Microarray Analysis of Lipopolysaccharide Potentiation of Trovafloxacin-Induced Liver Injury in Rats Suggests a Role for Proinflammatory Chemokines and Neutrophils (original) (raw)

Journal of Pharmacology and Experimental Therapeutics

Journal of Pharmacology and Experimental Therapeutics

Research ArticleTOXICOLOGY

Jeffrey F. Waring, Michael J. Liguori, James P. Luyendyk, Jane F. Maddox, Patricia E. Ganey, Robert F. Stachlewitz, Colin North, Eric A. G. Blomme and Robert A. Roth

Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1080-1087; DOI: https://doi.org/10.1124/jpet.105.096347

Jeffrey F. Waring

Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, Illinois (J.F.W., M.J.L., E.A.G.B.); Abbott Bioresearch Center, Worcester, Massachusetts (R.F.S.); and Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan (J.P.L., J.F.M., P.E.G., C.N., R.A.R.)

Michael J. Liguori

Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, Illinois (J.F.W., M.J.L., E.A.G.B.); Abbott Bioresearch Center, Worcester, Massachusetts (R.F.S.); and Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan (J.P.L., J.F.M., P.E.G., C.N., R.A.R.)

James P. Luyendyk

Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, Illinois (J.F.W., M.J.L., E.A.G.B.); Abbott Bioresearch Center, Worcester, Massachusetts (R.F.S.); and Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan (J.P.L., J.F.M., P.E.G., C.N., R.A.R.)

Jane F. Maddox

Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, Illinois (J.F.W., M.J.L., E.A.G.B.); Abbott Bioresearch Center, Worcester, Massachusetts (R.F.S.); and Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan (J.P.L., J.F.M., P.E.G., C.N., R.A.R.)

Patricia E. Ganey

Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, Illinois (J.F.W., M.J.L., E.A.G.B.); Abbott Bioresearch Center, Worcester, Massachusetts (R.F.S.); and Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan (J.P.L., J.F.M., P.E.G., C.N., R.A.R.)

Robert F. Stachlewitz

Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, Illinois (J.F.W., M.J.L., E.A.G.B.); Abbott Bioresearch Center, Worcester, Massachusetts (R.F.S.); and Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan (J.P.L., J.F.M., P.E.G., C.N., R.A.R.)

Colin North

Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, Illinois (J.F.W., M.J.L., E.A.G.B.); Abbott Bioresearch Center, Worcester, Massachusetts (R.F.S.); and Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan (J.P.L., J.F.M., P.E.G., C.N., R.A.R.)

Eric A. G. Blomme

Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, Illinois (J.F.W., M.J.L., E.A.G.B.); Abbott Bioresearch Center, Worcester, Massachusetts (R.F.S.); and Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan (J.P.L., J.F.M., P.E.G., C.N., R.A.R.)

Robert A. Roth

Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, Illinois (J.F.W., M.J.L., E.A.G.B.); Abbott Bioresearch Center, Worcester, Massachusetts (R.F.S.); and Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan (J.P.L., J.F.M., P.E.G., C.N., R.A.R.)

In this issue

Journal of Pharmacology and Experimental Therapeutics: 316 (3)

Research ArticleTOXICOLOGY

Microarray Analysis of Lipopolysaccharide Potentiation of Trovafloxacin-Induced Liver Injury in Rats Suggests a Role for Proinflammatory Chemokines and Neutrophils

Jeffrey F. Waring, Michael J. Liguori, James P. Luyendyk, Jane F. Maddox, Patricia E. Ganey, Robert F. Stachlewitz, Colin North, Eric A. G. Blomme and Robert A. Roth

Journal of Pharmacology and Experimental Therapeutics March 1, 2006, 316 (3) 1080-1087; DOI: https://doi.org/10.1124/jpet.105.096347

Research ArticleTOXICOLOGY

Microarray Analysis of Lipopolysaccharide Potentiation of Trovafloxacin-Induced Liver Injury in Rats Suggests a Role for Proinflammatory Chemokines and Neutrophils

Jeffrey F. Waring, Michael J. Liguori, James P. Luyendyk, Jane F. Maddox, Patricia E. Ganey, Robert F. Stachlewitz, Colin North, Eric A. G. Blomme and Robert A. Roth

Journal of Pharmacology and Experimental Therapeutics March 1, 2006, 316 (3) 1080-1087; DOI: https://doi.org/10.1124/jpet.105.096347

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