Anish Rajan | University of Kerala (original) (raw)

Papers by Anish Rajan

Research paper thumbnail of Synthesis of CeO2 nanostructures with its exceptional biological and chemocatalytic activities: a comparative study

Bulletin of Materials Science, 2021

A comparative study has been carried out on the synthesis of nanostructured CeO 2 through chemica... more A comparative study has been carried out on the synthesis of nanostructured CeO 2 through chemical and biological methods. CeO 2 nanoparticles have been synthesized chemically using oxalic acid. The as-synthesized nanoparticles have been stabilized using the capping agent, polyvinylpyrrolidone. The aqueous leaf extract of Annona reticulata has been utilized for the biofabrication of CeO 2 nanoparticles. XRD, TEM and Raman analyses have been carried out to determine the structure and formation of the as-synthesized products. Optical studies have been carried out through UV-visible absorption, photoluminescence, Fourier transform infrared and Raman spectroscopic techniques. The biosynthesized CeO 2 nanoparticles exhibit strong antioxidant activity as well as potent antidiabetic and wound healing activities in comparison to their chemically fabricated counterparts, extending the possibility for their application in pharmaceuticals. The biogenic nanoparticles also exhibit superior catalytic activity in the degradation of harmful dyes including methylene blue and eosin yellowish.

Research paper thumbnail of Synthesis of nanostructured CeO2 by chemical and biogenic methods: Optical properties and bioactivity

Ceramics International, 2020

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Research paper thumbnail of Antifungal activities of biogenic Au and CeO2 nanoparticles

PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS: ICAM 2019, 2019

In this study, we report the synthesis of gold and cerium oxide nanoparticles from the aqueous ex... more In this study, we report the synthesis of gold and cerium oxide nanoparticles from the aqueous extract of punica granatum fruit. The synthesized nanoparticles are characterized by analytical techniques such as UV-visible absorption spectrometry; X-ray diffraction spectroscopy and transmission electron microscopy. The biocompatible nature of biogenic nanoparticles is studied on L929 normal fibroblast cell lines. Furthermore, the antifungal potential of as fabricated nanoparticles is portrayed through two fungal species and possesses significant fungicidal effect, which provides promising approach for alternative nano-drug development.

Research paper thumbnail of Green synthesis of CeO2 nanostructures by using Morus nigra fruit extract and its antidiabetic activity

AIP Conference Proceedings, 2019

The present article reports a biogenic method of preparation of cerium oxide nanoparticles. Fruit... more The present article reports a biogenic method of preparation of cerium oxide nanoparticles. Fruit extract of Morus nigra has been explored for the fabrication of cerium oxide nanoparticles that are characterized with transmission electron microscopy (TEM), UV-visible absorption and X-ray diffraction spectroscopy (XRD). Morphology of the nanoparticles is examined by TEM and confirmed their crystalline structure with XRD. The cell viability of cerium oxide nanoparticles are studied using L929 cell lines, which confirmed its biocompatible nature. Furthermore, the synthesized nanoparticles are found to possess excellent antidiabetic activity that render for applications in biomedical field.The present article reports a biogenic method of preparation of cerium oxide nanoparticles. Fruit extract of Morus nigra has been explored for the fabrication of cerium oxide nanoparticles that are characterized with transmission electron microscopy (TEM), UV-visible absorption and X-ray diffraction spectroscopy (XRD). Morphology of the nanoparticles is examined by TEM and confirmed their crystalline structure with XRD. The cell viability of cerium oxide nanoparticles are studied using L929 cell lines, which confirmed its biocompatible nature. Furthermore, the synthesized nanoparticles are found to possess excellent antidiabetic activity that render for applications in biomedical field.

Research paper thumbnail of Elettaria cardamomum seed mediated rapid synthesis of gold nanoparticles and its biological activities

OpenNano, 2017

Plant mediated synthesis of metal nanoparticles has drawn the attention of researchers due to the... more Plant mediated synthesis of metal nanoparticles has drawn the attention of researchers due to their unique features and extensive application in various fields. The present report is on the unexploited environmentally benign rapid synthesis of gold nanoparticles of size 15.2 nm using the aqueous extract of Elettaria Cardamomum seeds. Studies on antioxidant, antibacterial and anticancer activities of the nanoparticles have been carried out. The invitro radical scavenging activity of the biogenic nanogold is found to be comparable to that of the reference. The as synthesized gold nanoparticles also exhibits antibacterial activity against a broad spectrum of bacterial pathogens. The antibacterial activity is found to be enhanced against S.aureus compared to E.coli and P.aeruginosa. Further, the obtained nanoparticles show excellent cytotoxic activity towards HeLa cancer cell lines.

Research paper thumbnail of Studies on catalytic, antioxidant, antibacterial and anticancer activities of biogenic gold nanoparticles

Journal of Molecular Liquids, 2015

Biosynthesis of nanoparticles of precious metals has been attaining a surge of interest in recent... more Biosynthesis of nanoparticles of precious metals has been attaining a surge of interest in recent years. In the present study, phytochemicals present in Areca catechu nut have been used for the synthesis of gold nanoparticles at 300 K, 373 K and under microwave irradiation of 2450 MHz. The synthesized nanoparticles have been characterized using UV-visible, TEM, XRD, and FTIR techniques. Perpetual changes in synthesis conditions are bestowed with appreciable morphological variation. An enhanced formation of monodispersed, spherical gold nanoparticles of size 13.7 nm could be obtained under microwave irradiation. XRD pattern confirms the crystalline nature of the as-synthesized nanoparticles. The biomolecules involved in the reduction and stabilization of nanoparticles have been identified using FTIR spectra. The catalytic efficiency of the synthesized gold nanoparticles of varying size distributions has been portrayed through the degradation of the organic pollutants, Methylene blue, Methyl orange, Eosin yellowish and 4-Nitrophenol. The observed size dependent catalytic activity may aid in the rapid elimination of industrial wastes leading to a green environment. The potential of the phytosynthesized nanogold in scavenging the harmful radical NO and the stable radical DPPH has been evaluated. In addition to its cytotoxic effect on HeLa cell lines, gold nanospheroids synthesized under microwave irradiation have been observed to exhibit an enhanced activity against a broad spectrum of bacterial pathogens as well.

Research paper thumbnail of Catalytic and antioxidant properties of biogenic silver nanoparticles synthesized using Areca catechu nut

Journal of Molecular Liquids, 2015

The paper reports a simple, versatile and ecofriendly protocol for the synthesis of silver nanopa... more The paper reports a simple, versatile and ecofriendly protocol for the synthesis of silver nanoparticles using the aqueous extract of Areca catechu nut and its application in catalysis and antioxidant activity. Nanoparticles of varying sizes have been synthesized at 300 K and 373 K. The synthesized nanoparticles are characterized by UV-visible spectroscopy, Transmission Electron Microscopy, X-ray diffraction analysis and Fourier Transform Infra-Red Spectroscopy. The newly formed silver nanoparticles are stable, spherical and crystalline with average particle size varying from 18.2 to 24.3 nm on changing the temperature. The phytochemicals involved in the reduction and stabilization of silver nanoparticles are identified using FTIR spectra. The synthesized silver nanoparticles show potent catalytic activity in the degradation of organic pollutants (methylene blue, Eosin-yellowish, methyl orange, and 4-nitrophenol). The catalytic activity is found to be size dependent and the degradation reaction is observed to obey pseudo-first order kinetics. Moreover, antioxidant studies on the as synthesized nanoparticles reveal efficient scavenging of the stable or harmful free radicals including DPPH, NO and OH. The catalytic and antioxidant activities of the biogenic nanoparticles would find applications in environmental and biomedical field.

Research paper thumbnail of Shape tailored green synthesis and catalytic properties of gold nanocrystals

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014

Research paper thumbnail of Biogenic synthesis of nanostructured Gd2O3: Structural, optical and bioactive properties

Ceramics International, 2019

Nanostructured Gd 2 O 3 has been synthesized using the leaf broth of Annona reticulate. The forma... more Nanostructured Gd 2 O 3 has been synthesized using the leaf broth of Annona reticulate. The formation of nanoparticles is confirmed by XRD and TEM analysis. UV-visible and PL studies are employed to characterize the optical nature of the samples and the thermal analysis of the as prepared material has been performed to ascertain the proper annealing temperature. XRD pattern shows cubic structure with average particle size of about 25 nm. FTIR spectra reveal the possible biomolecules responsible for the formation of nanoparticles and their stabilization. Raman spectrum with characteristic band located at 360 cm −1 for the F g mode supports the cubic phase of the nanostructured Gd 2 O 3. Biocompatibility of synthesized nanoparticles is evaluated by carrying out the cytotoxic test against normal fibroblast cell lines and surviving fraction of normal cell lines are found to be above 75% up to a concentration of 50μg/mL. The antimicrobial activity of developed nanoparticles are screened against K. Pneumonae and S.aureus bacterial cell lines and substantial inhibition zones are observed in the dose dependent study. Moreover, this study also investigates the antioxidant efficacy of Gd 2 O 3 nanoparticles using DPPH and superoxide free radical scavenging assays. With a concentration of 20μg/mL of the synthesized nanoparticles 70% scavenging is observed. The method of synthesis is simple, cost-effective and unexplored as it follows an ecofriendly protocol for the production of biologically active nanostructured Gd 2 O 3 .

Research paper thumbnail of Synthesis of CeO2 nanostructures with its exceptional biological and chemocatalytic activities: a comparative study

Bulletin of Materials Science, 2021

A comparative study has been carried out on the synthesis of nanostructured CeO 2 through chemica... more A comparative study has been carried out on the synthesis of nanostructured CeO 2 through chemical and biological methods. CeO 2 nanoparticles have been synthesized chemically using oxalic acid. The as-synthesized nanoparticles have been stabilized using the capping agent, polyvinylpyrrolidone. The aqueous leaf extract of Annona reticulata has been utilized for the biofabrication of CeO 2 nanoparticles. XRD, TEM and Raman analyses have been carried out to determine the structure and formation of the as-synthesized products. Optical studies have been carried out through UV-visible absorption, photoluminescence, Fourier transform infrared and Raman spectroscopic techniques. The biosynthesized CeO 2 nanoparticles exhibit strong antioxidant activity as well as potent antidiabetic and wound healing activities in comparison to their chemically fabricated counterparts, extending the possibility for their application in pharmaceuticals. The biogenic nanoparticles also exhibit superior catalytic activity in the degradation of harmful dyes including methylene blue and eosin yellowish.

Research paper thumbnail of Synthesis of nanostructured CeO2 by chemical and biogenic methods: Optical properties and bioactivity

Ceramics International, 2020

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Research paper thumbnail of Antifungal activities of biogenic Au and CeO2 nanoparticles

PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS: ICAM 2019, 2019

In this study, we report the synthesis of gold and cerium oxide nanoparticles from the aqueous ex... more In this study, we report the synthesis of gold and cerium oxide nanoparticles from the aqueous extract of punica granatum fruit. The synthesized nanoparticles are characterized by analytical techniques such as UV-visible absorption spectrometry; X-ray diffraction spectroscopy and transmission electron microscopy. The biocompatible nature of biogenic nanoparticles is studied on L929 normal fibroblast cell lines. Furthermore, the antifungal potential of as fabricated nanoparticles is portrayed through two fungal species and possesses significant fungicidal effect, which provides promising approach for alternative nano-drug development.

Research paper thumbnail of Green synthesis of CeO2 nanostructures by using Morus nigra fruit extract and its antidiabetic activity

AIP Conference Proceedings, 2019

The present article reports a biogenic method of preparation of cerium oxide nanoparticles. Fruit... more The present article reports a biogenic method of preparation of cerium oxide nanoparticles. Fruit extract of Morus nigra has been explored for the fabrication of cerium oxide nanoparticles that are characterized with transmission electron microscopy (TEM), UV-visible absorption and X-ray diffraction spectroscopy (XRD). Morphology of the nanoparticles is examined by TEM and confirmed their crystalline structure with XRD. The cell viability of cerium oxide nanoparticles are studied using L929 cell lines, which confirmed its biocompatible nature. Furthermore, the synthesized nanoparticles are found to possess excellent antidiabetic activity that render for applications in biomedical field.The present article reports a biogenic method of preparation of cerium oxide nanoparticles. Fruit extract of Morus nigra has been explored for the fabrication of cerium oxide nanoparticles that are characterized with transmission electron microscopy (TEM), UV-visible absorption and X-ray diffraction spectroscopy (XRD). Morphology of the nanoparticles is examined by TEM and confirmed their crystalline structure with XRD. The cell viability of cerium oxide nanoparticles are studied using L929 cell lines, which confirmed its biocompatible nature. Furthermore, the synthesized nanoparticles are found to possess excellent antidiabetic activity that render for applications in biomedical field.

Research paper thumbnail of Elettaria cardamomum seed mediated rapid synthesis of gold nanoparticles and its biological activities

OpenNano, 2017

Plant mediated synthesis of metal nanoparticles has drawn the attention of researchers due to the... more Plant mediated synthesis of metal nanoparticles has drawn the attention of researchers due to their unique features and extensive application in various fields. The present report is on the unexploited environmentally benign rapid synthesis of gold nanoparticles of size 15.2 nm using the aqueous extract of Elettaria Cardamomum seeds. Studies on antioxidant, antibacterial and anticancer activities of the nanoparticles have been carried out. The invitro radical scavenging activity of the biogenic nanogold is found to be comparable to that of the reference. The as synthesized gold nanoparticles also exhibits antibacterial activity against a broad spectrum of bacterial pathogens. The antibacterial activity is found to be enhanced against S.aureus compared to E.coli and P.aeruginosa. Further, the obtained nanoparticles show excellent cytotoxic activity towards HeLa cancer cell lines.

Research paper thumbnail of Studies on catalytic, antioxidant, antibacterial and anticancer activities of biogenic gold nanoparticles

Journal of Molecular Liquids, 2015

Biosynthesis of nanoparticles of precious metals has been attaining a surge of interest in recent... more Biosynthesis of nanoparticles of precious metals has been attaining a surge of interest in recent years. In the present study, phytochemicals present in Areca catechu nut have been used for the synthesis of gold nanoparticles at 300 K, 373 K and under microwave irradiation of 2450 MHz. The synthesized nanoparticles have been characterized using UV-visible, TEM, XRD, and FTIR techniques. Perpetual changes in synthesis conditions are bestowed with appreciable morphological variation. An enhanced formation of monodispersed, spherical gold nanoparticles of size 13.7 nm could be obtained under microwave irradiation. XRD pattern confirms the crystalline nature of the as-synthesized nanoparticles. The biomolecules involved in the reduction and stabilization of nanoparticles have been identified using FTIR spectra. The catalytic efficiency of the synthesized gold nanoparticles of varying size distributions has been portrayed through the degradation of the organic pollutants, Methylene blue, Methyl orange, Eosin yellowish and 4-Nitrophenol. The observed size dependent catalytic activity may aid in the rapid elimination of industrial wastes leading to a green environment. The potential of the phytosynthesized nanogold in scavenging the harmful radical NO and the stable radical DPPH has been evaluated. In addition to its cytotoxic effect on HeLa cell lines, gold nanospheroids synthesized under microwave irradiation have been observed to exhibit an enhanced activity against a broad spectrum of bacterial pathogens as well.

Research paper thumbnail of Catalytic and antioxidant properties of biogenic silver nanoparticles synthesized using Areca catechu nut

Journal of Molecular Liquids, 2015

The paper reports a simple, versatile and ecofriendly protocol for the synthesis of silver nanopa... more The paper reports a simple, versatile and ecofriendly protocol for the synthesis of silver nanoparticles using the aqueous extract of Areca catechu nut and its application in catalysis and antioxidant activity. Nanoparticles of varying sizes have been synthesized at 300 K and 373 K. The synthesized nanoparticles are characterized by UV-visible spectroscopy, Transmission Electron Microscopy, X-ray diffraction analysis and Fourier Transform Infra-Red Spectroscopy. The newly formed silver nanoparticles are stable, spherical and crystalline with average particle size varying from 18.2 to 24.3 nm on changing the temperature. The phytochemicals involved in the reduction and stabilization of silver nanoparticles are identified using FTIR spectra. The synthesized silver nanoparticles show potent catalytic activity in the degradation of organic pollutants (methylene blue, Eosin-yellowish, methyl orange, and 4-nitrophenol). The catalytic activity is found to be size dependent and the degradation reaction is observed to obey pseudo-first order kinetics. Moreover, antioxidant studies on the as synthesized nanoparticles reveal efficient scavenging of the stable or harmful free radicals including DPPH, NO and OH. The catalytic and antioxidant activities of the biogenic nanoparticles would find applications in environmental and biomedical field.

Research paper thumbnail of Shape tailored green synthesis and catalytic properties of gold nanocrystals

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014

Research paper thumbnail of Biogenic synthesis of nanostructured Gd2O3: Structural, optical and bioactive properties

Ceramics International, 2019

Nanostructured Gd 2 O 3 has been synthesized using the leaf broth of Annona reticulate. The forma... more Nanostructured Gd 2 O 3 has been synthesized using the leaf broth of Annona reticulate. The formation of nanoparticles is confirmed by XRD and TEM analysis. UV-visible and PL studies are employed to characterize the optical nature of the samples and the thermal analysis of the as prepared material has been performed to ascertain the proper annealing temperature. XRD pattern shows cubic structure with average particle size of about 25 nm. FTIR spectra reveal the possible biomolecules responsible for the formation of nanoparticles and their stabilization. Raman spectrum with characteristic band located at 360 cm −1 for the F g mode supports the cubic phase of the nanostructured Gd 2 O 3. Biocompatibility of synthesized nanoparticles is evaluated by carrying out the cytotoxic test against normal fibroblast cell lines and surviving fraction of normal cell lines are found to be above 75% up to a concentration of 50μg/mL. The antimicrobial activity of developed nanoparticles are screened against K. Pneumonae and S.aureus bacterial cell lines and substantial inhibition zones are observed in the dose dependent study. Moreover, this study also investigates the antioxidant efficacy of Gd 2 O 3 nanoparticles using DPPH and superoxide free radical scavenging assays. With a concentration of 20μg/mL of the synthesized nanoparticles 70% scavenging is observed. The method of synthesis is simple, cost-effective and unexplored as it follows an ecofriendly protocol for the production of biologically active nanostructured Gd 2 O 3 .