Ying-jun Zhang | Kunming institute of Botany (original) (raw)

Papers by Ying-jun Zhang

more than 300 species and occurs natively in arid and tropical regions of western hemisphere, par... more more than 300 species and occurs natively in arid and tropical regions of western hemisphere, particularly Mexico, and Central America. Among which, several species are of global economic importance, e.g., Agave sisalana, the source of sisal fibre, and other species, such as A. americana, growing world-wide as ornamentals. In China, several species of the genus Agave, such as A. americana and A. sisalana, are widely cultivated in the south part for the fibre industry and as important horticultural plants. Agave americana L., a very large plant with rosettes up to 12 feet broad, is used as an important source for not only textile fibre, but also steroidal sapogenins such as hecogenin and tigogenin in China. The plant is also used as folk medicine for its antiinflammatory and anti-fungus effects on the treatment of uterus blooding, scabies, etc. Since the chemical investigation on the fermented residues of the leaf-juice of A. sisalana led to the identification of some tigogenin glyco...

Molecules, 2019

This study was designed to explore the in vitro anticancer effects of the bioactive compounds iso... more This study was designed to explore the in vitro anticancer effects of the bioactive compounds isolated from Ricinodendron heudelotii on selected cancer cell lines. The leaves of the plant were extracted with ethanol and partitioned in sequence with petroleum ether, ethyl acetate, and n-butanol. The ethyl acetate fraction was phytochemically studied using thin layer chromatography (TLC) and column chromatography (CC). Structural elucidation of pure compounds obtained from the ethyl acetate fraction was done using mass spectra, 1H-NMR, and 13C-NMR analysis. The isolated compounds were subsequently screened using five different cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, SW-480, and normal lung epithelial cell line, BEAS-2B, to assess their cytotoxic effects. Nine compounds were isolated and structurally elucidated as gallic acid, gallic acid ethyl ester, corilagin, quercetin-3-O-rhamnoside, myricetin-3-O-rhamnoside, 1,4,6-tri-O-galloyl glucose, 3,4,6-tri-O-galloyl glucose, 1,2,...

Natural Products and Bioprospecting, 2017

Natural Product Research, 2014

Natural Products and Bioprospecting, Oct 1, 2014

RSC Advances

Nine new nontriterpenoids were identified from Panax notoginseng rot roots, and their cytotoxicit... more Nine new nontriterpenoids were identified from Panax notoginseng rot roots, and their cytotoxicities may be related to the EGFR inhibition.

Natural Products and Bioprospecting

A new seco-anthraquinone, crispuside A (1), and three new 3,4-dihydronaphthalen-1(2H)-ones, napth... more A new seco-anthraquinone, crispuside A (1), and three new 3,4-dihydronaphthalen-1(2H)-ones, napthalenones A-C (2–4), were isolated from the roots of Rumex crispus L., along with 10 known anthraquinones (6–14) and naphthalenone (5). Their structures were fully determined by extensive spectroscopic analyses, including ECD, and X-ray crystallography in case of compound 5, whose absolute configuration was determined for the first time. The isolates 1, 6–14 were evaluated for their anti-inflammatory and anti-fungal activity against three skin fungi, e.g., Epidermophyton floccosum, Trichophyton rubrum, and Microsporum gypseum. Most of the isolates showed weak anti-fungal and anti-inflammatory activity. Only compound 9 exhibited obvious anti-fungal activity against E. floccosum (MIC50 = 2.467 ± 0.03 μM) and M. gypseum (MIC50 = 4.673 ± 0.077 μM), while the MIC50 values of the positive control terbinafine were 1.287 ± 0.012 and 0.077 ± 0.00258 μM, respectively. The results indicated that sim...

Natural Products and Bioprospecting

Rumex L., a genus in Polygonaceae family with about 200 species, is growing widely around the wor... more Rumex L., a genus in Polygonaceae family with about 200 species, is growing widely around the world. Some Rumex species, called "sorrel" or "dock", have been used as food application and treatment of skin diseases and hemostasis after trauma by the local people of its growing areas for centuries. To date, 29 Rumex species have been studied to contain about 268 substances, including anthraquinones, flavonoids, naphthalenes, stilbenes, diterpene alkaloids, terpenes, lignans, and tannins. Crude extract of Rumex spp. and the pure isolates displayed various bioactivities, such as antibacterial, anti-inflammatory, antitumor, antioxidant, cardiovascular protection and antiaging activities. Rumex species have important potential to become a clinical medicinal source in future. This review covers research articles from 1900 to 2022, fetched from SciFinder, Web of Science, ResearchGate, CNKI and Google Scholar, using “Rumex” as a search term ("all fields") with n...

A new catechin derivative named as sterilin A (<b>1</b>), and three known compounds, ... more A new catechin derivative named as sterilin A (<b>1</b>), and three known compounds, (+)-catechin (<b>2</b>), kaji-ichigoside F1 (<b>3</b>) and 2α,3α,19α-trihydroxyurs-12-en-28-oic acid-28-<i>O</i>-β-D-xylopyranosyl-(1 → 2)-β-D-glucopyranoside (<b>4</b>), was isolated from the fresh fruits of <i>Rosa sterilis</i>. Their structures were elucidated by means of extensive spectroscopic analysis and by comparison with data reported in the literatures.

A novel highly oxygenated norbisabolane sesquiterpene, namely phyllanthacidoid U (1), along with ... more A novel highly oxygenated norbisabolane sesquiterpene, namely phyllanthacidoid U (1), along with nine known sesquiterpenes (2–10) was isolated from the roots and stems of <i>Phyllanthus acidus</i> (L.) Skeels (Phyllanthaceae), collected from Xishuangbanna, Yunnan province, China. Their structures were elucidated by means of extensive spectroscopic analysis and by comparison of their data with reported values in literatures. Instead of the C-13 ester <i>O</i>-glycosyl found mostly in the titled plant growing in Thailand, compound <b>1</b> possessed a rare <i>N</i>-<i>β</i>-glucosamine-2-<i>N</i>-acetate moiety linked directly to the carbonyl at C-13 through an amido bond. Moreover, the acyl group at C-10 in <b>1</b> was (<i>Z</i>)-2-(2-hydroxyethyl)-pent-2-enedioyl group, instead of benzoic or <i>p</i>-hydroxybenzoic moieties found commonly in the reported norbisabolane sesquit...

A new arbutin derivative, namely dunalianosides J (<b>1</b>), along with six known co... more A new arbutin derivative, namely dunalianosides J (<b>1</b>), along with six known compounds, arbutin (<b>2</b>), robustaside A (<b>3</b>), 6′-<i>O</i>-caffeoylarbutin (<b>4</b>), dunalianoside D (<b>5</b>), kaempferol 3-<i>O</i>-<i>β</i>-D-glucopyranoside (<b>6</b>) and kaempferol 3-<i>O</i>-<i>β</i>-D-sambubioside (<b>7</b>) were isolated from the leaves of <i>Vaccinium dunalianum</i> Wight (Ericaceae). The structure of <b>1</b> was elucidated by extensive 1D and 2D NMR, HR-MS and CD spectroscopic analyses. In which, kaempferol 3-<i>O</i>-<i>β</i>-D-sambubioside (<b>7</b>) was isolated from the genus <i>Vaccinium</i> for the first time.

Natural Product Research, 2020

Natural Product Research, 2019

Natural Product Research, 2018

RSC Adv., 2014

Eucalmaidials A and B, representing a new skeleton of phloroglucinol-coupled iphionane, were isol... more Eucalmaidials A and B, representing a new skeleton of phloroglucinol-coupled iphionane, were isolated from the juvenile leaves of Eucalyptus maideni.

Journal of the Brazilian Chemical Society, 2014

RSC Advances, 2015

Theoretical calculated electronic circular dichroism and Mosher’s method were applied to elucidat... more Theoretical calculated electronic circular dichroism and Mosher’s method were applied to elucidate the stereochemistry of cleistanthane diterpenoids.

Organic & biomolecular chemistry, Jan 21, 2014

During the process exploring anti-viral compounds from Phyllanthus species, eight new highly oxyg... more During the process exploring anti-viral compounds from Phyllanthus species, eight new highly oxygenated bisabolane sesquiterpenoid glycoside phyllaemblicins G1–G8 (1–8) were isolated from Phyllanthus emblica, along with three known compounds, phyllaemblicin F (9), phyllaemblic acid (10) and glochicoccin D (11). Phyllaemblicin G2 (2), bearing a tricyclo [3.1.1.1] oxygen bridge ring system, is an unusual sesquiterpenoid glycoside, while phyllaemblicins G6–G8 (6–8) are dimeric sesquiterpenoid glycosides with two norbisabolane units connecting through a disaccharide. All the structures were elucidated by the extensive analysis of HRMS and NMR data. The relative configuration of phyllaemblicin G2 was constructed based on heteronuclear coupling constants measurement, and the absolute configurations for all new compounds were established by calculated electronic circular dichroism (ECD) using time dependent density functional theory. The sesquiterpenoid glycoside dimers 6–9 displayed poten...

more than 300 species and occurs natively in arid and tropical regions of western hemisphere, par... more more than 300 species and occurs natively in arid and tropical regions of western hemisphere, particularly Mexico, and Central America. Among which, several species are of global economic importance, e.g., Agave sisalana, the source of sisal fibre, and other species, such as A. americana, growing world-wide as ornamentals. In China, several species of the genus Agave, such as A. americana and A. sisalana, are widely cultivated in the south part for the fibre industry and as important horticultural plants. Agave americana L., a very large plant with rosettes up to 12 feet broad, is used as an important source for not only textile fibre, but also steroidal sapogenins such as hecogenin and tigogenin in China. The plant is also used as folk medicine for its antiinflammatory and anti-fungus effects on the treatment of uterus blooding, scabies, etc. Since the chemical investigation on the fermented residues of the leaf-juice of A. sisalana led to the identification of some tigogenin glyco...

Molecules, 2019

This study was designed to explore the in vitro anticancer effects of the bioactive compounds iso... more This study was designed to explore the in vitro anticancer effects of the bioactive compounds isolated from Ricinodendron heudelotii on selected cancer cell lines. The leaves of the plant were extracted with ethanol and partitioned in sequence with petroleum ether, ethyl acetate, and n-butanol. The ethyl acetate fraction was phytochemically studied using thin layer chromatography (TLC) and column chromatography (CC). Structural elucidation of pure compounds obtained from the ethyl acetate fraction was done using mass spectra, 1H-NMR, and 13C-NMR analysis. The isolated compounds were subsequently screened using five different cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, SW-480, and normal lung epithelial cell line, BEAS-2B, to assess their cytotoxic effects. Nine compounds were isolated and structurally elucidated as gallic acid, gallic acid ethyl ester, corilagin, quercetin-3-O-rhamnoside, myricetin-3-O-rhamnoside, 1,4,6-tri-O-galloyl glucose, 3,4,6-tri-O-galloyl glucose, 1,2,...

Natural Products and Bioprospecting, 2017

Natural Product Research, 2014

Natural Products and Bioprospecting, Oct 1, 2014

RSC Advances

Nine new nontriterpenoids were identified from Panax notoginseng rot roots, and their cytotoxicit... more Nine new nontriterpenoids were identified from Panax notoginseng rot roots, and their cytotoxicities may be related to the EGFR inhibition.

Natural Products and Bioprospecting

A new seco-anthraquinone, crispuside A (1), and three new 3,4-dihydronaphthalen-1(2H)-ones, napth... more A new seco-anthraquinone, crispuside A (1), and three new 3,4-dihydronaphthalen-1(2H)-ones, napthalenones A-C (2–4), were isolated from the roots of Rumex crispus L., along with 10 known anthraquinones (6–14) and naphthalenone (5). Their structures were fully determined by extensive spectroscopic analyses, including ECD, and X-ray crystallography in case of compound 5, whose absolute configuration was determined for the first time. The isolates 1, 6–14 were evaluated for their anti-inflammatory and anti-fungal activity against three skin fungi, e.g., Epidermophyton floccosum, Trichophyton rubrum, and Microsporum gypseum. Most of the isolates showed weak anti-fungal and anti-inflammatory activity. Only compound 9 exhibited obvious anti-fungal activity against E. floccosum (MIC50 = 2.467 ± 0.03 μM) and M. gypseum (MIC50 = 4.673 ± 0.077 μM), while the MIC50 values of the positive control terbinafine were 1.287 ± 0.012 and 0.077 ± 0.00258 μM, respectively. The results indicated that sim...

Natural Products and Bioprospecting

Rumex L., a genus in Polygonaceae family with about 200 species, is growing widely around the wor... more Rumex L., a genus in Polygonaceae family with about 200 species, is growing widely around the world. Some Rumex species, called "sorrel" or "dock", have been used as food application and treatment of skin diseases and hemostasis after trauma by the local people of its growing areas for centuries. To date, 29 Rumex species have been studied to contain about 268 substances, including anthraquinones, flavonoids, naphthalenes, stilbenes, diterpene alkaloids, terpenes, lignans, and tannins. Crude extract of Rumex spp. and the pure isolates displayed various bioactivities, such as antibacterial, anti-inflammatory, antitumor, antioxidant, cardiovascular protection and antiaging activities. Rumex species have important potential to become a clinical medicinal source in future. This review covers research articles from 1900 to 2022, fetched from SciFinder, Web of Science, ResearchGate, CNKI and Google Scholar, using “Rumex” as a search term ("all fields") with n...

A new catechin derivative named as sterilin A (<b>1</b>), and three known compounds, ... more A new catechin derivative named as sterilin A (<b>1</b>), and three known compounds, (+)-catechin (<b>2</b>), kaji-ichigoside F1 (<b>3</b>) and 2α,3α,19α-trihydroxyurs-12-en-28-oic acid-28-<i>O</i>-β-D-xylopyranosyl-(1 → 2)-β-D-glucopyranoside (<b>4</b>), was isolated from the fresh fruits of <i>Rosa sterilis</i>. Their structures were elucidated by means of extensive spectroscopic analysis and by comparison with data reported in the literatures.

A novel highly oxygenated norbisabolane sesquiterpene, namely phyllanthacidoid U (1), along with ... more A novel highly oxygenated norbisabolane sesquiterpene, namely phyllanthacidoid U (1), along with nine known sesquiterpenes (2–10) was isolated from the roots and stems of <i>Phyllanthus acidus</i> (L.) Skeels (Phyllanthaceae), collected from Xishuangbanna, Yunnan province, China. Their structures were elucidated by means of extensive spectroscopic analysis and by comparison of their data with reported values in literatures. Instead of the C-13 ester <i>O</i>-glycosyl found mostly in the titled plant growing in Thailand, compound <b>1</b> possessed a rare <i>N</i>-<i>β</i>-glucosamine-2-<i>N</i>-acetate moiety linked directly to the carbonyl at C-13 through an amido bond. Moreover, the acyl group at C-10 in <b>1</b> was (<i>Z</i>)-2-(2-hydroxyethyl)-pent-2-enedioyl group, instead of benzoic or <i>p</i>-hydroxybenzoic moieties found commonly in the reported norbisabolane sesquit...

A new arbutin derivative, namely dunalianosides J (<b>1</b>), along with six known co... more A new arbutin derivative, namely dunalianosides J (<b>1</b>), along with six known compounds, arbutin (<b>2</b>), robustaside A (<b>3</b>), 6′-<i>O</i>-caffeoylarbutin (<b>4</b>), dunalianoside D (<b>5</b>), kaempferol 3-<i>O</i>-<i>β</i>-D-glucopyranoside (<b>6</b>) and kaempferol 3-<i>O</i>-<i>β</i>-D-sambubioside (<b>7</b>) were isolated from the leaves of <i>Vaccinium dunalianum</i> Wight (Ericaceae). The structure of <b>1</b> was elucidated by extensive 1D and 2D NMR, HR-MS and CD spectroscopic analyses. In which, kaempferol 3-<i>O</i>-<i>β</i>-D-sambubioside (<b>7</b>) was isolated from the genus <i>Vaccinium</i> for the first time.

Natural Product Research, 2020

Natural Product Research, 2019

Natural Product Research, 2018

RSC Adv., 2014

Eucalmaidials A and B, representing a new skeleton of phloroglucinol-coupled iphionane, were isol... more Eucalmaidials A and B, representing a new skeleton of phloroglucinol-coupled iphionane, were isolated from the juvenile leaves of Eucalyptus maideni.

Journal of the Brazilian Chemical Society, 2014

RSC Advances, 2015

Theoretical calculated electronic circular dichroism and Mosher’s method were applied to elucidat... more Theoretical calculated electronic circular dichroism and Mosher’s method were applied to elucidate the stereochemistry of cleistanthane diterpenoids.

Organic & biomolecular chemistry, Jan 21, 2014

During the process exploring anti-viral compounds from Phyllanthus species, eight new highly oxyg... more During the process exploring anti-viral compounds from Phyllanthus species, eight new highly oxygenated bisabolane sesquiterpenoid glycoside phyllaemblicins G1–G8 (1–8) were isolated from Phyllanthus emblica, along with three known compounds, phyllaemblicin F (9), phyllaemblic acid (10) and glochicoccin D (11). Phyllaemblicin G2 (2), bearing a tricyclo [3.1.1.1] oxygen bridge ring system, is an unusual sesquiterpenoid glycoside, while phyllaemblicins G6–G8 (6–8) are dimeric sesquiterpenoid glycosides with two norbisabolane units connecting through a disaccharide. All the structures were elucidated by the extensive analysis of HRMS and NMR data. The relative configuration of phyllaemblicin G2 was constructed based on heteronuclear coupling constants measurement, and the absolute configurations for all new compounds were established by calculated electronic circular dichroism (ECD) using time dependent density functional theory. The sesquiterpenoid glycoside dimers 6–9 displayed poten...