Nawaz Malik | University of Kashmir, Srinagar, J&K, India (original) (raw)

Papers by Nawaz Malik

India is one of the most vulnerable developing countries to suffer very often from various natura... more India is one of the most vulnerable developing countries to suffer very often from various natural disasters, namely drought, flood, cyclone, earth quake, landslide, forest fire, hail storm, locust, volcanic eruption, etc. Which strike causing a devastating impact on human life, economy and environment. Though it is almost impossible to fully recoup the damage caused by the disasters, it is possible to (i) minimize the potential risks by developing early warning strategies (ii) prepare and implement developmental plans to provide resilience to such disasters (iii) mobilize resources including communication and telemedicinal services, and (iv) to help in rehabilitation and post-disaster reconstruction. The article describes the natural disaster management and socio-political awareness among the human beings and disaster management for the well being of the society. Besides to find out the major impacts of natural disasters, Suitable Strategy to Mitigate the Disaster and Provide the S...

IOSR Journal of Environmental Science, Toxicology and Food Technology, 2013

It was only fifty years before that our scientists and experts on climate and environment started... more It was only fifty years before that our scientists and experts on climate and environment started the keen observation that something wrong is happening to our environment. The result was that the far-sighted people in the world began emphasizing that human community should take an approach of sustainable living, growth and development. A large number of national and international conferences on sustainable development have been held during the last 40 years to chalk out workable strategies to counter act the impending catastrophes, but till date all these conclaves have been proved to be futile exercises.

This paper focuses on the sustainable development of tourism in Uttarakhand. Uttarakhand is a sta... more This paper focuses on the sustainable development of tourism in Uttarakhand. Uttarakhand is a state in the Northern Himalayan Region in India and it has been a hot spot of tourism due to its magnificently diverse landscapes, high biodiversity enough religious tourist potential and rich cultural heritage, which has also generated a good source of income and employment to youths and rural masses. Tourism is one of the biggest and fastest-growing economic sectors in the global economy and has significant environmental, cultural, social, and economic effects, both positive and negative. Tourism has been noted as the world’s largest and fastest growing industry. The main objectives of the study are the formation of tourist circuits, to find out the problems and suggest a suitable plan for sustainable tourism development in Uttarakhand. A field based systematic survey was carried out on the basis of questionnaire in some selected tourism destinations to find out the problems and the data ...

Pakistan Journal of International Affairs, 2021

The history of Pakistan and Turkey has been marked by several common features with respect to the... more The history of Pakistan and Turkey has been marked by several common features with respect to the military’s predominant role in politics. The Armed Forces in both the states many a time intervened in the politics either directly by toppling down the elected civilian governments or indirectly by forcing the elected popular governments to step down. In the history of the two countries, military has been playing a crucial role in the political arena, and it has been considered by majority of the society as the savior in uncertain situations like civil wars, political chaos and natural crisis in the country. In this paper, the author attempts to examine comparatively the causes of the military tutelage and dominancy in the politics in Turkey and Pakistan in a historical perspective. And in the second part, the author attempts to compare and contrast the similarities in the nature of the military’s involvement in politics in both the states. In the last part of this paper, the author al...

ACS Omega, 2022

Acute myeloid leukemia (AML) is an aggressive blood cancer with limited effective chemotherapy op... more Acute myeloid leukemia (AML) is an aggressive blood cancer with limited effective chemotherapy options and negative patient outcomes. Food-derived molecules such as avocatin B (Avo B), a fatty-acid oxidation (FAO) inhibitor, are promising novel therapeutics. The roots of the Curcuma amada plants have been historically used in traditional medicine, but isolated bioactive compounds have seldom been studied. Here, we report that 2,4,6-trihydroxy-3,5-diprenyldihydrochalcone (M1), a bioactive from C. Amada, possesses novel anticancer activity. This in vitro study investigated the antileukemia properties of M1 and its effects on mitochondrial metabolism. In combination with Avo B, M1 synergistically reduced AML cell line viability and patientderived clonogenic growth with no effect on normal peripheral blood stem cells. Mechanistically, M1 alone inhibited mitochondria complex I, while the M1/Avo B combination inhibited FAO by 60%, a process essential to the synergy. These results identified a novel food-derived bioactive and its potential as a novel chemotherapeutic for AML.

Pakistan Journal of International Affairs, 2021

This article attempts to elucidate the female parliamentarian’s role in social and political chan... more This article attempts to elucidate the female parliamentarian’s role in social and political change in Pakistan by looking at it through the lens of the country’s historical progress. With an emphasis on historical evolution and current situation, the article also discusses social constraints that have made it difficult for women to engage in the political system in the past. Women’s political engagement should be enhanced in the future, and an assessment of these concerns may produce some helpful ideas. In this study article, researchers have examined employing a qualitative research approach which is also called market research method that focuses on acquiring data through open-ended and conversational dialogue. These qualitative research approaches allow for in-depth and additional probing and questioning of respondents based on their responses, where the researchers also seek to understand their purpose and sentiments. The study also finds that Women’s political empowerment acro...

Blood, 2021

Acute myeloid leukemia (AML) cells have an atypical metabolic phenotype characterized by increase... more Acute myeloid leukemia (AML) cells have an atypical metabolic phenotype characterized by increased mitochondrial mass, as well as a greater reliance on oxidative phosphorylation and fatty acid oxidation (FAO) for survival. To exploit this altered metabolism, we assessed publicly available databases to identify FAO enzyme overexpression. Very long chain acyl-CoA dehydrogenase (VLCAD; ACADVL) was found to be overexpressed and critical to leukemia cell mitochondrial metabolism. Genetic attenuation or pharmacological inhibition of VLCAD hindered mitochondrial respiration and FAO contribution to the tricarboxylic acid cycle, resulting in decreased viability, proliferation, clonogenic growth, and AML cell engraftment. Suppression of FAO at VLCAD triggered an increase in pyruvate dehydrogenase activity that was insufficient to increase glycolysis but resulted in adenosine triphosphate depletion and AML cell death, with no effect on normal hematopoietic cells. Together, these results demons...

International Journal of Current Microbiology and Applied Sciences, 2021

Scientific Reports, 2020

Avocado (Persea americana Mill.; Lauraceae) seed-derived polyhydroxylated fatty alcohols (PFAs) o... more Avocado (Persea americana Mill.; Lauraceae) seed-derived polyhydroxylated fatty alcohols (PFAs) or polyols (i.e., avocadene and avocadyne) are metabolic modulators that selectively induce apoptosis of leukemia stem cells and reverse pathologies associated with diet-induced obesity. Delivery systems containing avocado polyols have not been described. Herein, natural surface active properties of these polyols are characterized and incorporated into self-emulsifying drug delivery systems (SEDDS) that rely on molecular self-assembly to form fine, transparent, oil-in-water (O/W) microemulsions as small as 20 nanometers in diameter. Mechanistically, a 1:1 molar ratio of avocadene and avocadyne (i.e., avocatin B or AVO was shown to be a eutectic mixture which can be employed as a novel, bioactive, co-surfactant that significantly reduces droplet size of medium-chain triglyceride O/W emulsions stabilized with polysorbate 80. In vitro cytotoxicity of avocado polyol-SEDDS in acute myeloid leu...

Pakistan Journal of International Affairs, 2021

The history of Pakistan and Turkey has been marked by several common features with respect to the... more The history of Pakistan and Turkey has been marked by several common features with respect to the military’s predominant role in politics. The Armed Forces in both the states many a time intervened in the politics either directly by toppling down the elected civilian governments or indirectly by forcing the elected popular governments to step down. In the history of the two countries, military has been playing a crucial role in the political arena, and it has been considered by majority of the society as the savior in uncertain situations like civil wars, political chaos and natural crisis in the country. In this paper, the author attempts to examine comparatively the causes of the military tutelage and dominancy in the politics in Turkey and Pakistan in a historical perspective. And in the second part, the author attempts to compare and contrast the similarities in the nature of the military’s involvement in politics in both the states. In the last part of this paper, the author al...

Blood, 2019

Targeting cell metabolism has emerged as a viable treatment strategy in acute myeloid leukemia (A... more Targeting cell metabolism has emerged as a viable treatment strategy in acute myeloid leukemia (AML), a malignant hematological disease characterized by poor patient outcomes and limited chemotherapeutic options. Compared to the normal hematopoietic population, leukemia cells exhibit an altered phenotype characterized by increased mitochondrial mass as well as a greater reliance on oxidative phosphorylation and fatty acid oxidation (FAO) for survival. Mitochondrial FAO is a four-reaction process that catabolizes fatty acids to acetyl-CoA, generating reductive equivalents for the electron transport chain (ETC) and anaplerotic intermediates for the TCA cycle. Clinically approved FAO inhibitors, such as trimetazidine and ranolazine, are tissue-specific, targeting FAO in some tissues but affecting additional pathways in others. To better understand the potential clinical utility of targeting FAO, we systematically tested a panel of clinical and pre-clinical FAO inhibitors, reasoning tha...

ACS Omega, 2022

Acute myeloid leukemia (AML) is an aggressive blood cancer with limited effective chemotherapy op... more Acute myeloid leukemia (AML) is an aggressive blood cancer with limited effective chemotherapy options and negative patient outcomes. Food-derived molecules such as avocatin B (Avo B), a fatty-acid oxidation (FAO) inhibitor, are promising novel therapeutics. The roots of the Curcuma amada plants have been historically used in traditional medicine, but isolated bioactive compounds have seldom been studied. Here, we report that 2,4,6-trihydroxy-3,5-diprenyldihydrochalcone (M1), a bioactive from C. Amada, possesses novel anticancer activity. This in vitro study investigated the antileukemia properties of M1 and its effects on mitochondrial metabolism. In combination with Avo B, M1 synergistically reduced AML cell line viability and patientderived clonogenic growth with no effect on normal peripheral blood stem cells. Mechanistically, M1 alone inhibited mitochondria complex I, while the M1/Avo B combination inhibited FAO by 60%, a process essential to the synergy. These results identified a novel food-derived bioactive and its potential as a novel chemotherapeutic for AML.

Current Alzheimer research, Jan 9, 2018

PDGFβ receptors and their ligand, PDGF-BB, are upregulated in vivo after neuronal insults such as... more PDGFβ receptors and their ligand, PDGF-BB, are upregulated in vivo after neuronal insults such as ischemia. When applied exogenously, PDGF-BB is neuroprotective against excitotoxicity and HIV proteins. Given this growth factor's neuroprotective ability, we sought to determine if PDGF-BB would be neuroprotective against amyloid-β (1-42), one of the pathological agents associated with Alzheimer's disease (AD). In both primary hippocampal neurons and the human-derived neuroblastoma cell line, SH-SY5Y, amyloid- treatment for 24 h decreased surviving cell number in a concentration-dependent manner. Pretreatment with PDGF-BB failed to provide any neuroprotection against amyloid-β in primary neurons and only very limited protective effects in SH-SY5Y cells. In addition to its neuroprotective action, PDGF promotes cell growth and division in several systems, and the application of PDGF-BB alone to serum-starved SH-SY5Y cells resulted in an increase in cell number. Amyloid-β attenua...

Journal of natural products, Jan 22, 2018

Avocatin B, an avocado-derived compound mixture, was demonstrated recently to possess potent anti... more Avocatin B, an avocado-derived compound mixture, was demonstrated recently to possess potent anticancer activity by selectively targeting and eliminating leukemia stem cells. Avocatin B is a mixture of avocadene and avocadyne, two 17-carbon polyhydroxylated fatty alcohols (PFAs), first discovered in avocado seeds; their quantities in avocado pulp are unknown. Analytical methods to detect avocado seed PFAs have utilized NMR spectroscopy and GC-MS; both of these lack quantitative capacity and accuracy. Herein, we report a sensitive LC-MS method for the quantitation of avocadene and avocadyne in avocado seed and pulp. The method has a reliable and linear response range of 0.1-50 μM (0.03-17.2 ng/μL) for both avocadene and avocadyne ( r> 0.990) with a lower limit of quantitation (LLOQ) of 0.1 μM. The intra- and interassay accuracy and precision of the quality control (QC) samples at LLOQ showed ≤18.2% percentage error and ≤14.4% coefficient of variation (CV). The intra- and interassa...

ACM/IEEE SC 2000 Conference (SC'00), 2000

We present compiler technology for synthesizing sparse matrix code from (i) dense matrix code, an... more We present compiler technology for synthesizing sparse matrix code from (i) dense matrix code, and (ii) a description of the index structure of a sparse matrix. Our approach is to embed statement instances into a Cartesian product of statement iteration and data spaces, and to produce efficient sparse code by identifying common enumerations for multiple references to sparse matrices. The approach works for imperfectly-nested codes with dependences, and produces sparse code competitive with handwritten library code for the Basic Linear Algebra Subroutines (BLAS).

Pakistan Journal of International Affairs, 2021

This article attempts to elucidate the female parliamentarian’s role in social and political chan... more This article attempts to elucidate the female parliamentarian’s role in social and political change in Pakistan by looking at it through the lens of the country’s historical progress. With an emphasis on historical evolution and current situation, the article also discusses social constraints that have made it difficult for women to engage in the political system in the past. Women’s political engagement should be enhanced in the future, and an assessment of these concerns may produce some helpful ideas. In this study article, researchers have examined employing a qualitative research approach which is also called market research method that focuses on acquiring data through open-ended and conversational dialogue. These qualitative research approaches allow for in-depth and additional probing and questioning of respondents based on their responses, where the researchers also seek to understand their purpose and sentiments. The study also finds that Women’s political empowerment acro...

India is one of the most vulnerable developing countries to suffer very often from various natura... more India is one of the most vulnerable developing countries to suffer very often from various natural disasters, namely drought, flood, cyclone, earth quake, landslide, forest fire, hail storm, locust, volcanic eruption, etc. Which strike causing a devastating impact on human life, economy and environment. Though it is almost impossible to fully recoup the damage caused by the disasters, it is possible to (i) minimize the potential risks by developing early warning strategies (ii) prepare and implement developmental plans to provide resilience to such disasters (iii) mobilize resources including communication and telemedicinal services, and (iv) to help in rehabilitation and post-disaster reconstruction. The article describes the natural disaster management and socio-political awareness among the human beings and disaster management for the well being of the society. Besides to find out the major impacts of natural disasters, Suitable Strategy to Mitigate the Disaster and Provide the S...

IOSR Journal of Environmental Science, Toxicology and Food Technology, 2013

It was only fifty years before that our scientists and experts on climate and environment started... more It was only fifty years before that our scientists and experts on climate and environment started the keen observation that something wrong is happening to our environment. The result was that the far-sighted people in the world began emphasizing that human community should take an approach of sustainable living, growth and development. A large number of national and international conferences on sustainable development have been held during the last 40 years to chalk out workable strategies to counter act the impending catastrophes, but till date all these conclaves have been proved to be futile exercises.

This paper focuses on the sustainable development of tourism in Uttarakhand. Uttarakhand is a sta... more This paper focuses on the sustainable development of tourism in Uttarakhand. Uttarakhand is a state in the Northern Himalayan Region in India and it has been a hot spot of tourism due to its magnificently diverse landscapes, high biodiversity enough religious tourist potential and rich cultural heritage, which has also generated a good source of income and employment to youths and rural masses. Tourism is one of the biggest and fastest-growing economic sectors in the global economy and has significant environmental, cultural, social, and economic effects, both positive and negative. Tourism has been noted as the world’s largest and fastest growing industry. The main objectives of the study are the formation of tourist circuits, to find out the problems and suggest a suitable plan for sustainable tourism development in Uttarakhand. A field based systematic survey was carried out on the basis of questionnaire in some selected tourism destinations to find out the problems and the data ...

Pakistan Journal of International Affairs, 2021

The history of Pakistan and Turkey has been marked by several common features with respect to the... more The history of Pakistan and Turkey has been marked by several common features with respect to the military’s predominant role in politics. The Armed Forces in both the states many a time intervened in the politics either directly by toppling down the elected civilian governments or indirectly by forcing the elected popular governments to step down. In the history of the two countries, military has been playing a crucial role in the political arena, and it has been considered by majority of the society as the savior in uncertain situations like civil wars, political chaos and natural crisis in the country. In this paper, the author attempts to examine comparatively the causes of the military tutelage and dominancy in the politics in Turkey and Pakistan in a historical perspective. And in the second part, the author attempts to compare and contrast the similarities in the nature of the military’s involvement in politics in both the states. In the last part of this paper, the author al...

ACS Omega, 2022

Acute myeloid leukemia (AML) is an aggressive blood cancer with limited effective chemotherapy op... more Acute myeloid leukemia (AML) is an aggressive blood cancer with limited effective chemotherapy options and negative patient outcomes. Food-derived molecules such as avocatin B (Avo B), a fatty-acid oxidation (FAO) inhibitor, are promising novel therapeutics. The roots of the Curcuma amada plants have been historically used in traditional medicine, but isolated bioactive compounds have seldom been studied. Here, we report that 2,4,6-trihydroxy-3,5-diprenyldihydrochalcone (M1), a bioactive from C. Amada, possesses novel anticancer activity. This in vitro study investigated the antileukemia properties of M1 and its effects on mitochondrial metabolism. In combination with Avo B, M1 synergistically reduced AML cell line viability and patientderived clonogenic growth with no effect on normal peripheral blood stem cells. Mechanistically, M1 alone inhibited mitochondria complex I, while the M1/Avo B combination inhibited FAO by 60%, a process essential to the synergy. These results identified a novel food-derived bioactive and its potential as a novel chemotherapeutic for AML.

Pakistan Journal of International Affairs, 2021

This article attempts to elucidate the female parliamentarian’s role in social and political chan... more This article attempts to elucidate the female parliamentarian’s role in social and political change in Pakistan by looking at it through the lens of the country’s historical progress. With an emphasis on historical evolution and current situation, the article also discusses social constraints that have made it difficult for women to engage in the political system in the past. Women’s political engagement should be enhanced in the future, and an assessment of these concerns may produce some helpful ideas. In this study article, researchers have examined employing a qualitative research approach which is also called market research method that focuses on acquiring data through open-ended and conversational dialogue. These qualitative research approaches allow for in-depth and additional probing and questioning of respondents based on their responses, where the researchers also seek to understand their purpose and sentiments. The study also finds that Women’s political empowerment acro...

Blood, 2021

Acute myeloid leukemia (AML) cells have an atypical metabolic phenotype characterized by increase... more Acute myeloid leukemia (AML) cells have an atypical metabolic phenotype characterized by increased mitochondrial mass, as well as a greater reliance on oxidative phosphorylation and fatty acid oxidation (FAO) for survival. To exploit this altered metabolism, we assessed publicly available databases to identify FAO enzyme overexpression. Very long chain acyl-CoA dehydrogenase (VLCAD; ACADVL) was found to be overexpressed and critical to leukemia cell mitochondrial metabolism. Genetic attenuation or pharmacological inhibition of VLCAD hindered mitochondrial respiration and FAO contribution to the tricarboxylic acid cycle, resulting in decreased viability, proliferation, clonogenic growth, and AML cell engraftment. Suppression of FAO at VLCAD triggered an increase in pyruvate dehydrogenase activity that was insufficient to increase glycolysis but resulted in adenosine triphosphate depletion and AML cell death, with no effect on normal hematopoietic cells. Together, these results demons...

International Journal of Current Microbiology and Applied Sciences, 2021

Scientific Reports, 2020

Avocado (Persea americana Mill.; Lauraceae) seed-derived polyhydroxylated fatty alcohols (PFAs) o... more Avocado (Persea americana Mill.; Lauraceae) seed-derived polyhydroxylated fatty alcohols (PFAs) or polyols (i.e., avocadene and avocadyne) are metabolic modulators that selectively induce apoptosis of leukemia stem cells and reverse pathologies associated with diet-induced obesity. Delivery systems containing avocado polyols have not been described. Herein, natural surface active properties of these polyols are characterized and incorporated into self-emulsifying drug delivery systems (SEDDS) that rely on molecular self-assembly to form fine, transparent, oil-in-water (O/W) microemulsions as small as 20 nanometers in diameter. Mechanistically, a 1:1 molar ratio of avocadene and avocadyne (i.e., avocatin B or AVO was shown to be a eutectic mixture which can be employed as a novel, bioactive, co-surfactant that significantly reduces droplet size of medium-chain triglyceride O/W emulsions stabilized with polysorbate 80. In vitro cytotoxicity of avocado polyol-SEDDS in acute myeloid leu...

Pakistan Journal of International Affairs, 2021

The history of Pakistan and Turkey has been marked by several common features with respect to the... more The history of Pakistan and Turkey has been marked by several common features with respect to the military’s predominant role in politics. The Armed Forces in both the states many a time intervened in the politics either directly by toppling down the elected civilian governments or indirectly by forcing the elected popular governments to step down. In the history of the two countries, military has been playing a crucial role in the political arena, and it has been considered by majority of the society as the savior in uncertain situations like civil wars, political chaos and natural crisis in the country. In this paper, the author attempts to examine comparatively the causes of the military tutelage and dominancy in the politics in Turkey and Pakistan in a historical perspective. And in the second part, the author attempts to compare and contrast the similarities in the nature of the military’s involvement in politics in both the states. In the last part of this paper, the author al...

Blood, 2019

Targeting cell metabolism has emerged as a viable treatment strategy in acute myeloid leukemia (A... more Targeting cell metabolism has emerged as a viable treatment strategy in acute myeloid leukemia (AML), a malignant hematological disease characterized by poor patient outcomes and limited chemotherapeutic options. Compared to the normal hematopoietic population, leukemia cells exhibit an altered phenotype characterized by increased mitochondrial mass as well as a greater reliance on oxidative phosphorylation and fatty acid oxidation (FAO) for survival. Mitochondrial FAO is a four-reaction process that catabolizes fatty acids to acetyl-CoA, generating reductive equivalents for the electron transport chain (ETC) and anaplerotic intermediates for the TCA cycle. Clinically approved FAO inhibitors, such as trimetazidine and ranolazine, are tissue-specific, targeting FAO in some tissues but affecting additional pathways in others. To better understand the potential clinical utility of targeting FAO, we systematically tested a panel of clinical and pre-clinical FAO inhibitors, reasoning tha...

ACS Omega, 2022

Acute myeloid leukemia (AML) is an aggressive blood cancer with limited effective chemotherapy op... more Acute myeloid leukemia (AML) is an aggressive blood cancer with limited effective chemotherapy options and negative patient outcomes. Food-derived molecules such as avocatin B (Avo B), a fatty-acid oxidation (FAO) inhibitor, are promising novel therapeutics. The roots of the Curcuma amada plants have been historically used in traditional medicine, but isolated bioactive compounds have seldom been studied. Here, we report that 2,4,6-trihydroxy-3,5-diprenyldihydrochalcone (M1), a bioactive from C. Amada, possesses novel anticancer activity. This in vitro study investigated the antileukemia properties of M1 and its effects on mitochondrial metabolism. In combination with Avo B, M1 synergistically reduced AML cell line viability and patientderived clonogenic growth with no effect on normal peripheral blood stem cells. Mechanistically, M1 alone inhibited mitochondria complex I, while the M1/Avo B combination inhibited FAO by 60%, a process essential to the synergy. These results identified a novel food-derived bioactive and its potential as a novel chemotherapeutic for AML.

Current Alzheimer research, Jan 9, 2018

PDGFβ receptors and their ligand, PDGF-BB, are upregulated in vivo after neuronal insults such as... more PDGFβ receptors and their ligand, PDGF-BB, are upregulated in vivo after neuronal insults such as ischemia. When applied exogenously, PDGF-BB is neuroprotective against excitotoxicity and HIV proteins. Given this growth factor's neuroprotective ability, we sought to determine if PDGF-BB would be neuroprotective against amyloid-β (1-42), one of the pathological agents associated with Alzheimer's disease (AD). In both primary hippocampal neurons and the human-derived neuroblastoma cell line, SH-SY5Y, amyloid- treatment for 24 h decreased surviving cell number in a concentration-dependent manner. Pretreatment with PDGF-BB failed to provide any neuroprotection against amyloid-β in primary neurons and only very limited protective effects in SH-SY5Y cells. In addition to its neuroprotective action, PDGF promotes cell growth and division in several systems, and the application of PDGF-BB alone to serum-starved SH-SY5Y cells resulted in an increase in cell number. Amyloid-β attenua...

Journal of natural products, Jan 22, 2018

Avocatin B, an avocado-derived compound mixture, was demonstrated recently to possess potent anti... more Avocatin B, an avocado-derived compound mixture, was demonstrated recently to possess potent anticancer activity by selectively targeting and eliminating leukemia stem cells. Avocatin B is a mixture of avocadene and avocadyne, two 17-carbon polyhydroxylated fatty alcohols (PFAs), first discovered in avocado seeds; their quantities in avocado pulp are unknown. Analytical methods to detect avocado seed PFAs have utilized NMR spectroscopy and GC-MS; both of these lack quantitative capacity and accuracy. Herein, we report a sensitive LC-MS method for the quantitation of avocadene and avocadyne in avocado seed and pulp. The method has a reliable and linear response range of 0.1-50 μM (0.03-17.2 ng/μL) for both avocadene and avocadyne ( r> 0.990) with a lower limit of quantitation (LLOQ) of 0.1 μM. The intra- and interassay accuracy and precision of the quality control (QC) samples at LLOQ showed ≤18.2% percentage error and ≤14.4% coefficient of variation (CV). The intra- and interassa...

ACM/IEEE SC 2000 Conference (SC'00), 2000

We present compiler technology for synthesizing sparse matrix code from (i) dense matrix code, an... more We present compiler technology for synthesizing sparse matrix code from (i) dense matrix code, and (ii) a description of the index structure of a sparse matrix. Our approach is to embed statement instances into a Cartesian product of statement iteration and data spaces, and to produce efficient sparse code by identifying common enumerations for multiple references to sparse matrices. The approach works for imperfectly-nested codes with dependences, and produces sparse code competitive with handwritten library code for the Basic Linear Algebra Subroutines (BLAS).

Pakistan Journal of International Affairs, 2021

This article attempts to elucidate the female parliamentarian’s role in social and political chan... more This article attempts to elucidate the female parliamentarian’s role in social and political change in Pakistan by looking at it through the lens of the country’s historical progress. With an emphasis on historical evolution and current situation, the article also discusses social constraints that have made it difficult for women to engage in the political system in the past. Women’s political engagement should be enhanced in the future, and an assessment of these concerns may produce some helpful ideas. In this study article, researchers have examined employing a qualitative research approach which is also called market research method that focuses on acquiring data through open-ended and conversational dialogue. These qualitative research approaches allow for in-depth and additional probing and questioning of respondents based on their responses, where the researchers also seek to understand their purpose and sentiments. The study also finds that Women’s political empowerment acro...