suhair Al-Nimry | Jordan University of Science and Technology (original) (raw)

Papers by suhair Al-Nimry

Pharmaceutics

Microneedles (MNs) are considered to be a novel smart injection system that causes significantly ... more Microneedles (MNs) are considered to be a novel smart injection system that causes significantly low skin invasion upon puncturing, due to the micron-sized dimensions that pierce into the skin painlessly. This allows transdermal delivery of numerous therapeutic molecules, such as insulin and vaccines. The fabrication of MNs is carried out through conventional old methods such as molding, as well as through newer and more sophisticated technologies, such as three-dimensional (3D) printing, which is considered to be a superior, more accurate, and more time- and production-efficient method than conventional methods. Three-dimensional printing is becoming an innovative method that is used in education through building intricate models, as well as being employed in the synthesis of fabrics, medical devices, medical implants, and orthoses/prostheses. Moreover, it has revolutionary applications in the pharmaceutical, cosmeceutical, and medical fields. Having the capacity to design patient-...

Journal of the Meteorological Society of Japan. Ser. II, 1983

Indian Journal of Pharmaceutical Sciences, 2020

Al-Nimry et al.: RP-HPLC method for determination of Norethindrone The purpose of this investigat... more Al-Nimry et al.: RP-HPLC method for determination of Norethindrone The purpose of this investigation was to develop and validate a simple reversed phase-high-performance liquid chromatography method coupled with UV detector estimating norethindrone in plasma and tissues. A Thermo Scientific C18 column (250×4.6 mm ID, 5 µm pore size) and a mobile phase consisting of deionized water:acetonitrile (60:40, v/v) were used. The flow was isocratic at a rate of 1.3 ml/min and the wavelength of detection was 245 nm. Estradiol was used as internal standard. Validation of linearity, accuracy and precision, limits of detection and quantification, specificity and recovery was carried out according to the International Conference of Harmonization guidelines. The method was used in estimating the bioavailability of a controlled release nanoparticulate liquid formulation, administered to dogs. It was also used estimating adhesion potential of the same formulation to the GIT of mice. The method was simple and only liquid-liquid extraction was used in case of plasma samples. However, sample preparation was more complex in the case of tissue samples. It was linear in the range studied, accurate and precise. It was specific and the excipients used in preparing the formulation did not interfere with the method. The recovery was high and consistent. The bioavailability of the drug was enhanced after the administration of the nanoparticulate liquid formulation as compared to unformulated drug. The formulation adhered to the stomach and intestines for 48 h. After 48 h the concentration reached undetectable levels. In conclusion, a simple, linear, accurate and precise reversed phase-high-performance liquid chromatography method coupled with UV detection was developed, validated, and used successfully for the determination of norethindrone in plasma and adhesion to GIT tissues. The cost of the analysis was expected to be low sine the extraction procedure was simple and no radiolabeled internal standard was useds.

Journal of Applied Pharmaceutical Science

Several methods are available for the determination of norethindrone. These methods are either co... more Several methods are available for the determination of norethindrone. These methods are either complicated or need validation. The objective of this work was to develop and validate a simple reversed phase-high performance liquid chromatographic method for the determination of norethindrone in dissolution media. A Thermo Scientific C18 column (250 mm × 4.6 mm ID, 5 µm pore size) was used. A mobile phase consisting of deionized water: acetonitrile (50:50, v/v) and 5 ml/l acetic acid was used. The flow rate was 1.3 ml/minute and the wavelength of the detection was 245 nm. Validation of linearity, accuracy and precision, limit of detection, limit of quantification, specificity, and stability (degradation) was carried out according to the International Conference on Harmonization guidelines. The developed and validated method was used to study norethindrone release from a nanoparticulate liquid medicated formulation (LMF). The results indicated that the method was simple, accurate and precise, and met the acceptance criteria. The drug exhibited higher stability in basic media when compared to acidic media. Drug release from a LMF (nanoemulsion) followed zero order kinetics. In conclusion, a simple method was developed, validated, and used successfully in evaluating in vitro drug release from a sustained release/controlled release nanoparticulate LMF.

Current Pharmaceutical Analysis

Background: Omeprazole has poor water solubility, is unstable in acidic solutions, and undergoes ... more Background: Omeprazole has poor water solubility, is unstable in acidic solutions, and undergoes first pass metabolism which results in lowering its bioavailability. A solid Self-Nano Emulsifying Drug Delivery System (SNEDDS) was previously prepared to enhance its dissolution. Objective: Development and validation of a RP-HPLC method with UV detection for the determination of omeprazole in 0.1N HCl and in 0.01 M phosphate buffer (pH 7.4). Methods: Validation was according to the ICH Q2 (R1) guidelines in terms of linearity, accuracy and precision, lower limit of quantification, sensitivity, specificity, and robustness. The developed and validated method was used to study the in-vitro dissolution of the drug from the solid-SNEDDS, commercial products and of the unprocessed drug. The dissolution was studied in 500 ml of 0.1N HCl during the first 2 hours, and 900 mL of 0.01 M phosphate buffer (pH 7.4) during the last hour (37 ± 0.5 oC and 100 rpm). Results: The method was linear in the...

Pharmaceutical Development and Technology

Current Drug Delivery

Background: Asenapine maleate, an anti-schizophrenic drug, is a class II drug with low solubility... more Background: Asenapine maleate, an anti-schizophrenic drug, is a class II drug with low solubility and high permeability. This exerts rate-limiting effect on drug bioavailability. Objective: Improve the solubility/dissolution rate of asenapine maleate and hence the bioavailability using cocrystal approach. Method: Co-crystals were prepared using the solvent evaporation technique. Since the drug has H-bond acceptor count of 6, and H-bond donor count of 2, several co-formers were investigated. The co-crystals were evaluated using PXRD, FTIR spectroscopy, and DSC. Additionally, in-vitro dissolution studies were conducted. Results: The preparation of the co-crystals was successful. The PXRD patterns showed that the resultant mixture was crystalline, the FTIR confirmed the formation of H-bond between the drug and the co-formers and the DSC showed that the mixture exhibited a lower melting point as compared to the components and it was followed immediately by an exothermic peak, which conf...

Marine Drugs

There are several reviews that separately cover different aspects of fish gelatin including its p... more There are several reviews that separately cover different aspects of fish gelatin including its preparation, characteristics, modifications, and applications. Its packaging application in food industry is extensively covered but other applications are not covered or covered alongside with those of collagen. This review is comprehensive, specific to fish gelatin/hydrolysate and cites recent research. It covers cosmetic applications, intrinsic activities, and biomedical applications in wound dressing and wound healing, gene therapy, tissue engineering, implants, and bone substitutes. It also covers its pharmaceutical applications including manufacturing of capsules, coating of microparticles/oils, coating of tablets, stabilization of emulsions and drug delivery (microspheres, nanospheres, scaffolds, microneedles, and hydrogels). The main outcomes are that fish gelatin is immunologically safe, protects from the possibility of transmission of bovine spongiform encephalopathy and foot an...

Scientia Pharmaceutica

Asenapine maleate is an antipsychotic drug that is indicated in the treatment of schizophrenia an... more Asenapine maleate is an antipsychotic drug that is indicated in the treatment of schizophrenia and bipolar disorders. It has low aqueous solubility and high permeability (Class II drug) and undergoes an extensive first pass effect. These problems result in low oral bioavailability (<2%). To enhance its solubility/dissolution rate and hence bioavailability, co-crystals using different co-formers in different ratios were prepared and evaluated. To study the in vitro dissolution of the drug from these co-crystals into phosphate buffer (pH 6.8), an RP-HPLC method was developed and validated according to the ICH Q2R1 guidelines. The method was linear in the range 0.1–14 µg/mL (R > 0.9998) and accurate and precise. An ANOVA test indicated that calibration curves run on different days did not differ significantly. It was sensitive (lower limit of quantitation (LLOQ) = 25.03 ng/mL), specific (the co-formers did not interfere with the determination of the drug), and robust to small cha...

Pharmaceutical Development and Technology

Journal of Pharmaceutical Sciences

Journal of Applied Polymer Science, 2015

Jordan Journal of Pharmaceutical Sciences

ABSTRACT

The absorption rate of gliclazide is slow and variable among subjects probably due to poor dissol... more The absorption rate of gliclazide is slow and variable among subjects probably due to poor dissolution from the dosage form. The objective of this study was to enhance the dissolution rate of gliclazide by reducing the particle size. Gliclazide was precipitated from an acetone solution by adding an antisolvent (water) containing stabilizers. A combination of jets (flow rate of 20 ml/min), ultrasound, HPMC 4000, and sodium dodecyl sulfate was used to control particle size and particle size distribution. The effects of concentration of stabilizers, initial drug concentration in solution, time of insonation, antisolvent-to-solvent ratio, and ultrasound power on particle size and particle size distribution were studied. Precipitated drug particles were characterized by laser diffraction particle size analysis, SEM, FTIR spectroscopy, DSC, powder x-ray diffraction and in-vitro dissolution. With increasing almost all the studied parameters, the particle size of gliclazide initially decreased, exhibited a minimum, and then increased. Drug particles of glicazide with a mean particle size of 1.56 ± 0.09 μm and a narrow size distribution (d10/d50/d90 = 0.67/1.67/2.26) were precipitated as compared to unprocessed gliclazide with a mean particle size of 10.67 ± 0.04 μm and a wide size distribution (d10/ds50/d90 = 4.53/9.88/18.03). SEM images indicated changes in the particle morphology. Powder x-ray diffraction patterns and DSC curves indicated no changes in the chemical properties but only decrease in crystallinity and/or particle size. The dissolution rate was enhanced 2.55-fold. In conclusion, drug particles with small size and narrow size distribution were precipitated by selecting favorable process conditions, and dissolution was enhanced several folds.

International Journal of Pharmaceutics, 1997

... Fig. 7 illustrates the effect of pH on the adsorp tion of ketotifen (50 pg ml) at constant io... more ... Fig. 7 illustrates the effect of pH on the adsorp tion of ketotifen (50 pg ml) at constant ionic strength onto Avicel. ... E1Gamal, SS, Borate, NA and Naggar, VF. In vitro adsorption study of flurazepam on some antacids and excipients. Pharm. ... II. The effect of interfacial polymer films, bit. ...

Pharmaceutics

Microneedles (MNs) are considered to be a novel smart injection system that causes significantly ... more Microneedles (MNs) are considered to be a novel smart injection system that causes significantly low skin invasion upon puncturing, due to the micron-sized dimensions that pierce into the skin painlessly. This allows transdermal delivery of numerous therapeutic molecules, such as insulin and vaccines. The fabrication of MNs is carried out through conventional old methods such as molding, as well as through newer and more sophisticated technologies, such as three-dimensional (3D) printing, which is considered to be a superior, more accurate, and more time- and production-efficient method than conventional methods. Three-dimensional printing is becoming an innovative method that is used in education through building intricate models, as well as being employed in the synthesis of fabrics, medical devices, medical implants, and orthoses/prostheses. Moreover, it has revolutionary applications in the pharmaceutical, cosmeceutical, and medical fields. Having the capacity to design patient-...

Journal of the Meteorological Society of Japan. Ser. II, 1983

Indian Journal of Pharmaceutical Sciences, 2020

Al-Nimry et al.: RP-HPLC method for determination of Norethindrone The purpose of this investigat... more Al-Nimry et al.: RP-HPLC method for determination of Norethindrone The purpose of this investigation was to develop and validate a simple reversed phase-high-performance liquid chromatography method coupled with UV detector estimating norethindrone in plasma and tissues. A Thermo Scientific C18 column (250×4.6 mm ID, 5 µm pore size) and a mobile phase consisting of deionized water:acetonitrile (60:40, v/v) were used. The flow was isocratic at a rate of 1.3 ml/min and the wavelength of detection was 245 nm. Estradiol was used as internal standard. Validation of linearity, accuracy and precision, limits of detection and quantification, specificity and recovery was carried out according to the International Conference of Harmonization guidelines. The method was used in estimating the bioavailability of a controlled release nanoparticulate liquid formulation, administered to dogs. It was also used estimating adhesion potential of the same formulation to the GIT of mice. The method was simple and only liquid-liquid extraction was used in case of plasma samples. However, sample preparation was more complex in the case of tissue samples. It was linear in the range studied, accurate and precise. It was specific and the excipients used in preparing the formulation did not interfere with the method. The recovery was high and consistent. The bioavailability of the drug was enhanced after the administration of the nanoparticulate liquid formulation as compared to unformulated drug. The formulation adhered to the stomach and intestines for 48 h. After 48 h the concentration reached undetectable levels. In conclusion, a simple, linear, accurate and precise reversed phase-high-performance liquid chromatography method coupled with UV detection was developed, validated, and used successfully for the determination of norethindrone in plasma and adhesion to GIT tissues. The cost of the analysis was expected to be low sine the extraction procedure was simple and no radiolabeled internal standard was useds.

Journal of Applied Pharmaceutical Science

Several methods are available for the determination of norethindrone. These methods are either co... more Several methods are available for the determination of norethindrone. These methods are either complicated or need validation. The objective of this work was to develop and validate a simple reversed phase-high performance liquid chromatographic method for the determination of norethindrone in dissolution media. A Thermo Scientific C18 column (250 mm × 4.6 mm ID, 5 µm pore size) was used. A mobile phase consisting of deionized water: acetonitrile (50:50, v/v) and 5 ml/l acetic acid was used. The flow rate was 1.3 ml/minute and the wavelength of the detection was 245 nm. Validation of linearity, accuracy and precision, limit of detection, limit of quantification, specificity, and stability (degradation) was carried out according to the International Conference on Harmonization guidelines. The developed and validated method was used to study norethindrone release from a nanoparticulate liquid medicated formulation (LMF). The results indicated that the method was simple, accurate and precise, and met the acceptance criteria. The drug exhibited higher stability in basic media when compared to acidic media. Drug release from a LMF (nanoemulsion) followed zero order kinetics. In conclusion, a simple method was developed, validated, and used successfully in evaluating in vitro drug release from a sustained release/controlled release nanoparticulate LMF.

Current Pharmaceutical Analysis

Background: Omeprazole has poor water solubility, is unstable in acidic solutions, and undergoes ... more Background: Omeprazole has poor water solubility, is unstable in acidic solutions, and undergoes first pass metabolism which results in lowering its bioavailability. A solid Self-Nano Emulsifying Drug Delivery System (SNEDDS) was previously prepared to enhance its dissolution. Objective: Development and validation of a RP-HPLC method with UV detection for the determination of omeprazole in 0.1N HCl and in 0.01 M phosphate buffer (pH 7.4). Methods: Validation was according to the ICH Q2 (R1) guidelines in terms of linearity, accuracy and precision, lower limit of quantification, sensitivity, specificity, and robustness. The developed and validated method was used to study the in-vitro dissolution of the drug from the solid-SNEDDS, commercial products and of the unprocessed drug. The dissolution was studied in 500 ml of 0.1N HCl during the first 2 hours, and 900 mL of 0.01 M phosphate buffer (pH 7.4) during the last hour (37 ± 0.5 oC and 100 rpm). Results: The method was linear in the...

Pharmaceutical Development and Technology

Current Drug Delivery

Background: Asenapine maleate, an anti-schizophrenic drug, is a class II drug with low solubility... more Background: Asenapine maleate, an anti-schizophrenic drug, is a class II drug with low solubility and high permeability. This exerts rate-limiting effect on drug bioavailability. Objective: Improve the solubility/dissolution rate of asenapine maleate and hence the bioavailability using cocrystal approach. Method: Co-crystals were prepared using the solvent evaporation technique. Since the drug has H-bond acceptor count of 6, and H-bond donor count of 2, several co-formers were investigated. The co-crystals were evaluated using PXRD, FTIR spectroscopy, and DSC. Additionally, in-vitro dissolution studies were conducted. Results: The preparation of the co-crystals was successful. The PXRD patterns showed that the resultant mixture was crystalline, the FTIR confirmed the formation of H-bond between the drug and the co-formers and the DSC showed that the mixture exhibited a lower melting point as compared to the components and it was followed immediately by an exothermic peak, which conf...

Marine Drugs

There are several reviews that separately cover different aspects of fish gelatin including its p... more There are several reviews that separately cover different aspects of fish gelatin including its preparation, characteristics, modifications, and applications. Its packaging application in food industry is extensively covered but other applications are not covered or covered alongside with those of collagen. This review is comprehensive, specific to fish gelatin/hydrolysate and cites recent research. It covers cosmetic applications, intrinsic activities, and biomedical applications in wound dressing and wound healing, gene therapy, tissue engineering, implants, and bone substitutes. It also covers its pharmaceutical applications including manufacturing of capsules, coating of microparticles/oils, coating of tablets, stabilization of emulsions and drug delivery (microspheres, nanospheres, scaffolds, microneedles, and hydrogels). The main outcomes are that fish gelatin is immunologically safe, protects from the possibility of transmission of bovine spongiform encephalopathy and foot an...

Scientia Pharmaceutica

Asenapine maleate is an antipsychotic drug that is indicated in the treatment of schizophrenia an... more Asenapine maleate is an antipsychotic drug that is indicated in the treatment of schizophrenia and bipolar disorders. It has low aqueous solubility and high permeability (Class II drug) and undergoes an extensive first pass effect. These problems result in low oral bioavailability (<2%). To enhance its solubility/dissolution rate and hence bioavailability, co-crystals using different co-formers in different ratios were prepared and evaluated. To study the in vitro dissolution of the drug from these co-crystals into phosphate buffer (pH 6.8), an RP-HPLC method was developed and validated according to the ICH Q2R1 guidelines. The method was linear in the range 0.1–14 µg/mL (R > 0.9998) and accurate and precise. An ANOVA test indicated that calibration curves run on different days did not differ significantly. It was sensitive (lower limit of quantitation (LLOQ) = 25.03 ng/mL), specific (the co-formers did not interfere with the determination of the drug), and robust to small cha...

Pharmaceutical Development and Technology

Journal of Pharmaceutical Sciences

Journal of Applied Polymer Science, 2015

Jordan Journal of Pharmaceutical Sciences

ABSTRACT

The absorption rate of gliclazide is slow and variable among subjects probably due to poor dissol... more The absorption rate of gliclazide is slow and variable among subjects probably due to poor dissolution from the dosage form. The objective of this study was to enhance the dissolution rate of gliclazide by reducing the particle size. Gliclazide was precipitated from an acetone solution by adding an antisolvent (water) containing stabilizers. A combination of jets (flow rate of 20 ml/min), ultrasound, HPMC 4000, and sodium dodecyl sulfate was used to control particle size and particle size distribution. The effects of concentration of stabilizers, initial drug concentration in solution, time of insonation, antisolvent-to-solvent ratio, and ultrasound power on particle size and particle size distribution were studied. Precipitated drug particles were characterized by laser diffraction particle size analysis, SEM, FTIR spectroscopy, DSC, powder x-ray diffraction and in-vitro dissolution. With increasing almost all the studied parameters, the particle size of gliclazide initially decreased, exhibited a minimum, and then increased. Drug particles of glicazide with a mean particle size of 1.56 ± 0.09 μm and a narrow size distribution (d10/d50/d90 = 0.67/1.67/2.26) were precipitated as compared to unprocessed gliclazide with a mean particle size of 10.67 ± 0.04 μm and a wide size distribution (d10/ds50/d90 = 4.53/9.88/18.03). SEM images indicated changes in the particle morphology. Powder x-ray diffraction patterns and DSC curves indicated no changes in the chemical properties but only decrease in crystallinity and/or particle size. The dissolution rate was enhanced 2.55-fold. In conclusion, drug particles with small size and narrow size distribution were precipitated by selecting favorable process conditions, and dissolution was enhanced several folds.

International Journal of Pharmaceutics, 1997

... Fig. 7 illustrates the effect of pH on the adsorp tion of ketotifen (50 pg ml) at constant io... more ... Fig. 7 illustrates the effect of pH on the adsorp tion of ketotifen (50 pg ml) at constant ionic strength onto Avicel. ... E1Gamal, SS, Borate, NA and Naggar, VF. In vitro adsorption study of flurazepam on some antacids and excipients. Pharm. ... II. The effect of interfacial polymer films, bit. ...