Dr. Venkanna Banothu | Jntuh (original) (raw)

Papers by Dr. Venkanna Banothu

Research paper thumbnail of Investigation of Toll-Like Receptor-2 (2258G/A) and Interferon Gamma (+874T/A) Gene Polymorphisms among Infertile Women with Female Genital Tuberculosis

PLOS ONE, 2015

Background Toll-like receptor 2 (TLR2) and interferon-gamma (IFN-γ) coordinate with a diverse arr... more Background Toll-like receptor 2 (TLR2) and interferon-gamma (IFN-γ) coordinate with a diverse array of cellular programs through the transcriptional regulation of immunologically relevant genes and play an important role in immune system, reproductive physiology and basic pathology. Alterations in the functions of TLR2 2258G (guanine)/ A, IFN-γ (+874T/A) and signalling molecules that result from polymorphisms are often associated with susceptibility or resistance, which may, in turn, establish the innate host response to various infectious diseases. Presently, we proposed to investigate the risk of common single nucleotide polymorphism (SNP) of TLR2 and IFN-γ genes, for their effect on infertility in women with female genital tuberculosis (FGTB) and healthy women as controls. Methodology/Principal Findings Genotyping of TLR2 and IFN-γ gene polymorphisms was performed by amplification refractory mutation system multi-gene/multi-primer polymerase chain reaction followed by restriction fragment length polymorphism in 175 FGTB patients and 100 healthy control women (HCW). The TLR2 polymorphism [adenine (A) allele] was observed in 57.7 and 58.0% of FGTB patients and HCW, respectively. The IFN-γ (+874T/A) polymorphism (A allele) was significant in 74.3 and 71.0% of FGTB patients and HCW, respectively, while the odds ratios for the AA and TA genotypes for predisposition of FGTB were found to be 0.304 and 1.650 in HCW, respectively. The SNP of TLR2 was not associated with FGTB but the SNP of IFNγ was found to be associated with mycobacteria infections and to induce infertility.

Research paper thumbnail of Synthesis, Characterization, Antibacterial and Anticancer Activity of Some Novel Triazolyl Chromenone Derivatives

A series of newer seventeen coumarin linked 1,2,3-triazole derivatives have been synthesised by u... more A series of newer seventeen coumarin linked 1,2,3-triazole derivatives have been synthesised by utilising the approach of click chemistry. All of the synthesised compounds have been well characterized by an array of spectroscopic techniques such as 1H, 13C-NMR and MS. These compounds have been screened for antibacterial activity against Gram-positive and Gram-negative strains. In addition 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to determine cytotoxicity against two cell lines e.g., HOP-62 and Colo-205. Among the tested compounds 3a and 3k displayed promising activity.

Research paper thumbnail of Synthesis, Characterization and Antibacterial Activity of Some Novel C-7-Substituted-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine Derivatives

A number of pre-designed C-7-substituted-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine we... more A number of pre-designed C-7-substituted-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine were synthesized for the first time using Palladium catalyzed suzuki reactions in microwave with a ligand X-PHOS. A key intermediate 7-chloro-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine (7) was synthesized and treated with 20 different boronic acids to give 20 derivatives in good to excellent yields. All these compounds were tested for their antibacterial properties against four strains of bacterial microorganisms including two gram-positive and two gram-negative species. Out of twenty compounds, five compounds, compound 8, 16, 23, 24, 25 showed better activity against gram negative as well as gram positive strains.

Research paper thumbnail of Nonsteroidal anti‐inflammatory drugs based new 1,2,3‐triazole derivatives: Their design, one‐pot synthesis and in vitro evaluation

Journal of Heterocyclic Chemistry, 2021

Research paper thumbnail of Fluorenone Schiff base derivative complexes of ruthenium, rhodium and iridium exhibiting efficient antibacterial activity and DNA-binding affinity

Journal of Organometallic Chemistry, 2020

Abstract Metal precursors [(arene)MCl2]2 (arene = p-cymene, Cp∗; M = Ru, Rh and Ir) on reacting w... more Abstract Metal precursors [(arene)MCl2]2 (arene = p-cymene, Cp∗; M = Ru, Rh and Ir) on reacting with 9-fluorenone derivative ligands L1, L2 and L3 resulted in the formation of mononuclear bidentate cationic N∩N bonded complexes. The biological studies of these complexes such as antibacterial activity studies (against Gram-positive and Gram-negative bacteria) revealed significant antibacterial activity with complexes 4, 7 and 9 having the highest activity potency (in-vitro). Whilst for DNA-binding studies, the results revealed that complexes 4 and 5 displayed significant changes in their spectral features upon addition of SM-DNA, thus, indicating that these complexes bind to DNA with a significant affinity.

Research paper thumbnail of Novel 1,2,3‐triazolo phosphonate derivatives as potential antibacterial agents

Journal of Heterocyclic Chemistry, 2021

Research paper thumbnail of Arene platinum group metal complexes containing imino-quinolyl ligands: synthesis and antibacterial studies

Journal of Coordination Chemistry, 2020

Abstract Imino-quinolyl Schiff-base ligands have been prepared by the condensation reaction of su... more Abstract Imino-quinolyl Schiff-base ligands have been prepared by the condensation reaction of substituted 2-aminopyridine and quinoline-2-carbaldehyde. The reaction of [(arene)MCl2]2 with imino-quinolyl Schiff-base ligands leads to the formation of cationic complexes [(arene)M(L)Cl]+ (1–12). Single crystal X-ray diffraction studies were used to confirm the coordination mode and structures of these complexes. The molecular structures of these complexes revealed that they adopt characteristic three-legged piano stool geometry with the metal coordinating through a terminal chloride and imino-quinolyl ligands in a bidentate chelating NN′ fashion. The ligand coordinates to the metal center through the nitrogen of the quinoline and the imine nitrogen forming a five-membered metallacycle. These compounds were evaluated for their in vitro antibacterial activity by the agar well diffusion method against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae strains. Results show that all the ligands and complexes inhibited the growth of bacteria. Graphical Abstract

Research paper thumbnail of Synthesis, Chemotherapeutic Screening and Docking Studies of NSAID Inserted Peptide‐Triazole Hybrid Molecules

Research paper thumbnail of Synthesis of half sandwich platinum group metal complexes containing pyridyl benzothiazole hydrazones: Study of bonding modes and antimicrobial activity

Journal of Organometallic Chemistry, 2020

Abstract Pyridyl benzothiazole hydrazone derivatives containing ruthenium, rhodium and iridium co... more Abstract Pyridyl benzothiazole hydrazone derivatives containing ruthenium, rhodium and iridium complexes have been synthesized, characterized and evaluated for antimicrobial activity. Metal precursors of the type [(arene)RuCl2]2(arene = p-cymene, benzene), [Cp∗MCl2]2 (M = Rh/Ir) and pyridyl benzothiazole hydrazone ligands (L1 and L2) have been employed in this work. Complexes containing ligands L1 in 1:2 (M:L) ratio yielded only one type of cationic mononuclear complexes whereas ligand L2 in 1:2 (M:L) ratio yielded two types of cationic mononuclear complexes. In same manner ligand L2 in 1:1 (M:L) ratio also yielded two types of binuclear complexes with different modes of binding. All these complexes have been characterized by analytical, spectroscopic and single-crystal X-ray diffraction studies. Antibacterial studies of ligands and complexes have been carried out and were found to exhibit potent activity towards gram-positive and gram-negative bacteria.

Research paper thumbnail of Platinum group complexes containing salicylaldehyde based thiosemicarbazone ligands: Their synthesis, characterization, bonding modes, antibacterial and antioxidant studies

Journal of Organometallic Chemistry, 2020

When india connected to the global cyber revolution When india connected to the global cyber revo... more When india connected to the global cyber revolution When india connected to the global cyber revolution

Research paper thumbnail of Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes

European Journal of Medicinal Chemistry, 2020

A new library of pyrido-pyrrolidine hybrid compounds were designed, developed and screened for th... more A new library of pyrido-pyrrolidine hybrid compounds were designed, developed and screened for their antidiabetic property with α-glucosidase. The design is based on preliminary screening of key fragments identified from literature reported α-glucosidase inhibitors and antidiabetic compounds. The most active fragments were stitched to provide a pyrido-pyrrolidine hybrid molecule as a new motif. A library of these compounds were synthesized and screened against a series of α-glycosidases. Subsequently, compound 3k was the most efficacious analog with IC50 of 0.56 μM. Photoluminescence study and circular dichroism experiments indicated that compound 3k modulates the primary and secondary structure of the enzyme. It successfully brings down the fasting blood glucose level for streptozotocin (STZ, 70 mg/kg, Intraperitoneal) induced type I diabetic male Sprague-Dawley rats (250-320 g). At lower concentration, compound 3k slightly stimulates proliferation of BRIN-BD11 (α-glucose responsive beta cells from rat pancreas islets that secretes insulin) cells.

Research paper thumbnail of Assembly of Benzothiazine and Triazole in a Single Molecular Entity: Synthesis of -Oxicam Derived Novel Molecules as Potential Antibacterial/ Anti-cancer Agents

Mini-Reviews in Medicinal Chemistry, 2020

Background: Benzothiazine derivatives, because of their various biological activities have attrac... more Background: Benzothiazine derivatives, because of their various biological activities have attracted particular attention in Med Chem and drug discovery efforts. The synthetic modifications of 1,2-benzothiazine 1,1-dioxides have been undertaken in order to explore and identify novel compounds or new analogues possessing promising biological activities. In our effort we have designed -oxicam derived bezothiazine-1,2,3-triazole derivatives as potential antibacterial agents. Methods: These compounds were synthesized via a multi-step sequence involving the Cu catalyzed azide- alkyne cycloaddition (CuAAC) as a key step. The CuAAC proceeded at room temperature in DMF to afford 26 novel molecules in good (70-90%) yields. Results: All these compounds were tested for their antibacterial properties against four strains of bacterial microorganisms and subsequently cytotoxic properties against lung and colon cancer cell lines. The compound 4e showed activities against majority of the bacterial ...

Research paper thumbnail of Design and synthesis of oxaprozin‐1,3,4‐oxadiazole hybrids as potential anticancer and antibacterial agents

Journal of Heterocyclic Chemistry, 2020

Research paper thumbnail of Variable structural bonding modes and antibacterial studies of thiosemicarbazone ligands of ruthenium, rhodium, and iridium metal complexes

Journal of Coordination Chemistry, 2020

With the development of network technology, the construction level of network learning space is g... more With the development of network technology, the construction level of network learning space is getting higher, which is complementary to the traditional education modes to a certain extent. This paper takes higher vocational colleges as the research objects, aims at the characteristics of higher vocational education, integrates the advantages of resources, resource presentation forms and interaction modes in network learning space, analyzes every area of changes between teaching and learning under the support of network learning space, proposes new modes of higher vocational teaching and learning based on online learning space, and points out the problems that should be paid attention to when using the network learning space.

Research paper thumbnail of Synthesis of 1, 3, 4-Oxadiazole of NSAIDs and their Biological Properties

Asian Journal of Research in Chemistry, 2018

Research paper thumbnail of Synthesis and Antibacterial/Antitubercular/Antioxidant Activities of Compounds Containing Fluoroquinolone Ring Linked to a 4-thiazolidinone Moiety

Letters in Drug Design & Discovery, 2018

Research paper thumbnail of Biogenic synthesis of silver nanoparticles mediated by Theobroma cacao extract: enhanced antibacterial and photocatalytic activities

Journal of Materials Science: Materials in Electronics, 2019

We report the efficient biogenic synthesis of silver nanoparticles (Ag NPs) using silver nitrate ... more We report the efficient biogenic synthesis of silver nanoparticles (Ag NPs) using silver nitrate and extracts of different parts of Theobroma cacao: the husk (h-Ag NPs), pulp (p-Ag NPs), and seed (s-Ag NPs). In addition, we have tested the antibacterial and photocatalytic activities of the Ag-NPs. The Ag NPs obtained from husk, pulp, and seed extracts show variation in the particle size, dispersion, and morphology. UV–visible absorbance measurements reveal surface plasmon resonance bands at 425, 438, and 462 nm for the s-Ag, h-Ag, and p-Ag NPs, respectively. Transmission electron microscopy studies revealed the formation of monodisperse spherical Ag NPs with diameter ranging from 6 to 18 nm. Fourier transform infrared measurements of the as-synthesized Ag NPs indicate differences in the phytochemicals decorating the NP surfaces, which led to differences in the zeta potential, hydrodynamic radius, and polydispersity index. The p-Ag, h-Ag, and s-Ag NPs exhibited photocatalytic activity on exposure to sunlight from sun, achieving 35%, 29%, and 24% degradation of methylene blue (MB) within 60 min, respectively. Further, the p-Ag NPs showed 98.3% MB photodegradation after 180 min. The photocatalytic rate constants for the degradation of MB were also calculated. Finally, we found that the biogenic nanoparticles affect bacterial growth, possibly by causing protein leakage and cell death. The p-Ag NPs showed better antibacterial activity against Bacillus subtilis and Escherichia coli than h-Ag and s-Ag. The photocatalytic and antibacterial activities of the Ag NPs synthesized with T. cacao mainly depend on the particle size and the biomolecules on the surface of the NPs.

Research paper thumbnail of Synthesis of New Chiral (R)‐BINOL Derivatives under Microwave Irradiation and Evaluation of Their Antibacterial and α‐Glucosidase Inhibitory Activity

Research paper thumbnail of Quinazolin derivatives as emerging alpha-glucosidase inhibitors

European Journal of Chemistry, 2018

A series of C-7 substituted-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine have been synth... more A series of C-7 substituted-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine have been synthesized and biochemical assay was examined against α-glucosidase function inhibition activity. A structure activity and structure property relationship study was experimented to surface the new hit compound. This study led to the identification of C-7substituted quinazolines with minimum inhibitory concentrations (MICs) in the preffered micromolar range in addition with interesting physicochemical properties. Biological evaluation yielded eight analogs which rose with significant α-glucosidase inhibition potency (IC50 values < 2 μM, where reference compound (Acarbose) potency value is IC50 = 0.586 uM) and could be promising candidates for further lead optimization.

Research paper thumbnail of Synthesis and Biological Evaluation of New Ibuprofen‐1,3,4‐oxadiazole‐1,2,3‐triazole Hybrids

Journal of Heterocyclic Chemistry, 2018

Research paper thumbnail of Investigation of Toll-Like Receptor-2 (2258G/A) and Interferon Gamma (+874T/A) Gene Polymorphisms among Infertile Women with Female Genital Tuberculosis

PLOS ONE, 2015

Background Toll-like receptor 2 (TLR2) and interferon-gamma (IFN-γ) coordinate with a diverse arr... more Background Toll-like receptor 2 (TLR2) and interferon-gamma (IFN-γ) coordinate with a diverse array of cellular programs through the transcriptional regulation of immunologically relevant genes and play an important role in immune system, reproductive physiology and basic pathology. Alterations in the functions of TLR2 2258G (guanine)/ A, IFN-γ (+874T/A) and signalling molecules that result from polymorphisms are often associated with susceptibility or resistance, which may, in turn, establish the innate host response to various infectious diseases. Presently, we proposed to investigate the risk of common single nucleotide polymorphism (SNP) of TLR2 and IFN-γ genes, for their effect on infertility in women with female genital tuberculosis (FGTB) and healthy women as controls. Methodology/Principal Findings Genotyping of TLR2 and IFN-γ gene polymorphisms was performed by amplification refractory mutation system multi-gene/multi-primer polymerase chain reaction followed by restriction fragment length polymorphism in 175 FGTB patients and 100 healthy control women (HCW). The TLR2 polymorphism [adenine (A) allele] was observed in 57.7 and 58.0% of FGTB patients and HCW, respectively. The IFN-γ (+874T/A) polymorphism (A allele) was significant in 74.3 and 71.0% of FGTB patients and HCW, respectively, while the odds ratios for the AA and TA genotypes for predisposition of FGTB were found to be 0.304 and 1.650 in HCW, respectively. The SNP of TLR2 was not associated with FGTB but the SNP of IFNγ was found to be associated with mycobacteria infections and to induce infertility.

Research paper thumbnail of Synthesis, Characterization, Antibacterial and Anticancer Activity of Some Novel Triazolyl Chromenone Derivatives

A series of newer seventeen coumarin linked 1,2,3-triazole derivatives have been synthesised by u... more A series of newer seventeen coumarin linked 1,2,3-triazole derivatives have been synthesised by utilising the approach of click chemistry. All of the synthesised compounds have been well characterized by an array of spectroscopic techniques such as 1H, 13C-NMR and MS. These compounds have been screened for antibacterial activity against Gram-positive and Gram-negative strains. In addition 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to determine cytotoxicity against two cell lines e.g., HOP-62 and Colo-205. Among the tested compounds 3a and 3k displayed promising activity.

Research paper thumbnail of Synthesis, Characterization and Antibacterial Activity of Some Novel C-7-Substituted-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine Derivatives

A number of pre-designed C-7-substituted-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine we... more A number of pre-designed C-7-substituted-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine were synthesized for the first time using Palladium catalyzed suzuki reactions in microwave with a ligand X-PHOS. A key intermediate 7-chloro-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine (7) was synthesized and treated with 20 different boronic acids to give 20 derivatives in good to excellent yields. All these compounds were tested for their antibacterial properties against four strains of bacterial microorganisms including two gram-positive and two gram-negative species. Out of twenty compounds, five compounds, compound 8, 16, 23, 24, 25 showed better activity against gram negative as well as gram positive strains.

Research paper thumbnail of Nonsteroidal anti‐inflammatory drugs based new 1,2,3‐triazole derivatives: Their design, one‐pot synthesis and in vitro evaluation

Journal of Heterocyclic Chemistry, 2021

Research paper thumbnail of Fluorenone Schiff base derivative complexes of ruthenium, rhodium and iridium exhibiting efficient antibacterial activity and DNA-binding affinity

Journal of Organometallic Chemistry, 2020

Abstract Metal precursors [(arene)MCl2]2 (arene = p-cymene, Cp∗; M = Ru, Rh and Ir) on reacting w... more Abstract Metal precursors [(arene)MCl2]2 (arene = p-cymene, Cp∗; M = Ru, Rh and Ir) on reacting with 9-fluorenone derivative ligands L1, L2 and L3 resulted in the formation of mononuclear bidentate cationic N∩N bonded complexes. The biological studies of these complexes such as antibacterial activity studies (against Gram-positive and Gram-negative bacteria) revealed significant antibacterial activity with complexes 4, 7 and 9 having the highest activity potency (in-vitro). Whilst for DNA-binding studies, the results revealed that complexes 4 and 5 displayed significant changes in their spectral features upon addition of SM-DNA, thus, indicating that these complexes bind to DNA with a significant affinity.

Research paper thumbnail of Novel 1,2,3‐triazolo phosphonate derivatives as potential antibacterial agents

Journal of Heterocyclic Chemistry, 2021

Research paper thumbnail of Arene platinum group metal complexes containing imino-quinolyl ligands: synthesis and antibacterial studies

Journal of Coordination Chemistry, 2020

Abstract Imino-quinolyl Schiff-base ligands have been prepared by the condensation reaction of su... more Abstract Imino-quinolyl Schiff-base ligands have been prepared by the condensation reaction of substituted 2-aminopyridine and quinoline-2-carbaldehyde. The reaction of [(arene)MCl2]2 with imino-quinolyl Schiff-base ligands leads to the formation of cationic complexes [(arene)M(L)Cl]+ (1–12). Single crystal X-ray diffraction studies were used to confirm the coordination mode and structures of these complexes. The molecular structures of these complexes revealed that they adopt characteristic three-legged piano stool geometry with the metal coordinating through a terminal chloride and imino-quinolyl ligands in a bidentate chelating NN′ fashion. The ligand coordinates to the metal center through the nitrogen of the quinoline and the imine nitrogen forming a five-membered metallacycle. These compounds were evaluated for their in vitro antibacterial activity by the agar well diffusion method against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae strains. Results show that all the ligands and complexes inhibited the growth of bacteria. Graphical Abstract

Research paper thumbnail of Synthesis, Chemotherapeutic Screening and Docking Studies of NSAID Inserted Peptide‐Triazole Hybrid Molecules

Research paper thumbnail of Synthesis of half sandwich platinum group metal complexes containing pyridyl benzothiazole hydrazones: Study of bonding modes and antimicrobial activity

Journal of Organometallic Chemistry, 2020

Abstract Pyridyl benzothiazole hydrazone derivatives containing ruthenium, rhodium and iridium co... more Abstract Pyridyl benzothiazole hydrazone derivatives containing ruthenium, rhodium and iridium complexes have been synthesized, characterized and evaluated for antimicrobial activity. Metal precursors of the type [(arene)RuCl2]2(arene = p-cymene, benzene), [Cp∗MCl2]2 (M = Rh/Ir) and pyridyl benzothiazole hydrazone ligands (L1 and L2) have been employed in this work. Complexes containing ligands L1 in 1:2 (M:L) ratio yielded only one type of cationic mononuclear complexes whereas ligand L2 in 1:2 (M:L) ratio yielded two types of cationic mononuclear complexes. In same manner ligand L2 in 1:1 (M:L) ratio also yielded two types of binuclear complexes with different modes of binding. All these complexes have been characterized by analytical, spectroscopic and single-crystal X-ray diffraction studies. Antibacterial studies of ligands and complexes have been carried out and were found to exhibit potent activity towards gram-positive and gram-negative bacteria.

Research paper thumbnail of Platinum group complexes containing salicylaldehyde based thiosemicarbazone ligands: Their synthesis, characterization, bonding modes, antibacterial and antioxidant studies

Journal of Organometallic Chemistry, 2020

When india connected to the global cyber revolution When india connected to the global cyber revo... more When india connected to the global cyber revolution When india connected to the global cyber revolution

Research paper thumbnail of Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes

European Journal of Medicinal Chemistry, 2020

A new library of pyrido-pyrrolidine hybrid compounds were designed, developed and screened for th... more A new library of pyrido-pyrrolidine hybrid compounds were designed, developed and screened for their antidiabetic property with α-glucosidase. The design is based on preliminary screening of key fragments identified from literature reported α-glucosidase inhibitors and antidiabetic compounds. The most active fragments were stitched to provide a pyrido-pyrrolidine hybrid molecule as a new motif. A library of these compounds were synthesized and screened against a series of α-glycosidases. Subsequently, compound 3k was the most efficacious analog with IC50 of 0.56 μM. Photoluminescence study and circular dichroism experiments indicated that compound 3k modulates the primary and secondary structure of the enzyme. It successfully brings down the fasting blood glucose level for streptozotocin (STZ, 70 mg/kg, Intraperitoneal) induced type I diabetic male Sprague-Dawley rats (250-320 g). At lower concentration, compound 3k slightly stimulates proliferation of BRIN-BD11 (α-glucose responsive beta cells from rat pancreas islets that secretes insulin) cells.

Research paper thumbnail of Assembly of Benzothiazine and Triazole in a Single Molecular Entity: Synthesis of -Oxicam Derived Novel Molecules as Potential Antibacterial/ Anti-cancer Agents

Mini-Reviews in Medicinal Chemistry, 2020

Background: Benzothiazine derivatives, because of their various biological activities have attrac... more Background: Benzothiazine derivatives, because of their various biological activities have attracted particular attention in Med Chem and drug discovery efforts. The synthetic modifications of 1,2-benzothiazine 1,1-dioxides have been undertaken in order to explore and identify novel compounds or new analogues possessing promising biological activities. In our effort we have designed -oxicam derived bezothiazine-1,2,3-triazole derivatives as potential antibacterial agents. Methods: These compounds were synthesized via a multi-step sequence involving the Cu catalyzed azide- alkyne cycloaddition (CuAAC) as a key step. The CuAAC proceeded at room temperature in DMF to afford 26 novel molecules in good (70-90%) yields. Results: All these compounds were tested for their antibacterial properties against four strains of bacterial microorganisms and subsequently cytotoxic properties against lung and colon cancer cell lines. The compound 4e showed activities against majority of the bacterial ...

Research paper thumbnail of Design and synthesis of oxaprozin‐1,3,4‐oxadiazole hybrids as potential anticancer and antibacterial agents

Journal of Heterocyclic Chemistry, 2020

Research paper thumbnail of Variable structural bonding modes and antibacterial studies of thiosemicarbazone ligands of ruthenium, rhodium, and iridium metal complexes

Journal of Coordination Chemistry, 2020

With the development of network technology, the construction level of network learning space is g... more With the development of network technology, the construction level of network learning space is getting higher, which is complementary to the traditional education modes to a certain extent. This paper takes higher vocational colleges as the research objects, aims at the characteristics of higher vocational education, integrates the advantages of resources, resource presentation forms and interaction modes in network learning space, analyzes every area of changes between teaching and learning under the support of network learning space, proposes new modes of higher vocational teaching and learning based on online learning space, and points out the problems that should be paid attention to when using the network learning space.

Research paper thumbnail of Synthesis of 1, 3, 4-Oxadiazole of NSAIDs and their Biological Properties

Asian Journal of Research in Chemistry, 2018

Research paper thumbnail of Synthesis and Antibacterial/Antitubercular/Antioxidant Activities of Compounds Containing Fluoroquinolone Ring Linked to a 4-thiazolidinone Moiety

Letters in Drug Design & Discovery, 2018

Research paper thumbnail of Biogenic synthesis of silver nanoparticles mediated by Theobroma cacao extract: enhanced antibacterial and photocatalytic activities

Journal of Materials Science: Materials in Electronics, 2019

We report the efficient biogenic synthesis of silver nanoparticles (Ag NPs) using silver nitrate ... more We report the efficient biogenic synthesis of silver nanoparticles (Ag NPs) using silver nitrate and extracts of different parts of Theobroma cacao: the husk (h-Ag NPs), pulp (p-Ag NPs), and seed (s-Ag NPs). In addition, we have tested the antibacterial and photocatalytic activities of the Ag-NPs. The Ag NPs obtained from husk, pulp, and seed extracts show variation in the particle size, dispersion, and morphology. UV–visible absorbance measurements reveal surface plasmon resonance bands at 425, 438, and 462 nm for the s-Ag, h-Ag, and p-Ag NPs, respectively. Transmission electron microscopy studies revealed the formation of monodisperse spherical Ag NPs with diameter ranging from 6 to 18 nm. Fourier transform infrared measurements of the as-synthesized Ag NPs indicate differences in the phytochemicals decorating the NP surfaces, which led to differences in the zeta potential, hydrodynamic radius, and polydispersity index. The p-Ag, h-Ag, and s-Ag NPs exhibited photocatalytic activity on exposure to sunlight from sun, achieving 35%, 29%, and 24% degradation of methylene blue (MB) within 60 min, respectively. Further, the p-Ag NPs showed 98.3% MB photodegradation after 180 min. The photocatalytic rate constants for the degradation of MB were also calculated. Finally, we found that the biogenic nanoparticles affect bacterial growth, possibly by causing protein leakage and cell death. The p-Ag NPs showed better antibacterial activity against Bacillus subtilis and Escherichia coli than h-Ag and s-Ag. The photocatalytic and antibacterial activities of the Ag NPs synthesized with T. cacao mainly depend on the particle size and the biomolecules on the surface of the NPs.

Research paper thumbnail of Synthesis of New Chiral (R)‐BINOL Derivatives under Microwave Irradiation and Evaluation of Their Antibacterial and α‐Glucosidase Inhibitory Activity

Research paper thumbnail of Quinazolin derivatives as emerging alpha-glucosidase inhibitors

European Journal of Chemistry, 2018

A series of C-7 substituted-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine have been synth... more A series of C-7 substituted-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine have been synthesized and biochemical assay was examined against α-glucosidase function inhibition activity. A structure activity and structure property relationship study was experimented to surface the new hit compound. This study led to the identification of C-7substituted quinazolines with minimum inhibitory concentrations (MICs) in the preffered micromolar range in addition with interesting physicochemical properties. Biological evaluation yielded eight analogs which rose with significant α-glucosidase inhibition potency (IC50 values < 2 μM, where reference compound (Acarbose) potency value is IC50 = 0.586 uM) and could be promising candidates for further lead optimization.

Research paper thumbnail of Synthesis and Biological Evaluation of New Ibuprofen‐1,3,4‐oxadiazole‐1,2,3‐triazole Hybrids

Journal of Heterocyclic Chemistry, 2018