of some medicinal plants with wound healing and anti-infective properties.

Springer eBooks, 2013

Ephedrine is an alkaloid derived from various plants in the genus Ephedra (family Ephedraceae). T... more Ephedrine is an alkaloid derived from various plants in the genus Ephedra (family Ephedraceae). The alkaloid is comparable in actions to adrenaline. It has many medicinal and pharmaceutical applications; it is a bronchodilator to relieve shortness of breath, chest tightness, wheezing, and cough associated with bronchial asthma. Amino acids such as phenylalanine and tyrosine serve as the precursors for a large number of alkaloids, including ephedrine, capsaicin, and colchicines. Although ephedrine is produced by chemical synthesis or enzymatic methods, it is also obtained from Ephedra species. This chapter provides general information about Ephedra, ephedrine, and its derivatives, discusses methods to analyze them, and finally presents achievements in this area of science.

Biotechnology for Biofuels, Jan 29, 2015

Background: Photoautotrophic microalgae are a promising avenue for sustained biodiesel production... more Background: Photoautotrophic microalgae are a promising avenue for sustained biodiesel production, but are compromised by low yields of biomass and lipids at present. We are developing a chemical approach to improve microalgal accumulation of feedstock lipids as well as high-value alpha-linolenic acid which in turn might provide a driving force for biodiesel production. Results: We demonstrate the effectiveness of the small bioactive molecule "acetylcholine" on accumulation of biomass, total lipids, and alpha-linolenic acid in Chlorella sorokiniana. The effectiveness exists in different species of Chlorella. Moreover, the precursor and analogs of acetylcholine display increased effectiveness at higher applied doses, with maximal increases by 126, 80, and 60% over controls for biomass, total lipids, and alpha-linolenic acid, respectively. Production of calculated biodiesel was also improved by the precursor and analogs of acetylcholine. The biodiesel quality affected by changes in microalgal fatty acid composition was addressed. Conclusion: The chemical approach described here could improve the lipid yield and biodiesel production of photoautotrophic microalgae if combined with current genetic approaches.

Social Science Research Network, Dec 2, 2011

Action is needed to face the global threat arising from inconsistent rainfall, rise in temperatur... more Action is needed to face the global threat arising from inconsistent rainfall, rise in temperature, and salinization of farm lands which may be the product of climate change. As crops are adversely affected, man and animals may face famine. Plants are severely affected by abiotic stress (drought, salinity, alkalinity, and temperature), which impairs yield and results in loss to farmers and to the nation at large. However, microbes have been shown to be of great help in the fight against abiotic stress, via their biological activities at the rhizosphere of plants. The external application of chemical substances such as glycine betaine, proline, and nutrients has helped in sustaining plant growth and productive ability. In this review, we tried to understand the part played by bioinoculants in aiding plants to resist the negative consequences arising from abiotic stress and to suggest better practices that will be of help in today's farming systems. The fact that absolute protection and sustainability of plant yield under stress challenges has not been achieved by microbes, nutrients, nor the addition of chemicals (osmo-protectants) alone suggests that studies should focus on the integration of these units (microbes, nutrients, chemical stimulants, and osmo-protectants) into a strategy for achieving a complete tolerance to abiotic stress. Also, other species of microbes capable of shielding plant from stress, boosting yield and growth, providing nutrients, and protecting the plants from harmful invading pathogens should be sought.

Social Science Research Network, 2015

Currently, various valuable natural molecules have been identified and isolated from algae. There... more Currently, various valuable natural molecules have been identified and isolated from algae. Therefore, it is undoubted that they can represent a brilliant source of several chemical compounds which can find different biological applications, mainly in the field of human health and welfare. These compounds exhibit a wide range of biological actions including anti-viral, antioxidant, anti-allergic, anticancer, and anti-inflammatory. The potential exploitation of both macro- and micro-algae as source of valuable components, including carbohydrates, long chain fatty acids, pigments, proteins and vitamins, is encompassed in this review. Applications of these compounds in the pharmaceutical, neutracetical and food market are also discussed.

Water and salinity stresses are the major reasons to yield decreasing in the world. Potato is the... more Water and salinity stresses are the major reasons to yield decreasing in the world. Potato is the world's main tuber crops of the Solanaceae family which is one of the most economically important annual vegetable crop. The goal of this investigation was creation genetic modified potato cv. Agria with more tolerance to salinity stress and evaluating GMO potato properties. To create transgenic potato plant, mtlD gene (mannitol-1-phosphate dehydrogenase, E.C.1.1.1.17) was expressed to potato cv. Agria plant by using Agrobacterium tumefaciens. Transgenic potato was produced by transforming of mtlD gene to potato plant cv. Agria. Existence of recombinant gene in transgenic plants was approved by two ways 1. Polymerase Chain Reaction technique. 2. Measurement of physiological parameters. The transgenic potatoes and non-transgenic potatoes lines exhibited the different amounts of tolerance to salinity stress because in the transgenic lines mannitol accumulates that increased osmotic pressure in salinity stress. The salt tolerance of transgenic potato cv. Agria (+mtlD) was recorded higher than that of non-transgenic potato cv. Agria (-mtlD). Osmotic pressure in this transgenic potato plant was increased by accumulating of mannitol and existence of mannitol in potato plant approved that the mtlD gene was successfully expressed to potato cv. Agria.

Frontiers in bioscience, 2019

Harmful algal blooms in the past three decades appear to have grown in incidence, intensity and g... more Harmful algal blooms in the past three decades appear to have grown in incidence, intensity and geographical distribution with negative impacts on public health and economy values. Each year the algal biotoxins are responsible for more than 60.000 intoxications with an associated mortality rate of 1.5%. The present review summarizes current knowledge and perspectives on marine and freshwater algal toxins with an emphasis on different genus of algae capable to produce toxins and their physiology. The typologies of toxins, their chemical structure and mechanisms of action, the factors that stimulate their biosynthesis and the current techniques used for algal toxins removal will be also reviewed.

Frontiers in bioscience, 2018

Microfluidics is undoubtedly an influential technology that is currently revolutionizing the chem... more Microfluidics is undoubtedly an influential technology that is currently revolutionizing the chemical and biological studies by replicating laboratory benchtop technology on a miniature chip-scale device. In the area of drug delivery science, microfluidics offers advantages, such as precise dosage, ideal delivery, target-precise delivery, sustainable and controlled release, multiple dosing, and slight side effects. These advantages bring significant assets to the drug delivery systems. Microfluidic technology has been progressively used for fabrication of drug carriers, direct drug delivery systems, high-throughput screening, and formulation and immobilization of drugs. This review discusses the recent technological progress, outcomes and available opportunities for the usage of microfluidics systems in drug delivery systems.

Research Journal of Medical Sciences, Apr 1, 2010

Social Science Research Network, Feb 1, 2009

Glycyrrhiza glabra is widely used in bronchial problems such as catarrh, bronchitis, cold, flu an... more Glycyrrhiza glabra is widely used in bronchial problems such as catarrh, bronchitis, cold, flu and coughs and this plant has a useful secondary metabolite by the name of Lycorys and widely extracted from Bioreactors or hairy roots techniques, the initial step in aim to start a bioreactor is producing a friable callus which use for a suspension culture , A hormonal balance would be vital for producing this kind of callus, An experiment was conducted by the base of NAA and 2,4-D as auxins and 6-BA as cytokinins plant growing regulators in rang of 0.5-2.0 mg/l in a MS medium, Each experiment contained at least 20 replicates and the experiments were repeated three times. Data were documented up to 5 weeks of culture, well grown callus induced from explants were selected to transfer to MS medium with appropriate hormones for subculture. no calli were induced but When 2,4-D was used into MS medium, all explants formed white callus and induction rates increased with the increase of concentration of 2,4-D. It was found that the addition of high concentration of 6-BA into the MS medium in combination with 2,4-D had prompt effect on callus formation ,The maximum induction rate was recorded as 96 % in MS medium with 0.5 mg/l 2,4-D and 2 mg/l 6-BA with a light compact structure. However, MS medium with single 6-BA induced no callus in none of explants, although the combination of NAA and 6-BA could induce callus formation in explants, but callus turned brown. As previous primary experiments indicated that only high concentration of BA in combination with 2, 4-D or NAA in medium was relatively more suitable for subculture, the well grown callus were Selected for subculture on MS medium with 2.0 mg/l 6-BA in combination with 0.5-2 mg/l 2, 4-D or with 0.5-2.0 mg/l NAA to test their growing state. 40 days later after the callus were subculture on the MS with 6-BA and 2,4-D, they turned from green to white and became compact, while callus cultured on MS medium with 6-BA and NAA became loose, and spongy which was more suitable for continuous subculture and suspension culture. Therefore, MS medium supplemented with 0.5-2.0 mg/l NAA and 2.0 mg/l 6-BA was used for subsequent experiments. Through testing, it was found that the MS medium containing 2 mg/l 6-BA and 0.5 mg/l NAA had the maximum effect and was decided for subculture and cell suspension culture , By the base of this experiment and due the producing a friable callus for our aim its seems that explants of Glycyrrhiza glabra on MS medium by the maximum induction rate was recorded as 96 % in MS medium with 0.5 mg/l 2,4-D and 2 mg/l 6-BA with a light compact structure but it's not a suitable for callus induction ,using a hormonal dense with 1.0 mg/l NAA and 2 mg/l 6-BA by 91.6 induction rate with a Loose, spongy, friable structure which use in a suspension culture.

Social Science Research Network, Jul 15, 2011

Abstract: An experiment was performed to assess the wheat harvest yield using a CROPSYST model in... more Abstract: An experiment was performed to assess the wheat harvest yield using a CROPSYST model in2008-2009 at Rashmijan zone, the northern part of Fars province, Iran. The experiment was performedin a randomized complete block design and were ...

Social Science Research Network, Feb 15, 2016

Main objective of the research is cultivation and propagation of valuable medicinal plant Aspatag... more Main objective of the research is cultivation and propagation of valuable medicinal plant Aspatagus officinalis L. (Mary Washington) by hydroponics and in vitro combined method. From seeds of hydroponic plants were obtained in vitro plantlets. To obtain callus tissues various explants (hypocotyl, root, apical bud, stem segment) were separated from micro-plantlets. In vitro callus cultures were obtained. Biosynthetic possibility and activity of callus tissues in case of various growth regulators and concentrations were determined. All tested explants on MS nutrient medium with hormones (BAP-1.0 mg/l, 2.4D-2.0 mg/l and BAP-1.0 mg/l, 2.4D-0.5 mg/l, α-NAA-0.5 mg/l) inducted callus tissues. The replanting of callus was implemented once in a month, on the fresh nutrient medium. Viable callus cultures were obtained and used for induction of rhizogenesis and organogenesis. On MS medium optimum result was in case of callus from hypocotyl explant, with BAP-1.0 mg/l, 2.4D-0.5 mg/l and α-NAA-0.5 mg/l or Kinetin-1 mg/l concentration, which provided regeneration of 15-20 adventive shoots. Shoot-regenerants multiplicated micro-clonaly. Among tested phytohormones the best result was 0.5 mg/l IBA concentration, providing 62% rhizogenesis of shoot-regenetants. In spring, the rooted in vitro micro-plantlets after acclimatization were planted in the open air gravel hydroponic conditions for propagation.

Social Science Research Network, 2016

Cell-free extracts of six strains of Enterococcus species obtained from fermented foods were used... more Cell-free extracts of six strains of Enterococcus species obtained from fermented foods were used for the green synthesis of silver nanoparticles (AgNPs), which was characterized by UV-Vis spectroscopy, Fourier-transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). The biosynthesized AgNPs were dark brown in colour having surface plasmon resonance in the range of 420-442 nm. The spherical shaped AgNPs had sizes of 4-55 nm, whose formations were facilitated by proteins as indicated by the presence of peaks 1,635-1,637 and 3,275-3,313 cm-1 in the FTIR spectra. The energy dispersive x-ray (EDX) showed prominent presence of silver in the AgNPs colloidal solution, while the selected area electron diffraction was typified by the face-centred crystalline nature of silver. The particles inhibited the growth of multi-drug resistant clinical isolates of Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris, and also potentiated the activities of ampicillin, ciprofloxacin and cefuroxime in the AgNPs-antibiotic synergy studies. In addition, the prospective relevance of the particles as nanopreservative in paints was demonstrated with the inhibition of growth of Staphylococcus aureus, Pseudomonas aeruginosa, Aspergillus niger and A. flavus in AgNPs-paint admixture. This report further demonstrates the green synthesis of AgNPs by strains of Enterococcus species.

ABAH Bioflux, 2011

In today's world the usage of useful secondary metabolites derived from plants metabolisms pathwa... more In today's world the usage of useful secondary metabolites derived from plants metabolisms pathways plays important roles in pharmaceutical productions and applications. These metabolites such as Apigenin an anti-infection, anti-viral, anti-carcinogenic derived from Anthemis nobilis plants or Berberine an anti-microorganism, Anti diabetic, anti-inflammatory activity, anti-cancer, LDL cholesterol reducer derived from Berberis aquifolium, are constantly used in pharmaceutics. This paper tries to present some information about some of these metabolites and the usage of them.

Elsevier eBooks, 2013

ABSTRACT In today’s world, multidrug resistance appears to be one of the major health problems; h... more ABSTRACT In today’s world, multidrug resistance appears to be one of the major health problems; however, screening, discovering and presenting novel effectual phytochemicals from medicinal plants have provided a promising outlook. Phytomedicines have been used for treating diseases and infections since time immemorial, but identifying new phytochemicals and effectual treatment strategies are essential in the fight against multidrug-resistant bacteria. Currently, isolated compounds such as amangostin, carnosic acid, epigallocatechin gallate, linalool, myricetin, novoimanin, a-terpineol, and totarol, have exhibited synergistic activity with antibiotics against resistant bacteria. This chapter presents information on multidrug-resistant Gram-negative bacteria and the use of herbal extracts against them. Keywords: multidrug resistance, herbal extracts, Gram-negative bacteria, secondary metabolites.

Social Science Research Network, Jan 21, 2012

An experiment was conducted to estimate the influence of L-phenylalanine as a precursor on ephedr... more An experiment was conducted to estimate the influence of L-phenylalanine as a precursor on ephedrine and pseudo-ephedrine productions in Ephedra procera Fisch et C. A. Mey suspension culture. Our results indicated that, the highest amounts of 112.77 ± 0.54 μg·g–1 DW and 588.68 ± 1.84 μg·g–1 DW were achieved under the influence of 7.5 mM L-phenylalanine after 12 days for ephedrine and pseudo-ephedrine, respectively. Data also showed a positive correlation between the different levels of L-phenylalanine and the cell growth in the medium, but when the L-phenylalanine has reached 12.5 mM in the medium, the cell growth stopped.

Elsevier eBooks, 2017

Abstract Medicinal plants have been used against various diseases for thousands of years, and 80%... more Abstract Medicinal plants have been used against various diseases for thousands of years, and 80% of the worldwide population still depends on herbal medicines. The medicinal plants Artemisia nilagirica , Senegalia visco , Hypericum perforatum , Vaccinium microcarpum , and Curcuma longa are a few samples of plants that have been effectively used against skin diseases. This natural source has generously provided us with bioactive molecules, such as artemetin, lupeol, hypericin, hydroquinone, epicatechin, and curcumin, which have been used against acne, atopic dermatitis, skin cancer, and skin pigmentation disorders. This chapter presents a list of medicinal plants traditionally used for curing skin disorders, their bioactive molecules, and their modes of action.

Screening the Growth of Cyanobacteria Aphanothece under Photoautotrophic and Photoheterotrophic C... more Screening the Growth of Cyanobacteria Aphanothece under Photoautotrophic and Photoheterotrophic Conditions Ifti Ahmed1,2, Ali Parsaeimehr1, Ph.D., and Bertand Hankoua1, Ph.D. 1Department of Agriculture and Natural Resources Delaware State University, Dover, DE 19901 2Middletown High School, Middletown, DE 19709. Microalgae are used in different industrial sectors including, the biopharmaceutical and nutraceutical industries. The main objective of this study was to identify a high yield photoheterotrophic condition for the Cyanobacteria Aphanothece in aim to produce phycocyanin, and allophycocyanin metabolites with pharmaceutical values. In this study, a BG11 based media was used. To establish a photoheterotrophic conditions a ratio of glucose (0, 025, 0.5, 2, and 4%) as a carbon source was applied. Our results demonstrated, a higher yield of biomass under the photoheterotrophic conditions containing 2 % glucose (3.11 ± 0.35 g/L fresh weight, OD750=1.08 ±0.14 7th day; relative growth...

Biotechnology Reports

The CRISPR-Cas systems have offered a flexible, easy-to-use platform to precisely modify and cont... more The CRISPR-Cas systems have offered a flexible, easy-to-use platform to precisely modify and control the genomes of organisms in various fields, ranging from agricultural biotechnology to therapeutics. This system is extensively used in the study of infectious, progressive, and life-threatening genetic diseases for the improvement of quality and quantity of major crops and in the development of sustainable methods for the generation of biofuels. As CRISPR-Cas technology continues to evolve, it is becoming more controllable and precise with the addition of molecular regulators, which will provide benefits for everyone and save many lives. Studies on the constant growth of CRISPR technology are important due to its rapid development. In this paper, we present the current applications and progress of CRISPR-Cas genome editing systems in several fields of research, we further highlight the applications of anti-CRISPR molecules to regulate CRISPR-Cas gene editing systems, and we discuss ethical considerations in CRISPR-Cas applications.