Pratap Sanchetee | Jainvishwa Bharati University (original) (raw)
Papers by Pratap Sanchetee
The Indian Practitioner , 2018
Aging, though a graceful period, is associated with problems related to physical and mental healt... more Aging, though a graceful period, is associated with problems related to physical and mental health, social isolation, and financial crunch. This review aims to highlight the efficacy of meditation in promoting health
in the elderly population. A review of the literature suggests that mindfulness has promising beneficial effects on cognitive, emotional, and physiological parameters in the elderly. In a well-planned prospective, randomized, case-control study by us on 58 subjects (37 males and 21 females) who were administered a Preksha meditation for
4 months. At the end of 4 months period, there was an improvement in all domains of WHO Quality of Life-BREF (WHOQOL-BREF) ranging from 3 points to 5.7, i.e. psychological health (29.3%), physical health (24.1%), social health (12.1%)) and environmental health (29.3%) and in stress level (17.2%). There was also an improvement in depression and anxiety status as assessed by Hospital Anxiety and Depression Score (HADS). It can be concluded that meditation is a cost-effective, non-invasive intervention with minimal risk of adverse effects and can be safely recommended for the promotion of mental health in the elderly.
IntechOpen, 2021
Stroke remains a leading cause of adult disability. The social, physical, and psychological cons... more Stroke remains a leading cause of adult disability. The social, physical, and
psychological consequences of stroke are devastating. With a better understanding of causation and breakthrough advances in management, we are witnessing a greater population of stroke survivors with varying neurological and functional deficits. Poststroke rehabilitation is a multi-disciplinary and multi-modal endeavor, not a ‘one size fits all’ intervention. A combination of interventions may be better suited to treat motor and sensory impairments, cognitive problems, and psychological issues. There is great interest in exploring novel rehabilitation technologies to
augment conventional therapies to reduce neurological disability and improve function. Yoga and spirituality, though ancient practices are finding a bigger role in the field of rehabilitation. Despite good potential for recovery, these rehabilitative measures are underutilized; major barriers are limited availability, geographical distance, high cost, and lack of awareness about its benefits. While conventional measures are well engraved, this article reviews the recent stroke rehabilitation concepts.
Yoga Mimamsa , 2018
The pineal gland is a small but critical hormonal gland in our body. It is considered a regulatin... more The pineal gland is a small but critical hormonal gland in our body. It is considered a regulating or master gland that regulates the cycles within our bodies. Its purpose and function are still largely a mystery to science, and research on it yields exciting discoveries, especially on its connection to spirituality and higher states of consciousness. Descriptions of the human anatomy derived from religious texts are often omitted from the medical literature. It may be that over time, science will validate many of these spiritual truths and statements as being based in scientific and medical facts.
Indian Journal of Endocrinology and Metabolism, 2020
Background and Aims: Fasting has a long tradition in most cultures and has many health benefits. ... more Background and Aims: Fasting has a long tradition in most cultures and has many health benefits. Most of the studies are from daytime fasting
or intermittent fasting. There is paucity of data from complete fasting (no food and fruits, water only). This prospective study is conducted with
aims to study impact of complete fasting on clinical and biochemical parameters. Methods: One hundred ten participants of either gender who
voluntarily fasted (3‑30 days) were included and underwent clinical and biochemical examination before and after fasting. Results: A total
of 110 healthy volunteers (M: 27, F: 83) with mean age 51 ± 16 years (range 18‑86) and body mass index 27.1 ± 4.9 kg/m2 (16.1‑45.2) wer
studied. They had undergone fast for varying duration between 3‑30 days (short fast: 3‑7 days = 72; prolong fast: >7 days = 38). There wer
significant decrease in weight (66.8 ± 11.0 to 64.7 ± 11.1 kg, P < 0.0001), BMI (27.1 ± 4.9 to 26.2 ± 4.9 kg/m2
, P < 0.0001), systolic blood
pressure (130 ± 17 to 128 ± 15 mmHg, P = 0.012), serum globulin (3.10 ± 0.42 to 3.01 ± 0.41 mg/dl, P = 0.024), and serum high density
lipoprotein (48.3 ± 12.2 to 45.7 ± 12.6 mg/dl, P < 0.0001) post fasting. However, significant increase was observed in pulse rate (81 ± 10
to 83 ± 11 beat/min, P = 0.001), fasting plasma glucose (102.9 ± 35.0 to 132.0 ± 42.0 mg/dl, P < 0.0001), serum triglycerides (137.6 ± 68.3 to
149.0 ± 67.1 mg/dl, P = 0.031), very low density lipoprotein (22.0 ± 10.5 to 24.2 ± 11.1 mg/dl, P = 0.010), and serum cortisol levels(13.5 ± 5.9 to
17.2 ± 6.3 µg/dl, P < 0.0001). These changes were more pronounced with prolong fasting, but were not affected by gender. Conclusions: Fasting
results in improvement in anthropometric, physical and biochemical parameters related to physical health. It can be recommended as a mean
for improving quality of life
Current Research in Nutrition and Food Science, 2024
The practice of voluntary abstinence from food and drink for 16 to 48 hours is known as intermitt... more The practice of voluntary abstinence from food and drink for 16 to 48 hours is known as intermittent fasting (IF). Jain Ayambil, a type of intermittent fasting, where a special meal of boiled grains without spice, oil, milk, ghee, sugar, curd, fruits, or raw vegetables is taken once during the daytime. The aim of the study was to find out safety and its effect on plasma glucose, lipid profile, anthropometric and psychological parameters. We are reporting first ever scientific study on effect of Aymabil intermittent fasting on health parameters. The present study was carried out on 52 volunteers who did 9 days Ayambil fasting. Physical, and psychological assessments were done on the pre-fasting day (day 0), 4th day, and 9th day whereas biochemical examinations were carried out on pre-fasting (day 0) and 9th day of Ayambil fasting. Out of the total 52 participants (mean age of 52.77 ± 13.51 years), there were 28 (53.85%) females (51.54 ± 12.94) and 24 (46.15%) males (54.21 ± 14.30). A statistically significant reduction was observed for fasting blood glucose (p=0.002), HbA1c (p=0.002), body weight (p=0.001), BMI (p=0.001), diastolic BP (p=0.005), serum creatinine (p= 0.036), and a positive correlation was noted for Hamilton Depression Rating Scale (HDRS) (p=0.001) noted during Ayambil fasting. However, there was no
significant change in lipid profile. Our findings suggest that Ayambil fasting is beneficial to metabolic, psychological, and holistic health with no healthrelated hazards. It is a safe fasting method and exploration of more clinical studies on this can open newer futuristic directions as one of the therapeutic options for a variety of clinical situations.
Journal of Association of Physicians of India, Oct 1, 1996
IP Innovative Publication Pvt. Ltd., 2018
Aims: The present study aims at demonstrating changes in alpha wave frequency on electroencephalo... more Aims: The present study aims at demonstrating changes in alpha wave frequency on electroencephalograph (EEG) at two and
four months of preksha meditation training in young novice students.
Materials and Methods: Participants included 52 girls between the 17 to 21 years of age from a local college selected using a
convenience sampling technique. They were randomly divided into experimental (n = 29) and control (n = 26) groups. Study
duration was 4 months during which experimental group was administered a supervised PM training for 4 months. During this
period control group continued their normal activities without mediation practice. EEG was analyzed for alpha waves and
compared at base line, at 2 months and at 4 months.
Results: The mean value of alpha wave frequency (%) in control group at beginning was 49.65 ±21.598 which increased to
52.58±18.005 at 2 months. In experimental group, in beginning it was 49.52 ±18.169 which increased to 54.31±22.490 at 2
months. However, this increment was not statistically significant in both groups. A statistically significant increment in alpha
waves percentage to 66.59±9.493 was observed in experimental group after four months of PM which was significant at the
level of p<0.01. Conversely the changes in control group after 4 months were not significant rather the mean value decreased
to 48.88±17.653.
Conclusions: A significant increase in alpha waves was observed at 4 months of PM practice in young novice students. This
increase was observed at 4 months and not at 2 months suggesting that longer practice of meditation is needed to bring out
significant improvement.
Keywords: Preksha meditation, EEG, Alpha waves
Journal of Association of Physicians of India, 1990
Poisoning due to barium carbonate (rat poison) resulting in areflexic quadriplegia and respirator... more Poisoning due to barium carbonate (rat poison) resulting in areflexic quadriplegia and respiratory muscle paresis in a young patient is described. The various effects of barium salts on the human body and their treatment are highlighted.
Journal of Association of Physicians of India, 1992
The clinical and computed tomography (CT) features of 25 patients with peripartum CVT are describ... more The clinical and computed tomography (CT) features of 25 patients with peripartum CVT are described. Majority of the patients presented in postpartum period and did not receive proper antenatal care. Headache (92%), altered sensorium (80%, seizures (76%), papilloedema (80%) and hemiplegia (52%) were the common modes of presentation. CT findings included diffuse brain oedema (52%), haemorrhagic or nonhaemorrhagic infarctions on one or both sides of brain (48%), gyral enhancement (40%) and tentorial enhancement (16%). While 15 patients made good recovery, 3 cases (12%) died during acute stage of illness.
Journal of Association of Physicians of India, 1990
Meningoencephalitic syndrome can be caused by many infective agents. Over a period of 13 years, 1... more Meningoencephalitic syndrome can be caused by many infective agents. Over a period of 13 years, 15 of 170 cases of neurocysticercosis (NCC) presented as meningoencephalitis. The basis of diagnosis of NCC was positive subcutaneous nodule histopathology (4), CT scan (9) and autopsy (3) findings. The age of the patients ranged from 7-68 years (mean 32). Fever was encountered in 12, altered sensorium in 7, seizures in 10 and abnormal behaviour in 3 cases. All cases had papilloedema. Focal neurological signs included optic atrophy, lateral rectus palsy, hemiplegia, internuclear ophthalmoplegia and cerebellar ataxia. Cerebrospinal fluid was abnormal in 8 of 13 cases, leading to a suspicion of tuberculous meningitis. Twelve patients improved with therapy. Three cases ended fatally and autopsy confirmed the diagnosis.
Journal of Association of Physicians of India, 1999
To study the clinical course and outcome of toxoplasmic encephalitis (TE) in patients with acquir... more To study the clinical course and outcome of toxoplasmic encephalitis (TE) in patients with acquired immunodeficiency syndrome (AIDS). Patients infected with human immunodeficiency virus (HIV) and neurological abnormality compatible with diagnosis of TE were enrolled in the study. These patients were treated with combination of trimethoprim/sulfamethoxazole and pyrimethamine. Response to therapy was assessed by clinical examination and repeat CT/MRI scan done after three weeks of starting treatment. Those showing response were put on prophylactic therapy. A total of 451 patients of HIV infections were admitted to this centre during the study period, of these 11 patients were diagnosed to have TE. The common presenting symptoms were fever (80%), seizures (45%), headache (45%) and altered sensorium (25%). Focal neurological deficit was present in 80% of cases. Nine cases had ring-enhancing lesions on CT scan while in the remaining two patient's ring lesions were seen on MRI. These ...
Journal of Association of Physicians of India, 1996
We studied the clinical profile and etiology of 28 cases of ataxic hemiparesis. After a detailed ... more We studied the clinical profile and etiology of 28 cases of ataxic hemiparesis. After a detailed neurological examination, CT scan brain (plain and after IV contrast) was done in all. Age ranged from 18 to 80 years. Acute onset of symptoms was in 22, while 6 had insidious onset. 18 patients had major infarct, while 4 patients had lacunar infarct. 2 patients were found to have haematoma (1 following head injury) and 1 each had tuberculoma, meningioma, glioma and toxoplasma granuloma. The lesions were seen in various parts of brain stem, thalamus, basal ganglion, internal capsule and frontal, parietal and temporal region. Heterogeneity as regards to etiology and localisation is being highlighted.
Journal of Association of Physicians of India, 1990
We report a 35 year old lady who developed lumbosacral plexopathy immediately following regional ... more We report a 35 year old lady who developed lumbosacral plexopathy immediately following regional paracervical block anaesthesia for medical termination of pregnancy. There was only partial recovery at one year. The neurological deficit and its mechanisms are discussed.
Journal of Association of Physicians of India, 1990
Computed tomography (CT) is a very sensitive modality for the diagnosis of neurocysticercosis. Fi... more Computed tomography (CT) is a very sensitive modality for the diagnosis of neurocysticercosis. Fifty eight patients were evaluated by plain radiography and CT scans. The initial presentation was as seizure disorder (33), raised intracranial tension (19), meningoencephalitis (5) and psychiatric manifestation (1). Histologically confirmed subcutaneous nodules were seen in 20 cases and ocular cyst in 2 cases. CT scan showed multiple calcification in 8 cases, disc lesions in 30,ring lesions in 3, and a combination of disc and ring lesions in another 13 cases. Low attenuation lesions were seen in 4 cases in combination with disc/disc and ring lesions. All 58 cases had supratentorial lesions while 19 cases had infratentorial lesions in addition. Perifocal or generalised oedema was seen in 33 and 11 cases respectively. The ventricles were compressed in one case, large in 2 cases and normal in the rest. CT scan is valuable in the diagnosis of neurocysticercosis. Its significance is differen...
Journal of the Indian Medical Association, 1994
In 361 patients with strong clinical suspicion of secondary epilepsy magnetic resonance imaging (... more In 361 patients with strong clinical suspicion of secondary epilepsy magnetic resonance imaging (MRI) was performed. Three hundred and forty-five patients revealed a positive study. Maximum number of patients (28.3%) were in the age group of 2 to 12 years without any significant sex predilection. More than 70% patients presented with generalised seizures. MRI revealed definite evidence of tuberculoma in 98, neurocysticercosis in 86, tumour in 60 and cerebrovascular accident in 23 patients. There were 78 patients in miscellaneous group which included patients with magnetic resonance (MR) diagnosis of generalised or focal atrophy, demyelinating disease, hydrocephalus with or without basal exudates, calcification and disappearing lesion. In 16 patients MR was found to be within normal limits.
Indian Pediatrics, 1993
... of Brain Lesions in Tuberous Sclerosis by Magnetic Resonance Imaging Parveen Gulati A. Jena P... more ... of Brain Lesions in Tuberous Sclerosis by Magnetic Resonance Imaging Parveen Gulati A. Jena PC Sanchetee RP Tripathi Chandra Tuberous sclerosis is ... rosis in a clinically suspected case Acknowledgement The authors are thankful to Mr. Sita Ram and Mr. Yogesh Gupta for ...
Journal of Association of Physicians of India, 1994
Based on clinical evaluation and computed tomography (CT) of the brain, 30 cases of neurocysticer... more Based on clinical evaluation and computed tomography (CT) of the brain, 30 cases of neurocysticercosis were diagnosed. Diagnosis was supported by presence of histopathologically proven subcutaneous cysticerci in 12 cases. Three primary neurological syndromes were established i.e. epilepsy in 22 cases, increased intracranial tension in 6 cases and meningoencephalitis in 2 cases. Albendazole was administered orally in a dose of 15 mg/kg bodyweight/day for 30 days without prophylactic steroids. Follow up CT study at 3 months and 12 months revealed complete regression of all lesions in 2 cases, partial regressions in 14 cases and change in morphology in 4 cases. Transient appearence of fresh subcutaneous cysticerci as a side effect of therapy was noted in 4 cases. Albendazole, though acting slow, is considered a suitable alternative to praziquantel in medical management of parenchymal neurocysticercosis.
Journal of Association of Physicians of India, 1991
Seventeen cases of myasthenia gravis, aged 20-79 years, including one case of ocular myasthenia g... more Seventeen cases of myasthenia gravis, aged 20-79 years, including one case of ocular myasthenia gravis, seen over a 3 year period, were analysed. Dysphagia was the presenting symptom in two cases. One patient had ectopic thymus gland in relation to the cardiac border, which posed difficulty in diagnosis. A majority of the patients were on medical treatment, including neostigmine, prednisolone and azathioprim. Plasmapheresis was done in 4 cases during crisis, with significant benefit. One patient was put on intermittent ventilatory support for 14-16 hours a day for over 2 years; she died during a power failure. Seven patients were subjected to thymectomy.
Indian Journal of …, 1990
Cutaneous cysticerci are often a pointer to the involvement of internal organs. A series of 33 pa... more Cutaneous cysticerci are often a pointer to the involvement of internal organs. A series of 33 patients including 5 vegetarians, between 10 to 48 years age, were investigated. Almost half the patients presented with cutaneous cysts of less than one ...
The Indian Practitioner , 2018
Aging, though a graceful period, is associated with problems related to physical and mental healt... more Aging, though a graceful period, is associated with problems related to physical and mental health, social isolation, and financial crunch. This review aims to highlight the efficacy of meditation in promoting health
in the elderly population. A review of the literature suggests that mindfulness has promising beneficial effects on cognitive, emotional, and physiological parameters in the elderly. In a well-planned prospective, randomized, case-control study by us on 58 subjects (37 males and 21 females) who were administered a Preksha meditation for
4 months. At the end of 4 months period, there was an improvement in all domains of WHO Quality of Life-BREF (WHOQOL-BREF) ranging from 3 points to 5.7, i.e. psychological health (29.3%), physical health (24.1%), social health (12.1%)) and environmental health (29.3%) and in stress level (17.2%). There was also an improvement in depression and anxiety status as assessed by Hospital Anxiety and Depression Score (HADS). It can be concluded that meditation is a cost-effective, non-invasive intervention with minimal risk of adverse effects and can be safely recommended for the promotion of mental health in the elderly.
IntechOpen, 2021
Stroke remains a leading cause of adult disability. The social, physical, and psychological cons... more Stroke remains a leading cause of adult disability. The social, physical, and
psychological consequences of stroke are devastating. With a better understanding of causation and breakthrough advances in management, we are witnessing a greater population of stroke survivors with varying neurological and functional deficits. Poststroke rehabilitation is a multi-disciplinary and multi-modal endeavor, not a ‘one size fits all’ intervention. A combination of interventions may be better suited to treat motor and sensory impairments, cognitive problems, and psychological issues. There is great interest in exploring novel rehabilitation technologies to
augment conventional therapies to reduce neurological disability and improve function. Yoga and spirituality, though ancient practices are finding a bigger role in the field of rehabilitation. Despite good potential for recovery, these rehabilitative measures are underutilized; major barriers are limited availability, geographical distance, high cost, and lack of awareness about its benefits. While conventional measures are well engraved, this article reviews the recent stroke rehabilitation concepts.
Yoga Mimamsa , 2018
The pineal gland is a small but critical hormonal gland in our body. It is considered a regulatin... more The pineal gland is a small but critical hormonal gland in our body. It is considered a regulating or master gland that regulates the cycles within our bodies. Its purpose and function are still largely a mystery to science, and research on it yields exciting discoveries, especially on its connection to spirituality and higher states of consciousness. Descriptions of the human anatomy derived from religious texts are often omitted from the medical literature. It may be that over time, science will validate many of these spiritual truths and statements as being based in scientific and medical facts.
Indian Journal of Endocrinology and Metabolism, 2020
Background and Aims: Fasting has a long tradition in most cultures and has many health benefits. ... more Background and Aims: Fasting has a long tradition in most cultures and has many health benefits. Most of the studies are from daytime fasting
or intermittent fasting. There is paucity of data from complete fasting (no food and fruits, water only). This prospective study is conducted with
aims to study impact of complete fasting on clinical and biochemical parameters. Methods: One hundred ten participants of either gender who
voluntarily fasted (3‑30 days) were included and underwent clinical and biochemical examination before and after fasting. Results: A total
of 110 healthy volunteers (M: 27, F: 83) with mean age 51 ± 16 years (range 18‑86) and body mass index 27.1 ± 4.9 kg/m2 (16.1‑45.2) wer
studied. They had undergone fast for varying duration between 3‑30 days (short fast: 3‑7 days = 72; prolong fast: >7 days = 38). There wer
significant decrease in weight (66.8 ± 11.0 to 64.7 ± 11.1 kg, P < 0.0001), BMI (27.1 ± 4.9 to 26.2 ± 4.9 kg/m2
, P < 0.0001), systolic blood
pressure (130 ± 17 to 128 ± 15 mmHg, P = 0.012), serum globulin (3.10 ± 0.42 to 3.01 ± 0.41 mg/dl, P = 0.024), and serum high density
lipoprotein (48.3 ± 12.2 to 45.7 ± 12.6 mg/dl, P < 0.0001) post fasting. However, significant increase was observed in pulse rate (81 ± 10
to 83 ± 11 beat/min, P = 0.001), fasting plasma glucose (102.9 ± 35.0 to 132.0 ± 42.0 mg/dl, P < 0.0001), serum triglycerides (137.6 ± 68.3 to
149.0 ± 67.1 mg/dl, P = 0.031), very low density lipoprotein (22.0 ± 10.5 to 24.2 ± 11.1 mg/dl, P = 0.010), and serum cortisol levels(13.5 ± 5.9 to
17.2 ± 6.3 µg/dl, P < 0.0001). These changes were more pronounced with prolong fasting, but were not affected by gender. Conclusions: Fasting
results in improvement in anthropometric, physical and biochemical parameters related to physical health. It can be recommended as a mean
for improving quality of life
Current Research in Nutrition and Food Science, 2024
The practice of voluntary abstinence from food and drink for 16 to 48 hours is known as intermitt... more The practice of voluntary abstinence from food and drink for 16 to 48 hours is known as intermittent fasting (IF). Jain Ayambil, a type of intermittent fasting, where a special meal of boiled grains without spice, oil, milk, ghee, sugar, curd, fruits, or raw vegetables is taken once during the daytime. The aim of the study was to find out safety and its effect on plasma glucose, lipid profile, anthropometric and psychological parameters. We are reporting first ever scientific study on effect of Aymabil intermittent fasting on health parameters. The present study was carried out on 52 volunteers who did 9 days Ayambil fasting. Physical, and psychological assessments were done on the pre-fasting day (day 0), 4th day, and 9th day whereas biochemical examinations were carried out on pre-fasting (day 0) and 9th day of Ayambil fasting. Out of the total 52 participants (mean age of 52.77 ± 13.51 years), there were 28 (53.85%) females (51.54 ± 12.94) and 24 (46.15%) males (54.21 ± 14.30). A statistically significant reduction was observed for fasting blood glucose (p=0.002), HbA1c (p=0.002), body weight (p=0.001), BMI (p=0.001), diastolic BP (p=0.005), serum creatinine (p= 0.036), and a positive correlation was noted for Hamilton Depression Rating Scale (HDRS) (p=0.001) noted during Ayambil fasting. However, there was no
significant change in lipid profile. Our findings suggest that Ayambil fasting is beneficial to metabolic, psychological, and holistic health with no healthrelated hazards. It is a safe fasting method and exploration of more clinical studies on this can open newer futuristic directions as one of the therapeutic options for a variety of clinical situations.
Journal of Association of Physicians of India, Oct 1, 1996
IP Innovative Publication Pvt. Ltd., 2018
Aims: The present study aims at demonstrating changes in alpha wave frequency on electroencephalo... more Aims: The present study aims at demonstrating changes in alpha wave frequency on electroencephalograph (EEG) at two and
four months of preksha meditation training in young novice students.
Materials and Methods: Participants included 52 girls between the 17 to 21 years of age from a local college selected using a
convenience sampling technique. They were randomly divided into experimental (n = 29) and control (n = 26) groups. Study
duration was 4 months during which experimental group was administered a supervised PM training for 4 months. During this
period control group continued their normal activities without mediation practice. EEG was analyzed for alpha waves and
compared at base line, at 2 months and at 4 months.
Results: The mean value of alpha wave frequency (%) in control group at beginning was 49.65 ±21.598 which increased to
52.58±18.005 at 2 months. In experimental group, in beginning it was 49.52 ±18.169 which increased to 54.31±22.490 at 2
months. However, this increment was not statistically significant in both groups. A statistically significant increment in alpha
waves percentage to 66.59±9.493 was observed in experimental group after four months of PM which was significant at the
level of p<0.01. Conversely the changes in control group after 4 months were not significant rather the mean value decreased
to 48.88±17.653.
Conclusions: A significant increase in alpha waves was observed at 4 months of PM practice in young novice students. This
increase was observed at 4 months and not at 2 months suggesting that longer practice of meditation is needed to bring out
significant improvement.
Keywords: Preksha meditation, EEG, Alpha waves
Journal of Association of Physicians of India, 1990
Poisoning due to barium carbonate (rat poison) resulting in areflexic quadriplegia and respirator... more Poisoning due to barium carbonate (rat poison) resulting in areflexic quadriplegia and respiratory muscle paresis in a young patient is described. The various effects of barium salts on the human body and their treatment are highlighted.
Journal of Association of Physicians of India, 1992
The clinical and computed tomography (CT) features of 25 patients with peripartum CVT are describ... more The clinical and computed tomography (CT) features of 25 patients with peripartum CVT are described. Majority of the patients presented in postpartum period and did not receive proper antenatal care. Headache (92%), altered sensorium (80%, seizures (76%), papilloedema (80%) and hemiplegia (52%) were the common modes of presentation. CT findings included diffuse brain oedema (52%), haemorrhagic or nonhaemorrhagic infarctions on one or both sides of brain (48%), gyral enhancement (40%) and tentorial enhancement (16%). While 15 patients made good recovery, 3 cases (12%) died during acute stage of illness.
Journal of Association of Physicians of India, 1990
Meningoencephalitic syndrome can be caused by many infective agents. Over a period of 13 years, 1... more Meningoencephalitic syndrome can be caused by many infective agents. Over a period of 13 years, 15 of 170 cases of neurocysticercosis (NCC) presented as meningoencephalitis. The basis of diagnosis of NCC was positive subcutaneous nodule histopathology (4), CT scan (9) and autopsy (3) findings. The age of the patients ranged from 7-68 years (mean 32). Fever was encountered in 12, altered sensorium in 7, seizures in 10 and abnormal behaviour in 3 cases. All cases had papilloedema. Focal neurological signs included optic atrophy, lateral rectus palsy, hemiplegia, internuclear ophthalmoplegia and cerebellar ataxia. Cerebrospinal fluid was abnormal in 8 of 13 cases, leading to a suspicion of tuberculous meningitis. Twelve patients improved with therapy. Three cases ended fatally and autopsy confirmed the diagnosis.
Journal of Association of Physicians of India, 1999
To study the clinical course and outcome of toxoplasmic encephalitis (TE) in patients with acquir... more To study the clinical course and outcome of toxoplasmic encephalitis (TE) in patients with acquired immunodeficiency syndrome (AIDS). Patients infected with human immunodeficiency virus (HIV) and neurological abnormality compatible with diagnosis of TE were enrolled in the study. These patients were treated with combination of trimethoprim/sulfamethoxazole and pyrimethamine. Response to therapy was assessed by clinical examination and repeat CT/MRI scan done after three weeks of starting treatment. Those showing response were put on prophylactic therapy. A total of 451 patients of HIV infections were admitted to this centre during the study period, of these 11 patients were diagnosed to have TE. The common presenting symptoms were fever (80%), seizures (45%), headache (45%) and altered sensorium (25%). Focal neurological deficit was present in 80% of cases. Nine cases had ring-enhancing lesions on CT scan while in the remaining two patient's ring lesions were seen on MRI. These ...
Journal of Association of Physicians of India, 1996
We studied the clinical profile and etiology of 28 cases of ataxic hemiparesis. After a detailed ... more We studied the clinical profile and etiology of 28 cases of ataxic hemiparesis. After a detailed neurological examination, CT scan brain (plain and after IV contrast) was done in all. Age ranged from 18 to 80 years. Acute onset of symptoms was in 22, while 6 had insidious onset. 18 patients had major infarct, while 4 patients had lacunar infarct. 2 patients were found to have haematoma (1 following head injury) and 1 each had tuberculoma, meningioma, glioma and toxoplasma granuloma. The lesions were seen in various parts of brain stem, thalamus, basal ganglion, internal capsule and frontal, parietal and temporal region. Heterogeneity as regards to etiology and localisation is being highlighted.
Journal of Association of Physicians of India, 1990
We report a 35 year old lady who developed lumbosacral plexopathy immediately following regional ... more We report a 35 year old lady who developed lumbosacral plexopathy immediately following regional paracervical block anaesthesia for medical termination of pregnancy. There was only partial recovery at one year. The neurological deficit and its mechanisms are discussed.
Journal of Association of Physicians of India, 1990
Computed tomography (CT) is a very sensitive modality for the diagnosis of neurocysticercosis. Fi... more Computed tomography (CT) is a very sensitive modality for the diagnosis of neurocysticercosis. Fifty eight patients were evaluated by plain radiography and CT scans. The initial presentation was as seizure disorder (33), raised intracranial tension (19), meningoencephalitis (5) and psychiatric manifestation (1). Histologically confirmed subcutaneous nodules were seen in 20 cases and ocular cyst in 2 cases. CT scan showed multiple calcification in 8 cases, disc lesions in 30,ring lesions in 3, and a combination of disc and ring lesions in another 13 cases. Low attenuation lesions were seen in 4 cases in combination with disc/disc and ring lesions. All 58 cases had supratentorial lesions while 19 cases had infratentorial lesions in addition. Perifocal or generalised oedema was seen in 33 and 11 cases respectively. The ventricles were compressed in one case, large in 2 cases and normal in the rest. CT scan is valuable in the diagnosis of neurocysticercosis. Its significance is differen...
Journal of the Indian Medical Association, 1994
In 361 patients with strong clinical suspicion of secondary epilepsy magnetic resonance imaging (... more In 361 patients with strong clinical suspicion of secondary epilepsy magnetic resonance imaging (MRI) was performed. Three hundred and forty-five patients revealed a positive study. Maximum number of patients (28.3%) were in the age group of 2 to 12 years without any significant sex predilection. More than 70% patients presented with generalised seizures. MRI revealed definite evidence of tuberculoma in 98, neurocysticercosis in 86, tumour in 60 and cerebrovascular accident in 23 patients. There were 78 patients in miscellaneous group which included patients with magnetic resonance (MR) diagnosis of generalised or focal atrophy, demyelinating disease, hydrocephalus with or without basal exudates, calcification and disappearing lesion. In 16 patients MR was found to be within normal limits.
Indian Pediatrics, 1993
... of Brain Lesions in Tuberous Sclerosis by Magnetic Resonance Imaging Parveen Gulati A. Jena P... more ... of Brain Lesions in Tuberous Sclerosis by Magnetic Resonance Imaging Parveen Gulati A. Jena PC Sanchetee RP Tripathi Chandra Tuberous sclerosis is ... rosis in a clinically suspected case Acknowledgement The authors are thankful to Mr. Sita Ram and Mr. Yogesh Gupta for ...
Journal of Association of Physicians of India, 1994
Based on clinical evaluation and computed tomography (CT) of the brain, 30 cases of neurocysticer... more Based on clinical evaluation and computed tomography (CT) of the brain, 30 cases of neurocysticercosis were diagnosed. Diagnosis was supported by presence of histopathologically proven subcutaneous cysticerci in 12 cases. Three primary neurological syndromes were established i.e. epilepsy in 22 cases, increased intracranial tension in 6 cases and meningoencephalitis in 2 cases. Albendazole was administered orally in a dose of 15 mg/kg bodyweight/day for 30 days without prophylactic steroids. Follow up CT study at 3 months and 12 months revealed complete regression of all lesions in 2 cases, partial regressions in 14 cases and change in morphology in 4 cases. Transient appearence of fresh subcutaneous cysticerci as a side effect of therapy was noted in 4 cases. Albendazole, though acting slow, is considered a suitable alternative to praziquantel in medical management of parenchymal neurocysticercosis.
Journal of Association of Physicians of India, 1991
Seventeen cases of myasthenia gravis, aged 20-79 years, including one case of ocular myasthenia g... more Seventeen cases of myasthenia gravis, aged 20-79 years, including one case of ocular myasthenia gravis, seen over a 3 year period, were analysed. Dysphagia was the presenting symptom in two cases. One patient had ectopic thymus gland in relation to the cardiac border, which posed difficulty in diagnosis. A majority of the patients were on medical treatment, including neostigmine, prednisolone and azathioprim. Plasmapheresis was done in 4 cases during crisis, with significant benefit. One patient was put on intermittent ventilatory support for 14-16 hours a day for over 2 years; she died during a power failure. Seven patients were subjected to thymectomy.
Indian Journal of …, 1990
Cutaneous cysticerci are often a pointer to the involvement of internal organs. A series of 33 pa... more Cutaneous cysticerci are often a pointer to the involvement of internal organs. A series of 33 patients including 5 vegetarians, between 10 to 48 years age, were investigated. Almost half the patients presented with cutaneous cysts of less than one ...