Zwanden Sule Yahaya | Kaduna State University (original) (raw)
Papers by Zwanden Sule Yahaya
Natural and Life Sciences Communications, 2024
Mitracarpus scaber is a tropical herb used in ethnomedicine for the treatment of inflammation and... more Mitracarpus scaber is a tropical herb used in ethnomedicine for the treatment of inflammation and a variety of other diseases. The aim of this study was to develop a palm kernel-based emulgel containing Mitracarpus scarber and examine the product's physicochemical characteristics and anti-inflammatory efficacy on Wister rats. Different batches of emulgel comprising Mitracarpus scarber leaf extracts (MSE), different proportions of oils (palm kernel oil and/or liquid paraffin), and surfactants (tween-80 and/or Cremophor EL-30) were prepared. The freshly prepared and 5-month-old formulations, stored at room temperature (28 ± 2 °C), were evaluated for rheology, syneresis, and extract/excipient compatibility using Fourier transform infrared (FT-IR) spectroscopy. The spreadability, extrudability, and anti-inflammatory activity of the optimal formulation were compared with those of a commercial anti-inflammatory emulgel. Even after five months of storage, the created emulgels remained olive green and creamy, with a homogeneous texture, consistency, and glossy appearance. The optimized batch containing palm kernel oil, tween-80, and xanthan gum had the most stable characteristics, with no significant change in pH (P = 1.000) or FT-IR spectrum after 5 months of storage. It exhibited spreadability and extrudability of 12.75 cm2 and 600 g/cm2, respectively, compared to 16.82 cm2 and 400 g/cm2 for the commercial formulation. Four hours post-treatment, the anti-inflammatory effect of the optimized batch was significantly (P < 0.05) higher than that of the aqueous MSE dispersion. The obtained results demonstrate the prospects of palm kernel-based emulgel loaded with Mitracarpus scarber leaf extracts as an innovative therapeutic approach to inflammation treatment.
Journal of current biomedical research, Oct 31, 2023
This study focuses on the extraction and characterization of mucilage from Irvingia gabonensis se... more This study focuses on the extraction and characterization of mucilage from Irvingia gabonensis seeds and its potential uses. The extraction process was carried out using water and the mucilage was characterized using various physicochemical and rheological parameters. All confirmatory tests for mucilage carried out (Molisch, iodine and ruthenium red test) were positive. The outcomes demonstrated that the mucilage had a yield of 52.6 %, a swelling capacity of 88.65 %, hydration capacity of 1.78 and a viscosity of 1.1805 mPa S. This study highlights the importance of utilizing natural resources for sustainable development and provides insights for further research on the potential uses of mucilage from other plant sources.
Natural and Life Sciences Communications, 2024
Mitracarpus scaber is a tropical herb used in ethnomedicine for the treatment of inflammation an... more Mitracarpus scaber is a tropical herb used in ethnomedicine for
the treatment of inflammation and a variety of other diseases. The
aim of this study was to develop a palm kernel-based emulgel
containing Mitracarpus scarber and examine the product's
physicochemical characteristics and anti-inflammatory efficacy on
Wister rats. Different batches of emulgel comprising Mitracarpus
scarber leaf extracts (MSE), different proportions of oils (palm kernel
oil and/or liquid paraffin), and surfactants (tween-80 and/or
Cremophor EL-30) were prepared. The freshly prepared and
5-month-old formulations, stored at room temperature (28 ± 2 °C),
were evaluated for rheology, syneresis, and extract/excipient
compatibility using Fourier transform infrared (FT-IR) spectroscopy.
The spreadability, extrudability, and anti-inflammatory activity of the
optimal formulation were compared with those of a commercial
anti-inflammatory emulgel. Even after five months of storage, the
created emulgels remained olive green and creamy, with a
homogeneous texture, consistency, and glossy appearance. The
optimized batch containing palm kernel oil, tween-80, and xanthan
gum had the most stable characteristics, with no significant change
in pH (P = 1.000) or FT-IR spectrum after 5 months of storage.
It exhibited spreadability and extrudability of 12.75 cm2 and 600
g/cm2, respectively, compared to 16.82 cm2 and 400 g/cm2 for the
commercial formulation. Four hours post-treatment, the
anti-inflammatory effect of the optimized batch was significantly
(P < 0.05) higher than that of the aqueous MSE dispersion. The
obtained results demonstrate the prospects of palm kernel-based
emulgel loaded with Mitracarpus scarber leaf extracts as an
innovative therapeutic approach to inflammation treatment.
Tropical Journal of Pharmaceutical Research
Purpose: To investigate the suitability of sesame oil as an oily phase for diclofenac emulgel for... more Purpose: To investigate the suitability of sesame oil as an oily phase for diclofenac emulgel formulation. Methods: Different batches of emulgel comprising different proportions of oils (sesame oil and/or Labrafac CC), surfactants (Tween-80 and/or cremophor EL-30), and gelling agents (xanthan gum or gelatin) were prepared. The formulations were evaluated for rheology, syneresis, Fourier transform infrared (FTIR) spectroscopy, spreadability, extrudability, and anti-inflammatory activity. Results: Product characteristics of batches A2, A4, and A6 were not consistent with those of emulgels. Because Batch A1 showed characteristics that were the most stable, such as no pH changes, nonstatistically significant changes (p = 1.000) in the viscosity results, and least spectrum changes following FTIR investigation, it was selected as the best batch. It showed similar anti-inflammatory activity when compared with commercially available diclofenac emulgel, giving a 50 % higher anti-inflam...
Journal of pharmaceutical research international, Jul 24, 2018
Journal of Basic and Social Pharmacy, 2020
Background: Fast dissolving or orodispersible tablets are highly desirablein groups such as child... more Background: Fast dissolving or orodispersible tablets are highly desirablein groups such as children, uncooperative, nauseated, or those on reduced water intake to ease the difficulties associated with swallowing the conventional solid dosage forms. Objectives: The work aimed to evaluate the disintegrant property of sorghum starch-silicon dioxide co-processed mixture in the formulation of chlorpheniramine orodispersible tablets. Method: Different batches of orodispersible tablets of chlorpheniramine maleate (4 mg) were prepared by direct compression method using Avicel® as a bulking agent and four different types of disintegrants (sorghum starch, co-processed sorghum starch-colloidal silicon dioxide, sodium starch glycolate and croscarmellose sodium) at varying concentrations (5, 10 and 20 %). The formulated tablets were subjected to weight variation test, thickness, crushing strength, friability test, wetting time, water absorption ratio, disintegration test and in-vitro dissolution study. Results: For tablets above 250 mg, it is expected that not more than two tablets should deviate from the average weight by 5% and none should deviate by more than 10%, all the formulations yielded tablets within this specification. The disintegration time of tablets containing 10% of disintegrants was all less than 60 s except those containing sorghum starch (SS) which took a long time. Similarly, the time taken to release 50 % of the drug (t50%) for tablets containing 10% sorghum starch was 25 s, 5 s for tablets containing 10% sorghum starch-colloidal silicon dioxide excipient and 8 s for tablets containing 10% of either croscarmellose sodium or sodium starch glycolate. The differential scanning calorimetry study results suggested that the drug and the excipient are compatible. Conclusion: The results show that sorghum starch-silicon dioxide co-processed mixture can be used as an alternative to croscarmellose sodium and sodium starch glycolate in orodispersible tablet formulations.
Tropical Journal of Pharmaceutical Research, Nov 14, 2017
Journal of Basic and Social Pharmacy Research, 2020
Background: The oral route happens to be the most preferred route among the various routes of dru... more Background: The oral route happens to be the most preferred route among the various routes of drug delivery. However, the conventional dosage form has few limitations which could be resolved by modifying the existing dosage form. Sustained and controlled drug delivery systems help to maintain constant plasma drug concentration and retarding the release rate of drug thereby extending the duration of action. Objectives: To develop by co-processing technique a two-component excipient and evaluate its sustained release potential in ibuprofen tablet formulation. Method: Maize starch (MS) was co-processed with polyvinylpyrrolidone (PVP), acacia powder (ACA) and hydroxypropyl methylcellulose (HPMC) respectively at a ratio of 60:40 using the co-fusion method. The granules so formed were analyzed for flow properties and compatibility tests based on; angle of repose, flow rate, bulk and tapped densities (BD/TD), Hausner ratio (HR) and Carr’s Index (CI), Differential Scanning Calorimetry (DSC)...
Journal of research in pharmacy, 2023
Journal of Nanotechnology, 2023
Journal of Current Biomedical Research, 2023
This study focuses on the extraction and characterization of mucilage from Irvingia gabonensis se... more This study focuses on the extraction and characterization of mucilage from Irvingia gabonensis seeds and its potential uses. The extraction process was carried out using water and the mucilage was characterized using various physicochemical and rheological parameters. All confirmatory tests for mucilage carried out (Molisch, iodine and ruthenium red test) were positive. The outcomes demonstrated that the mucilage had a yield of 52.6 %, a swelling capacity of 88.65 %, hydration capacity of 1.78 and a viscosity of 1.1805 mPa S. This study highlights the importance of utilizing natural resources for sustainable development and provides insights for further research on the potential uses of mucilage from other plant sources.
Purpose: To investigate the suitability of sesame oil as an oily phase for diclofenac emulgel for... more Purpose: To investigate the suitability of sesame oil as an oily phase for diclofenac emulgel formulation. Methods: Different batches of emulgel comprising different proportions of oils (sesame oil and/or Labrafac CC), surfactants (Tween-80 and/or cremophor EL-30), and gelling agents (xanthan gum or gelatin) were prepared. The formulations were evaluated for rheology, syneresis, Fourier transform infrared (FTIR) spectroscopy, spreadability, extrudability, and anti-inflammatory activity. Results: Product characteristics of batches A2, A4, and A6 were not consistent with those of emulgels. Because Batch A1 showed characteristics that were the most stable, such as no pH changes, nonstatistically significant changes (p = 1.000) in the viscosity results, and least spectrum changes following FTIR investigation, it was selected as the best batch. It showed similar anti-inflammatory activity when compared with commercially available diclofenac emulgel, giving a 50 % higher anti-inflammatory effect than aqueous diclofenac dispersion. Conclusion: Sesame oil is a potential lipophilic component in emulgel formulations for topical delivery of hydrophobic drugs.
Journal of Research in Pharmacy
American Journal of Pharmacotherapy and Pharmaceutical Sciences, 2023
Objectives: The aim of this work is to assess the suitability of Parkia biglobosa mucilage (PBM) ... more Objectives: The aim of this work is to assess the suitability of Parkia biglobosa mucilage (PBM) as a suspending agent in metronidazole suspension. Methods and Materials: Metronidazole suspension was formulated with mucilage (0.1%, 0.5%, 1%, and 2% w/v) from P. biglobosa seeds as the suspending agent. Similar suspensions of metronidazole that contained (0.1%, 0.5%, 1%, and 2% w/v) tragacanth or gelatin were also prepared for comparison to PBM-based formulations. The suspensions were assessed for rheological properties, sedimentation volume, degree of flocculation, ease of redispersion, flow rate (flowability), and drug-excipient compatibility using Fourier-transform infrared spectroscopy. Results: Brownish metronidazole suspensions with a smooth and elegant appearance were obtained. After 2 weeks of storage at ambient temperature (28 ± 2°C), the ease of redispersion was in the following order: tragacanth < PBM < gelatin-containing formulations. The optimal pH of the formulatio...
American Journal of Pharmacotherapy and Pharmaceutical Sciences, 2023
is is an open-access article distributed under the terms of the Creative Commons Attribution-Non... more is is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
Materials
Cellulose is a non-toxic, bio-degradable, and renewable biopolymer which is abundantly available ... more Cellulose is a non-toxic, bio-degradable, and renewable biopolymer which is abundantly available in nature. The most common source of commercial microcrystalline cellulose is fibrous wood pulp. Cellulose and its derivatives have found wide commercial applications in the pharmaceutical, cosmetic, food, paper, textile, and engineering industries. This study aims to isolate and characterize cellulose forms from cocoa pod husk (CPH) and to assess its mechanical and disintegration properties as a direct compression excipient in metronidazole tablets. Two isolated cellulose types (i.e., cocoa alpha-cellulose (CAC) and cocoa microcrystalline cellulose (C-MCC)) were compared with avicel (AV). CAC and C-MCC were characterized for their physicochemical properties using Scanning Electron Microscopy (SEM), FTIR spectroscopy, Differential Scanning Calorimetry (DSC), and X-Ray Powder Diffraction (XRD). Metronidazole tablets were produced by direct compression with cellulose. The mechanical and di...
Journal of current biomedical research, Apr 30, 2022
Solid dispersion is widely utilized to promote the dissolution rate of molecules that are poorly ... more Solid dispersion is widely utilized to promote the dissolution rate of molecules that are poorly aqueous soluble. This study aimed at Dagogot et al.
Natural and Life Sciences Communications, 2024
Mitracarpus scaber is a tropical herb used in ethnomedicine for the treatment of inflammation and... more Mitracarpus scaber is a tropical herb used in ethnomedicine for the treatment of inflammation and a variety of other diseases. The aim of this study was to develop a palm kernel-based emulgel containing Mitracarpus scarber and examine the product's physicochemical characteristics and anti-inflammatory efficacy on Wister rats. Different batches of emulgel comprising Mitracarpus scarber leaf extracts (MSE), different proportions of oils (palm kernel oil and/or liquid paraffin), and surfactants (tween-80 and/or Cremophor EL-30) were prepared. The freshly prepared and 5-month-old formulations, stored at room temperature (28 ± 2 °C), were evaluated for rheology, syneresis, and extract/excipient compatibility using Fourier transform infrared (FT-IR) spectroscopy. The spreadability, extrudability, and anti-inflammatory activity of the optimal formulation were compared with those of a commercial anti-inflammatory emulgel. Even after five months of storage, the created emulgels remained olive green and creamy, with a homogeneous texture, consistency, and glossy appearance. The optimized batch containing palm kernel oil, tween-80, and xanthan gum had the most stable characteristics, with no significant change in pH (P = 1.000) or FT-IR spectrum after 5 months of storage. It exhibited spreadability and extrudability of 12.75 cm2 and 600 g/cm2, respectively, compared to 16.82 cm2 and 400 g/cm2 for the commercial formulation. Four hours post-treatment, the anti-inflammatory effect of the optimized batch was significantly (P < 0.05) higher than that of the aqueous MSE dispersion. The obtained results demonstrate the prospects of palm kernel-based emulgel loaded with Mitracarpus scarber leaf extracts as an innovative therapeutic approach to inflammation treatment.
Journal of current biomedical research, Oct 31, 2023
This study focuses on the extraction and characterization of mucilage from Irvingia gabonensis se... more This study focuses on the extraction and characterization of mucilage from Irvingia gabonensis seeds and its potential uses. The extraction process was carried out using water and the mucilage was characterized using various physicochemical and rheological parameters. All confirmatory tests for mucilage carried out (Molisch, iodine and ruthenium red test) were positive. The outcomes demonstrated that the mucilage had a yield of 52.6 %, a swelling capacity of 88.65 %, hydration capacity of 1.78 and a viscosity of 1.1805 mPa S. This study highlights the importance of utilizing natural resources for sustainable development and provides insights for further research on the potential uses of mucilage from other plant sources.
Natural and Life Sciences Communications, 2024
Mitracarpus scaber is a tropical herb used in ethnomedicine for the treatment of inflammation an... more Mitracarpus scaber is a tropical herb used in ethnomedicine for
the treatment of inflammation and a variety of other diseases. The
aim of this study was to develop a palm kernel-based emulgel
containing Mitracarpus scarber and examine the product's
physicochemical characteristics and anti-inflammatory efficacy on
Wister rats. Different batches of emulgel comprising Mitracarpus
scarber leaf extracts (MSE), different proportions of oils (palm kernel
oil and/or liquid paraffin), and surfactants (tween-80 and/or
Cremophor EL-30) were prepared. The freshly prepared and
5-month-old formulations, stored at room temperature (28 ± 2 °C),
were evaluated for rheology, syneresis, and extract/excipient
compatibility using Fourier transform infrared (FT-IR) spectroscopy.
The spreadability, extrudability, and anti-inflammatory activity of the
optimal formulation were compared with those of a commercial
anti-inflammatory emulgel. Even after five months of storage, the
created emulgels remained olive green and creamy, with a
homogeneous texture, consistency, and glossy appearance. The
optimized batch containing palm kernel oil, tween-80, and xanthan
gum had the most stable characteristics, with no significant change
in pH (P = 1.000) or FT-IR spectrum after 5 months of storage.
It exhibited spreadability and extrudability of 12.75 cm2 and 600
g/cm2, respectively, compared to 16.82 cm2 and 400 g/cm2 for the
commercial formulation. Four hours post-treatment, the
anti-inflammatory effect of the optimized batch was significantly
(P < 0.05) higher than that of the aqueous MSE dispersion. The
obtained results demonstrate the prospects of palm kernel-based
emulgel loaded with Mitracarpus scarber leaf extracts as an
innovative therapeutic approach to inflammation treatment.
Tropical Journal of Pharmaceutical Research
Purpose: To investigate the suitability of sesame oil as an oily phase for diclofenac emulgel for... more Purpose: To investigate the suitability of sesame oil as an oily phase for diclofenac emulgel formulation. Methods: Different batches of emulgel comprising different proportions of oils (sesame oil and/or Labrafac CC), surfactants (Tween-80 and/or cremophor EL-30), and gelling agents (xanthan gum or gelatin) were prepared. The formulations were evaluated for rheology, syneresis, Fourier transform infrared (FTIR) spectroscopy, spreadability, extrudability, and anti-inflammatory activity. Results: Product characteristics of batches A2, A4, and A6 were not consistent with those of emulgels. Because Batch A1 showed characteristics that were the most stable, such as no pH changes, nonstatistically significant changes (p = 1.000) in the viscosity results, and least spectrum changes following FTIR investigation, it was selected as the best batch. It showed similar anti-inflammatory activity when compared with commercially available diclofenac emulgel, giving a 50 % higher anti-inflam...
Journal of pharmaceutical research international, Jul 24, 2018
Journal of Basic and Social Pharmacy, 2020
Background: Fast dissolving or orodispersible tablets are highly desirablein groups such as child... more Background: Fast dissolving or orodispersible tablets are highly desirablein groups such as children, uncooperative, nauseated, or those on reduced water intake to ease the difficulties associated with swallowing the conventional solid dosage forms. Objectives: The work aimed to evaluate the disintegrant property of sorghum starch-silicon dioxide co-processed mixture in the formulation of chlorpheniramine orodispersible tablets. Method: Different batches of orodispersible tablets of chlorpheniramine maleate (4 mg) were prepared by direct compression method using Avicel® as a bulking agent and four different types of disintegrants (sorghum starch, co-processed sorghum starch-colloidal silicon dioxide, sodium starch glycolate and croscarmellose sodium) at varying concentrations (5, 10 and 20 %). The formulated tablets were subjected to weight variation test, thickness, crushing strength, friability test, wetting time, water absorption ratio, disintegration test and in-vitro dissolution study. Results: For tablets above 250 mg, it is expected that not more than two tablets should deviate from the average weight by 5% and none should deviate by more than 10%, all the formulations yielded tablets within this specification. The disintegration time of tablets containing 10% of disintegrants was all less than 60 s except those containing sorghum starch (SS) which took a long time. Similarly, the time taken to release 50 % of the drug (t50%) for tablets containing 10% sorghum starch was 25 s, 5 s for tablets containing 10% sorghum starch-colloidal silicon dioxide excipient and 8 s for tablets containing 10% of either croscarmellose sodium or sodium starch glycolate. The differential scanning calorimetry study results suggested that the drug and the excipient are compatible. Conclusion: The results show that sorghum starch-silicon dioxide co-processed mixture can be used as an alternative to croscarmellose sodium and sodium starch glycolate in orodispersible tablet formulations.
Tropical Journal of Pharmaceutical Research, Nov 14, 2017
Journal of Basic and Social Pharmacy Research, 2020
Background: The oral route happens to be the most preferred route among the various routes of dru... more Background: The oral route happens to be the most preferred route among the various routes of drug delivery. However, the conventional dosage form has few limitations which could be resolved by modifying the existing dosage form. Sustained and controlled drug delivery systems help to maintain constant plasma drug concentration and retarding the release rate of drug thereby extending the duration of action. Objectives: To develop by co-processing technique a two-component excipient and evaluate its sustained release potential in ibuprofen tablet formulation. Method: Maize starch (MS) was co-processed with polyvinylpyrrolidone (PVP), acacia powder (ACA) and hydroxypropyl methylcellulose (HPMC) respectively at a ratio of 60:40 using the co-fusion method. The granules so formed were analyzed for flow properties and compatibility tests based on; angle of repose, flow rate, bulk and tapped densities (BD/TD), Hausner ratio (HR) and Carr’s Index (CI), Differential Scanning Calorimetry (DSC)...
Journal of research in pharmacy, 2023
Journal of Nanotechnology, 2023
Journal of Current Biomedical Research, 2023
This study focuses on the extraction and characterization of mucilage from Irvingia gabonensis se... more This study focuses on the extraction and characterization of mucilage from Irvingia gabonensis seeds and its potential uses. The extraction process was carried out using water and the mucilage was characterized using various physicochemical and rheological parameters. All confirmatory tests for mucilage carried out (Molisch, iodine and ruthenium red test) were positive. The outcomes demonstrated that the mucilage had a yield of 52.6 %, a swelling capacity of 88.65 %, hydration capacity of 1.78 and a viscosity of 1.1805 mPa S. This study highlights the importance of utilizing natural resources for sustainable development and provides insights for further research on the potential uses of mucilage from other plant sources.
Purpose: To investigate the suitability of sesame oil as an oily phase for diclofenac emulgel for... more Purpose: To investigate the suitability of sesame oil as an oily phase for diclofenac emulgel formulation. Methods: Different batches of emulgel comprising different proportions of oils (sesame oil and/or Labrafac CC), surfactants (Tween-80 and/or cremophor EL-30), and gelling agents (xanthan gum or gelatin) were prepared. The formulations were evaluated for rheology, syneresis, Fourier transform infrared (FTIR) spectroscopy, spreadability, extrudability, and anti-inflammatory activity. Results: Product characteristics of batches A2, A4, and A6 were not consistent with those of emulgels. Because Batch A1 showed characteristics that were the most stable, such as no pH changes, nonstatistically significant changes (p = 1.000) in the viscosity results, and least spectrum changes following FTIR investigation, it was selected as the best batch. It showed similar anti-inflammatory activity when compared with commercially available diclofenac emulgel, giving a 50 % higher anti-inflammatory effect than aqueous diclofenac dispersion. Conclusion: Sesame oil is a potential lipophilic component in emulgel formulations for topical delivery of hydrophobic drugs.
Journal of Research in Pharmacy
American Journal of Pharmacotherapy and Pharmaceutical Sciences, 2023
Objectives: The aim of this work is to assess the suitability of Parkia biglobosa mucilage (PBM) ... more Objectives: The aim of this work is to assess the suitability of Parkia biglobosa mucilage (PBM) as a suspending agent in metronidazole suspension. Methods and Materials: Metronidazole suspension was formulated with mucilage (0.1%, 0.5%, 1%, and 2% w/v) from P. biglobosa seeds as the suspending agent. Similar suspensions of metronidazole that contained (0.1%, 0.5%, 1%, and 2% w/v) tragacanth or gelatin were also prepared for comparison to PBM-based formulations. The suspensions were assessed for rheological properties, sedimentation volume, degree of flocculation, ease of redispersion, flow rate (flowability), and drug-excipient compatibility using Fourier-transform infrared spectroscopy. Results: Brownish metronidazole suspensions with a smooth and elegant appearance were obtained. After 2 weeks of storage at ambient temperature (28 ± 2°C), the ease of redispersion was in the following order: tragacanth < PBM < gelatin-containing formulations. The optimal pH of the formulatio...
American Journal of Pharmacotherapy and Pharmaceutical Sciences, 2023
is is an open-access article distributed under the terms of the Creative Commons Attribution-Non... more is is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
Materials
Cellulose is a non-toxic, bio-degradable, and renewable biopolymer which is abundantly available ... more Cellulose is a non-toxic, bio-degradable, and renewable biopolymer which is abundantly available in nature. The most common source of commercial microcrystalline cellulose is fibrous wood pulp. Cellulose and its derivatives have found wide commercial applications in the pharmaceutical, cosmetic, food, paper, textile, and engineering industries. This study aims to isolate and characterize cellulose forms from cocoa pod husk (CPH) and to assess its mechanical and disintegration properties as a direct compression excipient in metronidazole tablets. Two isolated cellulose types (i.e., cocoa alpha-cellulose (CAC) and cocoa microcrystalline cellulose (C-MCC)) were compared with avicel (AV). CAC and C-MCC were characterized for their physicochemical properties using Scanning Electron Microscopy (SEM), FTIR spectroscopy, Differential Scanning Calorimetry (DSC), and X-Ray Powder Diffraction (XRD). Metronidazole tablets were produced by direct compression with cellulose. The mechanical and di...
Journal of current biomedical research, Apr 30, 2022
Solid dispersion is widely utilized to promote the dissolution rate of molecules that are poorly ... more Solid dispersion is widely utilized to promote the dissolution rate of molecules that are poorly aqueous soluble. This study aimed at Dagogot et al.