Raed Ennab | Jordan University of Science and Technology (original) (raw)

Papers by Raed Ennab

Research paper thumbnail of Risks of emergency vascular surgery in COVID-19 patients

Italian Journal of Vascular and Endovascular Surgery

coVId-19 is a global and highly contagious pandemic with substantial morbidity and mortality. It ... more coVId-19 is a global and highly contagious pandemic with substantial morbidity and mortality. It has affected the medical care of other diseases with recommendations to postpone elective surgical procedures to decrease infection rates. New surgical triage guidelines have been recommended by the Vascular surgery society to manage urgent and emergent conditions. coVId-19 patients especially severe cases have several pathological findings as demonstrated by clinical research. Some of these pathologies including thrombocytopenia, coagulopathy, and cardiac involvement are important to be considered by the vascular surgeon. the aim of this article was to review the literature and discuss these risks in relation to vascular surgery.

Research paper thumbnail of Nanocelluloses in Wound Healing Applications

Handbook of Nanocelluloses

Research paper thumbnail of Antibiotic Profile of Pathogenic Bacteria Isolated from Postsurgical Site Infections in Public Hospitals in Northern Jordan

Infection and Drug Resistance, 2022

Background: Surgical site infections are hospital-acquired, vary from one hospital to another, an... more Background: Surgical site infections are hospital-acquired, vary from one hospital to another, and can cause significant postoperative morbidity, mortality, and prolonged hospital stay. Objective: The main aim of the study was to identify the bacterial pathogens associated with surgical site infections and their antibiotic susceptibility in a public hospital in northern Jordan. Methods: Postsurgical wound samples were collected and processed in a microbiology laboratory using standard microbiological techniques. Antibiotic susceptibility tests were performed using 13 antibiotics covering the gram-positive and gram-negative bacteria using the disc diffusion test. Results: The bacterial species that were identified in this study include Escherichia coli 8 (29%), Pseudomonas aeruginosa 3 (11%), Proteus mirabilis 1 (3.5%), Klebsiella pneumoniae 4 (14%), Salmonella enterica 2 (7%), Staphylococcus aureus 8 (29%), Staphylococcus epidermidis 1 (3.5%), and Streptococcus pyogenes 1 (4%). The antibiotic profiles of these bacteria showed high resistance. The MAR indices showed that 17 of 28 bacteria isolated were above 0.2 indicating high resistance. Conclusion: Resistant bacteria are becoming more dominant in wound infections with a high prevalence of multidrug resistant isolates. Hospital disinfection and treatment protocols regarding the use of antibiotics should be practiced vigorously and monitored regularly to combat resistance.

Research paper thumbnail of A Case of Critical Lower-Limb Ischemia in a 29-Year-Old Man with Autoimmune Polyglandular Syndrome Type 1 (APS-1)

American Journal of Case Reports, 2020

Objective: Rare disease Background: Autoimmune polyglandular syndrome type 1 (APS-1) is an extrem... more Objective: Rare disease Background: Autoimmune polyglandular syndrome type 1 (APS-1) is an extremely rare autoimmune disorder with an autosomal recessive inheritance pattern. Its manifestations present in chronological sequence of the components mucocutaneous candidiasis, Addison disease, and hypoparathyroidism. Vascular calcification is a very rare manifestation of the disease, and it may be severe, causing critical lower-limb ischemia and significant morbidity. To the best of our knowledge, this is the first such case to be reported in Jordan and the Arab region. Case Report: We present the case of a 29-year-old patient diagnosed with autoimmune polyglandular syndrome type 1 (APS-1). He has Addison disease, hypoparathyroidism, and mucocutaneous candidiasis. He presented with features of critical lower-limb ischemia and bacterial infection of the left foot. The patient underwent a successful angioplasty, and received management of his bacterial and fungal infections and the chronic endocrinopathies. Conclusions: Autoimmune polyglandular syndrome type 1 (APS-1) is a very rare disorder. Recognizing its syndromic nature will facilitate an active search for the component diseases and the possible complications, which would allow early diagnosis and management. This applies to the rare vascular complications, which can lead to significant morbidity.

Research paper thumbnail of Early and mid-term evaluation of mechanical heart valve replacement

Research paper thumbnail of Seasonal Variation Effects on Perforated Peptic Ulcer - A systematic Review

Research paper thumbnail of SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

British Journal of Surgery, 2021

Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numb... more Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst ...

Research paper thumbnail of COVID-19: Underpinning Research for Detection, Therapeutics, and Vaccines Development

Pharmaceutical Nanotechnology, 2020

Objectives: The newly emerged coronavirus SARS-CoV-2, first reported in December 2019, has infect... more Objectives: The newly emerged coronavirus SARS-CoV-2, first reported in December 2019, has infected about five and a half million people globally and resulted in nearly 9063264 deaths until the 24th of June 2020. Nevertheless, the highly contagious virus has instigated an unimaginably rapid response from scientific and medical communities. Methods: Pioneering research on molecular mechanisms underlying the viral transmission, molecular pathogenicity, and potential treatments will be highlighted in this review. The development of antiviral drugs specific to SARS-CoV-2 is a complicated and tedious process. To accelerate scientific discoveries and advancement, researchers are consolidating available data from associated coronaviruses into a single pipeline, which can be readily made available to vaccine developers. Results: In order to find studies evaluating the COVID-19 virus epidemiology, repurposed drugs and potential vaccines, web searches and bibliographical bases have been used ...

Research paper thumbnail of Endovascular management of acute mesenteric ischemia in a young patient with thyrotoxicosis and atrial fibrillation: A case report and review of the literature

International Journal of Surgery Case Reports, 2020

INTRODUCTION: Acute mesenteric ischemia caused by an embolism resulting from atrial fibrillation ... more INTRODUCTION: Acute mesenteric ischemia caused by an embolism resulting from atrial fibrillation in a thyrotoxic young male patient is a rare event. Endovascular intervention is increasingly being considered as the primary modality of treatment in selected patients. PRESENTATION OF CASE: A 41-years male known to have hyperthyroidism presented with atrial fibrillation, acute mesenteric ischemia, splenic infarction, and left renal infarction. He was successfully managed with endovascular intervention of the superior mesenteric artery. DISCUSSION: Acute mesenteric ischemia has a high mortality rate. CT angiography is the investigation of choice for diagnosis of the mesenteric vessels occlusion and assessment of bowel ischemia. The clinical presentation guides into the treatment and the choice between open surgery and endovascular intervention as the primary modality of treatment. Thyrotoxicosis is a risky comorbid condition for any procedure to be done, so proper perioperative management is essential to decrease morbidity and mortality. CONCLUSION: Prompt diagnosis and management of acute mesenteric ischemia is essential to decrease the morbidity and mortality rates. Endovascular management can be considered as a primary modality of treatment in selected cases.

Research paper thumbnail of A Potential MRI Agent and an Anticancer Drug Encapsulated within CPMV Virus-Like Particles

Combinatorial Chemistry & High Throughput Screening, 2021

Background: Virus nanoparticles have been extensively studied over the past decades for theranost... more Background: Virus nanoparticles have been extensively studied over the past decades for theranostics applications. Viruses are well-characterized, naturally occurring nanoparticles that can be produced in high quantity with a high degree of similarity in both structure and composition. Objectives: The plant virus Cowpea Mosaic Virus (CPMV) has been innovatively used as a nanoscaffold. Utilization of the internal cavity of empty Virus-Like Particles (VLPs) for the inclusion of therapeutics within the capsid has opened many opportunities in drug delivery and imaging applications. Methods: The encapsidation of magnetic materials and anticancer drugs was achieved. SuperscriptCPMV denotes molecules attached to the external surface of CPMV and CPMVSubscript denotes molecules within the interior of the capsid. Results: Here, the generation of novel VLPs incorporating iron-platinum nanoparticles TCPMVFePt and cisplatin (Cis) (TCPMVCis) is reported. TCPMVCis exhibited a cytotoxic IC50 of TCP...

Research paper thumbnail of Early and Mid-term Evaluation of Aortic Valve Replacement

European Journal of Scientific Research

In this study we investigated the operative mortality and mid-term (up to eight years) results of... more In this study we investigated the operative mortality and mid-term (up to eight years) results of aortic valve replacement (AVR).it is retrospective data analysis of sixty four consecutive patients who underwent aortic valve replacement (AVR). The early and late morbidity and mortality were analyzed at our institution, from January 2001 to December 2008. Early and Mid-term Evaluation of Aortic Valve Replacement 503 Our results showed hospital mortality was 3.1% (2 patients). Complications recorded during the follow up study include: prosthetic valve endocarditis (6.2%), bleeding (6.2%), stroke (3.1%), and reoperation (1.6%). No structural valvular dysfunction and no valvular thromboses were reported, and we concluded that aortic valve replacement with mechanical valve may be performed with low morbidity and mortality.

Research paper thumbnail of Evaluation of Mechanical Valve Replacement at Jordan University Hospital

Jordan Medical Journal

Objective: To investigate the operative mortality and mid-term (up to eight years) results of mec... more Objective: To investigate the operative mortality and mid-term (up to eight years) results of mechanical valve replacement. Methods: Retrospective data analysis of 118 consecutive patients who underwent mechanical valve replacement. The early and late morbidity and mortality were analyzed at our institution, from January 2001 to December 2008. Results: Hospital mortality was 2.5% (3 patients). Complications recorded during the follow up study include: prosthetic valve endocarditis (3.4%), bleeding (3.4%), stroke (3.1%), and reoperation (.8%). No structural valvular dysfunction and no valvular thromboses were reported. Conclusion: Our data show that valves replacement with mechanical valve may be performed with low morbidity and mortality.

Research paper thumbnail of Poster Presentations; Efficacy of Human Adipose Tissue-Derived Stem Cells in Cardiac Muscle Repair in an Experimental Acute Myocardial Infarction Model Using Nude Rats Strain CRL: NIH-FOX1

Research paper thumbnail of The impact of COVID-19 on surgical practice in Jordan during the second outbreak: A survey

Annals of Medicine and Surgery, 2021

Background: COVID-19 is an acute respiratory pandemic with no available effective antiviral treat... more Background: COVID-19 is an acute respiratory pandemic with no available effective antiviral treatment or widely available effective vaccine. Surgical practice has faced widespread problems due to the pandemic including viral transmission risk and cross-infection, staffing problems, prioritizations of surgical procedures, and lack of beds due to occupancy of hospitals and ICU beds with COVID-19 patients. Methods: A survey was conducted between October 31 to November 4, 2020, through google forms. The questionnaire involved 16 questions sent to consultants and specialists of all general and special surgical specialties and subspecialties in Jordan. Results: We have got responses from surgeons of all public and private sectors in Jordan. There was a pronounced decline in the number of elective and emergency procedures performed during October 2020 due to COVID-19 pandemic related reasons. Conclusions: The impact of COVID-19 on the surgical practice in Jordan during October 2020 was moderate to prominent. Measures that could be made to alleviate this impact include the assignment of certain hospitals for covid-19 patients as a step before the establishment of field hospitals and the cooperation between the private and the public health sectors.

Research paper thumbnail of Efficacy of human adipose tissue-derived stem cells in cardiac muscle repair in an experimental acute myocardial infarction model using nude rats (Crl:NIH-Fox1RNU)

Comparative Clinical Pathology, 2010

This study was designed to compare the efficacy of intraventricular (IV), intramyocardial (IM) or... more This study was designed to compare the efficacy of intraventricular (IV), intramyocardial (IM) or combined IV and IM injections of human adipose tissue-derived stem cells (hADSCs) administered either immediately, 5, or 10 days after induction of acute myocardial infarction (AMI) in a nude rat model. Acute myocardial infarction was induced in 99, adult (250-350 g BW), male nude rats strain Crl:NIH-Fox1 RNU .

Research paper thumbnail of Difficult CABG in the Era of Stenting

Jordan Medical Journal, Mar 18, 2009

For the past three decades, coronary artery bypass grafting has been the standard treatment for p... more For the past three decades, coronary artery bypass grafting has been the standard treatment for patients with severe multivessel ischemic heart disease. In the past few years, however, it has been increasingly challenged by percutaneous coronary intervention. The increasing tendency to report interventional treatments being based on "patient or physician preference" is both inadequate and inappropriate, discussion of all interventions by a multidisciplinary team should be a minimum standard of care. In this report we present a patient with coronary artery disease who underwent coronary catheterization and stenting many times, and finally the decision was to do a coronary artery bypass grafting in which the saphenous vein anastomosis to the distal right coronary artery was done over an old stent.

Research paper thumbnail of Solitary Fibrous Tumor Arising from the Mediastinal Pleura: Case Report

Jordan Medical Journal, Sep 25, 2011

Research paper thumbnail of Difficult CABG in the Era of Stenting

Jordan Medical Journal

For the past three decades, coronary artery bypass grafting has been the standard treatment for p... more For the past three decades, coronary artery bypass grafting has been the standard treatment for patients with severe multivessel ischemic heart disease. In the past few years, however, it has been increasingly challenged by percutaneous coronary intervention. The increasing tendency to report interventional treatments being based on "patient or physician preference" is both inadequate and inappropriate, discussion of all interventions by a multidisciplinary team should be a minimum standard of care. In this report we present a patient with coronary artery disease who underwent coronary catheterization and stenting many times, and finally the decision was to do a coronary artery bypass grafting in which the saphenous vein anastomosis to the distal right coronary artery was done over an old stent.

Research paper thumbnail of Evaluation of Mechanical Valve Replacement at Jordan University Hospital

Jordan Medical Journal

Objective: To investigate the operative mortality and mid-term (up to eight years) results of mec... more Objective: To investigate the operative mortality and mid-term (up to eight years) results of mechanical valve replacement. Methods: Retrospective data analysis of 118 consecutive patients who underwent mechanical valve replacement. The early and late morbidity and mortality were analyzed at our institution, from January 2001 to December 2008. Results: Hospital mortality was 2.5% (3 patients). Complications recorded during the follow up study include: prosthetic valve endocarditis (3.4%), bleeding (3.4%), stroke (3.1%), and reoperation (.8%). No structural valvular dysfunction and no valvular thromboses were reported. Conclusion: Our data show that valves replacement with mechanical valve may be performed with low morbidity and mortality.

Research paper thumbnail of Descending Necrotising Mediastinitis, A Fatal Disease to Keep in Mind

Heart, Lung and Circulation, 2010

Descending necrotising mediastinitis, a term used by [1], is a rare and serious disease requiring... more Descending necrotising mediastinitis, a term used by [1], is a rare and serious disease requiring prompt diagnosis and immediate aggressive surgical therapy. It should be considered in the differential diagnosis of acute mediastinal widening. We report an unusual case of primary retropharyngeal abscess complicated by descending necrotising mediastinitis and bilateral empyema in a 56-year-old diabetic man. The diagnosis of descending necrotising mediastinitis (DNM) was established by the characteristic findings on computed tomography. The patient was treated by cervicotomy and staged bilateral posterolateral thoracotomy.

Research paper thumbnail of Risks of emergency vascular surgery in COVID-19 patients

Italian Journal of Vascular and Endovascular Surgery

coVId-19 is a global and highly contagious pandemic with substantial morbidity and mortality. It ... more coVId-19 is a global and highly contagious pandemic with substantial morbidity and mortality. It has affected the medical care of other diseases with recommendations to postpone elective surgical procedures to decrease infection rates. New surgical triage guidelines have been recommended by the Vascular surgery society to manage urgent and emergent conditions. coVId-19 patients especially severe cases have several pathological findings as demonstrated by clinical research. Some of these pathologies including thrombocytopenia, coagulopathy, and cardiac involvement are important to be considered by the vascular surgeon. the aim of this article was to review the literature and discuss these risks in relation to vascular surgery.

Research paper thumbnail of Nanocelluloses in Wound Healing Applications

Handbook of Nanocelluloses

Research paper thumbnail of Antibiotic Profile of Pathogenic Bacteria Isolated from Postsurgical Site Infections in Public Hospitals in Northern Jordan

Infection and Drug Resistance, 2022

Background: Surgical site infections are hospital-acquired, vary from one hospital to another, an... more Background: Surgical site infections are hospital-acquired, vary from one hospital to another, and can cause significant postoperative morbidity, mortality, and prolonged hospital stay. Objective: The main aim of the study was to identify the bacterial pathogens associated with surgical site infections and their antibiotic susceptibility in a public hospital in northern Jordan. Methods: Postsurgical wound samples were collected and processed in a microbiology laboratory using standard microbiological techniques. Antibiotic susceptibility tests were performed using 13 antibiotics covering the gram-positive and gram-negative bacteria using the disc diffusion test. Results: The bacterial species that were identified in this study include Escherichia coli 8 (29%), Pseudomonas aeruginosa 3 (11%), Proteus mirabilis 1 (3.5%), Klebsiella pneumoniae 4 (14%), Salmonella enterica 2 (7%), Staphylococcus aureus 8 (29%), Staphylococcus epidermidis 1 (3.5%), and Streptococcus pyogenes 1 (4%). The antibiotic profiles of these bacteria showed high resistance. The MAR indices showed that 17 of 28 bacteria isolated were above 0.2 indicating high resistance. Conclusion: Resistant bacteria are becoming more dominant in wound infections with a high prevalence of multidrug resistant isolates. Hospital disinfection and treatment protocols regarding the use of antibiotics should be practiced vigorously and monitored regularly to combat resistance.

Research paper thumbnail of A Case of Critical Lower-Limb Ischemia in a 29-Year-Old Man with Autoimmune Polyglandular Syndrome Type 1 (APS-1)

American Journal of Case Reports, 2020

Objective: Rare disease Background: Autoimmune polyglandular syndrome type 1 (APS-1) is an extrem... more Objective: Rare disease Background: Autoimmune polyglandular syndrome type 1 (APS-1) is an extremely rare autoimmune disorder with an autosomal recessive inheritance pattern. Its manifestations present in chronological sequence of the components mucocutaneous candidiasis, Addison disease, and hypoparathyroidism. Vascular calcification is a very rare manifestation of the disease, and it may be severe, causing critical lower-limb ischemia and significant morbidity. To the best of our knowledge, this is the first such case to be reported in Jordan and the Arab region. Case Report: We present the case of a 29-year-old patient diagnosed with autoimmune polyglandular syndrome type 1 (APS-1). He has Addison disease, hypoparathyroidism, and mucocutaneous candidiasis. He presented with features of critical lower-limb ischemia and bacterial infection of the left foot. The patient underwent a successful angioplasty, and received management of his bacterial and fungal infections and the chronic endocrinopathies. Conclusions: Autoimmune polyglandular syndrome type 1 (APS-1) is a very rare disorder. Recognizing its syndromic nature will facilitate an active search for the component diseases and the possible complications, which would allow early diagnosis and management. This applies to the rare vascular complications, which can lead to significant morbidity.

Research paper thumbnail of Early and mid-term evaluation of mechanical heart valve replacement

Research paper thumbnail of Seasonal Variation Effects on Perforated Peptic Ulcer - A systematic Review

Research paper thumbnail of SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

British Journal of Surgery, 2021

Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numb... more Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst ...

Research paper thumbnail of COVID-19: Underpinning Research for Detection, Therapeutics, and Vaccines Development

Pharmaceutical Nanotechnology, 2020

Objectives: The newly emerged coronavirus SARS-CoV-2, first reported in December 2019, has infect... more Objectives: The newly emerged coronavirus SARS-CoV-2, first reported in December 2019, has infected about five and a half million people globally and resulted in nearly 9063264 deaths until the 24th of June 2020. Nevertheless, the highly contagious virus has instigated an unimaginably rapid response from scientific and medical communities. Methods: Pioneering research on molecular mechanisms underlying the viral transmission, molecular pathogenicity, and potential treatments will be highlighted in this review. The development of antiviral drugs specific to SARS-CoV-2 is a complicated and tedious process. To accelerate scientific discoveries and advancement, researchers are consolidating available data from associated coronaviruses into a single pipeline, which can be readily made available to vaccine developers. Results: In order to find studies evaluating the COVID-19 virus epidemiology, repurposed drugs and potential vaccines, web searches and bibliographical bases have been used ...

Research paper thumbnail of Endovascular management of acute mesenteric ischemia in a young patient with thyrotoxicosis and atrial fibrillation: A case report and review of the literature

International Journal of Surgery Case Reports, 2020

INTRODUCTION: Acute mesenteric ischemia caused by an embolism resulting from atrial fibrillation ... more INTRODUCTION: Acute mesenteric ischemia caused by an embolism resulting from atrial fibrillation in a thyrotoxic young male patient is a rare event. Endovascular intervention is increasingly being considered as the primary modality of treatment in selected patients. PRESENTATION OF CASE: A 41-years male known to have hyperthyroidism presented with atrial fibrillation, acute mesenteric ischemia, splenic infarction, and left renal infarction. He was successfully managed with endovascular intervention of the superior mesenteric artery. DISCUSSION: Acute mesenteric ischemia has a high mortality rate. CT angiography is the investigation of choice for diagnosis of the mesenteric vessels occlusion and assessment of bowel ischemia. The clinical presentation guides into the treatment and the choice between open surgery and endovascular intervention as the primary modality of treatment. Thyrotoxicosis is a risky comorbid condition for any procedure to be done, so proper perioperative management is essential to decrease morbidity and mortality. CONCLUSION: Prompt diagnosis and management of acute mesenteric ischemia is essential to decrease the morbidity and mortality rates. Endovascular management can be considered as a primary modality of treatment in selected cases.

Research paper thumbnail of A Potential MRI Agent and an Anticancer Drug Encapsulated within CPMV Virus-Like Particles

Combinatorial Chemistry & High Throughput Screening, 2021

Background: Virus nanoparticles have been extensively studied over the past decades for theranost... more Background: Virus nanoparticles have been extensively studied over the past decades for theranostics applications. Viruses are well-characterized, naturally occurring nanoparticles that can be produced in high quantity with a high degree of similarity in both structure and composition. Objectives: The plant virus Cowpea Mosaic Virus (CPMV) has been innovatively used as a nanoscaffold. Utilization of the internal cavity of empty Virus-Like Particles (VLPs) for the inclusion of therapeutics within the capsid has opened many opportunities in drug delivery and imaging applications. Methods: The encapsidation of magnetic materials and anticancer drugs was achieved. SuperscriptCPMV denotes molecules attached to the external surface of CPMV and CPMVSubscript denotes molecules within the interior of the capsid. Results: Here, the generation of novel VLPs incorporating iron-platinum nanoparticles TCPMVFePt and cisplatin (Cis) (TCPMVCis) is reported. TCPMVCis exhibited a cytotoxic IC50 of TCP...

Research paper thumbnail of Early and Mid-term Evaluation of Aortic Valve Replacement

European Journal of Scientific Research

In this study we investigated the operative mortality and mid-term (up to eight years) results of... more In this study we investigated the operative mortality and mid-term (up to eight years) results of aortic valve replacement (AVR).it is retrospective data analysis of sixty four consecutive patients who underwent aortic valve replacement (AVR). The early and late morbidity and mortality were analyzed at our institution, from January 2001 to December 2008. Early and Mid-term Evaluation of Aortic Valve Replacement 503 Our results showed hospital mortality was 3.1% (2 patients). Complications recorded during the follow up study include: prosthetic valve endocarditis (6.2%), bleeding (6.2%), stroke (3.1%), and reoperation (1.6%). No structural valvular dysfunction and no valvular thromboses were reported, and we concluded that aortic valve replacement with mechanical valve may be performed with low morbidity and mortality.

Research paper thumbnail of Evaluation of Mechanical Valve Replacement at Jordan University Hospital

Jordan Medical Journal

Objective: To investigate the operative mortality and mid-term (up to eight years) results of mec... more Objective: To investigate the operative mortality and mid-term (up to eight years) results of mechanical valve replacement. Methods: Retrospective data analysis of 118 consecutive patients who underwent mechanical valve replacement. The early and late morbidity and mortality were analyzed at our institution, from January 2001 to December 2008. Results: Hospital mortality was 2.5% (3 patients). Complications recorded during the follow up study include: prosthetic valve endocarditis (3.4%), bleeding (3.4%), stroke (3.1%), and reoperation (.8%). No structural valvular dysfunction and no valvular thromboses were reported. Conclusion: Our data show that valves replacement with mechanical valve may be performed with low morbidity and mortality.

Research paper thumbnail of Poster Presentations; Efficacy of Human Adipose Tissue-Derived Stem Cells in Cardiac Muscle Repair in an Experimental Acute Myocardial Infarction Model Using Nude Rats Strain CRL: NIH-FOX1

Research paper thumbnail of The impact of COVID-19 on surgical practice in Jordan during the second outbreak: A survey

Annals of Medicine and Surgery, 2021

Background: COVID-19 is an acute respiratory pandemic with no available effective antiviral treat... more Background: COVID-19 is an acute respiratory pandemic with no available effective antiviral treatment or widely available effective vaccine. Surgical practice has faced widespread problems due to the pandemic including viral transmission risk and cross-infection, staffing problems, prioritizations of surgical procedures, and lack of beds due to occupancy of hospitals and ICU beds with COVID-19 patients. Methods: A survey was conducted between October 31 to November 4, 2020, through google forms. The questionnaire involved 16 questions sent to consultants and specialists of all general and special surgical specialties and subspecialties in Jordan. Results: We have got responses from surgeons of all public and private sectors in Jordan. There was a pronounced decline in the number of elective and emergency procedures performed during October 2020 due to COVID-19 pandemic related reasons. Conclusions: The impact of COVID-19 on the surgical practice in Jordan during October 2020 was moderate to prominent. Measures that could be made to alleviate this impact include the assignment of certain hospitals for covid-19 patients as a step before the establishment of field hospitals and the cooperation between the private and the public health sectors.

Research paper thumbnail of Efficacy of human adipose tissue-derived stem cells in cardiac muscle repair in an experimental acute myocardial infarction model using nude rats (Crl:NIH-Fox1RNU)

Comparative Clinical Pathology, 2010

This study was designed to compare the efficacy of intraventricular (IV), intramyocardial (IM) or... more This study was designed to compare the efficacy of intraventricular (IV), intramyocardial (IM) or combined IV and IM injections of human adipose tissue-derived stem cells (hADSCs) administered either immediately, 5, or 10 days after induction of acute myocardial infarction (AMI) in a nude rat model. Acute myocardial infarction was induced in 99, adult (250-350 g BW), male nude rats strain Crl:NIH-Fox1 RNU .

Research paper thumbnail of Difficult CABG in the Era of Stenting

Jordan Medical Journal, Mar 18, 2009

For the past three decades, coronary artery bypass grafting has been the standard treatment for p... more For the past three decades, coronary artery bypass grafting has been the standard treatment for patients with severe multivessel ischemic heart disease. In the past few years, however, it has been increasingly challenged by percutaneous coronary intervention. The increasing tendency to report interventional treatments being based on "patient or physician preference" is both inadequate and inappropriate, discussion of all interventions by a multidisciplinary team should be a minimum standard of care. In this report we present a patient with coronary artery disease who underwent coronary catheterization and stenting many times, and finally the decision was to do a coronary artery bypass grafting in which the saphenous vein anastomosis to the distal right coronary artery was done over an old stent.

Research paper thumbnail of Solitary Fibrous Tumor Arising from the Mediastinal Pleura: Case Report

Jordan Medical Journal, Sep 25, 2011

Research paper thumbnail of Difficult CABG in the Era of Stenting

Jordan Medical Journal

For the past three decades, coronary artery bypass grafting has been the standard treatment for p... more For the past three decades, coronary artery bypass grafting has been the standard treatment for patients with severe multivessel ischemic heart disease. In the past few years, however, it has been increasingly challenged by percutaneous coronary intervention. The increasing tendency to report interventional treatments being based on "patient or physician preference" is both inadequate and inappropriate, discussion of all interventions by a multidisciplinary team should be a minimum standard of care. In this report we present a patient with coronary artery disease who underwent coronary catheterization and stenting many times, and finally the decision was to do a coronary artery bypass grafting in which the saphenous vein anastomosis to the distal right coronary artery was done over an old stent.

Research paper thumbnail of Evaluation of Mechanical Valve Replacement at Jordan University Hospital

Jordan Medical Journal

Objective: To investigate the operative mortality and mid-term (up to eight years) results of mec... more Objective: To investigate the operative mortality and mid-term (up to eight years) results of mechanical valve replacement. Methods: Retrospective data analysis of 118 consecutive patients who underwent mechanical valve replacement. The early and late morbidity and mortality were analyzed at our institution, from January 2001 to December 2008. Results: Hospital mortality was 2.5% (3 patients). Complications recorded during the follow up study include: prosthetic valve endocarditis (3.4%), bleeding (3.4%), stroke (3.1%), and reoperation (.8%). No structural valvular dysfunction and no valvular thromboses were reported. Conclusion: Our data show that valves replacement with mechanical valve may be performed with low morbidity and mortality.

Research paper thumbnail of Descending Necrotising Mediastinitis, A Fatal Disease to Keep in Mind

Heart, Lung and Circulation, 2010

Descending necrotising mediastinitis, a term used by [1], is a rare and serious disease requiring... more Descending necrotising mediastinitis, a term used by [1], is a rare and serious disease requiring prompt diagnosis and immediate aggressive surgical therapy. It should be considered in the differential diagnosis of acute mediastinal widening. We report an unusual case of primary retropharyngeal abscess complicated by descending necrotising mediastinitis and bilateral empyema in a 56-year-old diabetic man. The diagnosis of descending necrotising mediastinitis (DNM) was established by the characteristic findings on computed tomography. The patient was treated by cervicotomy and staged bilateral posterolateral thoracotomy.