jean paul rodriguez | ITM - Instituto Tecnológico Metropolitano (original) (raw)
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Papers by jean paul rodriguez
Organic letters, Jan 3, 2017
Organocatalyzed enantioselective consecutive Michael addition of diethyl glutaconate to a nitro-o... more Organocatalyzed enantioselective consecutive Michael addition of diethyl glutaconate to a nitro-olefin/reductive cyclization sequence has been developed, directly providing NH-free trans,trans-2,3,4-trisubstituted pyrrolidines with typically >88:12 dr and >90% ee. The obtained structures are closely related to several molecules with high biological profiles, holding great promise for medicinal chemistry. In addition, their potential as direct organocatalysts in the enantioselective Michael addition promoted by enamine activation is also reported.
European Journal of Organic Chemistry, 2004
Also of interest is the one-pot formation of simple 3,5-disubstituted 1,4-dihydropyridines, which... more Also of interest is the one-pot formation of simple 3,5-disubstituted 1,4-dihydropyridines, which upon oxidation gave the pyridines involved in the total synthesis of the alkaloid iosalamarine.55 The key transformation consisted of a cyclocondensation of the sodium ...
ChemInform, 2013
ABSTRACT The diketoacid substrates are activated by BTU to react with nitroolefins or acrolein.
Although long known, 1,2- and 1,3-dicarbonyl compounds have recently come more and more to preval... more Although long known, 1,2- and 1,3-dicarbonyl compounds have recently come more and more to prevalence as ideal substrates for the invention of new stereoselective multiple bond-forming transformations (MBFTs). Herein, a critical appraisal is presented of some of the most spectacular of these MBFTs, which allow the formation from three up to six bonds in highly step- and atom-economical processes.
Organic letters, Jan 3, 2017
Organocatalyzed enantioselective consecutive Michael addition of diethyl glutaconate to a nitro-o... more Organocatalyzed enantioselective consecutive Michael addition of diethyl glutaconate to a nitro-olefin/reductive cyclization sequence has been developed, directly providing NH-free trans,trans-2,3,4-trisubstituted pyrrolidines with typically >88:12 dr and >90% ee. The obtained structures are closely related to several molecules with high biological profiles, holding great promise for medicinal chemistry. In addition, their potential as direct organocatalysts in the enantioselective Michael addition promoted by enamine activation is also reported.
European Journal of Organic Chemistry, 2004
Also of interest is the one-pot formation of simple 3,5-disubstituted 1,4-dihydropyridines, which... more Also of interest is the one-pot formation of simple 3,5-disubstituted 1,4-dihydropyridines, which upon oxidation gave the pyridines involved in the total synthesis of the alkaloid iosalamarine.55 The key transformation consisted of a cyclocondensation of the sodium ...
ChemInform, 2013
ABSTRACT The diketoacid substrates are activated by BTU to react with nitroolefins or acrolein.
Although long known, 1,2- and 1,3-dicarbonyl compounds have recently come more and more to preval... more Although long known, 1,2- and 1,3-dicarbonyl compounds have recently come more and more to prevalence as ideal substrates for the invention of new stereoselective multiple bond-forming transformations (MBFTs). Herein, a critical appraisal is presented of some of the most spectacular of these MBFTs, which allow the formation from three up to six bonds in highly step- and atom-economical processes.