R. Del Giorno | Karolinska Institutet (original) (raw)
Papers by R. Del Giorno
La Clinica terapeutica, 2010
Uraemia is a disease characterised by a significant oxidative stress, and it is a wide agreement ... more Uraemia is a disease characterised by a significant oxidative stress, and it is a wide agreement that oxidative stress which accompanies uraemia, increases the inflammatory state and promotes the alterations of tiny molecules such as amino acids, proteins, lipids, and carbohydrates. There are numerous records of how ROS are connected to the pathology of end stage renal disease (ESRD). The aim of this study is to assess the Total Antioxidant Capacity (TAC), the Thiolic Capacity (TC) and the Pro-Oxidant Capacity (POC) in the serum of patients undergoing dialysis treatment. Forthy-six patients have been recruited (32 men, 14 women; mean age 68.5±15.8) who received hemodialytic treatment triweekly. Three methods have been used: oxy adsorbent test (mmol/l) to determine TAC values; d-ROM test (mg/100 mg/H₂O₂) to determine POC; SHp-test (mmol/l) to determine TC. In patients who underwent hemodialysis, TAC levels were: pre-dialysis, 265.9±30.5; post-dialysis, 300.0±40.6; TC levels: pre-dial...
La Clinica terapeutica, 2010
The infection caused by HIV leads to an activation of the immune system, which involves local and... more The infection caused by HIV leads to an activation of the immune system, which involves local and systemic oxidative stress. In HIV-positive (HIV+) patients, oxidative damage is the result of HIV infection and its progression through the replication of the virus. We have examined 52 subjects: 26 HIV+ patients, and 26 healthy subjects (NC). Analysis of the parameters of the oxidant/antioxidant status (total antioxidant capacity (TAC), hydroperoxides (free radicals, PRO), thiols as thiolic capacity, TC) was carried out by means of the OXY-Absorbent test, the d-Rom test, and the -SHp test, respectively. Healthy subjects presented the following values: TAC (micromol/ml) 259.5+/-40.5; TC (micromol/l) 434.09+/-18.31; PRO (mg/dl) 54.09+/-7.3; CD4+ cells (cells/ml) 850+/-333. Values of HIV+ patients were the following: TAC 218.73+/-18.55 (ns vs NC; TC 250.88+/-93.11 (p 0.001 vs NC); PRO 110.5+/-23.61 (p 0.0005 vs NC); CD4+ cells 354+/-323.35 (p 0.0005 vs NC). The statistical analysis shows ...
La Clinica terapeutica, 2009
Systemic Sclerosis (SS) is a chronic inflammatory disease of the connective tissues, characterise... more Systemic Sclerosis (SS) is a chronic inflammatory disease of the connective tissues, characterised by alterations in the functions and structures of the small blood vessels (capillaries and arterioles) and by modifications associated with the disposition of collagen in the tissues. One of the most frequent complication of the SS is the pulmonary arterial hypertension (PAH). Aim of this study was to assess the various pathophysiological relationships betweens SS and PAH in order to establish whether the presence of this systemic disease can represent a risk factor. Ten patients affected by SS (9 women and 1 man, with a mean age of 55.7 +/- 11.4 years) were enrolled in our study, as inpatients at Dept. of Internal Medicine and Rheumatology Unit of Perugia University School of Medicine in the "Santa Maria" General Hospital in Terni, Italy. A control group of 10 clinically healthy subjects (CHS, 9 women and 1 man, ranging in age from 35 to 55 years) was also recruited in order...
Mediterranean Journal of Nutrition and Metabolism, 2009
La Clinica terapeutica, 2009
Various studies have confirmed the high incidence of skeletal homeostasis modifications in subjec... more Various studies have confirmed the high incidence of skeletal homeostasis modifications in subjects who are carriers of chronic HIV infections, and specific pharmacological treatments, which modify the metabolism and condition both the weight loss and the reshaping of the bones. The presence of a reduction in body mass index seems to contribute to the progressive deterioration of the skeletal framework. The aim of this study was to see whether the presence of HIV-seropositivity could constitute a risk factor for the development of osteoporosis/osteopenia, even in the light of the fact that our group was composed of patients with a concentrated age span well under the limit for both post-menopausal and senile osteoporosis, and with a median age superimposable for both sexes. Our study involved 26 HIV+ patients with an average duration of infection equal to 6.7 +/- 4.8 years, and a range of seropositive duration between 6 months to 16 years. The prominent ultrasonometrical parameters ...
![Research paper thumbnail of [84] PREVALENCE OF MAJOR CARDIOVASCULAR RISK FACTORS AND DISTANCE FROM THE LDL CHOLESTEROL TARGET AMONG DYSLIPIDEMIC SUBJECTS AT DIFFERENT CARDIOVASCULAR RISK](https://attachments.academia-assets.com/45105382/thumbnails/1.jpg)
](Nutrition, Metabolism and Cardiovascular Diseases, 2009
Background: Increased lipoprotein levels are considered a determinant of atherosclerosis appearan... more Background: Increased lipoprotein levels are considered a determinant of atherosclerosis appearance and progression. Altered lipoprotein profile is frequently part of a constellation of disorders whose combination increases atherosclerotic risk. We investigated among dyslipidemic subjects at different cardiovascular risk the prevalence of major cardiovascular risk factors and the distance from the LDL cholesterol target. Methods: Plasma lipid levels and assessment of major cardiovascular risk factors was performed among 1500 dyslipidemic subjects attending our Lipid Clinic. Traditional cardiovascular risk factors were evaluated and their distribution was studied in the entire cohort and among subjects with cardiovascular disease and/or cardiovascular risk equivalents. The distance of LDL cholesterol levels from reaching its target (target defined according to the number of cardiovascular risk factors and the Framingham risk score assessment: <100 mg/dl; <130 mg/dl; <160 mg/dl) was also evaluated. Results: Mean age of the cohort was 57±12 with a body mass index in the range of overweight (27.1±3.9) and a disturbed lipoprotein profile (total cholesterol 261±51 mg/dl, LDL cholesterol 167±49 mg/dl, triglycerides 197±125 mg/dl, HDL cholesterol 56±16 mg/dl). The prevalence of the following risk factors was obtained: family and personal history for early major cardiovascular diseases 14% and 6.9% respectively, current smoking 22% (number of cigarettes 14±10), diabetes 6.1% and known hypertension 42%. Statin and/or anti-hypertensive treatment was already prescribed in 22% and 40% subjects respectively. According to the number of cardiovascular risk factors and Framingham risk score assessment, the LDL cholesterol target was reached by 28% of the cohort with a mean distance from the target of 27±51 mg/dl. This distance was higher (32±50 mg/dl) when only subjects not taking statin treatment was considered. Among subjects at high cardiovascular risk, the distance from the target for LDL cholesterol (<100 mg/dl) was 54±60 mg/dl (64±62 mg/dl among high risk patients not taking statins). Conclusions: The presence of non lipid cardiovascular risk factors contributes significantly to increase the burden of risk among dyslipidemic subjects. The relatively high distance from reaching the LDL cholesterol target particularly among high risk, statin-untreated and at a less extent statintreated dyslipidemic subjects warrants a more aggressive LDL cholesterol lowering.
La Clinica terapeutica, 2010
Oxidative stress is defined as tissue damage caused by an imbalance between the excessive product... more Oxidative stress is defined as tissue damage caused by an imbalance between the excessive production of the oxidant components and an insufficient defence mechanism. It has been observed, as in patients with chronic kidney failure, that there exists a pro-oxidant state characterised by a higher level of reactive oxygen species (ROS), and that oxidative stress in dialysis patients can be aggravated by the activation of neutrophils associated with the production of free radicals. In patients undergoing dialysis even the molecules other than those of cytokines can accumulate and provoke an inflammatory response. This study proposes an analysis based on the total antioxidant capacity (TAC), thiol concentration (TC) and pro-oxidant capacity (POC) in the serum of various groups of patients: one group of dialysis subjects who had been undergoing substitutive treatment for more than ten years at the time of the study; one group of subjects with chronic renal insufficiency in its pre-termina...
La Clinica terapeutica, 2010
Uraemia is a disease characterised by a significant oxidative stress, and it is a wide agreement ... more Uraemia is a disease characterised by a significant oxidative stress, and it is a wide agreement that oxidative stress which accompanies uraemia, increases the inflammatory state and promotes the alterations of tiny molecules such as amino acids, proteins, lipids, and carbohydrates. There are numerous records of how ROS are connected to the pathology of end stage renal disease (ESRD). The aim of this study is to assess the Total Antioxidant Capacity (TAC), the Thiolic Capacity (TC) and the Pro-Oxidant Capacity (POC) in the serum of patients undergoing dialysis treatment. Forthy-six patients have been recruited (32 men, 14 women; mean age 68.5±15.8) who received hemodialytic treatment triweekly. Three methods have been used: oxy adsorbent test (mmol/l) to determine TAC values; d-ROM test (mg/100 mg/H₂O₂) to determine POC; SHp-test (mmol/l) to determine TC. In patients who underwent hemodialysis, TAC levels were: pre-dialysis, 265.9±30.5; post-dialysis, 300.0±40.6; TC levels: pre-dial...
La Clinica terapeutica, 2010
The infection caused by HIV leads to an activation of the immune system, which involves local and... more The infection caused by HIV leads to an activation of the immune system, which involves local and systemic oxidative stress. In HIV-positive (HIV+) patients, oxidative damage is the result of HIV infection and its progression through the replication of the virus. We have examined 52 subjects: 26 HIV+ patients, and 26 healthy subjects (NC). Analysis of the parameters of the oxidant/antioxidant status (total antioxidant capacity (TAC), hydroperoxides (free radicals, PRO), thiols as thiolic capacity, TC) was carried out by means of the OXY-Absorbent test, the d-Rom test, and the -SHp test, respectively. Healthy subjects presented the following values: TAC (micromol/ml) 259.5+/-40.5; TC (micromol/l) 434.09+/-18.31; PRO (mg/dl) 54.09+/-7.3; CD4+ cells (cells/ml) 850+/-333. Values of HIV+ patients were the following: TAC 218.73+/-18.55 (ns vs NC; TC 250.88+/-93.11 (p 0.001 vs NC); PRO 110.5+/-23.61 (p 0.0005 vs NC); CD4+ cells 354+/-323.35 (p 0.0005 vs NC). The statistical analysis shows ...
La Clinica terapeutica, 2009
Systemic Sclerosis (SS) is a chronic inflammatory disease of the connective tissues, characterise... more Systemic Sclerosis (SS) is a chronic inflammatory disease of the connective tissues, characterised by alterations in the functions and structures of the small blood vessels (capillaries and arterioles) and by modifications associated with the disposition of collagen in the tissues. One of the most frequent complication of the SS is the pulmonary arterial hypertension (PAH). Aim of this study was to assess the various pathophysiological relationships betweens SS and PAH in order to establish whether the presence of this systemic disease can represent a risk factor. Ten patients affected by SS (9 women and 1 man, with a mean age of 55.7 +/- 11.4 years) were enrolled in our study, as inpatients at Dept. of Internal Medicine and Rheumatology Unit of Perugia University School of Medicine in the "Santa Maria" General Hospital in Terni, Italy. A control group of 10 clinically healthy subjects (CHS, 9 women and 1 man, ranging in age from 35 to 55 years) was also recruited in order...
Mediterranean Journal of Nutrition and Metabolism, 2009
La Clinica terapeutica, 2009
Various studies have confirmed the high incidence of skeletal homeostasis modifications in subjec... more Various studies have confirmed the high incidence of skeletal homeostasis modifications in subjects who are carriers of chronic HIV infections, and specific pharmacological treatments, which modify the metabolism and condition both the weight loss and the reshaping of the bones. The presence of a reduction in body mass index seems to contribute to the progressive deterioration of the skeletal framework. The aim of this study was to see whether the presence of HIV-seropositivity could constitute a risk factor for the development of osteoporosis/osteopenia, even in the light of the fact that our group was composed of patients with a concentrated age span well under the limit for both post-menopausal and senile osteoporosis, and with a median age superimposable for both sexes. Our study involved 26 HIV+ patients with an average duration of infection equal to 6.7 +/- 4.8 years, and a range of seropositive duration between 6 months to 16 years. The prominent ultrasonometrical parameters ...
Nutrition, Metabolism and Cardiovascular Diseases, 2009
Background: Increased lipoprotein levels are considered a determinant of atherosclerosis appearan... more Background: Increased lipoprotein levels are considered a determinant of atherosclerosis appearance and progression. Altered lipoprotein profile is frequently part of a constellation of disorders whose combination increases atherosclerotic risk. We investigated among dyslipidemic subjects at different cardiovascular risk the prevalence of major cardiovascular risk factors and the distance from the LDL cholesterol target. Methods: Plasma lipid levels and assessment of major cardiovascular risk factors was performed among 1500 dyslipidemic subjects attending our Lipid Clinic. Traditional cardiovascular risk factors were evaluated and their distribution was studied in the entire cohort and among subjects with cardiovascular disease and/or cardiovascular risk equivalents. The distance of LDL cholesterol levels from reaching its target (target defined according to the number of cardiovascular risk factors and the Framingham risk score assessment: <100 mg/dl; <130 mg/dl; <160 mg/dl) was also evaluated. Results: Mean age of the cohort was 57±12 with a body mass index in the range of overweight (27.1±3.9) and a disturbed lipoprotein profile (total cholesterol 261±51 mg/dl, LDL cholesterol 167±49 mg/dl, triglycerides 197±125 mg/dl, HDL cholesterol 56±16 mg/dl). The prevalence of the following risk factors was obtained: family and personal history for early major cardiovascular diseases 14% and 6.9% respectively, current smoking 22% (number of cigarettes 14±10), diabetes 6.1% and known hypertension 42%. Statin and/or anti-hypertensive treatment was already prescribed in 22% and 40% subjects respectively. According to the number of cardiovascular risk factors and Framingham risk score assessment, the LDL cholesterol target was reached by 28% of the cohort with a mean distance from the target of 27±51 mg/dl. This distance was higher (32±50 mg/dl) when only subjects not taking statin treatment was considered. Among subjects at high cardiovascular risk, the distance from the target for LDL cholesterol (<100 mg/dl) was 54±60 mg/dl (64±62 mg/dl among high risk patients not taking statins). Conclusions: The presence of non lipid cardiovascular risk factors contributes significantly to increase the burden of risk among dyslipidemic subjects. The relatively high distance from reaching the LDL cholesterol target particularly among high risk, statin-untreated and at a less extent statintreated dyslipidemic subjects warrants a more aggressive LDL cholesterol lowering.
La Clinica terapeutica, 2010
Oxidative stress is defined as tissue damage caused by an imbalance between the excessive product... more Oxidative stress is defined as tissue damage caused by an imbalance between the excessive production of the oxidant components and an insufficient defence mechanism. It has been observed, as in patients with chronic kidney failure, that there exists a pro-oxidant state characterised by a higher level of reactive oxygen species (ROS), and that oxidative stress in dialysis patients can be aggravated by the activation of neutrophils associated with the production of free radicals. In patients undergoing dialysis even the molecules other than those of cytokines can accumulate and provoke an inflammatory response. This study proposes an analysis based on the total antioxidant capacity (TAC), thiol concentration (TC) and pro-oxidant capacity (POC) in the serum of various groups of patients: one group of dialysis subjects who had been undergoing substitutive treatment for more than ten years at the time of the study; one group of subjects with chronic renal insufficiency in its pre-termina...