Atsushi Tajima | Kanazawa University (original) (raw)

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Papers by Atsushi Tajima

Research paper thumbnail of Higher Intake of Vegetable Protein and Lower Intake of Animal Fats Reduce the Incidence of Diabetes in Non-Drinking Males: A Prospective Epidemiological Analysis of the Shika Study

Research paper thumbnail of Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans

Frontiers in Nutrition, Feb 22, 2021

Research paper thumbnail of Genome-wide association study identifies ERBB4 on 2q34 as a novel locus associated with sperm motility in Japanese men

Journal of Medical Genetics, Feb 16, 2018

Research paper thumbnail of The Role of Polygenic Susceptibility on Air Pollution-Associated Asthma between German and Japanese Elderly Women

International Journal of Environmental Research and Public Health, Aug 10, 2022

Research paper thumbnail of Glucokinase-maturity onset diabetes mellitus in the young suggested by factory-calibrated glucose monitoring data: a case report

Research paper thumbnail of A retrospective cohort study on the association between poor sleep quality in junior high school students and high hemoglobin A1c level in early adults with higher body mass index values

BMC Endocrine Disorders, Feb 15, 2022

Research paper thumbnail of Exploring the Genetic Basis of Dens Evaginatus Using Whole-Exome Sequencing

Applied sciences, Sep 6, 2022

Research paper thumbnail of Molecular features of tumor-derived genetic alterations in circulating cell-free DNA in virtue of autopsy analysis

Scientific Reports, Apr 16, 2021

Research paper thumbnail of A Targeted Genetic Association Study of the Rare Type of Osteomyelitis

Journal of Dental Research, Jan 24, 2020

Research paper thumbnail of Clinical and genetic characteristics of abnormal glucose tolerance in Japanese women in the first year after gestational diabetes mellitus

Journal of Diabetes Investigation, Oct 26, 2018

Research paper thumbnail of Relationship between fatty acid intake and chronic neck/shoulder/upper limb pain without elevated CRP in a Japanese population: a cross-sectional analysis of the Shika study

Journal of Nutritional Science, 2022

Research paper thumbnail of A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia

Haematologica, May 21, 2020

Research paper thumbnail of Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia

Haematologica, Mar 19, 2019

Research paper thumbnail of Medieval genomes from eastern Mongolia share a stable genetic profile over a millennium

Research paper thumbnail of Relationship between social capital and depressive symptoms: Differences according to resilience and gender in the Shika study

Journal of Affective Disorders Reports

Research paper thumbnail of Author Reply to Peer Reviews of Astroglial CD38 regulates social memory and synapse formation through SPARCL1 in the medial prefrontal cortex

Research paper thumbnail of Author Reply to Peer Reviews of The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity

Research paper thumbnail of A case of hepatic small vessel neoplasm without previously reported hotspot mutation of alpha subfamily of G proteins

Research paper thumbnail of Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method

Research paper thumbnail of Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation

Scientific reports, Jan 27, 2018

Mitochondrial DNA (mtDNA) mutations are found in many types of cancers and suspected to be involv... more Mitochondrial DNA (mtDNA) mutations are found in many types of cancers and suspected to be involved in carcinogenesis, although the mechanism has not been elucidated. In this study, we report that consecutive C-to-T mutations (hypermutations), a unique feature of mutations induced by APOBECs, are found in mtDNA from cervical dysplasia and oropharyngeal cancers. In vitro, we found that APOBEC3A (A3A) and 3B (A3B) expression, as well as mtDNA hypermutation, were induced in a cervical dysplastic cell line W12 when cultured in a differentiating condition. The ectopic expression of A3A or A3B was sufficient to hypermutate mtDNA. Fractionation of W12 cell lysates and immunocytochemical analysis revealed that A3A and A3B could be contained in mitochondrion. These results suggest that mtDNA hypermutation is induced upon keratinocyte differentiation, and shed light on its molecular mechanism, which involves A3s. The possible involvement of mtDNA hypermutations in carcinogenesis is also discu...

Research paper thumbnail of Higher Intake of Vegetable Protein and Lower Intake of Animal Fats Reduce the Incidence of Diabetes in Non-Drinking Males: A Prospective Epidemiological Analysis of the Shika Study

Research paper thumbnail of Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans

Frontiers in Nutrition, Feb 22, 2021

Research paper thumbnail of Genome-wide association study identifies ERBB4 on 2q34 as a novel locus associated with sperm motility in Japanese men

Journal of Medical Genetics, Feb 16, 2018

Research paper thumbnail of The Role of Polygenic Susceptibility on Air Pollution-Associated Asthma between German and Japanese Elderly Women

International Journal of Environmental Research and Public Health, Aug 10, 2022

Research paper thumbnail of Glucokinase-maturity onset diabetes mellitus in the young suggested by factory-calibrated glucose monitoring data: a case report

Research paper thumbnail of A retrospective cohort study on the association between poor sleep quality in junior high school students and high hemoglobin A1c level in early adults with higher body mass index values

BMC Endocrine Disorders, Feb 15, 2022

Research paper thumbnail of Exploring the Genetic Basis of Dens Evaginatus Using Whole-Exome Sequencing

Applied sciences, Sep 6, 2022

Research paper thumbnail of Molecular features of tumor-derived genetic alterations in circulating cell-free DNA in virtue of autopsy analysis

Scientific Reports, Apr 16, 2021

Research paper thumbnail of A Targeted Genetic Association Study of the Rare Type of Osteomyelitis

Journal of Dental Research, Jan 24, 2020

Research paper thumbnail of Clinical and genetic characteristics of abnormal glucose tolerance in Japanese women in the first year after gestational diabetes mellitus

Journal of Diabetes Investigation, Oct 26, 2018

Research paper thumbnail of Relationship between fatty acid intake and chronic neck/shoulder/upper limb pain without elevated CRP in a Japanese population: a cross-sectional analysis of the Shika study

Journal of Nutritional Science, 2022

Research paper thumbnail of A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia

Haematologica, May 21, 2020

Research paper thumbnail of Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia

Haematologica, Mar 19, 2019

Research paper thumbnail of Medieval genomes from eastern Mongolia share a stable genetic profile over a millennium

Research paper thumbnail of Relationship between social capital and depressive symptoms: Differences according to resilience and gender in the Shika study

Journal of Affective Disorders Reports

Research paper thumbnail of Author Reply to Peer Reviews of Astroglial CD38 regulates social memory and synapse formation through SPARCL1 in the medial prefrontal cortex

Research paper thumbnail of Author Reply to Peer Reviews of The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity

Research paper thumbnail of A case of hepatic small vessel neoplasm without previously reported hotspot mutation of alpha subfamily of G proteins

Research paper thumbnail of Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method

Research paper thumbnail of Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation

Scientific reports, Jan 27, 2018

Mitochondrial DNA (mtDNA) mutations are found in many types of cancers and suspected to be involv... more Mitochondrial DNA (mtDNA) mutations are found in many types of cancers and suspected to be involved in carcinogenesis, although the mechanism has not been elucidated. In this study, we report that consecutive C-to-T mutations (hypermutations), a unique feature of mutations induced by APOBECs, are found in mtDNA from cervical dysplasia and oropharyngeal cancers. In vitro, we found that APOBEC3A (A3A) and 3B (A3B) expression, as well as mtDNA hypermutation, were induced in a cervical dysplastic cell line W12 when cultured in a differentiating condition. The ectopic expression of A3A or A3B was sufficient to hypermutate mtDNA. Fractionation of W12 cell lysates and immunocytochemical analysis revealed that A3A and A3B could be contained in mitochondrion. These results suggest that mtDNA hypermutation is induced upon keratinocyte differentiation, and shed light on its molecular mechanism, which involves A3s. The possible involvement of mtDNA hypermutations in carcinogenesis is also discu...

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