Tatjana V Kanjevac | University of Kragujevac (original) (raw)
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Papers by Tatjana V Kanjevac
Deleted Journal, May 1, 2024
Current stem cell research & therapy, May 23, 2019
Mesenchymal stem cells (MSCs) are multipotent stem cells with wide-ranging clinical applications ... more Mesenchymal stem cells (MSCs) are multipotent stem cells with wide-ranging clinical applications due to their ability to regenerate tissue from mesenchymal origin and their capability of suppressing immune responses, thus reducing the likelihood of graft versus host disease after transplantation. MSCs can be isolated from a variety of sources including bone marrow, adipose tissue, umbilical cord blood, and immature teeth. Dental stem cells (DSCs) possess progenitor and immunomodulatory abilities as the other MSC types and because they can be easily isolated, are considered as attractive therapeutic agents in regenerative dentistry. Recently, it has been shown that DSCs seeded onto newly developed synthetic biomaterial scaffolds have retained their potential for proliferation and at the same time have enhanced capabilities for differentiation and immunosuppression. The scaffolds are becoming more efficient at MSC priming as researchers learn how short peptide sequences alter the adhesive and proliferative capabilities of the scaffolds by stimulating or inhibiting classical osteogenic pathways. New findings on how to modulate the inflammatory microenvironment, which can prime DSCs for differentiation, combined with the use of next generation scaffolds may significantly improve their therapeutic potential. In this review, we summarize current findings regarding DSCs as a potential regenerative therapy, including stem cell priming with inflammatory cytokines, types of scaffolds currently being explored and the modulation of scaffolds to regulate immune response and promote growth.
Vojnosanitetski pregled, 2021
Background/Aim. Radiology is a crucial part of dentists? everyday practice. It plays a vital role... more Background/Aim. Radiology is a crucial part of dentists? everyday practice. It plays a vital role in diagnosis, treatment planning and the follow-up care of patients. The aim of this study was to evaluate the knowledge of dentists in Serbia concerning the use of radiology in pediatric dentistry. Methods. In total, 252 dentists from across Serbia participated in the study. A questionnaire was created in order to examine dentists? knowledge about the use of radiology in pediatric dentistry. The questionnaire consisted of 39 questions. All questions were analyzed in SPSS 24 statistical software. Results. According to the results, 42.1% of dentists worked in private practice, 17.8% at University clinics and 40.1% in National Health Services. Out of total 252 respondents, only 82 (32.5%) had an x-ray unit. A total of 199 (79%) dentists replied they would diagnose early caries lesions only by inspection, but 30 (11.9%) dentists said they would make a diagnosis by doing both the inspection...
Oral Health & Preventive Dentistry, 2018
Chronic kidney disease (CKD) has become a worldwide public health problem. It is estimated that n... more Chronic kidney disease (CKD) has become a worldwide public health problem. It is estimated that nearly 90% of patients with chronic renal failure manifest some symptoms of oral disease. With advances in medical treatment, CKD patients are living longer and require oral care. Chronic kidney disease is often accompanied by disturbances in mineral metabolism which are classified as their own clinical entity known as CKD-mineral and bone disorder (CKD-MBD). CKD-MBD affects all aspects of bone physiology: bone volume, bone turnover and bone mineralization. Jaw bones affected with CKD-MBD can have important clinical implications for the survival and osseointegration of dental implants, success of bone regeneration therapy, and increased risk of bone loss in patients with periodontitis or risk of bone fracture. Assessment of bone turnover is the most important diagnostic tool to monitor progression of CKD-MBD. Bone biomarkers and radiographical examination of bone density may be particularly useful to both, diagnosis and monitoring of bone turnover. Cone beam computed tomography (CBCT) as a reliable method with many advantages over other radiographic methods can be used for analysis of jaw bone micro-architectural changes and may be of a great help in bone quality determination in CKD-MBD.
Biomedical Journal of Scientific and Technical Research, Feb 7, 2019
Serbian Journal of Experimental and Clinical Research, Mar 1, 2016
Stem Cell Reviews and Reports, Nov 25, 2017
Therapeutic Advances in Gastroenterology, 2018
Vojnosanitetski Pregled, 2023
Zdravstvena zaštita, 2020
Timočki medicinski glasnik, 2018
Medical review, 2018
Introduction. The aim of this study was to establish the number of roots and present the root can... more Introduction. The aim of this study was to establish the number of roots and present the root canal configuration in the maxillary and mandibular premolar teeth, and evaluate the relations among these characteristics with gender and teeth position in the Serbian population using cone-beam computed tomography. Material and Methods. Cone-beam computed tomography images of 570 teeth of 150 patients were evaluated. Teeth were classified into the following groups: maxillary first premolars, maxillary second premolars, mandibular first premolars and mandibular second premolars, and the number of roots and root canals per tooth, whereas root canal configurations were examined along with the tooth position and patients? gender. The root canal configuration was classified using Vertucci?s classification. Statistical significance was obtained using Chi square test. Results. In maxillary first premolars, two roots (53.5%) and two root canals (84.5%) were the most prevalent, as well as type IV ...
Serbian Journal of Experimental and Clinical Research, 2016
The design of platinum based drugs is not a new field of interest. Platinum complexes are widely ... more The design of platinum based drugs is not a new field of interest. Platinum complexes are widely used as anticancer agents and currently, approximately 30 platinum(II) and platinum(IV) entered into some of the phases of clinical trials. A special place in today’s research belongs to platinum complexes with diammine ligands. A large number of edda (ethylenediamine- N, N’-diacetate)-type ligands and their corresponding metal complexes has been successfully synthesized. This article summarizes recent progress in research on edda-type-platinum complexes. Some of these agents achieves better effect compared to the gold standard (cisplatin). It has been shown that there is a possible relationship between the length of the ligand ester group carbon chain and its cytotoxic effect. In most cases the longer the ester chain is the greater is the antitumor activity. Of particular interest are the noticeable effects of some new platinum compound with edda-type ligand on cell lines that are known...
Deleted Journal, May 1, 2024
Current stem cell research & therapy, May 23, 2019
Mesenchymal stem cells (MSCs) are multipotent stem cells with wide-ranging clinical applications ... more Mesenchymal stem cells (MSCs) are multipotent stem cells with wide-ranging clinical applications due to their ability to regenerate tissue from mesenchymal origin and their capability of suppressing immune responses, thus reducing the likelihood of graft versus host disease after transplantation. MSCs can be isolated from a variety of sources including bone marrow, adipose tissue, umbilical cord blood, and immature teeth. Dental stem cells (DSCs) possess progenitor and immunomodulatory abilities as the other MSC types and because they can be easily isolated, are considered as attractive therapeutic agents in regenerative dentistry. Recently, it has been shown that DSCs seeded onto newly developed synthetic biomaterial scaffolds have retained their potential for proliferation and at the same time have enhanced capabilities for differentiation and immunosuppression. The scaffolds are becoming more efficient at MSC priming as researchers learn how short peptide sequences alter the adhesive and proliferative capabilities of the scaffolds by stimulating or inhibiting classical osteogenic pathways. New findings on how to modulate the inflammatory microenvironment, which can prime DSCs for differentiation, combined with the use of next generation scaffolds may significantly improve their therapeutic potential. In this review, we summarize current findings regarding DSCs as a potential regenerative therapy, including stem cell priming with inflammatory cytokines, types of scaffolds currently being explored and the modulation of scaffolds to regulate immune response and promote growth.
Vojnosanitetski pregled, 2021
Background/Aim. Radiology is a crucial part of dentists? everyday practice. It plays a vital role... more Background/Aim. Radiology is a crucial part of dentists? everyday practice. It plays a vital role in diagnosis, treatment planning and the follow-up care of patients. The aim of this study was to evaluate the knowledge of dentists in Serbia concerning the use of radiology in pediatric dentistry. Methods. In total, 252 dentists from across Serbia participated in the study. A questionnaire was created in order to examine dentists? knowledge about the use of radiology in pediatric dentistry. The questionnaire consisted of 39 questions. All questions were analyzed in SPSS 24 statistical software. Results. According to the results, 42.1% of dentists worked in private practice, 17.8% at University clinics and 40.1% in National Health Services. Out of total 252 respondents, only 82 (32.5%) had an x-ray unit. A total of 199 (79%) dentists replied they would diagnose early caries lesions only by inspection, but 30 (11.9%) dentists said they would make a diagnosis by doing both the inspection...
Oral Health & Preventive Dentistry, 2018
Chronic kidney disease (CKD) has become a worldwide public health problem. It is estimated that n... more Chronic kidney disease (CKD) has become a worldwide public health problem. It is estimated that nearly 90% of patients with chronic renal failure manifest some symptoms of oral disease. With advances in medical treatment, CKD patients are living longer and require oral care. Chronic kidney disease is often accompanied by disturbances in mineral metabolism which are classified as their own clinical entity known as CKD-mineral and bone disorder (CKD-MBD). CKD-MBD affects all aspects of bone physiology: bone volume, bone turnover and bone mineralization. Jaw bones affected with CKD-MBD can have important clinical implications for the survival and osseointegration of dental implants, success of bone regeneration therapy, and increased risk of bone loss in patients with periodontitis or risk of bone fracture. Assessment of bone turnover is the most important diagnostic tool to monitor progression of CKD-MBD. Bone biomarkers and radiographical examination of bone density may be particularly useful to both, diagnosis and monitoring of bone turnover. Cone beam computed tomography (CBCT) as a reliable method with many advantages over other radiographic methods can be used for analysis of jaw bone micro-architectural changes and may be of a great help in bone quality determination in CKD-MBD.
Biomedical Journal of Scientific and Technical Research, Feb 7, 2019
Serbian Journal of Experimental and Clinical Research, Mar 1, 2016
Stem Cell Reviews and Reports, Nov 25, 2017
Therapeutic Advances in Gastroenterology, 2018
Vojnosanitetski Pregled, 2023
Zdravstvena zaštita, 2020
Timočki medicinski glasnik, 2018
Medical review, 2018
Introduction. The aim of this study was to establish the number of roots and present the root can... more Introduction. The aim of this study was to establish the number of roots and present the root canal configuration in the maxillary and mandibular premolar teeth, and evaluate the relations among these characteristics with gender and teeth position in the Serbian population using cone-beam computed tomography. Material and Methods. Cone-beam computed tomography images of 570 teeth of 150 patients were evaluated. Teeth were classified into the following groups: maxillary first premolars, maxillary second premolars, mandibular first premolars and mandibular second premolars, and the number of roots and root canals per tooth, whereas root canal configurations were examined along with the tooth position and patients? gender. The root canal configuration was classified using Vertucci?s classification. Statistical significance was obtained using Chi square test. Results. In maxillary first premolars, two roots (53.5%) and two root canals (84.5%) were the most prevalent, as well as type IV ...
Serbian Journal of Experimental and Clinical Research, 2016
The design of platinum based drugs is not a new field of interest. Platinum complexes are widely ... more The design of platinum based drugs is not a new field of interest. Platinum complexes are widely used as anticancer agents and currently, approximately 30 platinum(II) and platinum(IV) entered into some of the phases of clinical trials. A special place in today’s research belongs to platinum complexes with diammine ligands. A large number of edda (ethylenediamine- N, N’-diacetate)-type ligands and their corresponding metal complexes has been successfully synthesized. This article summarizes recent progress in research on edda-type-platinum complexes. Some of these agents achieves better effect compared to the gold standard (cisplatin). It has been shown that there is a possible relationship between the length of the ligand ester group carbon chain and its cytotoxic effect. In most cases the longer the ester chain is the greater is the antitumor activity. Of particular interest are the noticeable effects of some new platinum compound with edda-type ligand on cell lines that are known...