Faramarz Memari | Iran University of Medical Sciences (original) (raw)

Papers by Faramarz Memari

Rhinology journal, 2020

Background: Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease. Endoscopic sin... more Background: Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease. Endoscopic sinus surgery is recommended as a standard method when medical treatment fails. The effectiveness of various complementary surgical methods such as endoscopic partial middle-turbinectomy is controversial in the improvement of CRS symptoms in these patients. This study aimed to investigate the effect of endoscopic partial middle-turbinectomy on the quality of life (QOL) of patients with chronic rhinosinusitis and nasal polyps (CRSwNP) in Iran. Method: Ninety patients with CRSwNP of grades 3 and 4 were randomly assigned to either an intervention (45 patients) or control group (45 patients). In the control group, endoscopic sinus surgery without middle turbinectomy was performed and in the intervention group, endoscopic partial middle-turbinectomy was performed in addition to endoscopic sinus surgery. To evaluate the outcomes, the SNOT-22 QOL questionnaire was used, and the results were analyzed using SPSS version 24. Results: Most of the patients were male and had a mean age of 39 years. The mean SNOT-22 QOL questionnaire scores were 49.13±16.72 and 52.51±16.95 before surgery in the control and intervention groups respectively, which did not show any significant difference. In contrast, after endoscopic surgery these scores changed to 28.46±12.38 and 11.13±5.55 in the control and intervention groups, respectively< and there was a significant difference between both groups. Although there was a significant improvement in both groups, the patients in the intervention group experienced more improvement than the control group (41.4 (±16.46) vs 30.7 (±18.27), respectively Conclusion: According to this study, it appears that the use of endoscopic partial middle-turbinectomy in addition to endoscopic sinus surgery improves CRS symptoms and the QOL of patients compared with endoscopic sinus surgery alone.

Iranian Journal of Otorhinolaryngology, 2014

We investigated the effect of intratympanic dexamethasone on control of tinnitus and hearing loss... more We investigated the effect of intratympanic dexamethasone on control of tinnitus and hearing loss in patients with Menier’s disease. Materials and Methods:

Narrowing of the upper airway due to amyloidosis: A case report

Introduction: To report our experience with a large series of surgical procedures for removal of ... more Introduction: To report our experience with a large series of surgical procedures for removal of cerebellopontine angle (CPA) tumors using different approaches. Materials and Methods: This was a retrospective analysis of 50 patients (mean age, 49 years) with CPA tumors (predominantly acoustic neuroma) who underwent surgical removal using appropriate techniques (principally a translabyrinthine approach) during a 4-year period. Results: One death occurred during this study. There were nine cases (18%) of cerebrospinal fluid leak, and five patients (10%) were diagnosed as having bacterial meningitis. Complete gross tumor removal was not achieved in four patients (8%). Facial nerve function as measured by the House Brackmann system was recorded in all patients 1 year following surgery: 32% had a score of 1 or 2; 26% had a score of 3 or 4; and 8% had a score of 5 or 6. Other complications included four cases of wound infection. Conclusion: The translabyrinthine approach was predominantly...

2 To report our experience with a large series of surgical procedures for removal of cerebellopon... more 2 To report our experience with a large series of surgical procedures for removal of cerebellopontine angle (CPA) tumors using different approaches. Materials and Methods:

Avicenna Journal of Clinical Medicine, 2011

Introduction & Objective: Vertigo in the elderly is relatively common, but only a few studies are... more Introduction & Objective: Vertigo in the elderly is relatively common, but only a few studies are available. Vestibular rehabilitation (VR) therapy is an important therapeutic option in treating patients with significant balance deficits. The purpose of this study was to analyze the effect of vestibular rehabilitation on vertigo symptoms in elderly patients with benign paroxysmal positional vertigo (BPPV). Materials & Methods: In a clinical trial design, 46 patients older than 60 years (aged 61 to 72 years) with BPPV who referred to the ENT center of Imam Khomeini Hospital, Ahwaz, were studied. After an otologic evaluation, videonystagmography and dizziness handicap inventory (DHI) evaluations were performed for each case. Then, vestibular rehabilitation (VR) therapy was carried out by means of Epley maneuver. Efficacy of a VRT was tested by comparing pre-treatment with post-treatment VNG and DHI assessments. The data were analyzed by SPSS 16 software. Results: The average age of th...

Background and Aim: Vestibular evoked myogenic potentials (VEMP) originate from the saccule and t... more Background and Aim: Vestibular evoked myogenic potentials (VEMP) originate from the saccule and the inferior vestibular nerve. In this study, the prevalence of VEMP and latency of the p13 and n23 were compared between three groups of individuals, including symptomatic and asymptomatic Meniere's disease cases and normal participants. Methods: This study was conducted on 42 cases with the mean age of 40.48 years; thirty were Meniere's disease patients, of which 19 were symptomatic and 11 were asymptomatic; twelve were normal participants. The VEMP were recorded with 500 Hz tone bursts at 120 dBpeSPL. Then the prevalence and latency of the waves were analyzed and compared in the three above mentioned groups. Results: The prevalence of VEMP in symptomatic Meniere's disease patients (52.6%) was significantly less than asymptomatic individuals (90.9%) and also normal subjects (100%)(p<0.05). There was no significant difference between latencies of the waves in these three g...

Introduction: Meatoplasty is the final and essential step in performing effective canal wall down... more Introduction: Meatoplasty is the final and essential step in performing effective canal wall down surgery for chronic otitis media. In this article we review some previous techniques and discuss our preferred method. Materials and Methods: In this observational case series study, we used this technique in 53 patients (28 male and 25 female) between January 2005 and January 2008. Our survey was completed in 31 patients. Results: Twenty-six patients (83.9%) said their ear appeared normal after the procedure, but five patients (16.1%) complained of some minor change in the shape of their ear. Twenty-nine patients (93.5%) had a completely wide ear canal. The ear canal had some degree of stenosis in two patients (6.5%) post-operatively. Conclusion: This technique offers good functional and cosmetic results with minimal manipulation and minimal anatomic disruption.

Background: Resection of the petrous temporal bone to various degrees provides different levels o... more Background: Resection of the petrous temporal bone to various degrees provides different levels of access to lesions of the posterior fossa. However, precise distances of petrosal bone are not still clearly described due to the numerous variations of them which may lead to serious complications during transpetrosal surgeries. Objective: Our objective was to evaluate different distances of temporal bone in order to assess their variations and the possible correlations between them. Subjects and Methods: This anatomical study was performed on 60 temporal bones from 60 human cadavers in the years 2006 and 2007. All the bones contained an adequate portion of the petrous apex and attached fossa dura. Twelve landmarks were defined and 27 different distances were measured for each temporal bone using two-point caliper. Results: The less variation was observed in the distance between the origin of corda tympani and corda in pyramidal direction with the less variations in Z-score (2.95); whe...

Iranian Journal of Otorhinolaryngology, 2017

Introduction: Meatoplasty is the final and essential step in performing effective canal wall down... more Introduction: Meatoplasty is the final and essential step in performing effective canal wall down surgery for chronic otitis media. In this article we review some previous techniques and discuss our preferred method. Materials and Methods: In this observational case series study, we used this technique in 53 patients (28 male and 25 female) between January 2005 and January 2008. Our survey was completed in 31 patients. Results: Twenty-six patients (83.9%) said their ear appeared normal after the procedure, but five patients (16.1%) complained of some minor change in the shape of their ear. Twenty-nine patients (93.5%) had a completely wide ear canal. The ear canal had some degree of stenosis in two patients (6.5%) post-operatively. Conclusion: This technique offers good functional and cosmetic results with minimal manipulation and minimal anatomic disruption.

Iranian Journal of Otorhinolaryngology, 2014

Introduction: We investigated the effect of intratympanic dexamethasone on control of tinnitus an... more Introduction: We investigated the effect of intratympanic dexamethasone on control of tinnitus and hearing loss in patients with Meniere’s disease. Materials and Methods: 100 consecutive patients with a diagnosis of Menier's disease according to the 1995 criteria of The American Academy of Otolaryngology – Head and Neck Surgery (AAO–HNS) who remained symptomatic despite medical therapy were assigned to receive intratympanic dexamethasone. The results were assessed with respect to changes in hearing symptoms and tinnitus. Results: Hearing improvement and improvement in SDS was observed in 52% and 35% of patients, respectively. Tinnitus score was improved in 57% of patients. There was no relationship between age, sex, duration of disease, unilaterality of disease, or response to therapy. Conclusion: Intratympanic dexamethasone may be effective in the symptomatic control of hearing loss and tinnitus in Meniere’s disease.

European Archives of Oto-Rhino-Laryngology, 2019

PurposeTo evaluate the efficacy of single low dose (75 mg) preoperative pregabalin in reducing po... more PurposeTo evaluate the efficacy of single low dose (75 mg) preoperative pregabalin in reducing post-operative pain of septorhinoplasty.MethodsA double blind single center Randomized controlled trial based on block randomization. In the pregabalin group (PG) 34 participants received 75 mg pregabalin orally one hour before anesthesia induction while in control group (CG) 34 participants received a placebo. Pain and sedation were repeatedly measured with Visual Analouge Scale (VAS) and Riker Sedation-Agitation Scale (RSAS) respectively, 0.5, 1, 2, 6, 24 hours postextubation. Cumulative doses of fentanyl and ibuprofen received in both groups were compared.ResultsThirty-two of the participants in PG and 33 of the participants in CG completed the study. The Mean VAS pain score was less in PG versus CG 30 min postoperatively (2.30 ± 1.30 vs. 4.85 ± 1.17), one hour (2.28 ± 0.92 vs. 4.27 ± 0.78), two hours (2.11 ± 0.88 vs. 3.60 ± 0.61) and six hours (1.47 0.62 vs. 2.76 ± 0.91) but not 24-hours postoperatively (0.84 ± 0.62 vs. 1.09 ± 0.92). Participants in the PG were less agitated during early post-extubation period (at 10 min: RSAS 3.93 ± 0.43 vs. 4.42 ± 0.50) and more alert during the first hour post-extubation (at 60 min: RSAS 3.90 ± 0.29 vs. 3.36 ± 0.69). The total dose of rescue fentanyl and ibuprofen was lower in the PG compared to the CG.ConclusionsA single dose of 75 mg pregabalin is very effective for pain control after septorhinoplasty procedure when administered one hour before anesthesia induction. Side effects are rare and opioid sparing was noted.Trial registrationClinical trial number: IRCT2017043033706N1

Auris Nasus Larynx, 2014

To evaluate the efficacy of a novel technique of using rotation flap of canal skin in patients wi... more To evaluate the efficacy of a novel technique of using rotation flap of canal skin in patients with total or subtotal tympanic membrane (TM) perforation with no anterior residual tympanic membrane. A retrospective study of 50 patients with total or subtotal perforation repaired with rotation flap of canal skin. Clinical and audiometric data were recorded. The overall perforation closure rate was 96%. A statistically significant shortened healing time was observed. The rotation flap of canal skin could be an effective and safe technique for perforations with no anterior residual TM.

Journal of voice : official journal of the Voice Foundation, 2008

Werner's syndrome (WS) is a rare hereditary disorder which is characterized by clinical sign... more Werner's syndrome (WS) is a rare hereditary disorder which is characterized by clinical signs of premature aging. A 31-year-old man presented with a 12-year history of hoarseness. Also noted were diabetes mellitus, cataracts, scleroderma-like skin atrophy, osteoporosis, and hypogonadism. A clinical diagnosis of WS was made. Laryngoscopy revealed bowed vocal folds resulting in a spindle-shaped closure with glottal incompetence during phonation. We used Gortex for medialization of the middle part of vocal fold to correct the glottal gap in this patient. Despite correction of glottal incompetence in patients with WS, quality of voice could not be improved to that of age-matched normal individuals.

Infectious Agents and Cancer, 2012

Background Although Helicobacter Pylori (HP) was detected in some cases of chronic laryngitis, th... more Background Although Helicobacter Pylori (HP) was detected in some cases of chronic laryngitis, the results were not confirmed by polymerase chain reaction (PCR). By this time, it has not been found in laryngeal lesions by in house PCR, the most sensitive method for detecting the genome tracks. Regarding the previous results and also few numbers of studies about the presence of HP in benign laryngeal lesions, specifically by PCR, we aimed to investigate the presence of HP in benign laryngeal lesions by in-house PCR. Methods The samples were taken from 55 patients with benign laryngeal lesions and frozen in −20°C. One milliliter (ml) of lysis buffer was added to 100 mg (mg) of each sample and the tube was placed in 56°C overnight. Then DNA extraction was carried out. Results To find HP DNA, in-house PCR was performed that revealed 5 positive results among 55 patients with benign laryngeal lesions. Of them, 3 were polyp, 1 was nodule and 1 was papilloma. Conclusion Although the number ...

Headache: The Journal of Head and Face Pain, 2010

European Archives of Oto-Rhino-Laryngology, 2011

Journal of Clinical Medicine Research

A 37 year-old woman was referred to our hospital complaining of dyspnea and bilateral swelling of... more A 37 year-old woman was referred to our hospital complaining of dyspnea and bilateral swelling of the submandibular region which were developed 6 months ago. Although the submandibular glands seemed to be diffusely enlarged, with suspicion to amyloidosis, an incisional biopsy of one gland stained with Congo red was performed but normal glandular tissue was found. As a result, abdominal fat pad biopsy was done to confirm the diagnosis. Further review of MRI data indicated that the submandibular swelling was due to down-shifting of the submandibular glands brought about by enlargement of the tongue and floor-of-mouth muscles. Abdominal fat pad biopsy showed deposition of amyloid fibrils. Findings were consistent with amyloidosis. In this case the most remarkable findings were swelling in submandibular area secondary to down-shifting of the submandibular glands and macroglossia which had partially compromised the airway. Abdominal fat pad biopsy is easier and less invasive than other m...

Rhinology journal, 2020

Background: Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease. Endoscopic sin... more Background: Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease. Endoscopic sinus surgery is recommended as a standard method when medical treatment fails. The effectiveness of various complementary surgical methods such as endoscopic partial middle-turbinectomy is controversial in the improvement of CRS symptoms in these patients. This study aimed to investigate the effect of endoscopic partial middle-turbinectomy on the quality of life (QOL) of patients with chronic rhinosinusitis and nasal polyps (CRSwNP) in Iran. Method: Ninety patients with CRSwNP of grades 3 and 4 were randomly assigned to either an intervention (45 patients) or control group (45 patients). In the control group, endoscopic sinus surgery without middle turbinectomy was performed and in the intervention group, endoscopic partial middle-turbinectomy was performed in addition to endoscopic sinus surgery. To evaluate the outcomes, the SNOT-22 QOL questionnaire was used, and the results were analyzed using SPSS version 24. Results: Most of the patients were male and had a mean age of 39 years. The mean SNOT-22 QOL questionnaire scores were 49.13±16.72 and 52.51±16.95 before surgery in the control and intervention groups respectively, which did not show any significant difference. In contrast, after endoscopic surgery these scores changed to 28.46±12.38 and 11.13±5.55 in the control and intervention groups, respectively< and there was a significant difference between both groups. Although there was a significant improvement in both groups, the patients in the intervention group experienced more improvement than the control group (41.4 (±16.46) vs 30.7 (±18.27), respectively Conclusion: According to this study, it appears that the use of endoscopic partial middle-turbinectomy in addition to endoscopic sinus surgery improves CRS symptoms and the QOL of patients compared with endoscopic sinus surgery alone.

Iranian Journal of Otorhinolaryngology, 2014

We investigated the effect of intratympanic dexamethasone on control of tinnitus and hearing loss... more We investigated the effect of intratympanic dexamethasone on control of tinnitus and hearing loss in patients with Menier’s disease. Materials and Methods:

Narrowing of the upper airway due to amyloidosis: A case report

Introduction: To report our experience with a large series of surgical procedures for removal of ... more Introduction: To report our experience with a large series of surgical procedures for removal of cerebellopontine angle (CPA) tumors using different approaches. Materials and Methods: This was a retrospective analysis of 50 patients (mean age, 49 years) with CPA tumors (predominantly acoustic neuroma) who underwent surgical removal using appropriate techniques (principally a translabyrinthine approach) during a 4-year period. Results: One death occurred during this study. There were nine cases (18%) of cerebrospinal fluid leak, and five patients (10%) were diagnosed as having bacterial meningitis. Complete gross tumor removal was not achieved in four patients (8%). Facial nerve function as measured by the House Brackmann system was recorded in all patients 1 year following surgery: 32% had a score of 1 or 2; 26% had a score of 3 or 4; and 8% had a score of 5 or 6. Other complications included four cases of wound infection. Conclusion: The translabyrinthine approach was predominantly...

2 To report our experience with a large series of surgical procedures for removal of cerebellopon... more 2 To report our experience with a large series of surgical procedures for removal of cerebellopontine angle (CPA) tumors using different approaches. Materials and Methods:

Avicenna Journal of Clinical Medicine, 2011

Introduction & Objective: Vertigo in the elderly is relatively common, but only a few studies are... more Introduction & Objective: Vertigo in the elderly is relatively common, but only a few studies are available. Vestibular rehabilitation (VR) therapy is an important therapeutic option in treating patients with significant balance deficits. The purpose of this study was to analyze the effect of vestibular rehabilitation on vertigo symptoms in elderly patients with benign paroxysmal positional vertigo (BPPV). Materials & Methods: In a clinical trial design, 46 patients older than 60 years (aged 61 to 72 years) with BPPV who referred to the ENT center of Imam Khomeini Hospital, Ahwaz, were studied. After an otologic evaluation, videonystagmography and dizziness handicap inventory (DHI) evaluations were performed for each case. Then, vestibular rehabilitation (VR) therapy was carried out by means of Epley maneuver. Efficacy of a VRT was tested by comparing pre-treatment with post-treatment VNG and DHI assessments. The data were analyzed by SPSS 16 software. Results: The average age of th...

Background and Aim: Vestibular evoked myogenic potentials (VEMP) originate from the saccule and t... more Background and Aim: Vestibular evoked myogenic potentials (VEMP) originate from the saccule and the inferior vestibular nerve. In this study, the prevalence of VEMP and latency of the p13 and n23 were compared between three groups of individuals, including symptomatic and asymptomatic Meniere's disease cases and normal participants. Methods: This study was conducted on 42 cases with the mean age of 40.48 years; thirty were Meniere's disease patients, of which 19 were symptomatic and 11 were asymptomatic; twelve were normal participants. The VEMP were recorded with 500 Hz tone bursts at 120 dBpeSPL. Then the prevalence and latency of the waves were analyzed and compared in the three above mentioned groups. Results: The prevalence of VEMP in symptomatic Meniere's disease patients (52.6%) was significantly less than asymptomatic individuals (90.9%) and also normal subjects (100%)(p<0.05). There was no significant difference between latencies of the waves in these three g...

Introduction: Meatoplasty is the final and essential step in performing effective canal wall down... more Introduction: Meatoplasty is the final and essential step in performing effective canal wall down surgery for chronic otitis media. In this article we review some previous techniques and discuss our preferred method. Materials and Methods: In this observational case series study, we used this technique in 53 patients (28 male and 25 female) between January 2005 and January 2008. Our survey was completed in 31 patients. Results: Twenty-six patients (83.9%) said their ear appeared normal after the procedure, but five patients (16.1%) complained of some minor change in the shape of their ear. Twenty-nine patients (93.5%) had a completely wide ear canal. The ear canal had some degree of stenosis in two patients (6.5%) post-operatively. Conclusion: This technique offers good functional and cosmetic results with minimal manipulation and minimal anatomic disruption.

Background: Resection of the petrous temporal bone to various degrees provides different levels o... more Background: Resection of the petrous temporal bone to various degrees provides different levels of access to lesions of the posterior fossa. However, precise distances of petrosal bone are not still clearly described due to the numerous variations of them which may lead to serious complications during transpetrosal surgeries. Objective: Our objective was to evaluate different distances of temporal bone in order to assess their variations and the possible correlations between them. Subjects and Methods: This anatomical study was performed on 60 temporal bones from 60 human cadavers in the years 2006 and 2007. All the bones contained an adequate portion of the petrous apex and attached fossa dura. Twelve landmarks were defined and 27 different distances were measured for each temporal bone using two-point caliper. Results: The less variation was observed in the distance between the origin of corda tympani and corda in pyramidal direction with the less variations in Z-score (2.95); whe...

Iranian Journal of Otorhinolaryngology, 2017

Introduction: Meatoplasty is the final and essential step in performing effective canal wall down... more Introduction: Meatoplasty is the final and essential step in performing effective canal wall down surgery for chronic otitis media. In this article we review some previous techniques and discuss our preferred method. Materials and Methods: In this observational case series study, we used this technique in 53 patients (28 male and 25 female) between January 2005 and January 2008. Our survey was completed in 31 patients. Results: Twenty-six patients (83.9%) said their ear appeared normal after the procedure, but five patients (16.1%) complained of some minor change in the shape of their ear. Twenty-nine patients (93.5%) had a completely wide ear canal. The ear canal had some degree of stenosis in two patients (6.5%) post-operatively. Conclusion: This technique offers good functional and cosmetic results with minimal manipulation and minimal anatomic disruption.

Iranian Journal of Otorhinolaryngology, 2014

Introduction: We investigated the effect of intratympanic dexamethasone on control of tinnitus an... more Introduction: We investigated the effect of intratympanic dexamethasone on control of tinnitus and hearing loss in patients with Meniere’s disease. Materials and Methods: 100 consecutive patients with a diagnosis of Menier's disease according to the 1995 criteria of The American Academy of Otolaryngology – Head and Neck Surgery (AAO–HNS) who remained symptomatic despite medical therapy were assigned to receive intratympanic dexamethasone. The results were assessed with respect to changes in hearing symptoms and tinnitus. Results: Hearing improvement and improvement in SDS was observed in 52% and 35% of patients, respectively. Tinnitus score was improved in 57% of patients. There was no relationship between age, sex, duration of disease, unilaterality of disease, or response to therapy. Conclusion: Intratympanic dexamethasone may be effective in the symptomatic control of hearing loss and tinnitus in Meniere’s disease.

European Archives of Oto-Rhino-Laryngology, 2019

PurposeTo evaluate the efficacy of single low dose (75 mg) preoperative pregabalin in reducing po... more PurposeTo evaluate the efficacy of single low dose (75 mg) preoperative pregabalin in reducing post-operative pain of septorhinoplasty.MethodsA double blind single center Randomized controlled trial based on block randomization. In the pregabalin group (PG) 34 participants received 75 mg pregabalin orally one hour before anesthesia induction while in control group (CG) 34 participants received a placebo. Pain and sedation were repeatedly measured with Visual Analouge Scale (VAS) and Riker Sedation-Agitation Scale (RSAS) respectively, 0.5, 1, 2, 6, 24 hours postextubation. Cumulative doses of fentanyl and ibuprofen received in both groups were compared.ResultsThirty-two of the participants in PG and 33 of the participants in CG completed the study. The Mean VAS pain score was less in PG versus CG 30 min postoperatively (2.30 ± 1.30 vs. 4.85 ± 1.17), one hour (2.28 ± 0.92 vs. 4.27 ± 0.78), two hours (2.11 ± 0.88 vs. 3.60 ± 0.61) and six hours (1.47 0.62 vs. 2.76 ± 0.91) but not 24-hours postoperatively (0.84 ± 0.62 vs. 1.09 ± 0.92). Participants in the PG were less agitated during early post-extubation period (at 10 min: RSAS 3.93 ± 0.43 vs. 4.42 ± 0.50) and more alert during the first hour post-extubation (at 60 min: RSAS 3.90 ± 0.29 vs. 3.36 ± 0.69). The total dose of rescue fentanyl and ibuprofen was lower in the PG compared to the CG.ConclusionsA single dose of 75 mg pregabalin is very effective for pain control after septorhinoplasty procedure when administered one hour before anesthesia induction. Side effects are rare and opioid sparing was noted.Trial registrationClinical trial number: IRCT2017043033706N1

Auris Nasus Larynx, 2014

To evaluate the efficacy of a novel technique of using rotation flap of canal skin in patients wi... more To evaluate the efficacy of a novel technique of using rotation flap of canal skin in patients with total or subtotal tympanic membrane (TM) perforation with no anterior residual tympanic membrane. A retrospective study of 50 patients with total or subtotal perforation repaired with rotation flap of canal skin. Clinical and audiometric data were recorded. The overall perforation closure rate was 96%. A statistically significant shortened healing time was observed. The rotation flap of canal skin could be an effective and safe technique for perforations with no anterior residual TM.

Journal of voice : official journal of the Voice Foundation, 2008

Werner's syndrome (WS) is a rare hereditary disorder which is characterized by clinical sign... more Werner's syndrome (WS) is a rare hereditary disorder which is characterized by clinical signs of premature aging. A 31-year-old man presented with a 12-year history of hoarseness. Also noted were diabetes mellitus, cataracts, scleroderma-like skin atrophy, osteoporosis, and hypogonadism. A clinical diagnosis of WS was made. Laryngoscopy revealed bowed vocal folds resulting in a spindle-shaped closure with glottal incompetence during phonation. We used Gortex for medialization of the middle part of vocal fold to correct the glottal gap in this patient. Despite correction of glottal incompetence in patients with WS, quality of voice could not be improved to that of age-matched normal individuals.

Infectious Agents and Cancer, 2012

Background Although Helicobacter Pylori (HP) was detected in some cases of chronic laryngitis, th... more Background Although Helicobacter Pylori (HP) was detected in some cases of chronic laryngitis, the results were not confirmed by polymerase chain reaction (PCR). By this time, it has not been found in laryngeal lesions by in house PCR, the most sensitive method for detecting the genome tracks. Regarding the previous results and also few numbers of studies about the presence of HP in benign laryngeal lesions, specifically by PCR, we aimed to investigate the presence of HP in benign laryngeal lesions by in-house PCR. Methods The samples were taken from 55 patients with benign laryngeal lesions and frozen in −20°C. One milliliter (ml) of lysis buffer was added to 100 mg (mg) of each sample and the tube was placed in 56°C overnight. Then DNA extraction was carried out. Results To find HP DNA, in-house PCR was performed that revealed 5 positive results among 55 patients with benign laryngeal lesions. Of them, 3 were polyp, 1 was nodule and 1 was papilloma. Conclusion Although the number ...

Headache: The Journal of Head and Face Pain, 2010

European Archives of Oto-Rhino-Laryngology, 2011

Journal of Clinical Medicine Research

A 37 year-old woman was referred to our hospital complaining of dyspnea and bilateral swelling of... more A 37 year-old woman was referred to our hospital complaining of dyspnea and bilateral swelling of the submandibular region which were developed 6 months ago. Although the submandibular glands seemed to be diffusely enlarged, with suspicion to amyloidosis, an incisional biopsy of one gland stained with Congo red was performed but normal glandular tissue was found. As a result, abdominal fat pad biopsy was done to confirm the diagnosis. Further review of MRI data indicated that the submandibular swelling was due to down-shifting of the submandibular glands brought about by enlargement of the tongue and floor-of-mouth muscles. Abdominal fat pad biopsy showed deposition of amyloid fibrils. Findings were consistent with amyloidosis. In this case the most remarkable findings were swelling in submandibular area secondary to down-shifting of the submandibular glands and macroglossia which had partially compromised the airway. Abdominal fat pad biopsy is easier and less invasive than other m...