Srećko Trifunović | University of Kragujevac (original) (raw)
Papers by Srećko Trifunović
Zeitschrift für Kristallographie
Inorganic Chemistry, 1988
... DuSan J. RadanoviC,la Milos I. Djuran,la Vesna D. Miletie,' Chris Maricondi,lb ... more ... DuSan J. RadanoviC,la Milos I. Djuran,la Vesna D. Miletie,' Chris Maricondi,lb and Bodie E. Douglas*lc Received October 8. 1987 The trans(OSO6) geometrical isomer of the cobalt(II1) complex of ethylenediamine-N-acetic-N,N',N'-tri-3-propionic acid (H4eda3p) ... (12) Legg, J. I ...
Polyhedron, 2000
S-Alkyl (R=benzyl, methyl, ethyl, propyl and butyl) derivatives of thiosalicylic acid and the cor... more S-Alkyl (R=benzyl, methyl, ethyl, propyl and butyl) derivatives of thiosalicylic acid and the corresponding palladium(II) complexes were prepared and their structures were proposed on the basis of infrared, 1H and 13C NMR spectroscopy. The cis geometrical configurations of the isolated complexes were proposed on the basis of an X-ray structural study of the bis(S-benzyl-thiosalicylate)–palladium(II), [Pd(S-bz-thiosal)2] complex.Antimicrobial activity of the tested
ChemInform, 2003
The review summarizes the results of recent studies on edda-type metal complexes. It focuses on w... more The review summarizes the results of recent studies on edda-type metal complexes. It focuses on work published during the period 1984–2001. The metals include are Co, Cr, Cu, Ni, Zn, Mn, Sn, Fe, V, Rh, Pt, Ru, whereas edda-type represents ethylenediamine-N,N′-diacetate, ethylenediamine-N,N-di-acetate, N,N′-dimethylethylenediamine-N,N′-diacetate, N,N′-diethylethylenediamine-N,N′-diacetate, 1,2-cyclo-hexanediamine-N,N′-diacetate, N,N′-dimethyl-1,2-cyclohexanediamine-N,N′-diacetate, ethylenediamine-N,N′-di-3-propionate, N,N′-dimethylethylenediamine-N,N′-di-3-propionate, ethylenediamine-N,N′-di-S-α-propionate, N,N′-dimethyl-ethylenediamine-N,N′-di-α-propionate, 1,3-propanediamine-N,N′-diacetate (trimethylenediamine-N,N′-diacetate), 1,3-propanediamine-N,N′-di-3-propionate (trimethylenediamine-N,N′-di-3-propionate), N,N′-dimethylethylenediamine-N,N′-di-α-butyrate, N,N′-diethylethylenediamine-N,N′-di-α-butyrate, 1-diethylenetriamineacetate (8-amino-3,6-diazao-ctanoate), ethylenepropylenetriamineacetate (9-amino-3,6-diazaoc-
Journal of the Serbian Chemical Society, 2011
Soil samples taken from the Ap horizont of arable land and meadows at ten different localities we... more Soil samples taken from the Ap horizont of arable land and meadows at ten different localities were analyzed for different forms of manganese, including total (HF), pseudo-total (HNO 3 ), 0.1 M HCl-extractable and diethylentriaminepentaacetic acid (DTPA)-extractable. A sequential fractional procedure was used for Mn portioning into fractions: water soluble and exchangeable Mn (I), specifically adsorbed Mn with carbonates (II), reductant releasable Mn in oxides (III), Mn bonded with organic matter (IV) and Mn structurally bonded in silicates (residual fraction) (V). Serbian vertisols have a normal Mn content, comparable with similar soils. The total (HF) and pseudototal (HNO 3 ) Mn contents were not correlated with soil properties, whereas the humus content positively influenced the 0.1 M HCl-extractable Mn in soil (r = = 0.49). Soil pH and CaCO 3 (r = 0.57 and 0.43) showed significant negative correlations with the DTPA-extractable Mn, respectively. The different extraction methods showed similar patterns of Mn content in arable and meadow soils. The sequential fractional procedure showed that reductant releasable Mn occluded in oxides of Fe and Mn was the prevailing Mn fraction in soil, however, water soluble and exchangeable Mn and Mn bonded with organic matter had significant correlations with most of the examined soil characteristics. Potential Mn toxicity in vertisols could be observed under lower pH and saturated conditions.
Journal of the Serbian Chemical Society, 2011
Journal of The Serbian Chemical Society, 2005
Three octahedral chromium(III) complexes of the general formula Na[Cr(S,S-eddp)L] . 2H 2 O, where... more Three octahedral chromium(III) complexes of the general formula Na[Cr(S,S-eddp)L] . 2H 2 O, where eddp = the tetradentate O-N-N-O-type ligand ethylenediamine-N,N'-di-S,S-2-propionate and L = a bidentate O-O-type ligand, either oxalate or malonate, were prepared. The complexes were synthesized by the reaction of chromium(III) chloride, S,S-eddp and malonic acid or sodium oxalate, at 60 ºC. The complexes were isolated chromatographically and the geometric configuration of the complexes was proposed on the basis of their infrared and electronic absorption spectra.
Journal of the Serbian Chemical Society, 2002
A new bidentate ligand butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamate (bmFpdtc) was prepared, a... more A new bidentate ligand butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamate (bmFpdtc) was prepared, as the sodium salt. In the reaction of hexaaminecobalt(III) chloride with NabmFpdtc, the corresponding tris[butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamato]cobalt(III), [Co(bmFpdtc) 3 ] complex was prepared. The complex was characterized by elemental analysis, infrared, electronic absorption, 1 H and 13 C-NMR spectroscopy.
Journal of the Serbian Chemical Society, 2008
In the reaction of ruthenium(III) chloride and an edda-like ligand ethylenediamine-N,N'-di-S,S-2-... more In the reaction of ruthenium(III) chloride and an edda-like ligand ethylenediamine-N,N'-di-S,S-2-propionic acid (S,S-eddp) in aqueous solution led to the formation of only one of the three possible geometrical isomers potassium-s-cis-dichlorido-(ethylenediamine-N,N'-di-S,S-2-propionato)-ruthenate(III)--trihydrate, s-cis-K[Ru(S,S-eddp)Cl 2 ]·3H 2 O. The assumed geometry of the complex was based on its electronic absorption and infrared spectra.
Inorganica Chimica Acta, 1994
were prepared, chromatographically separated into two geometrical isomers with respect to the N-O... more were prepared, chromatographically separated into two geometrical isomers with respect to the N-O chelate ring size [trans (O,O,) and trans(OJ], and resolved. The 'H NMR, electronic absorption and circular dichroism (CD) spectra were used to characterize the complexes.
Inorganica Chimica Acta, 1988
ABSTRACT The complexes Kcis-eq-[Co(ed3a)CN], Kcis-eq-[Co(med3a)CN)], and Ktrans-eq-[Co(ed3a)CN] w... more ABSTRACT The complexes Kcis-eq-[Co(ed3a)CN], Kcis-eq-[Co(med3a)CN)], and Ktrans-eq-[Co(ed3a)CN] were synthesized and characterized. The 1H and 13C NMR spectra obtained with a 300 MHz spectrometer are reported and compared to corresponding aqua and nitro complexes. The PMR spectra show good resolution for all protons, including those of the ethylenediamine backbone. The NMR spectra of the cyano complexes are most similar to those of the corresponding nitro complexes. The major changes in the 13C NMR spectra can be explained based on β-substituent effects involving the N-methyl group or conversion from the cis-eq to the trans-eq isomers. Racemic NH4[Co(ed3a)CN]·2H2O·0.5CH3OH was found to be triclinic, P-1 with the cell dimensions: a = 6.597(2), b = 7.783(4), c = 15.72(1) Å, α = 88.63(5), β = 85.55(5), and γ = 69.89(4)°. There are two molecules in the unit cell.
Journal of the Serbian Chemical Society, 2011
ABSTRACT (S,S)-Ethylenediamine-N,N'-di-2-propanoic acid hydrochloride, (S,S)-H(2)eddp cen... more ABSTRACT (S,S)-Ethylenediamine-N,N'-di-2-propanoic acid hydrochloride, (S,S)-H(2)eddp center dot HCl, was prepared and its crystal structure determined. The compound was characterized by infrared and H-1- and C-13-NMR spectroscopy. It forms P1 in the space group of a triclinic crystal system with a = 5.3902(2) angstrom, b = 5.8967(2) angstrom, c = 10.3319(2) angstrom, alpha = 99.625(2)degrees beta = 91.645(2)degrees, gamma = = 109.995(2)degrees and Z = 1.
Inorganica Chimica Acta, 2012
Inorganica Chimica Acta, 1989
... 12 (1973), p. 1524. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (4). ... more ... 12 (1973), p. 1524. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (4). 15. WT Jordan and JI Legg. Inorg. Chem. ... MULTAN '82, University of York, UK (1982). 31. DT Cromer and JB Mann. Acta Crystallogr., Sect. A 24 (1968), p. 321. Full Text via CrossRef. 32. ...
Journal of the Serbian Chemical Society, 2009
The reaction of K 2 [PdCl 4 ] with (S,S)-(i-Pr) 2 eddip diester (diisopropyl (S,S)-2,2'-(1,2-etha... more The reaction of K 2 [PdCl 4 ] with (S,S)-(i-Pr) 2 eddip diester (diisopropyl (S,S)-2,2'-(1,2-ethanediyldiimino)dipropanoate) resulted in {PdCl 2 [(S,S)-(i--Pr) 2 eddip-κ 2 N,N']} (1) and {PdCl[(S,S)-(i-Pr)eddip-κ 2 N,N',κO]}
Journal of the Serbian Chemical Society, 2013
Palladium(II) complexes (1–4) of general formula [PdCl2(R2-S,S-eddp)] with bidentate N,N’-ligands... more Palladium(II) complexes (1–4) of general formula [PdCl2(R2-S,S-eddp)] with bidentate N,N’-ligands, O,O'-dialkyl esters (R = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,N’-di-2-(4-methyl)pentanoic acid (S,S-eddp) were prepared and characterized by microanalysis, infrared and UV/Vis spectroscopy. The ligands and its complexes were tested for their in vitro antimicrobial activity against 15 species of bacteria and fungi. Testing is performed by the microdilution method, with the minimum inhibitory concentration (MIC) and the minimum microbicidal concentration (MMC) being determined. The MIC values were in range from 4.9 ěg cm–3 to > 5000 ěg cm–3 while MMC values ranged from 78 ěg cm–3 to > 5000 ěg cm–3. Palladium(II) complexes [PdCl2(Ln)] (n, 1–4) have statistically significant higher activity than the corresponding ligands. Complex 4 displayed the strongest activity among all tested compounds.
Journal of the Serbian Chemical Society, 2013
Journal of the Serbian Chemical Society, 2014
A novel (S,S)-R 2 eddip ester, O,O′-diisopentyl-(S,S)-ethylenediamine--N,N′-di-2-propanoate dihyd... more A novel (S,S)-R 2 eddip ester, O,O′-diisopentyl-(S,S)-ethylenediamine--N,N′-di-2-propanoate dihydrochloride (1) was synthesized and characterized by IR, 1 H-and 13 C-NMR spectroscopy, mass spectroscopy and elemental analysis. In vitro antitumor action of 1, and two more R 2 eddip esters, dialkyl (S,S)-ethylenediamine-N,N′-di-2-propanoate dihydrochlorides, obtained before (alkyl = n-Bu or n-Pe, 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast (MRC-5), using the microculture tetrazolium test MTT assay. Esters 1-3 showed higher cytotoxicity and better selectivity in comparison to cisplatin, used as reference compound. The highest activity was expressed by 1, with IC 50 (Fem-x) value of 1.51±0.09 µM.
Journal of Molecular Structure, 2013
Palladium(II) complexes (1–4) of general formula [PdCl2(R2-S,S-eddp)] with bidentate N,N’-ligands... more Palladium(II) complexes (1–4) of general formula [PdCl2(R2-S,S-eddp)] with bidentate N,N’-ligands, O,O'-dialkyl esters (R = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,N’-di-2-(4-methyl)pentanoic acid (S,S-eddp) were prepared and characterized by microanalysis, infrared and UV/Vis spectroscopy. The ligands and its complexes were tested for their in vitro antimicrobial activity against 15 species of bacteria and fungi. Testing is performed by the microdilution method, with the minimum inhibitory concentration (MIC) and the minimum microbicidal concentration (MMC) being determined. The MIC values were in range from 4.9 ěg cm–3 to > 5000 ěg cm–3 while MMC values ranged from 78 ěg cm–3 to > 5000 ěg cm–3. Palladium(II) complexes [PdCl2(Ln)] (n, 1–4) have statistically significant higher activity than the corresponding ligands. Complex 4 displayed the strongest activity among all tested compounds.
Zeitschrift für Kristallographie
Inorganic Chemistry, 1988
... DuSan J. RadanoviC,la Milos I. Djuran,la Vesna D. Miletie,' Chris Maricondi,lb ... more ... DuSan J. RadanoviC,la Milos I. Djuran,la Vesna D. Miletie,' Chris Maricondi,lb and Bodie E. Douglas*lc Received October 8. 1987 The trans(OSO6) geometrical isomer of the cobalt(II1) complex of ethylenediamine-N-acetic-N,N',N'-tri-3-propionic acid (H4eda3p) ... (12) Legg, J. I ...
Polyhedron, 2000
S-Alkyl (R=benzyl, methyl, ethyl, propyl and butyl) derivatives of thiosalicylic acid and the cor... more S-Alkyl (R=benzyl, methyl, ethyl, propyl and butyl) derivatives of thiosalicylic acid and the corresponding palladium(II) complexes were prepared and their structures were proposed on the basis of infrared, 1H and 13C NMR spectroscopy. The cis geometrical configurations of the isolated complexes were proposed on the basis of an X-ray structural study of the bis(S-benzyl-thiosalicylate)–palladium(II), [Pd(S-bz-thiosal)2] complex.Antimicrobial activity of the tested
ChemInform, 2003
The review summarizes the results of recent studies on edda-type metal complexes. It focuses on w... more The review summarizes the results of recent studies on edda-type metal complexes. It focuses on work published during the period 1984–2001. The metals include are Co, Cr, Cu, Ni, Zn, Mn, Sn, Fe, V, Rh, Pt, Ru, whereas edda-type represents ethylenediamine-N,N′-diacetate, ethylenediamine-N,N-di-acetate, N,N′-dimethylethylenediamine-N,N′-diacetate, N,N′-diethylethylenediamine-N,N′-diacetate, 1,2-cyclo-hexanediamine-N,N′-diacetate, N,N′-dimethyl-1,2-cyclohexanediamine-N,N′-diacetate, ethylenediamine-N,N′-di-3-propionate, N,N′-dimethylethylenediamine-N,N′-di-3-propionate, ethylenediamine-N,N′-di-S-α-propionate, N,N′-dimethyl-ethylenediamine-N,N′-di-α-propionate, 1,3-propanediamine-N,N′-diacetate (trimethylenediamine-N,N′-diacetate), 1,3-propanediamine-N,N′-di-3-propionate (trimethylenediamine-N,N′-di-3-propionate), N,N′-dimethylethylenediamine-N,N′-di-α-butyrate, N,N′-diethylethylenediamine-N,N′-di-α-butyrate, 1-diethylenetriamineacetate (8-amino-3,6-diazao-ctanoate), ethylenepropylenetriamineacetate (9-amino-3,6-diazaoc-
Journal of the Serbian Chemical Society, 2011
Soil samples taken from the Ap horizont of arable land and meadows at ten different localities we... more Soil samples taken from the Ap horizont of arable land and meadows at ten different localities were analyzed for different forms of manganese, including total (HF), pseudo-total (HNO 3 ), 0.1 M HCl-extractable and diethylentriaminepentaacetic acid (DTPA)-extractable. A sequential fractional procedure was used for Mn portioning into fractions: water soluble and exchangeable Mn (I), specifically adsorbed Mn with carbonates (II), reductant releasable Mn in oxides (III), Mn bonded with organic matter (IV) and Mn structurally bonded in silicates (residual fraction) (V). Serbian vertisols have a normal Mn content, comparable with similar soils. The total (HF) and pseudototal (HNO 3 ) Mn contents were not correlated with soil properties, whereas the humus content positively influenced the 0.1 M HCl-extractable Mn in soil (r = = 0.49). Soil pH and CaCO 3 (r = 0.57 and 0.43) showed significant negative correlations with the DTPA-extractable Mn, respectively. The different extraction methods showed similar patterns of Mn content in arable and meadow soils. The sequential fractional procedure showed that reductant releasable Mn occluded in oxides of Fe and Mn was the prevailing Mn fraction in soil, however, water soluble and exchangeable Mn and Mn bonded with organic matter had significant correlations with most of the examined soil characteristics. Potential Mn toxicity in vertisols could be observed under lower pH and saturated conditions.
Journal of the Serbian Chemical Society, 2011
Journal of The Serbian Chemical Society, 2005
Three octahedral chromium(III) complexes of the general formula Na[Cr(S,S-eddp)L] . 2H 2 O, where... more Three octahedral chromium(III) complexes of the general formula Na[Cr(S,S-eddp)L] . 2H 2 O, where eddp = the tetradentate O-N-N-O-type ligand ethylenediamine-N,N'-di-S,S-2-propionate and L = a bidentate O-O-type ligand, either oxalate or malonate, were prepared. The complexes were synthesized by the reaction of chromium(III) chloride, S,S-eddp and malonic acid or sodium oxalate, at 60 ºC. The complexes were isolated chromatographically and the geometric configuration of the complexes was proposed on the basis of their infrared and electronic absorption spectra.
Journal of the Serbian Chemical Society, 2002
A new bidentate ligand butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamate (bmFpdtc) was prepared, a... more A new bidentate ligand butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamate (bmFpdtc) was prepared, as the sodium salt. In the reaction of hexaaminecobalt(III) chloride with NabmFpdtc, the corresponding tris[butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamato]cobalt(III), [Co(bmFpdtc) 3 ] complex was prepared. The complex was characterized by elemental analysis, infrared, electronic absorption, 1 H and 13 C-NMR spectroscopy.
Journal of the Serbian Chemical Society, 2008
In the reaction of ruthenium(III) chloride and an edda-like ligand ethylenediamine-N,N'-di-S,S-2-... more In the reaction of ruthenium(III) chloride and an edda-like ligand ethylenediamine-N,N'-di-S,S-2-propionic acid (S,S-eddp) in aqueous solution led to the formation of only one of the three possible geometrical isomers potassium-s-cis-dichlorido-(ethylenediamine-N,N'-di-S,S-2-propionato)-ruthenate(III)--trihydrate, s-cis-K[Ru(S,S-eddp)Cl 2 ]·3H 2 O. The assumed geometry of the complex was based on its electronic absorption and infrared spectra.
Inorganica Chimica Acta, 1994
were prepared, chromatographically separated into two geometrical isomers with respect to the N-O... more were prepared, chromatographically separated into two geometrical isomers with respect to the N-O chelate ring size [trans (O,O,) and trans(OJ], and resolved. The 'H NMR, electronic absorption and circular dichroism (CD) spectra were used to characterize the complexes.
Inorganica Chimica Acta, 1988
ABSTRACT The complexes Kcis-eq-[Co(ed3a)CN], Kcis-eq-[Co(med3a)CN)], and Ktrans-eq-[Co(ed3a)CN] w... more ABSTRACT The complexes Kcis-eq-[Co(ed3a)CN], Kcis-eq-[Co(med3a)CN)], and Ktrans-eq-[Co(ed3a)CN] were synthesized and characterized. The 1H and 13C NMR spectra obtained with a 300 MHz spectrometer are reported and compared to corresponding aqua and nitro complexes. The PMR spectra show good resolution for all protons, including those of the ethylenediamine backbone. The NMR spectra of the cyano complexes are most similar to those of the corresponding nitro complexes. The major changes in the 13C NMR spectra can be explained based on β-substituent effects involving the N-methyl group or conversion from the cis-eq to the trans-eq isomers. Racemic NH4[Co(ed3a)CN]·2H2O·0.5CH3OH was found to be triclinic, P-1 with the cell dimensions: a = 6.597(2), b = 7.783(4), c = 15.72(1) Å, α = 88.63(5), β = 85.55(5), and γ = 69.89(4)°. There are two molecules in the unit cell.
Journal of the Serbian Chemical Society, 2011
ABSTRACT (S,S)-Ethylenediamine-N,N'-di-2-propanoic acid hydrochloride, (S,S)-H(2)eddp cen... more ABSTRACT (S,S)-Ethylenediamine-N,N'-di-2-propanoic acid hydrochloride, (S,S)-H(2)eddp center dot HCl, was prepared and its crystal structure determined. The compound was characterized by infrared and H-1- and C-13-NMR spectroscopy. It forms P1 in the space group of a triclinic crystal system with a = 5.3902(2) angstrom, b = 5.8967(2) angstrom, c = 10.3319(2) angstrom, alpha = 99.625(2)degrees beta = 91.645(2)degrees, gamma = = 109.995(2)degrees and Z = 1.
Inorganica Chimica Acta, 2012
Inorganica Chimica Acta, 1989
... 12 (1973), p. 1524. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (4). ... more ... 12 (1973), p. 1524. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (4). 15. WT Jordan and JI Legg. Inorg. Chem. ... MULTAN '82, University of York, UK (1982). 31. DT Cromer and JB Mann. Acta Crystallogr., Sect. A 24 (1968), p. 321. Full Text via CrossRef. 32. ...
Journal of the Serbian Chemical Society, 2009
The reaction of K 2 [PdCl 4 ] with (S,S)-(i-Pr) 2 eddip diester (diisopropyl (S,S)-2,2'-(1,2-etha... more The reaction of K 2 [PdCl 4 ] with (S,S)-(i-Pr) 2 eddip diester (diisopropyl (S,S)-2,2'-(1,2-ethanediyldiimino)dipropanoate) resulted in {PdCl 2 [(S,S)-(i--Pr) 2 eddip-κ 2 N,N']} (1) and {PdCl[(S,S)-(i-Pr)eddip-κ 2 N,N',κO]}
Journal of the Serbian Chemical Society, 2013
Palladium(II) complexes (1–4) of general formula [PdCl2(R2-S,S-eddp)] with bidentate N,N’-ligands... more Palladium(II) complexes (1–4) of general formula [PdCl2(R2-S,S-eddp)] with bidentate N,N’-ligands, O,O'-dialkyl esters (R = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,N’-di-2-(4-methyl)pentanoic acid (S,S-eddp) were prepared and characterized by microanalysis, infrared and UV/Vis spectroscopy. The ligands and its complexes were tested for their in vitro antimicrobial activity against 15 species of bacteria and fungi. Testing is performed by the microdilution method, with the minimum inhibitory concentration (MIC) and the minimum microbicidal concentration (MMC) being determined. The MIC values were in range from 4.9 ěg cm–3 to > 5000 ěg cm–3 while MMC values ranged from 78 ěg cm–3 to > 5000 ěg cm–3. Palladium(II) complexes [PdCl2(Ln)] (n, 1–4) have statistically significant higher activity than the corresponding ligands. Complex 4 displayed the strongest activity among all tested compounds.
Journal of the Serbian Chemical Society, 2013
Journal of the Serbian Chemical Society, 2014
A novel (S,S)-R 2 eddip ester, O,O′-diisopentyl-(S,S)-ethylenediamine--N,N′-di-2-propanoate dihyd... more A novel (S,S)-R 2 eddip ester, O,O′-diisopentyl-(S,S)-ethylenediamine--N,N′-di-2-propanoate dihydrochloride (1) was synthesized and characterized by IR, 1 H-and 13 C-NMR spectroscopy, mass spectroscopy and elemental analysis. In vitro antitumor action of 1, and two more R 2 eddip esters, dialkyl (S,S)-ethylenediamine-N,N′-di-2-propanoate dihydrochlorides, obtained before (alkyl = n-Bu or n-Pe, 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast (MRC-5), using the microculture tetrazolium test MTT assay. Esters 1-3 showed higher cytotoxicity and better selectivity in comparison to cisplatin, used as reference compound. The highest activity was expressed by 1, with IC 50 (Fem-x) value of 1.51±0.09 µM.
Journal of Molecular Structure, 2013
Palladium(II) complexes (1–4) of general formula [PdCl2(R2-S,S-eddp)] with bidentate N,N’-ligands... more Palladium(II) complexes (1–4) of general formula [PdCl2(R2-S,S-eddp)] with bidentate N,N’-ligands, O,O'-dialkyl esters (R = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,N’-di-2-(4-methyl)pentanoic acid (S,S-eddp) were prepared and characterized by microanalysis, infrared and UV/Vis spectroscopy. The ligands and its complexes were tested for their in vitro antimicrobial activity against 15 species of bacteria and fungi. Testing is performed by the microdilution method, with the minimum inhibitory concentration (MIC) and the minimum microbicidal concentration (MMC) being determined. The MIC values were in range from 4.9 ěg cm–3 to > 5000 ěg cm–3 while MMC values ranged from 78 ěg cm–3 to > 5000 ěg cm–3. Palladium(II) complexes [PdCl2(Ln)] (n, 1–4) have statistically significant higher activity than the corresponding ligands. Complex 4 displayed the strongest activity among all tested compounds.