Waseem Dar | University of Kashmir, Srinagar, J&K, India (original) (raw)

Papers by Waseem Dar

Journal of Family Medicine and Primary Care

Annals of Indian Academy of Neurology, 2021

929 Moebius syndrome presents as congenital, nonprogressive unilateral or bilateral facial and ho... more 929 Moebius syndrome presents as congenital, nonprogressive unilateral or bilateral facial and horizontal gaze palsy.[1,2] A 16‐year‐old male presented to our center with restricted eye movements with turning of head sideways to look at, inability to blow out the cheeks, and accumulation of food between teeth and cheeks since childhood. There was no history of drooling and he didn’t report any recurrent childhood ear infections. On examination, patient had gaze‐evoked nystagmus, horizontal gaze restriction with bilateral medial and lateral rectus palsy with preserved vertical movements. There was micrognathia, bilateral facial palsy (predominant lower face involvement), tongue atrophy, and tongue fasciculations. Intelligence quotient of the patient was normal. MRI of the brain revealed brainstem hypoplasia and straightening of the floor of the fourth ventricle [Figure 1].

Annals of Indian Academy of Neurology, 2021

Annals of Indian Academy of Neurology ¦ Volume 25 ¦ Issue 1 ¦ January‐February 2022 161 and secon... more Annals of Indian Academy of Neurology ¦ Volume 25 ¦ Issue 1 ¦ January‐February 2022 161 and second and third cervical dorsal root ganglia comprised a chain of contiguous ganglia.[1] This could explain the associated tinnitus, hearing loss, nausea, vomiting, vertigo, and nystagmus found in some cases. A retrospective study of 102 patients with Ramsay Hunt Syndrome (RHS) done in 1988 showed that only 10% of the patients achieved complete recovery.[2] Varicella‐Zoster vasculopathy (VZV) is a distinct complication of zoster infection leading to infarction or hemorrhage with MR angiogram abnormalities. Pietersen had reported 2,500 cases of peripheral facial nerve palsies, and in this study, a complete recovery was achieved only in 21% of the herpes zoster oticus cases.[3] Predisposing factors for reactivation include diabetes mellitus, spinal anesthesia, malignancies, and conditions associated with immune suppression such as lymphoma, steroid therapy, immunosuppressive agents, and acquired immunodeficiency syndrome (AIDS). However, none of these were evident in our patient. We describe an immunocompromised patient who developed brainstem and cerebellar involvement following RHS. Our patient presented with vesicular rash and left ear pain, following which he developed bilateral facial palsy, flaccid dysarthria, and dysphagia, which suggested brainstem involvement. He then developed gait ataxia, which suggested cerebellar involvement. Acute cerebellar involvement following VZV infection is well known in children, however, rare in adults. The MRI features, CSF analysis, and pure tone audiometry also correlated with the clinical picture. After 5 days of intravenous pulse methylprednisolone and intravenous acyclovir, the patient showed significant improvement in gait ataxia and mild improvement in dysphagia. Timely initiation of steroids and antiviral agents is the key to recovery.[4] However, dysarthria and bilateral facial paresis did not improve. The prognosis of facial palsy in RHS remains poor.[5] The recovery in this patient can be attributed to the pharmacological intervention or the natural course of the disease. The neurological illness being due to axonal spread of the virus, rather than a vasculopathy is supported by the fact that the course of the disease was progressive, rather than multiple transient ischemic attacks, with no evidence of diffusion restriction or angiogram abnormality on magnetic resonance imaging, and the T2 hyperintensities were not respecting strict vascular territories. A similar observation was noted by Hu et al. in 2003.[6] The CSF VZV PCR is sensitive as well as a specific biomarker for zoster infection with neurological symptoms.[7] It has been postulated that mutations in genes participating in the toll‐like receptor 3 (TLR3) pathway may predispose to encephalitis caused by VZV.[8]

Hepatitis B infection is a major public health problem. Approximately two billion people worldwid... more Hepatitis B infection is a major public health problem. Approximately two billion people worldwide have been infected with hepatitis B virus (HBV) during their lifetime. In some patients Hepatitis B may get converted into a dormant stage and get reactivated during immunosupression like chemotherapy. Hepatitis B complicates management of cancers as reactivation of hepatitis B not only increases morbidity and mortality but also prolongs chemotherapy and may result in inadequate outcomes. Several approaches have been developed to prevent reactivation of hepatitis B in cancer patients. One such approach is active immunization of all cancer patients. The present study has been done to understand the problem of hepatitis B in cancer patients and to evaluate the efficacy of vaccination in prevention of hepatitis B in cancer patients.

Background & Objectives: Polycystic ovarian syndrome (PCOS) is a common cause of infertility in w... more Background & Objectives: Polycystic ovarian syndrome (PCOS) is a common cause of infertility in women of reproductive age group. Antiepileptic drugs, notably sodium valproate, has been linked to PCOS in various studies. Such an association has significant implications given rampant use of sodium valproate, particularly in such women. The purpose of the study was to compare the incidence of PCOS in women taking valproate or phenytoin monotherapy with healthy controls. Methods: Thirty five women on valproate monotherapy and 28 women on phenytoin were compared with 43 healthy women. Results: Mean BMI was 24.46 kg/m2 (SD 4.19) in valproate group, 23.37 kg/m2 (SD 3.67) in phenytoin group and 22.12 kg/m2 (SD 3.29) in control group. Menstrual dysfunction was seen in 40% patients in valproate group which was significant as compared to phenytoin group (14%) and control group (12%). Polycystic ovaries were seen on ultrasonography in 37% patients in valproate group, 18% in phenytoin group and ...

International Surgery Journal, 2017

Cryptorchidism (or maldescended testis) is a common problem encountered in pediatric age groups. ... more Cryptorchidism (or maldescended testis) is a common problem encountered in pediatric age groups. Despite more than 100 years of research, many aspects of cryptorchidism are not well defined and remain controversial. However, cryptorchidism clearly has deleterious effects on the testis over time. These include an increased risk for testicular tumor development and a propensity for torsion. In cases of bilateral undescended testis, infertility is a concern. The role of diagnostic tools such as ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI) in localizing a non-palpable testis have been associated with low sensitivity and specificity rate. European Society for Paediatric Urology (ESPU) guidelines on paediatric urology and cryptorchidism states that "there is no reliable examination to confirm or exclude an intraabdominal, inguinal or absent/vanishing testis except for diagnostic laparoscopy. Torsion of an intraabdominal testis is a rare cause of acute low...

Acta Neurologica Belgica, 2021

To report various neurological syndromes, CSF findings, imaging and diagnostic methods used in ne... more To report various neurological syndromes, CSF findings, imaging and diagnostic methods used in neurobrucellosis patients admitted in our Neurology department over a period of 6 years. Case records of patients admitted to our department from August 2014 to May 2020 were searched for neurobrucellosis and data were obtained. A total of 19 patients were diagnosed as neurobrucellosis over a period of 6 years. Ten patients had chronic meningitis, five had VIII nerve involvement, one had optic neuritis, two had acute meningitis, one had subacute meningitis, four had myelopathy, five had polyradiculitis and two had spondylodiscitis. CSF was abnormal in 17 patients. Neutrophilic pleocytosis was seen in 12 patients who included nine patients with chronic symptomatology. Brain imaging was abnormal in three chronic meningitis patients. One had diffuse meningeal enhancement, another had hydrocephalus while the third patient had meningeal enhancement with basal exudates and contrast enhancement of bilateral VIII nerve. One of the patients of acute meningitis had hydrocephalus while the other one had bilateral T2/FLAIR hyperintensities with enhancement of meninges and leptomeningeal vessels. Elevated antibody titers only in serum was seen in six patients while elevated antibody titers only in CSF was seen in seven patients. Four patients had elevated antibody titers in both serum and CSF. CSF culture was positive in three patients. Neurobrucellosis is a rare clinical complication of brucellosis but may pose a problem in diagnosis as it can mimic tuberculosis. Involvement of VIII nerve and neurophilic pleocytosis in CSF despite chronic symptomatology can be diagnostic clues favoring neurobrucellosis.

Journal of Postgraduate Medicine, Education and Research, 2017

Introduction Rheumatoid arthritis (RA) is an autoimmune disease characterized by periods of remis... more Introduction Rheumatoid arthritis (RA) is an autoimmune disease characterized by periods of remission and flares of symmetrical joint inflammation slowly progressing to joint and cartilage destruction leading to deformities. Evidence is accumulating suggesting vitamin D deficiency and its correlation in autoimmune diseases including RA. Aims of study (1) Estimation of vitamin D levels in RA patients. (2) Correlation of vitamin D levels with severity of the disease. Materials and methods A study population of 50 included 25 cases and 25 controls. Both males and females of 30 to 40 years of age were taken for this study. Patients of RA having any other autoimmune disease were excluded. Twenty-five healthy adults, whose ages were between 30 and 40 years, both male and female, free from any systemic illness were taken as controls. Routine systematic examination and detailed joint examination were done. Disease activity was measured in patients of RA according to Disease Activity Score (...

Asian Pacific Journal of Health Sciences, 2015

Disseminated fungal disease most commonly found in patients with hematologic malignancies or immu... more Disseminated fungal disease most commonly found in patients with hematologic malignancies or immunecompromised state, is rarely seen. Though the reported prevalence ranges from 20% to 40%, most fungal microabscesses occur in leukemic patients and are caused by candida albicans; others include cryptococcosis, mucormycosis and histoplasmosis. Hepatosplenic candidiasis also known as chronic disseminated candidiasis has been described in patients with acute leukemia following recovering from neutropenia, pathogenesis of which is not understood, thought to be due to exacerbated inflammatory reaction resulting in an immune reconstitution inflammatory syndrome. The purpose of presenting this case is to describe variable presentation of disseminated candidiasis which can be presenting feature of acute leukemia even without neutropenia and atypical radiological pattern in hepatosplenic candidiasis.

Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology

Inflammatory myofibroblastic tumors (IMTs) are rare, benign lesions most often seen in the lung o... more Inflammatory myofibroblastic tumors (IMTs) are rare, benign lesions most often seen in the lung of young adults but can occur in children, in various sites. They mimic, clinically and radiologically, malignant tumors - especially sarcomas and lymphomas. The aim was to review the clinical, radiological, and pathological data of children with a diagnosis of IMT referred to our department. This retrospective study was conducted at the Department of Medical and Paediatric Oncology, Regional Cancer Centre, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India from January 2014 to December 2015. Among 288 pediatric tumors registered during the study, 5 (1.73%) had the diagnosis of IMTs. The main symptoms were abdominal distension and pain in 60% (three cases), breathlessness and cough in 20% (one case), and right axillary area swelling in 20% (one case). In three patients, complete surgical excision was done, whereas another patient with retroperitoneal mass had...

Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology

Chemotherapy has an increasing potential for cure and palliation of most forms of cancer in diffe... more Chemotherapy has an increasing potential for cure and palliation of most forms of cancer in different stages. However, its use is associated with a multitude of side effects some very common and few very rare. We present two patients of metastatic nonsmall lung cancer who had severe forms of hand-foot syndrome with two different classes of antineoplastic drugs and have to discontinue chemotherapy.

Indian Journal of Medical and Paediatric Oncology, 2016

Introduction: Lung cancer is one of the most common causes of cancer deaths worldwide. Adenocarci... more Introduction: Lung cancer is one of the most common causes of cancer deaths worldwide. Adenocarcinoma is taking over squamous cell lung cancer as the predominant histological subtype. Several cytotoxic drugs are available for the treatment of lung cancer, but side effects limit their use. Recently, targeted therapies for cancers have come into clinical practice. Aims and Objectives: To determine the prevalence of epidermal growth factor receptor (EGFR) mutation in adenocarcinoma lung in a North Indian population and its relation with different clinical variables. Materials and Methods: A total of 57 patients who met inclusion criteria were recruited into the study. Relevant history, clinical examination and investigations were done. EGFR mutation was done in all patients. Results: A total of twenty patients tested positive for EGFR mutation. EGFR was more frequently detected in female patients (53.8%), while as only 19.4% of the male patients expressed EGFR mutation, which was stati...

International Journal of Clinical & Medical Imaging, 2016

Journal of General Practice, 2015

Dengue infection may cause neurological complications ranging from encephalitis to radiculitis an... more Dengue infection may cause neurological complications ranging from encephalitis to radiculitis and result in disability and morbidity. We here present a case of Polyradiculomyelopathy with bilateral optic neuritis secondary to Dengue infection that showed minimal improvement despite timely steroids and plasma exchange.

Journal of General Practice, 2015

Pulmonary Aspergilloma is a saprophytic colonization of a lung cavity by Aspergillus spp most oft... more Pulmonary Aspergilloma is a saprophytic colonization of a lung cavity by Aspergillus spp most often by Aspergillus fumigatus. It is usually secondary i.e. it occurs in a pre-existing cavity often as a result of old healed pulmonary tuberculosis. Pulmonary Aspergilloma complicating active tuberculosis is rare. We report a case of sputum positive tuberculosis complicated by pulmonary Aspergilloma.

Journal of Family Medicine and Primary Care

Annals of Indian Academy of Neurology, 2021

929 Moebius syndrome presents as congenital, nonprogressive unilateral or bilateral facial and ho... more 929 Moebius syndrome presents as congenital, nonprogressive unilateral or bilateral facial and horizontal gaze palsy.[1,2] A 16‐year‐old male presented to our center with restricted eye movements with turning of head sideways to look at, inability to blow out the cheeks, and accumulation of food between teeth and cheeks since childhood. There was no history of drooling and he didn’t report any recurrent childhood ear infections. On examination, patient had gaze‐evoked nystagmus, horizontal gaze restriction with bilateral medial and lateral rectus palsy with preserved vertical movements. There was micrognathia, bilateral facial palsy (predominant lower face involvement), tongue atrophy, and tongue fasciculations. Intelligence quotient of the patient was normal. MRI of the brain revealed brainstem hypoplasia and straightening of the floor of the fourth ventricle [Figure 1].

Annals of Indian Academy of Neurology, 2021

Annals of Indian Academy of Neurology ¦ Volume 25 ¦ Issue 1 ¦ January‐February 2022 161 and secon... more Annals of Indian Academy of Neurology ¦ Volume 25 ¦ Issue 1 ¦ January‐February 2022 161 and second and third cervical dorsal root ganglia comprised a chain of contiguous ganglia.[1] This could explain the associated tinnitus, hearing loss, nausea, vomiting, vertigo, and nystagmus found in some cases. A retrospective study of 102 patients with Ramsay Hunt Syndrome (RHS) done in 1988 showed that only 10% of the patients achieved complete recovery.[2] Varicella‐Zoster vasculopathy (VZV) is a distinct complication of zoster infection leading to infarction or hemorrhage with MR angiogram abnormalities. Pietersen had reported 2,500 cases of peripheral facial nerve palsies, and in this study, a complete recovery was achieved only in 21% of the herpes zoster oticus cases.[3] Predisposing factors for reactivation include diabetes mellitus, spinal anesthesia, malignancies, and conditions associated with immune suppression such as lymphoma, steroid therapy, immunosuppressive agents, and acquired immunodeficiency syndrome (AIDS). However, none of these were evident in our patient. We describe an immunocompromised patient who developed brainstem and cerebellar involvement following RHS. Our patient presented with vesicular rash and left ear pain, following which he developed bilateral facial palsy, flaccid dysarthria, and dysphagia, which suggested brainstem involvement. He then developed gait ataxia, which suggested cerebellar involvement. Acute cerebellar involvement following VZV infection is well known in children, however, rare in adults. The MRI features, CSF analysis, and pure tone audiometry also correlated with the clinical picture. After 5 days of intravenous pulse methylprednisolone and intravenous acyclovir, the patient showed significant improvement in gait ataxia and mild improvement in dysphagia. Timely initiation of steroids and antiviral agents is the key to recovery.[4] However, dysarthria and bilateral facial paresis did not improve. The prognosis of facial palsy in RHS remains poor.[5] The recovery in this patient can be attributed to the pharmacological intervention or the natural course of the disease. The neurological illness being due to axonal spread of the virus, rather than a vasculopathy is supported by the fact that the course of the disease was progressive, rather than multiple transient ischemic attacks, with no evidence of diffusion restriction or angiogram abnormality on magnetic resonance imaging, and the T2 hyperintensities were not respecting strict vascular territories. A similar observation was noted by Hu et al. in 2003.[6] The CSF VZV PCR is sensitive as well as a specific biomarker for zoster infection with neurological symptoms.[7] It has been postulated that mutations in genes participating in the toll‐like receptor 3 (TLR3) pathway may predispose to encephalitis caused by VZV.[8]

Hepatitis B infection is a major public health problem. Approximately two billion people worldwid... more Hepatitis B infection is a major public health problem. Approximately two billion people worldwide have been infected with hepatitis B virus (HBV) during their lifetime. In some patients Hepatitis B may get converted into a dormant stage and get reactivated during immunosupression like chemotherapy. Hepatitis B complicates management of cancers as reactivation of hepatitis B not only increases morbidity and mortality but also prolongs chemotherapy and may result in inadequate outcomes. Several approaches have been developed to prevent reactivation of hepatitis B in cancer patients. One such approach is active immunization of all cancer patients. The present study has been done to understand the problem of hepatitis B in cancer patients and to evaluate the efficacy of vaccination in prevention of hepatitis B in cancer patients.

Background & Objectives: Polycystic ovarian syndrome (PCOS) is a common cause of infertility in w... more Background & Objectives: Polycystic ovarian syndrome (PCOS) is a common cause of infertility in women of reproductive age group. Antiepileptic drugs, notably sodium valproate, has been linked to PCOS in various studies. Such an association has significant implications given rampant use of sodium valproate, particularly in such women. The purpose of the study was to compare the incidence of PCOS in women taking valproate or phenytoin monotherapy with healthy controls. Methods: Thirty five women on valproate monotherapy and 28 women on phenytoin were compared with 43 healthy women. Results: Mean BMI was 24.46 kg/m2 (SD 4.19) in valproate group, 23.37 kg/m2 (SD 3.67) in phenytoin group and 22.12 kg/m2 (SD 3.29) in control group. Menstrual dysfunction was seen in 40% patients in valproate group which was significant as compared to phenytoin group (14%) and control group (12%). Polycystic ovaries were seen on ultrasonography in 37% patients in valproate group, 18% in phenytoin group and ...

International Surgery Journal, 2017

Cryptorchidism (or maldescended testis) is a common problem encountered in pediatric age groups. ... more Cryptorchidism (or maldescended testis) is a common problem encountered in pediatric age groups. Despite more than 100 years of research, many aspects of cryptorchidism are not well defined and remain controversial. However, cryptorchidism clearly has deleterious effects on the testis over time. These include an increased risk for testicular tumor development and a propensity for torsion. In cases of bilateral undescended testis, infertility is a concern. The role of diagnostic tools such as ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI) in localizing a non-palpable testis have been associated with low sensitivity and specificity rate. European Society for Paediatric Urology (ESPU) guidelines on paediatric urology and cryptorchidism states that "there is no reliable examination to confirm or exclude an intraabdominal, inguinal or absent/vanishing testis except for diagnostic laparoscopy. Torsion of an intraabdominal testis is a rare cause of acute low...

Acta Neurologica Belgica, 2021

To report various neurological syndromes, CSF findings, imaging and diagnostic methods used in ne... more To report various neurological syndromes, CSF findings, imaging and diagnostic methods used in neurobrucellosis patients admitted in our Neurology department over a period of 6 years. Case records of patients admitted to our department from August 2014 to May 2020 were searched for neurobrucellosis and data were obtained. A total of 19 patients were diagnosed as neurobrucellosis over a period of 6 years. Ten patients had chronic meningitis, five had VIII nerve involvement, one had optic neuritis, two had acute meningitis, one had subacute meningitis, four had myelopathy, five had polyradiculitis and two had spondylodiscitis. CSF was abnormal in 17 patients. Neutrophilic pleocytosis was seen in 12 patients who included nine patients with chronic symptomatology. Brain imaging was abnormal in three chronic meningitis patients. One had diffuse meningeal enhancement, another had hydrocephalus while the third patient had meningeal enhancement with basal exudates and contrast enhancement of bilateral VIII nerve. One of the patients of acute meningitis had hydrocephalus while the other one had bilateral T2/FLAIR hyperintensities with enhancement of meninges and leptomeningeal vessels. Elevated antibody titers only in serum was seen in six patients while elevated antibody titers only in CSF was seen in seven patients. Four patients had elevated antibody titers in both serum and CSF. CSF culture was positive in three patients. Neurobrucellosis is a rare clinical complication of brucellosis but may pose a problem in diagnosis as it can mimic tuberculosis. Involvement of VIII nerve and neurophilic pleocytosis in CSF despite chronic symptomatology can be diagnostic clues favoring neurobrucellosis.

Journal of Postgraduate Medicine, Education and Research, 2017

Introduction Rheumatoid arthritis (RA) is an autoimmune disease characterized by periods of remis... more Introduction Rheumatoid arthritis (RA) is an autoimmune disease characterized by periods of remission and flares of symmetrical joint inflammation slowly progressing to joint and cartilage destruction leading to deformities. Evidence is accumulating suggesting vitamin D deficiency and its correlation in autoimmune diseases including RA. Aims of study (1) Estimation of vitamin D levels in RA patients. (2) Correlation of vitamin D levels with severity of the disease. Materials and methods A study population of 50 included 25 cases and 25 controls. Both males and females of 30 to 40 years of age were taken for this study. Patients of RA having any other autoimmune disease were excluded. Twenty-five healthy adults, whose ages were between 30 and 40 years, both male and female, free from any systemic illness were taken as controls. Routine systematic examination and detailed joint examination were done. Disease activity was measured in patients of RA according to Disease Activity Score (...

Asian Pacific Journal of Health Sciences, 2015

Disseminated fungal disease most commonly found in patients with hematologic malignancies or immu... more Disseminated fungal disease most commonly found in patients with hematologic malignancies or immunecompromised state, is rarely seen. Though the reported prevalence ranges from 20% to 40%, most fungal microabscesses occur in leukemic patients and are caused by candida albicans; others include cryptococcosis, mucormycosis and histoplasmosis. Hepatosplenic candidiasis also known as chronic disseminated candidiasis has been described in patients with acute leukemia following recovering from neutropenia, pathogenesis of which is not understood, thought to be due to exacerbated inflammatory reaction resulting in an immune reconstitution inflammatory syndrome. The purpose of presenting this case is to describe variable presentation of disseminated candidiasis which can be presenting feature of acute leukemia even without neutropenia and atypical radiological pattern in hepatosplenic candidiasis.

Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology

Inflammatory myofibroblastic tumors (IMTs) are rare, benign lesions most often seen in the lung o... more Inflammatory myofibroblastic tumors (IMTs) are rare, benign lesions most often seen in the lung of young adults but can occur in children, in various sites. They mimic, clinically and radiologically, malignant tumors - especially sarcomas and lymphomas. The aim was to review the clinical, radiological, and pathological data of children with a diagnosis of IMT referred to our department. This retrospective study was conducted at the Department of Medical and Paediatric Oncology, Regional Cancer Centre, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India from January 2014 to December 2015. Among 288 pediatric tumors registered during the study, 5 (1.73%) had the diagnosis of IMTs. The main symptoms were abdominal distension and pain in 60% (three cases), breathlessness and cough in 20% (one case), and right axillary area swelling in 20% (one case). In three patients, complete surgical excision was done, whereas another patient with retroperitoneal mass had...

Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology

Chemotherapy has an increasing potential for cure and palliation of most forms of cancer in diffe... more Chemotherapy has an increasing potential for cure and palliation of most forms of cancer in different stages. However, its use is associated with a multitude of side effects some very common and few very rare. We present two patients of metastatic nonsmall lung cancer who had severe forms of hand-foot syndrome with two different classes of antineoplastic drugs and have to discontinue chemotherapy.

Indian Journal of Medical and Paediatric Oncology, 2016

Introduction: Lung cancer is one of the most common causes of cancer deaths worldwide. Adenocarci... more Introduction: Lung cancer is one of the most common causes of cancer deaths worldwide. Adenocarcinoma is taking over squamous cell lung cancer as the predominant histological subtype. Several cytotoxic drugs are available for the treatment of lung cancer, but side effects limit their use. Recently, targeted therapies for cancers have come into clinical practice. Aims and Objectives: To determine the prevalence of epidermal growth factor receptor (EGFR) mutation in adenocarcinoma lung in a North Indian population and its relation with different clinical variables. Materials and Methods: A total of 57 patients who met inclusion criteria were recruited into the study. Relevant history, clinical examination and investigations were done. EGFR mutation was done in all patients. Results: A total of twenty patients tested positive for EGFR mutation. EGFR was more frequently detected in female patients (53.8%), while as only 19.4% of the male patients expressed EGFR mutation, which was stati...

International Journal of Clinical & Medical Imaging, 2016

Journal of General Practice, 2015

Dengue infection may cause neurological complications ranging from encephalitis to radiculitis an... more Dengue infection may cause neurological complications ranging from encephalitis to radiculitis and result in disability and morbidity. We here present a case of Polyradiculomyelopathy with bilateral optic neuritis secondary to Dengue infection that showed minimal improvement despite timely steroids and plasma exchange.

Journal of General Practice, 2015

Pulmonary Aspergilloma is a saprophytic colonization of a lung cavity by Aspergillus spp most oft... more Pulmonary Aspergilloma is a saprophytic colonization of a lung cavity by Aspergillus spp most often by Aspergillus fumigatus. It is usually secondary i.e. it occurs in a pre-existing cavity often as a result of old healed pulmonary tuberculosis. Pulmonary Aspergilloma complicating active tuberculosis is rare. We report a case of sputum positive tuberculosis complicated by pulmonary Aspergilloma.