Hajera Tabassum | King Saud University (original) (raw)
Papers by Hajera Tabassum
American-Eurasian Journal of Agricultural and Environmental Science, 2010
Recently, natural products have been evaluated as sources of antimicrobial agents with efficacies... more Recently, natural products have been evaluated as sources of antimicrobial agents with efficacies against a variety of microorganisms. This study described the antibacterial and antifungal activities of pomegranate peel extract (rind), seed extract, juice and whole fruit on the selected bacteria and fungi. The peel extract has shown highest antimicrobial activity compared to other extracts. Among the selected bacterial and fungal cultures, the highest antibacterial activity was recorded against Staphylococcus aureus and among fungi high activity against Aspergillus niger was recorded.
Separations
A newly UHPLC-MS/MS method development and validation for S-Allyl Cysteine was used to evaluate t... more A newly UHPLC-MS/MS method development and validation for S-Allyl Cysteine was used to evaluate the comparative pharmacokinetic parameters. SC PLGA NPs (S-Allyl Cysteine Poly (D,L-lactide-co-glycolic acid) Nanoparticles) were developed by the emulsion solvent evaporation method. SC PLGA NPs showed their drug loading and encapsulation efficiency to be 5.13 ± 0.10% and 82.36 ± 4.01%, respectively. SC PLGA NPs showed a spherical morphology of an average size (134.8 ± 4.61 nm), PDI: 0.277 ± 0.004, and −25.3 ± 1.03 mV Zeta-Potential (ZP), and is suitable for oral delivery. The development and validation of the UHPLC-MS/MS bioanalytical method were performed successfully for PK-parameter examinations with 1.219 min RT, MS (162.00/73.10), and a total run-time of 2.0 min. Additionally, 1.0–1000.0 ng/mL was a linear range with inter- and intra-day accuracy of 92.55–99.40%, followed by a precision of 1.88–4.23%. SC PLGA NP’s oral bioavailability was significantly higher (** p < 0.01) in co...
International Journal of Molecular Sciences
Humans exploit heavy metals for various industrial and economic reasons. Although some heavy meta... more Humans exploit heavy metals for various industrial and economic reasons. Although some heavy metals are essential for normal physiology, others such as Tellurium (Te), Thallium (TI), antimony (Sb), and Osmium (Os) are highly toxic and can lead to Polycystic Ovarian Syndrome (PCOS), a common female factor of infertility. The current study was undertaken to determine levels of the heavy metals TI, Te, Sb and Os in serum of PCOS females (n = 50) compared to healthy non-PCOS controls (n = 56), and to relate such levels with Total Antioxidant Capacity (TAC), activity of key antioxidant enzymes, oxidative stress marker levels and redox status. PCOS serum samples demonstrated significantly higher levels of TI, Te, Sb and Os and diminished TAC compared to control (p < 0.001). Furthermore, there was significant inhibition of SOD, CAT and several glutathione-related enzyme activities in sera of PCOS patients with concurrent elevations in superoxide anions, hydrogen and lipid peroxides, and...
A newly UHPLC-MS/MS method development and validation for S-Allyl Cysteine was used to evaluate t... more A newly UHPLC-MS/MS method development and validation for S-Allyl Cysteine was used to evaluate the comparative pharmacokinetic parameters. SC PLGA NPs were developed by the emulsion solvent evaporation method. SC PLGA NPs showed their drug loading and encapsulation efficiency i.e. 5.13±0.10% and 82.36±4.01%, respectively. SC PLGA NPs showed a spherical morphology on an average size (134.8±4.61nm), PDI: 0.277±0.004, and −25.3±1.03mV zeta-potential is suitable for oral delivery. Development and validation of the UHPLC-MS/MS bioanalytical method were performed successfully for PK-parameters examinations with 1.219-minutes RT, MS (162.00/73.10), and a total run-time was 2.0-minutes. 1.0–1000.0ng/mL was a linear-range with inter & intra-day accuracy (92.55–99.40%) followed by precision (1.88–4.23%). SC PLGA NPs oral bioavailability was significantly higher (**p<0.01) as compared to SC-S treated groups (iv & oral). We found that the antimicrobial activity of SC PLGA NPs was more effec...
Molecules, Feb 13, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Asian Pacific Journal of Tropical Biomedicine
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud Univer... more Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia E-mail : manalkhalid2005@yahoo.com, sarjumand13@gmail.com, muskaanht@yahoo.com, sfatima2013@yahoo.com, noura_jameil@yahoo.com Manuscript received online 29 October 2013, revised 08 November 2013, accepted 09 January 2014 Approximately 5% of the world's population carries trait genes for haemoglobin disorders, mainly, sickle cell disease and thalassemia. Haemoglobin disorders are genetic blood diseases due to inheritance of mutant haemoglobin genes from both, generally healthy parents. Sickle cell disease and <strong>β</strong>-thalassaemia are most common in eastern province of Saudi Arabia. The present study was undertaken to analyze the variation in levels of haemoglobin (<strong>Hb</strong>) types in different haemoglobin disorders in samples of patients from Riyadh, Saudi Arabia by <strong>CAE</strong> and <s...
Carpathian Journal of Food Science and Technology
International Food Research Journal
Green synthesis of silver nanoparticles (AgNPs) has consistently revolutionised the field of nano... more Green synthesis of silver nanoparticles (AgNPs) has consistently revolutionised the field of nanotechnology, and bio-based AgNPs have emerged as efficient therapeutic tools in biomedical science. The present work focused on the synthesis and characterisation of eco-friendly AgNPs from Brassica nigra (BN), and the evaluation of antibacterial, antifungal, anticancer, and antioxidant activity in the MCF-7 human breast cancer cells. The characteristics of BN-AgNPs was studied using ultraviolet-visible (UV-Vis) spectroscopy, particle size analysis, electro kinetic/zeta potential analysis, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Elemental composition was determined using energy-dispersive spectroscopy (EDX). UV-Vis spectroscopy confirmed the formation of BN-AgNPs. The TEM micrographs showed that BN-AgNPs were spherical and well distributed in the solution without aggregation. Anticancer activity was determined at different BN-AgNPs concentrations in...
International Journal of Medical and Health Research, 2020
Biomedical Research-tokyo, 2015
Preeclampsia is characterized by new-onset hypertension, proteinuria and is responsible for subst... more Preeclampsia is characterized by new-onset hypertension, proteinuria and is responsible for substantial maternal and fetal morbidity. The electrolytes like sodium, potassium and chloride contribute significantly in the functioning of the vascular smooth muscles and may play an important role in the aetiopathogenesis of hypertension. The present study was undertaken to evaluate the role of serum ionized sodium, potassium and chloride levels as a predisposing factor in the genesis of preeclampsia and to find out the association of these elements with blood pressure in preeclamptic pregnant women living in Riyadh, Saudi Arabia. One hundred and twenty subjects were enrolled in this case-controlled study and divided into three groups; control, highrisk of preeclampsia (HR) and preeclampsia (PET) of 40 each. Blood samples were obtained from all the patients and the serum levels of sodium, potassium and chloride were determined. Statistical analysis was performed by one way ANOVA and Pears...
Biomedical Research-tokyo, 2016
Vitamin D plays a critical role in bone metabolism and many cellular and immunological processes.... more Vitamin D plays a critical role in bone metabolism and many cellular and immunological processes. Serum 25-hydroxyvitamin D3 [25(OH)D3] is produced in the skin in response to exposure to ultraviolet radiation, and is a good indicator of vitamin D status. The aim of this study was to determine summer/ winter differences in serum 25(OH)D3 and Parathyroid Hormone (PTH) in Saudi pre and postmenopausal women and in adult males. We focused on the interaction of Vitamin D with other biochemical markers of bone metabolism like PTH, ALP and Calcium and how it varies on seasonal changes. The subjects were 115 Saudi adults divided into three groups; 31 males, 42 premenopausal and 42 postmenopausal women. They were medically examined twice, in summer (April-July 2014) and winter (December 2014-February 2015) months. 25(OH)D3, PTH, TSH, ALP, calcium and inorganic phosphorus were estimated and found that status of vitamin D varies significantly with seasonal changes (highest being in summer), age...
Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and is associated with dyslipid... more Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and is associated with dyslipidemia and disturbed liver function. Aim of the present work is to assess the liver enzymes and to find its association with hyperlipidemic profile in T2DM. Total of 157 subjects were studied and divided into two groups; diabetes (n=81) and non-diabetes (n=76). Various biochemical parameters like fasting glucose, post prandial glucose, HbA1c, total cho- lesterol (TC), triglycerides (Tg), high density lipoprotein cholesterol (HDL-C), alanine amino transferase (ALT), aspar- tate amino transferase (AST) and gamma-glutamyl transferase (GGT) were analyzed by ROCHE module Cobas 6000 (C501 & C601) analyzer, kits were procured by ROCHE diagnostics. Low density lipoprotein cholesterol (LDL-C) was estimated by Freidwald's formula. Statistical analysis was performed by applying student t test and Pearson's cor- relation coefficient, at 0.0001 and 0.05 level of significance, respectively. All ...
Biomedical Research-tokyo, 2014
Diabetic nephropathy is the consequence of diabetes mellitus (DM) and it is characterized by cont... more Diabetic nephropathy is the consequence of diabetes mellitus (DM) and it is characterized by continuous albuminuria. The aim of the study was to investigate and correlate the lipid profile abnormalities in different stages of albuminuria to understand the checkpoint before progression to end stage renal disease (ESRD). A total of 154 type 2 diabetic patients were included in the study. Urine samples of all patients were subject to biochemical analysis and divided into diabetes with normoalbuminuria (n=52), diabetes with microalbuminuria (n=51), and diabetes with overt proteinuria (n=51) groups, depending upon urinary albumin creatinine ratio (ACR) of 300 mg/24 hours respectively. Statistical analysis was done by using One Way ANOVA and Pearson’s correlation coefficient. All lipid profile parameters, such as total cholesterol (TC), triglycerides (Tg), low density lipoprotein (LDL), very low density lipoprotein (VLDL) mean values except high density lipoprotein cholesterol (HDL-C) wer...
Auto immune thyroid disease (AITD) is the common organ specific autoimmune disorder, Hashimoto th... more Auto immune thyroid disease (AITD) is the common organ specific autoimmune disorder, Hashimoto thyroiditis (HT) and Grave's disease (GD) are its well-known sequelae. It occurs due to loss of tolerance to autoantigens thyroid peroxidase (TPO), thyroglobulin (Tg), thyroid stimulating hormone receptor (TSH-R) which leads to the infiltration of the gland. T cells in chronic autoimmune thyroiditis (cAIT) induce apoptosis in thyroid follicular cells and cause destruction of the gland. Presences of TPO antibodies are common in HT and GD, while Tg has been reported as an independent predictor of thyroid malignancy. Cytokines are small proteins play an important role in autoimmunity, by stimulating B and T cells. Various cytokines IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL- 14, TNF-α and IFN-γ are found in thyroid follicular cells which enhance inflammatory response with nitric oxide (NO) and prostaglandins.
International journal of pharma and bio sciences, 2012
The present study describes the antibacterial activity of five selected fruits on four pathogenic... more The present study describes the antibacterial activity of five selected fruits on four pathogenic bacteria isolated from patients suffering with wound infections. Ethanolic extracts of fruits were more effective than aqueous extracts. Punica granatum has shown highest antibacterial activity followed by Malus domestica, Citrus limonium and Citrus limetta. Lowest antibacterial activity was recorded for Solanum lycospersicum. Among all bacteria tested highest antibacterial activity was recorded against S. aureus and least was recorded for K. pneumoniae.
International Journal of Gynecology & Obstetrics
Auto immune thyroid disease (AITD) is the common organ specific autoimmune disorder, Hashimoto th... more Auto immune thyroid disease (AITD) is the common organ specific autoimmune disorder, Hashimoto thyroiditis (HT) and Grave's disease (GD) are its well-known sequelae. It occurs due to loss of tolerance to autoantigens thyroid peroxidase (TPO), thyroglobulin (Tg), thyroid stimulating hormone receptor (TSH-R) which leads to the infiltration of the gland. T cells in chronic autoimmune thyroiditis (cAIT) induce apoptosis in thyroid follicular cells and cause destruction of the gland. Presences of TPO antibodies are common in HT and GD, while Tg has been reported as an independent predictor of thyroid malignancy. Cytokines are small proteins play an important role in autoimmunity, by stimulating B and T cells. Various cytokines IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-14, TNF-α and IFN-γ are found in thyroid follicular cells which enhance inflammatory response with nitric oxide (NO) and prostaglandins.
American-Eurasian Journal of Agricultural and Environmental Science, 2010
3 Abstract: Recently, natural products have been evaluated as sources of antimicrobial agents wit... more 3 Abstract: Recently, natural products have been evaluated as sources of antimicrobial agents with efficacies against a variety of microorganisms. This study described the antibacterial and antifungal activities of pomegranate peel extract (rind), seed extract, juice and whole fruit on the selected bacteria and fungi. The peel extract has shown highest antimicrobial activity compared to other extracts. Among the selected bacterial and fungal cultures, the highest antibacterial activity was recorded against Staphylococcus aureus and among fungi high activity against Aspergillus niger was recorded.
International journal of clinical and experimental pathology, 2014
Preeclampsia complicates 2-8% of all pregnancies and is one of the leading causes of maternal mor... more Preeclampsia complicates 2-8% of all pregnancies and is one of the leading causes of maternal mortality and pre-term delivery in world. In concern to the increasing number of preeclamptic cases and lack of data about the interrelation between levels of trace elements and preeclampsia, we conducted a hospital based case-control study to assess the risk of preeclampsia in relation to concentrations of trace elements like copper, manganese and zinc in a hospital in Riyadh, Saudi Arabia. The study consisted of 120 pregnant women divided into three groups of 40 each--control, HR group and the PET group. The serum levels of Cu, Mn and Zn were estimated by inductively coupled plasma optical emission spectrometry. Analysis of trace elements revealed that mean values of Cu, Mn and Zn were 2.01±0.43, 0.125±0.07 and 1.30±0.83 mg/L respectively in control. In preeclamptic group, the mean values of Cu, Mn and Zn were 1.554±0.53, 0.072±0.06 and 0.67±0.59 mg/L respectively. Levels of Cu and Zn wer...
American-Eurasian Journal of Agricultural and Environmental Science, 2010
Recently, natural products have been evaluated as sources of antimicrobial agents with efficacies... more Recently, natural products have been evaluated as sources of antimicrobial agents with efficacies against a variety of microorganisms. This study described the antibacterial and antifungal activities of pomegranate peel extract (rind), seed extract, juice and whole fruit on the selected bacteria and fungi. The peel extract has shown highest antimicrobial activity compared to other extracts. Among the selected bacterial and fungal cultures, the highest antibacterial activity was recorded against Staphylococcus aureus and among fungi high activity against Aspergillus niger was recorded.
Separations
A newly UHPLC-MS/MS method development and validation for S-Allyl Cysteine was used to evaluate t... more A newly UHPLC-MS/MS method development and validation for S-Allyl Cysteine was used to evaluate the comparative pharmacokinetic parameters. SC PLGA NPs (S-Allyl Cysteine Poly (D,L-lactide-co-glycolic acid) Nanoparticles) were developed by the emulsion solvent evaporation method. SC PLGA NPs showed their drug loading and encapsulation efficiency to be 5.13 ± 0.10% and 82.36 ± 4.01%, respectively. SC PLGA NPs showed a spherical morphology of an average size (134.8 ± 4.61 nm), PDI: 0.277 ± 0.004, and −25.3 ± 1.03 mV Zeta-Potential (ZP), and is suitable for oral delivery. The development and validation of the UHPLC-MS/MS bioanalytical method were performed successfully for PK-parameter examinations with 1.219 min RT, MS (162.00/73.10), and a total run-time of 2.0 min. Additionally, 1.0–1000.0 ng/mL was a linear range with inter- and intra-day accuracy of 92.55–99.40%, followed by a precision of 1.88–4.23%. SC PLGA NP’s oral bioavailability was significantly higher (** p < 0.01) in co...
International Journal of Molecular Sciences
Humans exploit heavy metals for various industrial and economic reasons. Although some heavy meta... more Humans exploit heavy metals for various industrial and economic reasons. Although some heavy metals are essential for normal physiology, others such as Tellurium (Te), Thallium (TI), antimony (Sb), and Osmium (Os) are highly toxic and can lead to Polycystic Ovarian Syndrome (PCOS), a common female factor of infertility. The current study was undertaken to determine levels of the heavy metals TI, Te, Sb and Os in serum of PCOS females (n = 50) compared to healthy non-PCOS controls (n = 56), and to relate such levels with Total Antioxidant Capacity (TAC), activity of key antioxidant enzymes, oxidative stress marker levels and redox status. PCOS serum samples demonstrated significantly higher levels of TI, Te, Sb and Os and diminished TAC compared to control (p < 0.001). Furthermore, there was significant inhibition of SOD, CAT and several glutathione-related enzyme activities in sera of PCOS patients with concurrent elevations in superoxide anions, hydrogen and lipid peroxides, and...
A newly UHPLC-MS/MS method development and validation for S-Allyl Cysteine was used to evaluate t... more A newly UHPLC-MS/MS method development and validation for S-Allyl Cysteine was used to evaluate the comparative pharmacokinetic parameters. SC PLGA NPs were developed by the emulsion solvent evaporation method. SC PLGA NPs showed their drug loading and encapsulation efficiency i.e. 5.13±0.10% and 82.36±4.01%, respectively. SC PLGA NPs showed a spherical morphology on an average size (134.8±4.61nm), PDI: 0.277±0.004, and −25.3±1.03mV zeta-potential is suitable for oral delivery. Development and validation of the UHPLC-MS/MS bioanalytical method were performed successfully for PK-parameters examinations with 1.219-minutes RT, MS (162.00/73.10), and a total run-time was 2.0-minutes. 1.0–1000.0ng/mL was a linear-range with inter & intra-day accuracy (92.55–99.40%) followed by precision (1.88–4.23%). SC PLGA NPs oral bioavailability was significantly higher (**p<0.01) as compared to SC-S treated groups (iv & oral). We found that the antimicrobial activity of SC PLGA NPs was more effec...
Molecules, Feb 13, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Asian Pacific Journal of Tropical Biomedicine
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud Univer... more Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia E-mail : manalkhalid2005@yahoo.com, sarjumand13@gmail.com, muskaanht@yahoo.com, sfatima2013@yahoo.com, noura_jameil@yahoo.com Manuscript received online 29 October 2013, revised 08 November 2013, accepted 09 January 2014 Approximately 5% of the world's population carries trait genes for haemoglobin disorders, mainly, sickle cell disease and thalassemia. Haemoglobin disorders are genetic blood diseases due to inheritance of mutant haemoglobin genes from both, generally healthy parents. Sickle cell disease and <strong>β</strong>-thalassaemia are most common in eastern province of Saudi Arabia. The present study was undertaken to analyze the variation in levels of haemoglobin (<strong>Hb</strong>) types in different haemoglobin disorders in samples of patients from Riyadh, Saudi Arabia by <strong>CAE</strong> and <s...
Carpathian Journal of Food Science and Technology
International Food Research Journal
Green synthesis of silver nanoparticles (AgNPs) has consistently revolutionised the field of nano... more Green synthesis of silver nanoparticles (AgNPs) has consistently revolutionised the field of nanotechnology, and bio-based AgNPs have emerged as efficient therapeutic tools in biomedical science. The present work focused on the synthesis and characterisation of eco-friendly AgNPs from Brassica nigra (BN), and the evaluation of antibacterial, antifungal, anticancer, and antioxidant activity in the MCF-7 human breast cancer cells. The characteristics of BN-AgNPs was studied using ultraviolet-visible (UV-Vis) spectroscopy, particle size analysis, electro kinetic/zeta potential analysis, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Elemental composition was determined using energy-dispersive spectroscopy (EDX). UV-Vis spectroscopy confirmed the formation of BN-AgNPs. The TEM micrographs showed that BN-AgNPs were spherical and well distributed in the solution without aggregation. Anticancer activity was determined at different BN-AgNPs concentrations in...
International Journal of Medical and Health Research, 2020
Biomedical Research-tokyo, 2015
Preeclampsia is characterized by new-onset hypertension, proteinuria and is responsible for subst... more Preeclampsia is characterized by new-onset hypertension, proteinuria and is responsible for substantial maternal and fetal morbidity. The electrolytes like sodium, potassium and chloride contribute significantly in the functioning of the vascular smooth muscles and may play an important role in the aetiopathogenesis of hypertension. The present study was undertaken to evaluate the role of serum ionized sodium, potassium and chloride levels as a predisposing factor in the genesis of preeclampsia and to find out the association of these elements with blood pressure in preeclamptic pregnant women living in Riyadh, Saudi Arabia. One hundred and twenty subjects were enrolled in this case-controlled study and divided into three groups; control, highrisk of preeclampsia (HR) and preeclampsia (PET) of 40 each. Blood samples were obtained from all the patients and the serum levels of sodium, potassium and chloride were determined. Statistical analysis was performed by one way ANOVA and Pears...
Biomedical Research-tokyo, 2016
Vitamin D plays a critical role in bone metabolism and many cellular and immunological processes.... more Vitamin D plays a critical role in bone metabolism and many cellular and immunological processes. Serum 25-hydroxyvitamin D3 [25(OH)D3] is produced in the skin in response to exposure to ultraviolet radiation, and is a good indicator of vitamin D status. The aim of this study was to determine summer/ winter differences in serum 25(OH)D3 and Parathyroid Hormone (PTH) in Saudi pre and postmenopausal women and in adult males. We focused on the interaction of Vitamin D with other biochemical markers of bone metabolism like PTH, ALP and Calcium and how it varies on seasonal changes. The subjects were 115 Saudi adults divided into three groups; 31 males, 42 premenopausal and 42 postmenopausal women. They were medically examined twice, in summer (April-July 2014) and winter (December 2014-February 2015) months. 25(OH)D3, PTH, TSH, ALP, calcium and inorganic phosphorus were estimated and found that status of vitamin D varies significantly with seasonal changes (highest being in summer), age...
Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and is associated with dyslipid... more Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and is associated with dyslipidemia and disturbed liver function. Aim of the present work is to assess the liver enzymes and to find its association with hyperlipidemic profile in T2DM. Total of 157 subjects were studied and divided into two groups; diabetes (n=81) and non-diabetes (n=76). Various biochemical parameters like fasting glucose, post prandial glucose, HbA1c, total cho- lesterol (TC), triglycerides (Tg), high density lipoprotein cholesterol (HDL-C), alanine amino transferase (ALT), aspar- tate amino transferase (AST) and gamma-glutamyl transferase (GGT) were analyzed by ROCHE module Cobas 6000 (C501 & C601) analyzer, kits were procured by ROCHE diagnostics. Low density lipoprotein cholesterol (LDL-C) was estimated by Freidwald's formula. Statistical analysis was performed by applying student t test and Pearson's cor- relation coefficient, at 0.0001 and 0.05 level of significance, respectively. All ...
Biomedical Research-tokyo, 2014
Diabetic nephropathy is the consequence of diabetes mellitus (DM) and it is characterized by cont... more Diabetic nephropathy is the consequence of diabetes mellitus (DM) and it is characterized by continuous albuminuria. The aim of the study was to investigate and correlate the lipid profile abnormalities in different stages of albuminuria to understand the checkpoint before progression to end stage renal disease (ESRD). A total of 154 type 2 diabetic patients were included in the study. Urine samples of all patients were subject to biochemical analysis and divided into diabetes with normoalbuminuria (n=52), diabetes with microalbuminuria (n=51), and diabetes with overt proteinuria (n=51) groups, depending upon urinary albumin creatinine ratio (ACR) of 300 mg/24 hours respectively. Statistical analysis was done by using One Way ANOVA and Pearson’s correlation coefficient. All lipid profile parameters, such as total cholesterol (TC), triglycerides (Tg), low density lipoprotein (LDL), very low density lipoprotein (VLDL) mean values except high density lipoprotein cholesterol (HDL-C) wer...
Auto immune thyroid disease (AITD) is the common organ specific autoimmune disorder, Hashimoto th... more Auto immune thyroid disease (AITD) is the common organ specific autoimmune disorder, Hashimoto thyroiditis (HT) and Grave's disease (GD) are its well-known sequelae. It occurs due to loss of tolerance to autoantigens thyroid peroxidase (TPO), thyroglobulin (Tg), thyroid stimulating hormone receptor (TSH-R) which leads to the infiltration of the gland. T cells in chronic autoimmune thyroiditis (cAIT) induce apoptosis in thyroid follicular cells and cause destruction of the gland. Presences of TPO antibodies are common in HT and GD, while Tg has been reported as an independent predictor of thyroid malignancy. Cytokines are small proteins play an important role in autoimmunity, by stimulating B and T cells. Various cytokines IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL- 14, TNF-α and IFN-γ are found in thyroid follicular cells which enhance inflammatory response with nitric oxide (NO) and prostaglandins.
International journal of pharma and bio sciences, 2012
The present study describes the antibacterial activity of five selected fruits on four pathogenic... more The present study describes the antibacterial activity of five selected fruits on four pathogenic bacteria isolated from patients suffering with wound infections. Ethanolic extracts of fruits were more effective than aqueous extracts. Punica granatum has shown highest antibacterial activity followed by Malus domestica, Citrus limonium and Citrus limetta. Lowest antibacterial activity was recorded for Solanum lycospersicum. Among all bacteria tested highest antibacterial activity was recorded against S. aureus and least was recorded for K. pneumoniae.
International Journal of Gynecology & Obstetrics
Auto immune thyroid disease (AITD) is the common organ specific autoimmune disorder, Hashimoto th... more Auto immune thyroid disease (AITD) is the common organ specific autoimmune disorder, Hashimoto thyroiditis (HT) and Grave's disease (GD) are its well-known sequelae. It occurs due to loss of tolerance to autoantigens thyroid peroxidase (TPO), thyroglobulin (Tg), thyroid stimulating hormone receptor (TSH-R) which leads to the infiltration of the gland. T cells in chronic autoimmune thyroiditis (cAIT) induce apoptosis in thyroid follicular cells and cause destruction of the gland. Presences of TPO antibodies are common in HT and GD, while Tg has been reported as an independent predictor of thyroid malignancy. Cytokines are small proteins play an important role in autoimmunity, by stimulating B and T cells. Various cytokines IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-14, TNF-α and IFN-γ are found in thyroid follicular cells which enhance inflammatory response with nitric oxide (NO) and prostaglandins.
American-Eurasian Journal of Agricultural and Environmental Science, 2010
3 Abstract: Recently, natural products have been evaluated as sources of antimicrobial agents wit... more 3 Abstract: Recently, natural products have been evaluated as sources of antimicrobial agents with efficacies against a variety of microorganisms. This study described the antibacterial and antifungal activities of pomegranate peel extract (rind), seed extract, juice and whole fruit on the selected bacteria and fungi. The peel extract has shown highest antimicrobial activity compared to other extracts. Among the selected bacterial and fungal cultures, the highest antibacterial activity was recorded against Staphylococcus aureus and among fungi high activity against Aspergillus niger was recorded.
International journal of clinical and experimental pathology, 2014
Preeclampsia complicates 2-8% of all pregnancies and is one of the leading causes of maternal mor... more Preeclampsia complicates 2-8% of all pregnancies and is one of the leading causes of maternal mortality and pre-term delivery in world. In concern to the increasing number of preeclamptic cases and lack of data about the interrelation between levels of trace elements and preeclampsia, we conducted a hospital based case-control study to assess the risk of preeclampsia in relation to concentrations of trace elements like copper, manganese and zinc in a hospital in Riyadh, Saudi Arabia. The study consisted of 120 pregnant women divided into three groups of 40 each--control, HR group and the PET group. The serum levels of Cu, Mn and Zn were estimated by inductively coupled plasma optical emission spectrometry. Analysis of trace elements revealed that mean values of Cu, Mn and Zn were 2.01±0.43, 0.125±0.07 and 1.30±0.83 mg/L respectively in control. In preeclamptic group, the mean values of Cu, Mn and Zn were 1.554±0.53, 0.072±0.06 and 0.67±0.59 mg/L respectively. Levels of Cu and Zn wer...