temesgen mulugeta | Jimma University (original) (raw)
Papers by temesgen mulugeta
Infection and Drug Resistance
Traditional medicines have been used to treat malaria for thousands of years and are the source o... more Traditional medicines have been used to treat malaria for thousands of years and are the source of the two main groups (artemisinin and quinine derivatives) of modern anti-malarial drugs. Objective: To assess the preference, practice, and factors associated with the practice of traditional medicine for malaria management. Methods: A community-based cross-sectional study was conducted among 403 residents of Jimma town, Southwest Ethiopia. The data were collected by interviewing selected households. A simple random sampling technique was used to select the households. The data were analyzed using SPSS version 26, and descriptive statistics were used for describing and summarizing the data. A multivariable logistic regression model was used to identify factors associated with the practice of traditional medicine. The medicinal plants were tabulated in excel 2010 with their parts used, route of administration and side effects reported. The relative frequency of citation (RFC) was calculated, and the commonly used traditional medicines were reported. Results: More than half (64.1%) of the participants practiced traditional medicine. Age [AOR (95% CI) = 1.04 (1.01, 1.07)], family size [AOR (95% CI) = 1.78(1.42, 2.23)] and not having information on traditional medicine use for malaria [AOR (95% CI) = 0.95 (0.03, 0.31)] were factors associated with the practice of traditional medicine. However, only 10.6% of the participants preferred to use traditional medicine. Lepidium sativum (RFC= 0.016), Allium sativum (RFC= 0.014), and Zingiber officinale (RFC= 0.012) were the commonly used herbal products. Conclusions and Recommendations: Even though the preference to use traditional medicine was low, the community practiced traditional medicine for malaria management. Age, family size and information about traditional medicine use for malaria management were associated with the practice of traditional medicine. Lepidium sativum, Sativum allium and Zingiber officinale were the commonly used traditional medicines. The stakeholders are advised to act accordingly.
The Open Nursing Journal
Background: Optimal outcomes and quality of life in patients with heart failure (HF) depend on ef... more Background: Optimal outcomes and quality of life in patients with heart failure (HF) depend on effective self-care activities. However, patients may experience difficulties, and their performance may be inconsistent. Aim: To determine the level of adherence to self-care behaviors and associated factors among adult HF patients attending chronic follow-up care at Jimma University Medical Center (JUMC). Methods: A cross-sectional study was conducted between August and September 2021. Data were collected through face-to-face interviews and by reviewing patients’ medical records. The collected data were analyzed using SPSS version 25 and the findings were presented in frequency, percentage, mean (SD), and median (IQR). Multivariate logistic regression was performed to determine factors associated with adherence to self-care behaviors. Odds ratios with 95% confidence intervals and p-values were used to report the findings. Results: Out of 266 HF patients, 50.0% had good adherence towards ...
HIV/AIDS - Research and Palliative Care, 2021
Background: The right to safe and effective treatment is an exclusive right that depends on the r... more Background: The right to safe and effective treatment is an exclusive right that depends on the robustness of the domestic health care system. Methods: A facility-based cross-sectional study was conducted from January 01 to February 01, 2020. Ten eligible hospitals and 12 randomly selected health centers were parts of this study. A total of 66 RRFs and 308 bin cards were reviewed. Data were collected through observation, record and report review, and physical count using an observational checklist. In addition, 44 semi structured interviews were conducted. The collected data were entered to MS Excel sheet and analysed using SPSS (version 20) software. The correlation test result was determined statistically significant at p<0.05. Results: Twenty-two public health facilities were included in the study of which 16 (72.72%) health facilities had at least one stock out. Availability of ARVs had very strong positive correlation ship with bin card updating practice (r=0.9 1, P<0.01), inventory accuracy rate (r=0.912, P<0.015) and very strong negative correlation ship with wastage rate (r = −0.66, P<0.001). The wastage rate due to expiration and loss was 3.9%. The mean bin card accuracy was 90.6%. RRF reports were accurate 17 (77.3%), complete 7(32%) and reported on time 14 (63.64%). Only 8 (36.36%) health facilities met acceptable storage conditions. Conclusion: The availability of bin cards and reports and resupply forms was promising, but the data quality remains low. The majority of health facilities did not meet acceptable storage conditions and had frequent stock-outs.
HIV/AIDS - Research and Palliative Care, 2021
BMC Health Services Research, 2022
Background Pharmaceutical compounding ensures access of individuals with specific requirements to... more Background Pharmaceutical compounding ensures access of individuals with specific requirements to individualized therapy. However, there is an inconsistency of compounded medication quality. Therefore, advancing the rational use of compounded medication is essential for patient safety and medication effectiveness. Objective The presented study was aimed to investigate the healthcare practitioners’ knowledge, perception, and practice of extemporaneous compounding and its contribution to the prevalence of antimicrobial resistance. Method A descriptive cross-sectional survey using a structured questionnaire was conducted. The study participants were 300 healthcare practitioners working in Jimma University Medical Center, hospital pharmacies, and community pharmacies in Jimma and Mettu Town, Southwest Ethiopia. Results Most respondents were pharmacists (62.7%) and first-degree holders (48.3%). The majority of them had experience in administering (57.7%), preparing (38%), prescribing (21...
Women's Health, 2022
Introduction: Abnormal uterine bleeding is any bleeding that deviates from normal menstruations. ... more Introduction: Abnormal uterine bleeding is any bleeding that deviates from normal menstruations. It differs in terms of frequency of bleeding, duration, and the pattern of bleeding during menstrual cycle or menopause. It is a major gynecological problem for medical visits among women in the reproductive aged group. However, data on abnormal uterine bleeding in Ethiopia are limited. Therefore, this study aimed to assess the abnormal uterine bleeding and associated factors among reproductive age women in Jimma town, Southwest Ethiopia. Methods: Community-based cross-sectional study was employed from 1 January to 30 April 2020. Six hundred sixty women were selected by using systematic random sampling. Data were collected by using semi-structured questionnaires. Data were entered into EPI data version 3.1 and analyzed by using SPSS version 25 software. All predictor’s variables with p value <0.25 in bivariable analysis were entered into multivariable logistic regression analysis. Var...
Canadian Respiratory Journal, 2020
Background. The pandemic of coronavirus disease 2019 (COVID‐19) caused by severe acute respirator... more Background. The pandemic of coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in an unprecedented public health challenge worldwide. Despite urgent and extensive global efforts, the existing evidence is inconclusive regarding the medications used for the treatment of COVID-19. Purpose. To generate an up-to-date evidence for the clinical safety and efficacy of hydroxychloroquine (HCQ) with or without azithromycin (AZ) among patients treated for COVID-19. Data Source. PubMed, Cochrane CENTRAL, LITCOVID, Web of Science, SCOPUS, BioRxiv, Embase, MedRxiv, and Wiley online library were searched from 2019/12/30 to 2020/05/23. Study Selection. Three investigators assessed the quality of the studies. Data Extraction. Data about study characteristics, effect estimates, and the quality of the studies were extracted by two independent reviewers and cross-checked by the third reviewer. Data Synthesis. The data of 6,782 (HCQ group,...
PLOS ONE
Background Determining the status of asthma control and identifying risk factors for poor asthma ... more Background Determining the status of asthma control and identifying risk factors for poor asthma control is a key strategy for curbing the negative health impacts and the financial burden of the disease. Therefore, this review was aimed to determine the rate of asthma control and assess the predictors of uncontrolled asthma in Ethiopia. Methods PubMed, Web of Science, and Google Scholar searches were performed using key terms; “asthma, bronchial asthma, control, controlled, uncontrolled and Ethiopia” up to October 16, 2020. University repositories were also searched to retrieve gray literature. The results were presented as a prevalence rate with a 95% confidence interval (CI). Subgroup analysis and meta-regression were performed to identify the sources of heterogeneity in the outcomes. Results From 1,388 patients, based on the Global Initiative for Asthma (GINA) symptom control, the rate of the uncontrolled asthma was 45.0% (95% CI 34.0% - 56.0%) with a considerable heterogeneity b...
Journal of Research in Pharmacy
The coronavirus disease-19 (COVID-19) pandemic has challenged and forced the community pharmacies... more The coronavirus disease-19 (COVID-19) pandemic has challenged and forced the community pharmacies across the world to take various measures to prevent its spread. This survey was conducted to assess the community pharmacy practice and challenges in Ethiopia amid the coronavirus disease-19 pandemic. The survey was conducted involving 67 community pharmacy professionals in Jimma and Mizan-Aman towns in the period from November 25 to December 10, 2020. A checklist was used for the data collection, and descriptive analysis was conducted using SPSS V.22. In this study, druggists were higher in proportion than pharmacists (64.2% vs. 35.8%). Of the stock of the COVID-19 infection protection supplies, facemask was well-stocked (73.1%), whereas most respondents (73.1%) reported no stock of face shields. Practicing a distance of >1 meter from the customers (85.1%) and keeping hand hygiene (83.6%) were among the measures reported to prevent cross-infection. Above two-third of the respondents reported an increase in verbal queries of the COVID-19 information (68.7%). Financial implication (89.6%) and staff cross-infection risk (89.6%) were the major worries reported by the respondents. In this study, some of the sociodemographic information were identified to affect the COVID-19 precautionary measures and challenges. In conclusion, the present study revealed problem with availability of some of the COVID-19 prevention supplies, like face shields (73.1%), requiring effort to avail. An increase in COVID-19 related queries from customers was also reported. The COVID-19 precautionary measures, such as practicing hand hygiene, physical distancing, and others were reported. The reported financial and other challenges of the COVID-19 needs mitigation measures.
Archives of Gynecology and Obstetrics
Background Globally, antimicrobial resistance (AMR) restricted the armamentarium of the health ca... more Background Globally, antimicrobial resistance (AMR) restricted the armamentarium of the health care providers against infectious diseases, mainly due to the emergence of multidrug resistant. This review is aimed at providing contemporary bacterial profile and antimicrobial resistance pattern among pregnant women with significant bacteriuria. Methods Electronic biomedical databases and indexing services such as PubMed/MEDLINE, Web of Science, EMBASE and Google Scholar were searched. Original records of research articles, available online from 2008 to 2021, addressing the prevalence of significant bacteriuria and AMR pattern among pregnant women and written in English were identified and screened. The relevant data were extracted from included studies using a format prepared in Microsoft Excel and exported to STATA 14.0 software for the outcome measure analyses and subgrouping. Results The data of 5894 urine samples from 20 included studies conducted in 8 regions of the country were p...
Background: Delay in Tuberculosis (TB) case detection and treatment may worsen the prognosis of t... more Background: Delay in Tuberculosis (TB) case detection and treatment may worsen the prognosis of the disease and spread of infection. The detection of a TB case in the country is through whereby people with symptoms are expected to go to health facilities for further investigation. Therefore, it is important to determine the factors responsible for the delay in seeking care in order to develop strategies to address them. Objectives: The objective of this study is to assess socio-cultural factors associated with patient delay in seeking care among tuberculosis patients attending TB clinics of Jimma University Specialized Hospital, Jimma Health Center and Shenen Gibe Hospital. Methods: A cross-sectional study was conducted from February 9 to 20/2015 involving 64, 27 and 14 TB patients from Jimma University Specialized Hospital, Jimma Health Center and Shenen Gibe Hospital TB clinics respectively. A face to face interview of selected TB patients was carried out at each TB clinic. The da...
Journal of Pharmaceutical Health Care and Sciences
Background Human immune deficiency virus (HIV) increases the susceptibility to primary infection ... more Background Human immune deficiency virus (HIV) increases the susceptibility to primary infection or reinfection and the risk of tuberculosis (TB) reactivation for patients with latent TB. There was no current report on the rate of active TB infection among HIV-1 infected patients in our teaching and referral hospital. Therefore, this study was aimed to determine the prevalence and factors associated with active TB infection among HIV-1 infected patients. Methods Hospital-based retrospective cross-sectional study was conducted at the Anti-Retroviral Therapy (ART) chronic follow-up clinic. Systematic random sampling was used to include the patients. A structured questionnaire was used to collect data. Data were analyzed using SPSS version 25. Descriptive statistics were used to describe the findings and multivariate logistic regression was performed to identify factors associated with active TB infection. Result 150 HIV-1 infected patients (female 54.7%) were included. The median (int...
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2020
Background Adequate foot care and regular foot examinations along with optimal glycemic control a... more Background Adequate foot care and regular foot examinations along with optimal glycemic control are effective strategies to prevent foot ulceration. Aim The aim of this study was to describe the patterns of foot self-care practice among diabetic patients attending an ambulatory clinic. Methods A descriptive cross-sectional study was conducted at the ambulatory clinic of Jimma Medical Center. A consecutive sampling technique was used. The data were analyzed by SPSS version 20 and descriptive statistics were used to describe the findings. Results A total of 370 diabetic patients (55.9% male and 68.4% type 2) were interviewed. The mean (±SD) age of the patients was 46.47±13.63 years. Over one-third (35.7%) of the patients had a previous history of foot ulcer. The majority of the patients self-inspect (92.5%) and wash (82.7%) their foot at least daily, respectively. In this study, 12.2% of the patients never inspected the inside of their footwear before putting them on and 42.4% of the ...
Infection and Drug Resistance
Purpose: To assess traditional medicine practice claims by the community for the prevention and t... more Purpose: To assess traditional medicine practice claims by the community for the prevention and treatment of COVID-19. Methods: A community-based cross-sectional study design was conducted among 422 households of Jimma Zone, and the data were collected by interviewing individuals from the selected households. The medicinal plants were recorded on Microsoft excel 2010 with their parts used, dosage form, route of administration and source of plants and tabulated in the table. Descriptive statistics were used to describe and organize the data. The Relative Frequency of Citation (RFC) was calculated for each traditional medicine to identify the top 10 medicinal products. Results: Around 46% of participants used traditional medicines for the prevention and treatment of COVID-19. The study recorded 32 herbal and non-herbal medicinal products. Garlic (RFC: 0.166), ginger (RFC: 0.133), lemon (RFC: 0.133), garden cress (RFC: 0.069) and "Damakase" (RFC: 0.031) were the frequently used herbal medicines. Seeds (47.22%) and leaves (30.56%) were the most used parts of medicinal plants. Most preparation of medicinal plants (90.63%) was administered through the oral route. The majority of medicinal plants were from home gardens. Conclusions and Recommendations: Around half of the participants practiced traditional medicines for COVID-19. Garlic, ginger, lemon, garden cress and "Damakase" were the frequently used herbal products. Seeds and leaves were regularly used parts. The oral route is the most used route of administration. The majority of medicinal plants were from home gardens. This quantity of traditional medicine practice is probably challenging to control the pandemic. However, it might open possibilities for pharmaceutical industries and researchers to look into the effectiveness and safety of claimed medicinal products. Therefore, all responsible bodies are advocated to behave accordingly.
Clinical, Cosmetic and Investigational Dermatology
Background: Burn is a serious public health problem and a leading cause of disability and disfigu... more Background: Burn is a serious public health problem and a leading cause of disability and disfigurement. However, there was no published study from our Hospital Burn Unit that assessed the clinical profiles and the outcomes of burn patients. Objective: This study was aimed to assess the clinical profiles and the outcomes of patients admitted with burn injuries. Methods: Hospital-based retrospective cross-sectional study was conducted at the Burn Unit of JMC. Systematic random sampling was used to include the burn patients. Data were analyzed using SPSS version 25. Descriptive statistics, chi-square (χ 2), and student-t-test were performed to describe and assess the relationships between the variables. Multivariate logistic regression was performed to determine the factors affecting the length of hospital stays. Results: One hundred twenty-four burn patients (51.6% female) were included. The majority (79.84%) of the patients were in the age category of less than 29 years. Scalds (47.6%) were the most common cause of burns with three times in females. The extremities (93.5%) were the most frequently affected areas. Patients with second-degree superficial burns accounted for 61.3% of all patients. In 95.88% of the patients, the total body surface area burn (TBSA) was below 20%. Lactated ringers (69.4%) and tramadol (71.0%) were the most frequently used IV fluid for resuscitation and analgesic agent for pain, respectively. Patients who undergo any of the surgical procedures stayed in the hospital for greater than 30 days more than 4 times likely (OR = 4.8, 95% CI 2.08-11.2, P < 0.001). Conclusion: Scalds are the most common cause of burn injury, particularly in patients aged less than 14 years. Educating the community about the risk groups, household safety precautions, and early seeking medical care may reduce the incidence and morbidity of burn injuries.
Open Access Rheumatology: Research and Reviews
Background: Rheumatic heart disease (RHD) is the long-term consequence of acute rheumatic fever (... more Background: Rheumatic heart disease (RHD) is the long-term consequence of acute rheumatic fever (ARF), continues unabated among middle-income and low-income countries. Thus, this study aimed to assess clinical characteristics, echocardiographic characteristics, and management practice of RHD patients. Methods: Hospital-based prospective cross-sectional study was used. The data were collected from medical records of consecutive patients admitted to medical wards during the study period. The data were cleaned and analyzed using SPSS version 20. Descriptive statistics were used to describe the data. Chi-square was used to compare proportions between categorical variables. Results: Forty-seven patients with a median (IQR) age of 28.0 (17.0-40.0) years were included. Pan systolic murmur was reported in 91.50% of patients. Forty-two (89.4%) of patients were presented with congestive heart failure and 23 (48.9%) with atrial fibrillation. Mitral valve leaflet thickening and calcification with restriction of motion were reported in 91.5% of patients. Mitral regurgitation (MR) (87.2%) and stenosis (MS) (85.1%) were the most common valvular lesions. The combinations of three (MR+MS+TR) 14 (29.8%) and four (MR+MS+TR+AR) 13 (27.7%) valve diseases were most commonly reported. Diuretics (95.7%), anticoagulants (38.3%), digoxin (36.2%), and beta-blockers (34.0%) were among the commonly prescribed medications. Conclusion: Rheumatic heart disease affected younger adults. Pansystolic murmur was reported in nearly all patients. Congestive heart failure and atrial fibrillation were common clinical presentations. Morphologic changes in mitral valve and pathologic mitral regurgitation were the most common echocardiographic reports. Cardiovascular medications were commonly utilized for symptomatic management of complications Therefore, echocardiography should be done routinely for patients with RHD, focusing on younger adults, to facilitate diagnosis and treatment before complications develop.
Infection and Drug Resistance
Traditional medicines have been used to treat malaria for thousands of years and are the source o... more Traditional medicines have been used to treat malaria for thousands of years and are the source of the two main groups (artemisinin and quinine derivatives) of modern anti-malarial drugs. Objective: To assess the preference, practice, and factors associated with the practice of traditional medicine for malaria management. Methods: A community-based cross-sectional study was conducted among 403 residents of Jimma town, Southwest Ethiopia. The data were collected by interviewing selected households. A simple random sampling technique was used to select the households. The data were analyzed using SPSS version 26, and descriptive statistics were used for describing and summarizing the data. A multivariable logistic regression model was used to identify factors associated with the practice of traditional medicine. The medicinal plants were tabulated in excel 2010 with their parts used, route of administration and side effects reported. The relative frequency of citation (RFC) was calculated, and the commonly used traditional medicines were reported. Results: More than half (64.1%) of the participants practiced traditional medicine. Age [AOR (95% CI) = 1.04 (1.01, 1.07)], family size [AOR (95% CI) = 1.78(1.42, 2.23)] and not having information on traditional medicine use for malaria [AOR (95% CI) = 0.95 (0.03, 0.31)] were factors associated with the practice of traditional medicine. However, only 10.6% of the participants preferred to use traditional medicine. Lepidium sativum (RFC= 0.016), Allium sativum (RFC= 0.014), and Zingiber officinale (RFC= 0.012) were the commonly used herbal products. Conclusions and Recommendations: Even though the preference to use traditional medicine was low, the community practiced traditional medicine for malaria management. Age, family size and information about traditional medicine use for malaria management were associated with the practice of traditional medicine. Lepidium sativum, Sativum allium and Zingiber officinale were the commonly used traditional medicines. The stakeholders are advised to act accordingly.
The Open Nursing Journal
Background: Optimal outcomes and quality of life in patients with heart failure (HF) depend on ef... more Background: Optimal outcomes and quality of life in patients with heart failure (HF) depend on effective self-care activities. However, patients may experience difficulties, and their performance may be inconsistent. Aim: To determine the level of adherence to self-care behaviors and associated factors among adult HF patients attending chronic follow-up care at Jimma University Medical Center (JUMC). Methods: A cross-sectional study was conducted between August and September 2021. Data were collected through face-to-face interviews and by reviewing patients’ medical records. The collected data were analyzed using SPSS version 25 and the findings were presented in frequency, percentage, mean (SD), and median (IQR). Multivariate logistic regression was performed to determine factors associated with adherence to self-care behaviors. Odds ratios with 95% confidence intervals and p-values were used to report the findings. Results: Out of 266 HF patients, 50.0% had good adherence towards ...
HIV/AIDS - Research and Palliative Care, 2021
Background: The right to safe and effective treatment is an exclusive right that depends on the r... more Background: The right to safe and effective treatment is an exclusive right that depends on the robustness of the domestic health care system. Methods: A facility-based cross-sectional study was conducted from January 01 to February 01, 2020. Ten eligible hospitals and 12 randomly selected health centers were parts of this study. A total of 66 RRFs and 308 bin cards were reviewed. Data were collected through observation, record and report review, and physical count using an observational checklist. In addition, 44 semi structured interviews were conducted. The collected data were entered to MS Excel sheet and analysed using SPSS (version 20) software. The correlation test result was determined statistically significant at p<0.05. Results: Twenty-two public health facilities were included in the study of which 16 (72.72%) health facilities had at least one stock out. Availability of ARVs had very strong positive correlation ship with bin card updating practice (r=0.9 1, P<0.01), inventory accuracy rate (r=0.912, P<0.015) and very strong negative correlation ship with wastage rate (r = −0.66, P<0.001). The wastage rate due to expiration and loss was 3.9%. The mean bin card accuracy was 90.6%. RRF reports were accurate 17 (77.3%), complete 7(32%) and reported on time 14 (63.64%). Only 8 (36.36%) health facilities met acceptable storage conditions. Conclusion: The availability of bin cards and reports and resupply forms was promising, but the data quality remains low. The majority of health facilities did not meet acceptable storage conditions and had frequent stock-outs.
HIV/AIDS - Research and Palliative Care, 2021
BMC Health Services Research, 2022
Background Pharmaceutical compounding ensures access of individuals with specific requirements to... more Background Pharmaceutical compounding ensures access of individuals with specific requirements to individualized therapy. However, there is an inconsistency of compounded medication quality. Therefore, advancing the rational use of compounded medication is essential for patient safety and medication effectiveness. Objective The presented study was aimed to investigate the healthcare practitioners’ knowledge, perception, and practice of extemporaneous compounding and its contribution to the prevalence of antimicrobial resistance. Method A descriptive cross-sectional survey using a structured questionnaire was conducted. The study participants were 300 healthcare practitioners working in Jimma University Medical Center, hospital pharmacies, and community pharmacies in Jimma and Mettu Town, Southwest Ethiopia. Results Most respondents were pharmacists (62.7%) and first-degree holders (48.3%). The majority of them had experience in administering (57.7%), preparing (38%), prescribing (21...
Women's Health, 2022
Introduction: Abnormal uterine bleeding is any bleeding that deviates from normal menstruations. ... more Introduction: Abnormal uterine bleeding is any bleeding that deviates from normal menstruations. It differs in terms of frequency of bleeding, duration, and the pattern of bleeding during menstrual cycle or menopause. It is a major gynecological problem for medical visits among women in the reproductive aged group. However, data on abnormal uterine bleeding in Ethiopia are limited. Therefore, this study aimed to assess the abnormal uterine bleeding and associated factors among reproductive age women in Jimma town, Southwest Ethiopia. Methods: Community-based cross-sectional study was employed from 1 January to 30 April 2020. Six hundred sixty women were selected by using systematic random sampling. Data were collected by using semi-structured questionnaires. Data were entered into EPI data version 3.1 and analyzed by using SPSS version 25 software. All predictor’s variables with p value <0.25 in bivariable analysis were entered into multivariable logistic regression analysis. Var...
Canadian Respiratory Journal, 2020
Background. The pandemic of coronavirus disease 2019 (COVID‐19) caused by severe acute respirator... more Background. The pandemic of coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in an unprecedented public health challenge worldwide. Despite urgent and extensive global efforts, the existing evidence is inconclusive regarding the medications used for the treatment of COVID-19. Purpose. To generate an up-to-date evidence for the clinical safety and efficacy of hydroxychloroquine (HCQ) with or without azithromycin (AZ) among patients treated for COVID-19. Data Source. PubMed, Cochrane CENTRAL, LITCOVID, Web of Science, SCOPUS, BioRxiv, Embase, MedRxiv, and Wiley online library were searched from 2019/12/30 to 2020/05/23. Study Selection. Three investigators assessed the quality of the studies. Data Extraction. Data about study characteristics, effect estimates, and the quality of the studies were extracted by two independent reviewers and cross-checked by the third reviewer. Data Synthesis. The data of 6,782 (HCQ group,...
PLOS ONE
Background Determining the status of asthma control and identifying risk factors for poor asthma ... more Background Determining the status of asthma control and identifying risk factors for poor asthma control is a key strategy for curbing the negative health impacts and the financial burden of the disease. Therefore, this review was aimed to determine the rate of asthma control and assess the predictors of uncontrolled asthma in Ethiopia. Methods PubMed, Web of Science, and Google Scholar searches were performed using key terms; “asthma, bronchial asthma, control, controlled, uncontrolled and Ethiopia” up to October 16, 2020. University repositories were also searched to retrieve gray literature. The results were presented as a prevalence rate with a 95% confidence interval (CI). Subgroup analysis and meta-regression were performed to identify the sources of heterogeneity in the outcomes. Results From 1,388 patients, based on the Global Initiative for Asthma (GINA) symptom control, the rate of the uncontrolled asthma was 45.0% (95% CI 34.0% - 56.0%) with a considerable heterogeneity b...
Journal of Research in Pharmacy
The coronavirus disease-19 (COVID-19) pandemic has challenged and forced the community pharmacies... more The coronavirus disease-19 (COVID-19) pandemic has challenged and forced the community pharmacies across the world to take various measures to prevent its spread. This survey was conducted to assess the community pharmacy practice and challenges in Ethiopia amid the coronavirus disease-19 pandemic. The survey was conducted involving 67 community pharmacy professionals in Jimma and Mizan-Aman towns in the period from November 25 to December 10, 2020. A checklist was used for the data collection, and descriptive analysis was conducted using SPSS V.22. In this study, druggists were higher in proportion than pharmacists (64.2% vs. 35.8%). Of the stock of the COVID-19 infection protection supplies, facemask was well-stocked (73.1%), whereas most respondents (73.1%) reported no stock of face shields. Practicing a distance of >1 meter from the customers (85.1%) and keeping hand hygiene (83.6%) were among the measures reported to prevent cross-infection. Above two-third of the respondents reported an increase in verbal queries of the COVID-19 information (68.7%). Financial implication (89.6%) and staff cross-infection risk (89.6%) were the major worries reported by the respondents. In this study, some of the sociodemographic information were identified to affect the COVID-19 precautionary measures and challenges. In conclusion, the present study revealed problem with availability of some of the COVID-19 prevention supplies, like face shields (73.1%), requiring effort to avail. An increase in COVID-19 related queries from customers was also reported. The COVID-19 precautionary measures, such as practicing hand hygiene, physical distancing, and others were reported. The reported financial and other challenges of the COVID-19 needs mitigation measures.
Archives of Gynecology and Obstetrics
Background Globally, antimicrobial resistance (AMR) restricted the armamentarium of the health ca... more Background Globally, antimicrobial resistance (AMR) restricted the armamentarium of the health care providers against infectious diseases, mainly due to the emergence of multidrug resistant. This review is aimed at providing contemporary bacterial profile and antimicrobial resistance pattern among pregnant women with significant bacteriuria. Methods Electronic biomedical databases and indexing services such as PubMed/MEDLINE, Web of Science, EMBASE and Google Scholar were searched. Original records of research articles, available online from 2008 to 2021, addressing the prevalence of significant bacteriuria and AMR pattern among pregnant women and written in English were identified and screened. The relevant data were extracted from included studies using a format prepared in Microsoft Excel and exported to STATA 14.0 software for the outcome measure analyses and subgrouping. Results The data of 5894 urine samples from 20 included studies conducted in 8 regions of the country were p...
Background: Delay in Tuberculosis (TB) case detection and treatment may worsen the prognosis of t... more Background: Delay in Tuberculosis (TB) case detection and treatment may worsen the prognosis of the disease and spread of infection. The detection of a TB case in the country is through whereby people with symptoms are expected to go to health facilities for further investigation. Therefore, it is important to determine the factors responsible for the delay in seeking care in order to develop strategies to address them. Objectives: The objective of this study is to assess socio-cultural factors associated with patient delay in seeking care among tuberculosis patients attending TB clinics of Jimma University Specialized Hospital, Jimma Health Center and Shenen Gibe Hospital. Methods: A cross-sectional study was conducted from February 9 to 20/2015 involving 64, 27 and 14 TB patients from Jimma University Specialized Hospital, Jimma Health Center and Shenen Gibe Hospital TB clinics respectively. A face to face interview of selected TB patients was carried out at each TB clinic. The da...
Journal of Pharmaceutical Health Care and Sciences
Background Human immune deficiency virus (HIV) increases the susceptibility to primary infection ... more Background Human immune deficiency virus (HIV) increases the susceptibility to primary infection or reinfection and the risk of tuberculosis (TB) reactivation for patients with latent TB. There was no current report on the rate of active TB infection among HIV-1 infected patients in our teaching and referral hospital. Therefore, this study was aimed to determine the prevalence and factors associated with active TB infection among HIV-1 infected patients. Methods Hospital-based retrospective cross-sectional study was conducted at the Anti-Retroviral Therapy (ART) chronic follow-up clinic. Systematic random sampling was used to include the patients. A structured questionnaire was used to collect data. Data were analyzed using SPSS version 25. Descriptive statistics were used to describe the findings and multivariate logistic regression was performed to identify factors associated with active TB infection. Result 150 HIV-1 infected patients (female 54.7%) were included. The median (int...
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2020
Background Adequate foot care and regular foot examinations along with optimal glycemic control a... more Background Adequate foot care and regular foot examinations along with optimal glycemic control are effective strategies to prevent foot ulceration. Aim The aim of this study was to describe the patterns of foot self-care practice among diabetic patients attending an ambulatory clinic. Methods A descriptive cross-sectional study was conducted at the ambulatory clinic of Jimma Medical Center. A consecutive sampling technique was used. The data were analyzed by SPSS version 20 and descriptive statistics were used to describe the findings. Results A total of 370 diabetic patients (55.9% male and 68.4% type 2) were interviewed. The mean (±SD) age of the patients was 46.47±13.63 years. Over one-third (35.7%) of the patients had a previous history of foot ulcer. The majority of the patients self-inspect (92.5%) and wash (82.7%) their foot at least daily, respectively. In this study, 12.2% of the patients never inspected the inside of their footwear before putting them on and 42.4% of the ...
Infection and Drug Resistance
Purpose: To assess traditional medicine practice claims by the community for the prevention and t... more Purpose: To assess traditional medicine practice claims by the community for the prevention and treatment of COVID-19. Methods: A community-based cross-sectional study design was conducted among 422 households of Jimma Zone, and the data were collected by interviewing individuals from the selected households. The medicinal plants were recorded on Microsoft excel 2010 with their parts used, dosage form, route of administration and source of plants and tabulated in the table. Descriptive statistics were used to describe and organize the data. The Relative Frequency of Citation (RFC) was calculated for each traditional medicine to identify the top 10 medicinal products. Results: Around 46% of participants used traditional medicines for the prevention and treatment of COVID-19. The study recorded 32 herbal and non-herbal medicinal products. Garlic (RFC: 0.166), ginger (RFC: 0.133), lemon (RFC: 0.133), garden cress (RFC: 0.069) and "Damakase" (RFC: 0.031) were the frequently used herbal medicines. Seeds (47.22%) and leaves (30.56%) were the most used parts of medicinal plants. Most preparation of medicinal plants (90.63%) was administered through the oral route. The majority of medicinal plants were from home gardens. Conclusions and Recommendations: Around half of the participants practiced traditional medicines for COVID-19. Garlic, ginger, lemon, garden cress and "Damakase" were the frequently used herbal products. Seeds and leaves were regularly used parts. The oral route is the most used route of administration. The majority of medicinal plants were from home gardens. This quantity of traditional medicine practice is probably challenging to control the pandemic. However, it might open possibilities for pharmaceutical industries and researchers to look into the effectiveness and safety of claimed medicinal products. Therefore, all responsible bodies are advocated to behave accordingly.
Clinical, Cosmetic and Investigational Dermatology
Background: Burn is a serious public health problem and a leading cause of disability and disfigu... more Background: Burn is a serious public health problem and a leading cause of disability and disfigurement. However, there was no published study from our Hospital Burn Unit that assessed the clinical profiles and the outcomes of burn patients. Objective: This study was aimed to assess the clinical profiles and the outcomes of patients admitted with burn injuries. Methods: Hospital-based retrospective cross-sectional study was conducted at the Burn Unit of JMC. Systematic random sampling was used to include the burn patients. Data were analyzed using SPSS version 25. Descriptive statistics, chi-square (χ 2), and student-t-test were performed to describe and assess the relationships between the variables. Multivariate logistic regression was performed to determine the factors affecting the length of hospital stays. Results: One hundred twenty-four burn patients (51.6% female) were included. The majority (79.84%) of the patients were in the age category of less than 29 years. Scalds (47.6%) were the most common cause of burns with three times in females. The extremities (93.5%) were the most frequently affected areas. Patients with second-degree superficial burns accounted for 61.3% of all patients. In 95.88% of the patients, the total body surface area burn (TBSA) was below 20%. Lactated ringers (69.4%) and tramadol (71.0%) were the most frequently used IV fluid for resuscitation and analgesic agent for pain, respectively. Patients who undergo any of the surgical procedures stayed in the hospital for greater than 30 days more than 4 times likely (OR = 4.8, 95% CI 2.08-11.2, P < 0.001). Conclusion: Scalds are the most common cause of burn injury, particularly in patients aged less than 14 years. Educating the community about the risk groups, household safety precautions, and early seeking medical care may reduce the incidence and morbidity of burn injuries.
Open Access Rheumatology: Research and Reviews
Background: Rheumatic heart disease (RHD) is the long-term consequence of acute rheumatic fever (... more Background: Rheumatic heart disease (RHD) is the long-term consequence of acute rheumatic fever (ARF), continues unabated among middle-income and low-income countries. Thus, this study aimed to assess clinical characteristics, echocardiographic characteristics, and management practice of RHD patients. Methods: Hospital-based prospective cross-sectional study was used. The data were collected from medical records of consecutive patients admitted to medical wards during the study period. The data were cleaned and analyzed using SPSS version 20. Descriptive statistics were used to describe the data. Chi-square was used to compare proportions between categorical variables. Results: Forty-seven patients with a median (IQR) age of 28.0 (17.0-40.0) years were included. Pan systolic murmur was reported in 91.50% of patients. Forty-two (89.4%) of patients were presented with congestive heart failure and 23 (48.9%) with atrial fibrillation. Mitral valve leaflet thickening and calcification with restriction of motion were reported in 91.5% of patients. Mitral regurgitation (MR) (87.2%) and stenosis (MS) (85.1%) were the most common valvular lesions. The combinations of three (MR+MS+TR) 14 (29.8%) and four (MR+MS+TR+AR) 13 (27.7%) valve diseases were most commonly reported. Diuretics (95.7%), anticoagulants (38.3%), digoxin (36.2%), and beta-blockers (34.0%) were among the commonly prescribed medications. Conclusion: Rheumatic heart disease affected younger adults. Pansystolic murmur was reported in nearly all patients. Congestive heart failure and atrial fibrillation were common clinical presentations. Morphologic changes in mitral valve and pathologic mitral regurgitation were the most common echocardiographic reports. Cardiovascular medications were commonly utilized for symptomatic management of complications Therefore, echocardiography should be done routinely for patients with RHD, focusing on younger adults, to facilitate diagnosis and treatment before complications develop.