Machindra Chavan | Savitribai Phule University of Pune (original) (raw)

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Papers by Machindra Chavan

Inflammopharmacology, 2011

The Annona squamosa L. bark was collected from Ahmednagar district, India. 18-Acetoxy-ent-kaur-16... more The Annona squamosa L. bark was collected from Ahmednagar district, India. 18-Acetoxy-ent-kaur-16-ene was isolated from petroleum ether extract (PE) and studied for its analgesic and anti-inflammatory activities. 18-Acetoxy-ent-kaur-16-ene at the doses of 12.5 and 25 mg/kg, and PE at a dose of 50 mg/kg exhibited significant analgesic along with anti-inflammatory activity.

Phytomedicine, 2010

Caryophyllene oxide was isolated from an unsaponified petroleum ether extract of the bark of Anno... more Caryophyllene oxide was isolated from an unsaponified petroleum ether extract of the bark of Annona squamosa and studied for its analgesic and anti-inflammatory activity. Caryophyllene oxide at the doses of 12.5 and 25 mg/kg body wt. and unsaponified petroleum ether extract at a dose of 50 mg/kg body wt. showed significant central as well as peripheral analgesic, along with anti-inflammatory, activity. These activities of caryophyllene oxide were comparable with the standard drug used in the respective experiments.

Natural Product Research, 2009

The unsaponified chloroform extract of Annona squamosa L. bark has been analysed by gas chromatog... more The unsaponified chloroform extract of Annona squamosa L. bark has been analysed by gas chromatography-mass spectrometry (GC-MS) and was shown to consist of the conventional, even carbon number dominant distribution of saturated n-alkane homologues (C(14)-C(26)). The heptadecane (5.75%) was the only odd carbon number hydrocarbon. The total amount of hydrocarbons found in the unsaponified chloroform extract was 24.60%.

For the past few decades, compounds from natural sources have been gaining importance because of ... more For the past few decades, compounds from natural sources have been gaining importance because of the vast chemical diversity they offer. This has led to phenomenal increase in the demand for herbal medicines in the last two decades and need has been felt for ensuring the quality, safety, and efficacy of herbal drugs. Phytochemical evaluation is one of the tools for the quality assessment, which include preliminary phytochemical screening, chemoprofiling, and marker compound analysis using modern analytical techniques. High-performance thin-layer chromatography (HPTLC) has been emerged as an important tool for the qualitative, semiquantitative, and quantitative phytochemical analysis of the herbal drugs and formulations. This includes developing TLC fingerprinting profiles and estimation of biomarkers. This review has an attempt to focus on the theoretical considerations of HPTLC and some examples of herbal drugs and formulations analyzed by HPTLC.

Natural Product Research, 2012

The sesquiterpene fraction of Annona reticulata bark was studied by GC/MS. Three major components... more The sesquiterpene fraction of Annona reticulata bark was studied by GC/MS. Three major components were identified: copaene (35.40%), patchoulane (13.49%) and 1H-cycloprop(e)azulene (22.77%). The fraction was also screened for its analgesic and anti-inflammatory activities. The sesquiterpene fraction at doses 12.5 and 25 mg kg−1 and the unsaponified petroleum ether extract at a dose of 50 mg kg−1 exhibited significant central as well as peripheral analgesic and anti-inflammatory activities. These activities were comparable with the standard drugs used in the respective experiments.

Natural Product Research, 2011

The sesquiterpene fraction of Annona reticulata bark was studied by GC/MS. Three major components... more The sesquiterpene fraction of Annona reticulata bark was studied by GC/MS. Three major components were identified: copaene (35.40%), patchoulane (13.49%) and 1H-cycloprop(e)azulene (22.77%). The fraction was also screened for its analgesic and anti-inflammatory activities. The sesquiterpene fraction at doses 12.5 and 25 mg kg−1 and the unsaponified petroleum ether extract at a dose of 50 mg kg−1 exhibited significant central as well as peripheral analgesic and anti-inflammatory activities. These activities were comparable with the standard drugs used in the respective experiments.

Natural Product Research, 2006

... References. 1. Kirtikar, KR and Basu, BD. 1991. Indian Medicinal Plants, , 2nd Edn, Vol. 1, 6... more ... References. 1. Kirtikar, KR and Basu, BD. 1991. Indian Medicinal Plants, , 2nd Edn, Vol. 1, 66Deheradun, , India: Bishen Singh Mahendra Pal Sigh. 2. Dash, GK, Ganapathy, S, Suresh, P, Panda, SK and Sahu, SK. 2001. Ind. J. Nat. ...

Inflammopharmacology, 2011

The Annona squamosa L. bark was collected from Ahmednagar district, India. 18-Acetoxy-ent-kaur-16... more The Annona squamosa L. bark was collected from Ahmednagar district, India. 18-Acetoxy-ent-kaur-16-ene was isolated from petroleum ether extract (PE) and studied for its analgesic and anti-inflammatory activities. 18-Acetoxy-ent-kaur-16-ene at the doses of 12.5 and 25 mg/kg, and PE at a dose of 50 mg/kg exhibited significant analgesic along with anti-inflammatory activity.

Phytomedicine, 2010

Caryophyllene oxide was isolated from an unsaponified petroleum ether extract of the bark of Anno... more Caryophyllene oxide was isolated from an unsaponified petroleum ether extract of the bark of Annona squamosa and studied for its analgesic and anti-inflammatory activity. Caryophyllene oxide at the doses of 12.5 and 25 mg/kg body wt. and unsaponified petroleum ether extract at a dose of 50 mg/kg body wt. showed significant central as well as peripheral analgesic, along with anti-inflammatory, activity. These activities of caryophyllene oxide were comparable with the standard drug used in the respective experiments.

Natural Product Research, 2009

The unsaponified chloroform extract of Annona squamosa L. bark has been analysed by gas chromatog... more The unsaponified chloroform extract of Annona squamosa L. bark has been analysed by gas chromatography-mass spectrometry (GC-MS) and was shown to consist of the conventional, even carbon number dominant distribution of saturated n-alkane homologues (C(14)-C(26)). The heptadecane (5.75%) was the only odd carbon number hydrocarbon. The total amount of hydrocarbons found in the unsaponified chloroform extract was 24.60%.

For the past few decades, compounds from natural sources have been gaining importance because of ... more For the past few decades, compounds from natural sources have been gaining importance because of the vast chemical diversity they offer. This has led to phenomenal increase in the demand for herbal medicines in the last two decades and need has been felt for ensuring the quality, safety, and efficacy of herbal drugs. Phytochemical evaluation is one of the tools for the quality assessment, which include preliminary phytochemical screening, chemoprofiling, and marker compound analysis using modern analytical techniques. High-performance thin-layer chromatography (HPTLC) has been emerged as an important tool for the qualitative, semiquantitative, and quantitative phytochemical analysis of the herbal drugs and formulations. This includes developing TLC fingerprinting profiles and estimation of biomarkers. This review has an attempt to focus on the theoretical considerations of HPTLC and some examples of herbal drugs and formulations analyzed by HPTLC.

Natural Product Research, 2012

The sesquiterpene fraction of Annona reticulata bark was studied by GC/MS. Three major components... more The sesquiterpene fraction of Annona reticulata bark was studied by GC/MS. Three major components were identified: copaene (35.40%), patchoulane (13.49%) and 1H-cycloprop(e)azulene (22.77%). The fraction was also screened for its analgesic and anti-inflammatory activities. The sesquiterpene fraction at doses 12.5 and 25 mg kg−1 and the unsaponified petroleum ether extract at a dose of 50 mg kg−1 exhibited significant central as well as peripheral analgesic and anti-inflammatory activities. These activities were comparable with the standard drugs used in the respective experiments.

Natural Product Research, 2011

The sesquiterpene fraction of Annona reticulata bark was studied by GC/MS. Three major components... more The sesquiterpene fraction of Annona reticulata bark was studied by GC/MS. Three major components were identified: copaene (35.40%), patchoulane (13.49%) and 1H-cycloprop(e)azulene (22.77%). The fraction was also screened for its analgesic and anti-inflammatory activities. The sesquiterpene fraction at doses 12.5 and 25 mg kg−1 and the unsaponified petroleum ether extract at a dose of 50 mg kg−1 exhibited significant central as well as peripheral analgesic and anti-inflammatory activities. These activities were comparable with the standard drugs used in the respective experiments.

Natural Product Research, 2006

... References. 1. Kirtikar, KR and Basu, BD. 1991. Indian Medicinal Plants, , 2nd Edn, Vol. 1, 6... more ... References. 1. Kirtikar, KR and Basu, BD. 1991. Indian Medicinal Plants, , 2nd Edn, Vol. 1, 66Deheradun, , India: Bishen Singh Mahendra Pal Sigh. 2. Dash, GK, Ganapathy, S, Suresh, P, Panda, SK and Sahu, SK. 2001. Ind. J. Nat. ...