kunal pal | Jadavpur University, Kolkata, India (original) (raw)
Papers by kunal pal
CrystEngComm
This work reports the variations in the fluorescence and ultra-high dielectric properties of vari... more This work reports the variations in the fluorescence and ultra-high dielectric properties of various boehmite nano-structures.
SN Applied Sciences
In this study design, the PEGylated silver decorated graphene nanocomposites (NGO-AgNPs-PEG) were... more In this study design, the PEGylated silver decorated graphene nanocomposites (NGO-AgNPs-PEG) were successfully prepared by eco-friendly non-toxic green synthesis following a novel syn-graphenization method using the aqueous leaf extract of Azadirachta indica (A. indica) (neem) as reducing agent. The prepared Smart pH stimuli responded nanoplatform was thoroughly characterized by various analytical techniques. Since a functional nanocarrier is very essential for cancer therapy, it could quickly guide the loaded anticancer drug to the tumor site to decrease the side effect. In order to overcome the side effects of doxorubicin (DOX), an anticancer drug, it was incorporated into amino PEGylated NGO-AgNPs nanocomposites. Considering drug loading and release studies, it may be concluded that improved drug loading efficiency (218%) and more pH-responsive controlled release (following Korsmeyer-Peppas model release kinetics) of DOX from NGO-AgNPs-PEG lead to a promising nanocarrier for the anticancer drug. The cytotoxicity study results, on HaCaT cell lines, indicated DOX-loaded PEGylated functionalized nanographene oxides, as compared to free DOX, had lesser harmful effect on normal cells than cancer cells. Increased cytotoxicity was exhibited in the cancerous cells (HeLa cell lines) treated with DOX loaded PEGylated silver functionalized nanographene oxide compared to covalently conjugated NGO-DOX. So, the effective delivery and release of the anticancer drug into acidic microenvironment of the targeted tumour cells would bring out higher therapeutic efficacy than pure NGO. Such a gold standard biocompatible PEGylated silver decorated NGO theranostic nanoplatform may be an excellent nano cargo for targeted and controlled drug delivery in cancer therapy.
HIGHLIGHTS • CTAB assisted CdS nanowires prepared having uniform diameter of 65 nm. • Hydrazine m... more HIGHLIGHTS • CTAB assisted CdS nanowires prepared having uniform diameter of 65 nm. • Hydrazine monohydrate assisted ZnO nanorods having uniform length of 2000-4000 nm. • The mixed band gap of CdS-Felix is increased by AE g = 0.35 eV. • The mixed band gap of ZnO-Felix is decreased by AE g =-0.22 eV. • Interesting features from photoluminescence behavior of such hybrid structure.
Academia Letters, 2021
Presently, cancer is one of the most challenging diseases threatening human health and the occurr... more Presently, cancer is one of the most challenging diseases threatening human health and the occurrence of cancer continues to increase day by day. Breast cancer is the most commonly diagnosed cancer and it is responsible for 25% of all cancer cases and 15% of all cancer deaths among females across the globe. Among the different sub-type of breast cancer, TNBC refers to the most aggressive breast cancer phenotype where ER (Estrogen receptor) PR(Progesterone receptor) and HER2(Human Epidermal Growth Factor receptor 2) are negative. Most common treatments like surgery, radiation, and chemotherapy are not enough for metastatic TNBC treatment. Over the past decade, natural therapeutic has emerged as an alternative effective agent against several grave ailments. Extensive research has proved that the natural therapeutic agent, Curcumin derived from the rhizome of Curcuma longa has shown therapeutic activity against umpteen cancerous cells including triple-negative breast cancer (TNBC) cells. Despite its various advantages, curcumin exhibit low efficacy and low bioavailability when administered as a free drug. Taking a cue from the previous researchers, we have developed different drug delivery systems which include the isoreticular nanoscale metal-organic frameworks (IRMOF) nanoparticles and polymeric micro vehicles synthesized from PLGA which is a biodegradable copolymer where hydrophobic curcumin can be loaded comfortably by coprecipitation method and thereby increases its bioavailability [1,2 ]. Our major emphasis was to enhance the circulation time, tumor localization, controlled delivery of the therapeutics. Another focus of our work included enhancing the targeting capacity of these vehicles by the conjugation of some active targeting ligands. The extensive literature survey made us aware
Journal of alloys and compounds, 2018
In this article, nanostructures of boehmite (γ-AlOOH) have been successfully synthesized in a 2 t... more In this article, nanostructures of boehmite (γ-AlOOH) have been successfully synthesized in a 2 time varied, facile and cost effective hydrothermal route. The samples have been characterized 3 by using X-Ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), 4 Transmission Electron Microscope (TEM) and Fourier Transform Infrared (FTIR) spectroscopy. 5 Our samples exhibit remarkably high photoluminescence emission intensity and dielectric 6 constant (3.71 x 10 6 for BH12 sample) with a nominal dielectric tangent loss. A detailed growth 7 mechanism including the nucleation and self assembly of our nanomaterial has been discussed. Moreover, we are the first to report here the electrical properties of the boehmite nanoparticles.
A 2-hydroxy-5-methylisophthalaldehyde (HMP) based Schiff-base ligand (HL) was successfully develo... more A 2-hydroxy-5-methylisophthalaldehyde (HMP) based Schiff-base ligand (HL) was successfully developed as a fluorescent and colorimetric chemosensor for dual detection of Zn 2+ and Cu 2+ ions in HEPES buffer medium (H 2 O:Methanol = 9:1 (v/v), pH= 7.4). Interestingly, in presence of Zn 2+ around 16 times increment in fluor-escence intensity and in presence of Cu 2+ ~ 174 times decrease in fluorescence intensity has been observed. The 1:2 binding modes for both HL-Zn 2+ /Cu 2+ complexes are proved by fluorescence measurements, ESI-MS analysis and DFT-Calculations. The reversibility and regeneration process of HL are also established using Na 2 EDTA. It has been observed that Chemosensor HL exhibits a rapid change in fluorescence intensity within pH range 6–8 against Zn 2+ and Cu 2+ ions. Low detection limit was found to be 1.059 × 10-9 (M) and 3.53 × 10-9 (M) for Zn 2+ and Cu 2+ ions respectively. These values also suggest that the chemosensor HL has great potential to detect Zn 2+ and Cu 2+ ions in environmental and biological studies.
The present article reports three different grain morphologies of boehmite nanoparticles: spheric... more The present article reports three different grain morphologies of boehmite nanoparticles: spherical (EBH), needle-shaped (UBH) and flower-like (HBH). EBH possesses the highest surface area, whereas HBH has the lowest. A novel synthesis route for spherical (EBH) boehmite nanostructures using ethylenediamine has been reported here. Moreover, we have compared the growth mechanisms and morphology-dependent changes in the optical and electrical properties of the three samples. The band gap energies were evaluated to be 5.30 eV, 5.44 and 5.87 eV for EBH, UBH and HBH, respectively. Strong photoluminescence (PL) emission for all the nanostructures, the highest for HBH, was noted. The lowest surface area of HBH provides a surface with fewer defects; this seals the possibility of energy loss via non-radiative recombination of electrons and holes, which enhances the PL intensity. The dielectric constants for EBH, UBH and HBH are 1.49 × 10 6 , 1.14 × 10 5 , and 7.14 × 10 4 , respectively. Variations in the dielectric loss tangents and temperature-dependent electrical properties of the three morphologies were evaluated in support. Also, the ac conductivity and impedance analyses are in good accordance with our dielectric analysis. The present investigation may be highly beneficial in developing biosensors, bio-imaging, and fabricating cost-effective energy storage devices.
Colloids and surfaces. B, Biointerfaces, Jan 23, 2018
Development of fluorescent erbium doped hydroxyapatite (eHAp)-chitosan nanocomposite film is repo... more Development of fluorescent erbium doped hydroxyapatite (eHAp)-chitosan nanocomposite film is reported. Nanocrystalline eHAp has been synthesized by hydrothermal assisted precipitation method using erbium (III) ions as dopant. Physico-chemical characterization by UV/Visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), photoluminiscence spectroscopy (PL) and Field emission scanning electron microscopy(FESEM) confirmed incorporation and uniform distribution of eHAp in the chitosan films. Strong antimicrobial activity was observed using eHAp incorporated chitosan films against E. coli and S. aureus by contact inhibition on agar plates. On the other hand, excellent biocompatibility was observed with human lung fibroblast cells (WI-38) which showed strong attachment and proliferation on the chitosan films with minimal cytotoxicity. Moreover, the doped films showed good biodegradation and mineralization behavior after 2 weeks in simulated body flui...
CrystEngComm
This work reports the variations in the fluorescence and ultra-high dielectric properties of vari... more This work reports the variations in the fluorescence and ultra-high dielectric properties of various boehmite nano-structures.
SN Applied Sciences
In this study design, the PEGylated silver decorated graphene nanocomposites (NGO-AgNPs-PEG) were... more In this study design, the PEGylated silver decorated graphene nanocomposites (NGO-AgNPs-PEG) were successfully prepared by eco-friendly non-toxic green synthesis following a novel syn-graphenization method using the aqueous leaf extract of Azadirachta indica (A. indica) (neem) as reducing agent. The prepared Smart pH stimuli responded nanoplatform was thoroughly characterized by various analytical techniques. Since a functional nanocarrier is very essential for cancer therapy, it could quickly guide the loaded anticancer drug to the tumor site to decrease the side effect. In order to overcome the side effects of doxorubicin (DOX), an anticancer drug, it was incorporated into amino PEGylated NGO-AgNPs nanocomposites. Considering drug loading and release studies, it may be concluded that improved drug loading efficiency (218%) and more pH-responsive controlled release (following Korsmeyer-Peppas model release kinetics) of DOX from NGO-AgNPs-PEG lead to a promising nanocarrier for the anticancer drug. The cytotoxicity study results, on HaCaT cell lines, indicated DOX-loaded PEGylated functionalized nanographene oxides, as compared to free DOX, had lesser harmful effect on normal cells than cancer cells. Increased cytotoxicity was exhibited in the cancerous cells (HeLa cell lines) treated with DOX loaded PEGylated silver functionalized nanographene oxide compared to covalently conjugated NGO-DOX. So, the effective delivery and release of the anticancer drug into acidic microenvironment of the targeted tumour cells would bring out higher therapeutic efficacy than pure NGO. Such a gold standard biocompatible PEGylated silver decorated NGO theranostic nanoplatform may be an excellent nano cargo for targeted and controlled drug delivery in cancer therapy.
HIGHLIGHTS • CTAB assisted CdS nanowires prepared having uniform diameter of 65 nm. • Hydrazine m... more HIGHLIGHTS • CTAB assisted CdS nanowires prepared having uniform diameter of 65 nm. • Hydrazine monohydrate assisted ZnO nanorods having uniform length of 2000-4000 nm. • The mixed band gap of CdS-Felix is increased by AE g = 0.35 eV. • The mixed band gap of ZnO-Felix is decreased by AE g =-0.22 eV. • Interesting features from photoluminescence behavior of such hybrid structure.
Academia Letters, 2021
Presently, cancer is one of the most challenging diseases threatening human health and the occurr... more Presently, cancer is one of the most challenging diseases threatening human health and the occurrence of cancer continues to increase day by day. Breast cancer is the most commonly diagnosed cancer and it is responsible for 25% of all cancer cases and 15% of all cancer deaths among females across the globe. Among the different sub-type of breast cancer, TNBC refers to the most aggressive breast cancer phenotype where ER (Estrogen receptor) PR(Progesterone receptor) and HER2(Human Epidermal Growth Factor receptor 2) are negative. Most common treatments like surgery, radiation, and chemotherapy are not enough for metastatic TNBC treatment. Over the past decade, natural therapeutic has emerged as an alternative effective agent against several grave ailments. Extensive research has proved that the natural therapeutic agent, Curcumin derived from the rhizome of Curcuma longa has shown therapeutic activity against umpteen cancerous cells including triple-negative breast cancer (TNBC) cells. Despite its various advantages, curcumin exhibit low efficacy and low bioavailability when administered as a free drug. Taking a cue from the previous researchers, we have developed different drug delivery systems which include the isoreticular nanoscale metal-organic frameworks (IRMOF) nanoparticles and polymeric micro vehicles synthesized from PLGA which is a biodegradable copolymer where hydrophobic curcumin can be loaded comfortably by coprecipitation method and thereby increases its bioavailability [1,2 ]. Our major emphasis was to enhance the circulation time, tumor localization, controlled delivery of the therapeutics. Another focus of our work included enhancing the targeting capacity of these vehicles by the conjugation of some active targeting ligands. The extensive literature survey made us aware
Journal of alloys and compounds, 2018
In this article, nanostructures of boehmite (γ-AlOOH) have been successfully synthesized in a 2 t... more In this article, nanostructures of boehmite (γ-AlOOH) have been successfully synthesized in a 2 time varied, facile and cost effective hydrothermal route. The samples have been characterized 3 by using X-Ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), 4 Transmission Electron Microscope (TEM) and Fourier Transform Infrared (FTIR) spectroscopy. 5 Our samples exhibit remarkably high photoluminescence emission intensity and dielectric 6 constant (3.71 x 10 6 for BH12 sample) with a nominal dielectric tangent loss. A detailed growth 7 mechanism including the nucleation and self assembly of our nanomaterial has been discussed. Moreover, we are the first to report here the electrical properties of the boehmite nanoparticles.
A 2-hydroxy-5-methylisophthalaldehyde (HMP) based Schiff-base ligand (HL) was successfully develo... more A 2-hydroxy-5-methylisophthalaldehyde (HMP) based Schiff-base ligand (HL) was successfully developed as a fluorescent and colorimetric chemosensor for dual detection of Zn 2+ and Cu 2+ ions in HEPES buffer medium (H 2 O:Methanol = 9:1 (v/v), pH= 7.4). Interestingly, in presence of Zn 2+ around 16 times increment in fluor-escence intensity and in presence of Cu 2+ ~ 174 times decrease in fluorescence intensity has been observed. The 1:2 binding modes for both HL-Zn 2+ /Cu 2+ complexes are proved by fluorescence measurements, ESI-MS analysis and DFT-Calculations. The reversibility and regeneration process of HL are also established using Na 2 EDTA. It has been observed that Chemosensor HL exhibits a rapid change in fluorescence intensity within pH range 6–8 against Zn 2+ and Cu 2+ ions. Low detection limit was found to be 1.059 × 10-9 (M) and 3.53 × 10-9 (M) for Zn 2+ and Cu 2+ ions respectively. These values also suggest that the chemosensor HL has great potential to detect Zn 2+ and Cu 2+ ions in environmental and biological studies.
The present article reports three different grain morphologies of boehmite nanoparticles: spheric... more The present article reports three different grain morphologies of boehmite nanoparticles: spherical (EBH), needle-shaped (UBH) and flower-like (HBH). EBH possesses the highest surface area, whereas HBH has the lowest. A novel synthesis route for spherical (EBH) boehmite nanostructures using ethylenediamine has been reported here. Moreover, we have compared the growth mechanisms and morphology-dependent changes in the optical and electrical properties of the three samples. The band gap energies were evaluated to be 5.30 eV, 5.44 and 5.87 eV for EBH, UBH and HBH, respectively. Strong photoluminescence (PL) emission for all the nanostructures, the highest for HBH, was noted. The lowest surface area of HBH provides a surface with fewer defects; this seals the possibility of energy loss via non-radiative recombination of electrons and holes, which enhances the PL intensity. The dielectric constants for EBH, UBH and HBH are 1.49 × 10 6 , 1.14 × 10 5 , and 7.14 × 10 4 , respectively. Variations in the dielectric loss tangents and temperature-dependent electrical properties of the three morphologies were evaluated in support. Also, the ac conductivity and impedance analyses are in good accordance with our dielectric analysis. The present investigation may be highly beneficial in developing biosensors, bio-imaging, and fabricating cost-effective energy storage devices.
Colloids and surfaces. B, Biointerfaces, Jan 23, 2018
Development of fluorescent erbium doped hydroxyapatite (eHAp)-chitosan nanocomposite film is repo... more Development of fluorescent erbium doped hydroxyapatite (eHAp)-chitosan nanocomposite film is reported. Nanocrystalline eHAp has been synthesized by hydrothermal assisted precipitation method using erbium (III) ions as dopant. Physico-chemical characterization by UV/Visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), photoluminiscence spectroscopy (PL) and Field emission scanning electron microscopy(FESEM) confirmed incorporation and uniform distribution of eHAp in the chitosan films. Strong antimicrobial activity was observed using eHAp incorporated chitosan films against E. coli and S. aureus by contact inhibition on agar plates. On the other hand, excellent biocompatibility was observed with human lung fibroblast cells (WI-38) which showed strong attachment and proliferation on the chitosan films with minimal cytotoxicity. Moreover, the doped films showed good biodegradation and mineralization behavior after 2 weeks in simulated body flui...