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Research paper thumbnail of Outcomes of assisted reproduction treatment after dopamine agonist -cabergoline-for prevention of ovarian hyper stimulation syndrome

Background: Release of vascular endothelial growth factor (VEGF) by ovaries in response to HCG ad... more Background: Release of vascular endothelial growth factor (VEGF) by ovaries in response to HCG administration is one of the main mechanisms of ovarian hyper stimulation syndrome. Since Dopamine/dopamine re-ceptor2 (Dp-r2) pathway activity-mediated by VEGF/ Vascular endothelial growth factor receptor 2 (VEGFR-2) signaling-, is associated with angiogenic events, dopamine agonists were used for the management of severe forms of OHSS. In order to assess the effects of Cabergoline on angiogenesis in the human endometrium, and subsequently its impacts on the implantation rate this study was conducted. Methods: This historical cohort study was conducted based on existing data of 115 patients (20-40 years) whom underwent assisted reproductive treatment (ART) and with a high probability for developing OHSS between March 2007 and September 2008. Forty five cases received Cabergoline were compared to 70 control subjects. The statistical methods used were: Unpaired t-test for continuous variables and the chi-square test (or Fisher's exact test if required) for categorical variables. Results: None of the patients (treatment or control group) developed OHSS. The etiologies of infertility and administration of GnRH agonist or antagonist protocols were similar in two groups (p>0.2). Number of transferred embryos and zygote intra-fallopian transfer (ZIFT) did not differ between the two groups (p≥0.06). Im-plantation rate in treatment (3.1%) and control (6.6%) subjects was similar (p=0.4). No significant difference was observed in fertilization rate, chemical, clinical and ongoing pregnancies between the two groups (p>0.5). Conclusion: Cabergoline can be safely administered in ART protocols to prevent OHSS, without compromising ART outcomes.

Research paper thumbnail of Recurrent IVF failure and hereditary thrombophilia

Iranian journal of reproductive medicine, 2014

The largest percentage of failed invitro fertilization (IVF (cycles, are due to lack of implantat... more The largest percentage of failed invitro fertilization (IVF (cycles, are due to lack of implantation. As hereditary thrombophilia can cause in placentation failure, it may have a role in recurrent IVF failure. Aim of this case-control study was to determine whether hereditary thrombophilia is more prevalent in women with recurrent IVF failures. Case group comprised 96 infertile women, with a history of recurrent IVF failure. Control group was comprised of 95 healthy women with proven fertility who had conceived spontaneously. All participants were assessed for the presence of inherited thrombophilias including: factor V Leiden, methilen tetrahydrofolate reductase (MTHFR) mutation, prothrombin mutation, homocystein level, protein S and C deficiency, antithrombin III (AT-III) deficiency and plasminogen activator inhibitor-1 (PAI-1) mutation. Presence of thrombophilia was compared between groups. Having at least one thrombophilia known as a risk factor for recurrent IVF failure (95% CI...

Research paper thumbnail of The effect of misoprostol on intraoperative blood loss after myomectomy

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2015

Research paper thumbnail of The influence of dexamethasone on postoperative nausea and vomiting in patients undergoing gynecologic laparoscopic surgeries: A randomised, controlled, double blind trial

Journal of Turkish Society of Obstetric and Gynecology, 2014

Research paper thumbnail of The effect of magnesium sulphate on postoperative analgesia requirements in gynecological surgeries

Journal of Turkish Society of Obstetric and Gynecology, 2015

Research paper thumbnail of Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis

Medical Science Monitor, 2013

To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains... more To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis.

Research paper thumbnail of Five Years’ Experience on Hysteroscopy in Abnormal Vaginal Bleeding

Journal of Minimally Invasive Surgical Sciences, 2013

Background: Hysteroscopy is the gold standard method for diagnosis of intrauterine pathologies. C... more Background: Hysteroscopy is the gold standard method for diagnosis of intrauterine pathologies. Current study is a review of hysteroscopic findings performed over a period of 5 years in patients with abnormal uterine bleeding (AUB). Objective: The aim of this study was a review of hysteroscopic findings performed over a period of 5 years in patients with abnormal uterine bleeding (AUB).

Research paper thumbnail of Outcomes of assisted reproduction treatment after dopamine agonist -cabergoline-for prevention of ovarian hyper stimulation syndrome

Background: Release of vascular endothelial growth factor (VEGF) by ovaries in response to HCG ad... more Background: Release of vascular endothelial growth factor (VEGF) by ovaries in response to HCG administration is one of the main mechanisms of ovarian hyper stimulation syndrome. Since Dopamine/dopamine re-ceptor2 (Dp-r2) pathway activity-mediated by VEGF/ Vascular endothelial growth factor receptor 2 (VEGFR-2) signaling-, is associated with angiogenic events, dopamine agonists were used for the management of severe forms of OHSS. In order to assess the effects of Cabergoline on angiogenesis in the human endometrium, and subsequently its impacts on the implantation rate this study was conducted. Methods: This historical cohort study was conducted based on existing data of 115 patients (20-40 years) whom underwent assisted reproductive treatment (ART) and with a high probability for developing OHSS between March 2007 and September 2008. Forty five cases received Cabergoline were compared to 70 control subjects. The statistical methods used were: Unpaired t-test for continuous variables and the chi-square test (or Fisher's exact test if required) for categorical variables. Results: None of the patients (treatment or control group) developed OHSS. The etiologies of infertility and administration of GnRH agonist or antagonist protocols were similar in two groups (p>0.2). Number of transferred embryos and zygote intra-fallopian transfer (ZIFT) did not differ between the two groups (p≥0.06). Im-plantation rate in treatment (3.1%) and control (6.6%) subjects was similar (p=0.4). No significant difference was observed in fertilization rate, chemical, clinical and ongoing pregnancies between the two groups (p>0.5). Conclusion: Cabergoline can be safely administered in ART protocols to prevent OHSS, without compromising ART outcomes.

Research paper thumbnail of Recurrent IVF failure and hereditary thrombophilia

Iranian journal of reproductive medicine, 2014

The largest percentage of failed invitro fertilization (IVF (cycles, are due to lack of implantat... more The largest percentage of failed invitro fertilization (IVF (cycles, are due to lack of implantation. As hereditary thrombophilia can cause in placentation failure, it may have a role in recurrent IVF failure. Aim of this case-control study was to determine whether hereditary thrombophilia is more prevalent in women with recurrent IVF failures. Case group comprised 96 infertile women, with a history of recurrent IVF failure. Control group was comprised of 95 healthy women with proven fertility who had conceived spontaneously. All participants were assessed for the presence of inherited thrombophilias including: factor V Leiden, methilen tetrahydrofolate reductase (MTHFR) mutation, prothrombin mutation, homocystein level, protein S and C deficiency, antithrombin III (AT-III) deficiency and plasminogen activator inhibitor-1 (PAI-1) mutation. Presence of thrombophilia was compared between groups. Having at least one thrombophilia known as a risk factor for recurrent IVF failure (95% CI...

Research paper thumbnail of The effect of misoprostol on intraoperative blood loss after myomectomy

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2015

Research paper thumbnail of The influence of dexamethasone on postoperative nausea and vomiting in patients undergoing gynecologic laparoscopic surgeries: A randomised, controlled, double blind trial

Journal of Turkish Society of Obstetric and Gynecology, 2014

Research paper thumbnail of The effect of magnesium sulphate on postoperative analgesia requirements in gynecological surgeries

Journal of Turkish Society of Obstetric and Gynecology, 2015

Research paper thumbnail of Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis

Medical Science Monitor, 2013

To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains... more To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis.

Research paper thumbnail of Five Years’ Experience on Hysteroscopy in Abnormal Vaginal Bleeding

Journal of Minimally Invasive Surgical Sciences, 2013

Background: Hysteroscopy is the gold standard method for diagnosis of intrauterine pathologies. C... more Background: Hysteroscopy is the gold standard method for diagnosis of intrauterine pathologies. Current study is a review of hysteroscopic findings performed over a period of 5 years in patients with abnormal uterine bleeding (AUB). Objective: The aim of this study was a review of hysteroscopic findings performed over a period of 5 years in patients with abnormal uterine bleeding (AUB).

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