Istabraq Musa | Johns Hopkins University (original) (raw)
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Papers by Istabraq Musa
Neuro-Oncology
Atypical teratoid rhabdoid tumor (ATRT) is a rare, aggressive pediatric brain tumor. It is charac... more Atypical teratoid rhabdoid tumor (ATRT) is a rare, aggressive pediatric brain tumor. It is characterized by inactivation of SMARCB1 gene. There is currently no standard of care for treatment. LP-184 is an analog of acylfulvene. LP-184 induces cell-cycle arrest and cell apoptosis through alkylation of DNA and RNA. Previously, LP-184 was shown to have preclinical efficacy in temozolomide-resistant human glioblastoma cell lines. Additionally, it was reported that loss of SMARB1 increases sensitivity to LP-184. Therefore, we hypothesized that LP-184 may be effective against ATRTs. We have evaluated the effect of LP-184 in multiple ATRT cell lines, including CHLA06, CHLA266, and BT37. Treatment with LP-184 showed that LP-184 inhibits cell growth from 10nM to 200nM concentrations in an ATRT cell line (CellTiter Blue assay for BT37 p<0.0001 by t-test). We have identified an IC50 of 23.92nM. LP-184 induced apoptosis 96 hours after treatment in several ATRT cell lines as demonstrated by i...
Current Ophthalmology Reports
Purpose of Review This article reviews socioeconomic elements that impact the access to glaucoma ... more Purpose of Review This article reviews socioeconomic elements that impact the access to glaucoma care, early intervention in susceptible patients, and longevity of treatment and patient compliance in various demographic groups. Recent Findings Socioeconomic factors such as insurance eligibility, education, income, marital status, and access to technology can deeply impact the diagnosis and long-term treatment of glaucoma patients. Depending on the severity, and/or urgency of care, many individuals who face these barriers forgo annual eye exams, leading to a higher incidence of untreated glaucoma. Summary Early intervention and regular follow-up are essential for patient compliance in the management of glaucoma. Routine eye care leads to earlier detection and can improve management options and reduce the severity of disease burden.
Neuro-Oncology
Atypical teratoid rhabdoid tumor (ATRT) is a rare, aggressive pediatric brain tumor. It is charac... more Atypical teratoid rhabdoid tumor (ATRT) is a rare, aggressive pediatric brain tumor. It is characterized by inactivation of SMARCB1 gene. There is currently no standard of care for treatment. LP-184 is an analog of acylfulvene. LP-184 induces cell-cycle arrest and cell apoptosis through alkylation of DNA and RNA. Previously, LP-184 was shown to have preclinical efficacy in temozolomide-resistant human glioblastoma cell lines. Additionally, it was reported that loss of SMARB1 increases sensitivity to LP-184. Therefore, we hypothesized that LP-184 may be effective against ATRTs. We have evaluated the effect of LP-184 in multiple ATRT cell lines, including CHLA06, CHLA266, and BT37. Treatment with LP-184 showed that LP-184 inhibits cell growth from 10nM to 200nM concentrations in an ATRT cell line (CellTiter Blue assay for BT37 p<0.0001 by t-test). We have identified an IC50 of 23.92nM. LP-184 induced apoptosis 96 hours after treatment in several ATRT cell lines as demonstrated by i...
Current Ophthalmology Reports
Purpose of Review This article reviews socioeconomic elements that impact the access to glaucoma ... more Purpose of Review This article reviews socioeconomic elements that impact the access to glaucoma care, early intervention in susceptible patients, and longevity of treatment and patient compliance in various demographic groups. Recent Findings Socioeconomic factors such as insurance eligibility, education, income, marital status, and access to technology can deeply impact the diagnosis and long-term treatment of glaucoma patients. Depending on the severity, and/or urgency of care, many individuals who face these barriers forgo annual eye exams, leading to a higher incidence of untreated glaucoma. Summary Early intervention and regular follow-up are essential for patient compliance in the management of glaucoma. Routine eye care leads to earlier detection and can improve management options and reduce the severity of disease burden.