MAY ALSENANI | King Saud University (original) (raw)

Papers by MAY ALSENANI

Research paper thumbnail of Teeth segmentation by optical radiographic images using VGG-16 deep learning convolution architecture with R-CNN network approach for biomedical sensing applications

Optical and Quantum Electronics

Research paper thumbnail of The role of intraregional dexamethasone injection in the treatment of recurrent tongue mucocele (clinical trial): A case report

Medical Science

Mucocele is the most common minor salivary gland-associated disease of the oral cavity. It involv... more Mucocele is the most common minor salivary gland-associated disease of the oral cavity. It involves mucin accumulation causing limited swelling. In recent years, extensive evidence has been published about the usage of intralesional corticosteroid injection in treating mucoceles in adult patients. The aim of the present case report was to assess the effectiveness of intralesional dexamethasone injection in the treatment of mucocele. Two histological types exist: Extravasation and retention. One of the most common oral lesions to be biopsied in pediatric patients is mucocele. Mucoceles can appear at any site of the oral mucosa where minor salivary glands are present. The significant number of cases should be properly conducted in order to check for any prior trauma because the diagnosis is mostly clinical in nature. The lower lip area is where extravasation mucocele most frequently appears, while retention mucoceles can be found at any other site. Mucoceles can affect anybody, however young people are most frequently affected (20-30 years old). Clinically they consist of a soft, bluish and transparent cystic swelling which normally resolves spontaneously. Surgery is commonly used as a kind of treatment. However, other treatments including CO2 laser, cryosurgery, steroid injections and 7 micromarsupialization are also advised. This report reports a case of recurrence of mucocele on the tongue's ventral surface that was unsuccessfully managed five times. Intraregional dexamethasone injection (0.5 ml of 2 g) was found more effective than surgical removal.

Research paper thumbnail of Knowledge and awareness assessment of cross-contamination of dental floss containers in King Saud University dental hospital clinics

Research paper thumbnail of Factors Influencing Study Choices, Career Preferences, andInterest in Oral Medicine Among Senior Dental Students in Riyadh,Kingdom of Saudi Arabia, A Cross-Sectional Study

EC Dental Science, Sep 25, 2021

Research paper thumbnail of Prevalence and severity of temporomandibular disorders among university students in Riyadh

The Saudi Dental Journal, 2015

The aim of this study was to evaluate the prevalence and severity of temporomandibular disorders ... more The aim of this study was to evaluate the prevalence and severity of temporomandibular disorders (TMDs) among male university students in Riyadh, Saudi Arabia. The role of relevant medical and dental histories in the assessment of TMD in this Arab population was also addressed. Methods: Required information was collected via a questionnaire. The first part of the questionnaire was used to obtain the medical and dental histories of participants. The second part included 10 questions regarding common TMD symptoms. Fonseca's anamnestic index (FAI) was used to classify TMD severity as ''no dysfunction'', ''light dysfunction'', ''moderate dysfunction'', or ''severe dysfunction''. Results: Of the 600 distributed questionnaires, 400 questionnaires were completed (response rate: 66.6%). Mean age of eligible participants was 21.90 ± 1.79 years. Psychological stress (30.5%) and direct restorations (77%) were the most commonly reported items on the medical and dental histories respectively for the total number of participants. According to the FAI, 53.2% of participants were classified as having no dysfunction, followed by light (36.1%), moderate (9.6%), and severe dysfunction (1.1%). Conclusions: Based on the FAI, mild to moderate prevalence of TMD appears to exist among male university students in Riyadh. Histories of psychological stress and dental treatment were

Research paper thumbnail of The Requirement of p53 in Oral MSC differentiation Which Leads to Kaposi’s Sarcoma

P53 is considered one of the most important defense proteins against cancer.Although the p53 muta... more P53 is considered one of the most important defense proteins against cancer.Although the p53 mutation is associated with many cancers, its mutation is never found in Kaposi’s sarcoma (KS), raising a possibility that functional p53 may play a role in KS development. To assess the role of p53 in Kaposi’s sarcoma tumor, shRNA-mediated gene silencing was used to knockdown p53 expression. We examined Kaposi’s sarcomaassociated herpesvirus (KSHV)-infected periodontal ligaments stem cells (PDLSC) for osteogenic differentiation and endothelial angiogenesis, and we observed noticeable decreases in osteogenic differentiation and angiogenesis when p53 expression was knocked down in KSHV-infected PDLSCs by p53 specific shRNA. The results suggest that p53 plays an essential role in sarcoma development of KSHV infected mesenchymal stem cells.

Research paper thumbnail of Odontogenic tumors: analysis of 188 cases from Saudi Arabia

Annals of Saudi Medicine, 2015

Background and oBjectives: Odontogenic tumors (OTs) represent an uncommon group of lesions that a... more Background and oBjectives: Odontogenic tumors (OTs) represent an uncommon group of lesions that arise from the tooth-forming apparatus. They pose a significant diagnostic and management challenge. There is a lack of data among the Saudi population. The aim of the study was to establish the relative frequency of the various histological types of OTs. design and settings: A retrospective study of 188 cases of OTs using the histopathology archives of the College of Dentistry, King Saud University. Methods: The histopathology archives of the College of Dentistry, King Saud University were reviewed from January 1984 to December 2010 for OTs. The age and gender of the patients, tumor site, and histopathologic typing were analyzed. results: A total of 188 (4.3%) patients met the criteria for being classified as an OT. Odontogenic keratocystic tumor (36.7%) was the most commonly diagnosed, followed by ameloblastoma (25.0%), odontoma (14.9%), and odontogenic myxoma (6.4%). Two cases of malignant OTs (1.1%) are found. The male-to-female ratio was 1.4:1. The most frequently affected area was the posterior mandible (48.9%), followed by the anterior maxilla (22.9%). conclusion: This is a relatively large series of OTs revealing aspects of similarities and differences with those of previous studies of populations in Africa, Asia, and the Americas. The findings of the present study may be useful as a guide for clinicians who need to make clinical judgments prior to biopsy about the most probable diagnosis. Published cases of OTs have been found to vary depending on the affected population. 4,5 In Saudi Arabia, a few case reports are avaialbe. 6,7 The aim of the present study was to establish the relative frequency of the various histological types of OTs over a period of 27 years using the histopathology archives of the of the College of Dentistry, King Saud University. The latest WHO classification criteria were applied and the results were compared with previously reported cases of OTs from other populations. Methods This study was conducted in compliance with the "Ethical Principles for Medical Research Involving Human Subjects" statement of the Helsinki Declaration and was approved by the Committee of Ethics in Research of the College of Dentistry Research Center original article odontogenic tuMorS Ann Saudi Med 2015 March-April www.annsaudimed.net

Research paper thumbnail of Insights into Epigenetics Mechanisms in Oral Squamous Cell Carcinoma

Saudi Journal of Oral and Dental Research

Oral squamous cell carcinoma (OSCC) is one of the most common oral cancers accounting for 96% of ... more Oral squamous cell carcinoma (OSCC) is one of the most common oral cancers accounting for 96% of all head and neck cancers. Beside the different endogenous and environmental risk factors, epigenetics play an important role in causing OSCC. Epigenetics shed light on the presence of inherited changes in the phenotype of a gene with the absence of an alteration in the DNA sequence. The epigenetic modifications can result in the emersion of cancer, autoimmune diseases, aging and other diseases. Under several circumstances, DNA undergoes methylation. This methylation might be related to normal development or serious diseases like cancer. DNA methylation is a heritable biochemical modification occurs predominantly by transferal of a methyl group to C-5 position of the cytosine ring (CpGs) which may cause epigenetic disturbances. This review aims toward investigating the genetics in literature to help in diagnosing OSCC with new modalities that are less invasive compared to histopathology. Studied genes including ECAD, DAPK, MGMT and P53 has different methylation frequencies in relation to OSCC which may be related to their significant role in early diagnosis and prognosis. Since genetics has a major role in OSCC, we searched most recently reported genes and technologies seeking early detection and treatment of OSCC results in a better prognosis and more conservative treatment.

Research paper thumbnail of Teeth segmentation by optical radiographic images using VGG-16 deep learning convolution architecture with R-CNN network approach for biomedical sensing applications

Optical and Quantum Electronics

Research paper thumbnail of The role of intraregional dexamethasone injection in the treatment of recurrent tongue mucocele (clinical trial): A case report

Medical Science

Mucocele is the most common minor salivary gland-associated disease of the oral cavity. It involv... more Mucocele is the most common minor salivary gland-associated disease of the oral cavity. It involves mucin accumulation causing limited swelling. In recent years, extensive evidence has been published about the usage of intralesional corticosteroid injection in treating mucoceles in adult patients. The aim of the present case report was to assess the effectiveness of intralesional dexamethasone injection in the treatment of mucocele. Two histological types exist: Extravasation and retention. One of the most common oral lesions to be biopsied in pediatric patients is mucocele. Mucoceles can appear at any site of the oral mucosa where minor salivary glands are present. The significant number of cases should be properly conducted in order to check for any prior trauma because the diagnosis is mostly clinical in nature. The lower lip area is where extravasation mucocele most frequently appears, while retention mucoceles can be found at any other site. Mucoceles can affect anybody, however young people are most frequently affected (20-30 years old). Clinically they consist of a soft, bluish and transparent cystic swelling which normally resolves spontaneously. Surgery is commonly used as a kind of treatment. However, other treatments including CO2 laser, cryosurgery, steroid injections and 7 micromarsupialization are also advised. This report reports a case of recurrence of mucocele on the tongue's ventral surface that was unsuccessfully managed five times. Intraregional dexamethasone injection (0.5 ml of 2 g) was found more effective than surgical removal.

Research paper thumbnail of Knowledge and awareness assessment of cross-contamination of dental floss containers in King Saud University dental hospital clinics

Research paper thumbnail of Factors Influencing Study Choices, Career Preferences, andInterest in Oral Medicine Among Senior Dental Students in Riyadh,Kingdom of Saudi Arabia, A Cross-Sectional Study

EC Dental Science, Sep 25, 2021

Research paper thumbnail of Prevalence and severity of temporomandibular disorders among university students in Riyadh

The Saudi Dental Journal, 2015

The aim of this study was to evaluate the prevalence and severity of temporomandibular disorders ... more The aim of this study was to evaluate the prevalence and severity of temporomandibular disorders (TMDs) among male university students in Riyadh, Saudi Arabia. The role of relevant medical and dental histories in the assessment of TMD in this Arab population was also addressed. Methods: Required information was collected via a questionnaire. The first part of the questionnaire was used to obtain the medical and dental histories of participants. The second part included 10 questions regarding common TMD symptoms. Fonseca's anamnestic index (FAI) was used to classify TMD severity as ''no dysfunction'', ''light dysfunction'', ''moderate dysfunction'', or ''severe dysfunction''. Results: Of the 600 distributed questionnaires, 400 questionnaires were completed (response rate: 66.6%). Mean age of eligible participants was 21.90 ± 1.79 years. Psychological stress (30.5%) and direct restorations (77%) were the most commonly reported items on the medical and dental histories respectively for the total number of participants. According to the FAI, 53.2% of participants were classified as having no dysfunction, followed by light (36.1%), moderate (9.6%), and severe dysfunction (1.1%). Conclusions: Based on the FAI, mild to moderate prevalence of TMD appears to exist among male university students in Riyadh. Histories of psychological stress and dental treatment were

Research paper thumbnail of The Requirement of p53 in Oral MSC differentiation Which Leads to Kaposi’s Sarcoma

P53 is considered one of the most important defense proteins against cancer.Although the p53 muta... more P53 is considered one of the most important defense proteins against cancer.Although the p53 mutation is associated with many cancers, its mutation is never found in Kaposi’s sarcoma (KS), raising a possibility that functional p53 may play a role in KS development. To assess the role of p53 in Kaposi’s sarcoma tumor, shRNA-mediated gene silencing was used to knockdown p53 expression. We examined Kaposi’s sarcomaassociated herpesvirus (KSHV)-infected periodontal ligaments stem cells (PDLSC) for osteogenic differentiation and endothelial angiogenesis, and we observed noticeable decreases in osteogenic differentiation and angiogenesis when p53 expression was knocked down in KSHV-infected PDLSCs by p53 specific shRNA. The results suggest that p53 plays an essential role in sarcoma development of KSHV infected mesenchymal stem cells.

Research paper thumbnail of Odontogenic tumors: analysis of 188 cases from Saudi Arabia

Annals of Saudi Medicine, 2015

Background and oBjectives: Odontogenic tumors (OTs) represent an uncommon group of lesions that a... more Background and oBjectives: Odontogenic tumors (OTs) represent an uncommon group of lesions that arise from the tooth-forming apparatus. They pose a significant diagnostic and management challenge. There is a lack of data among the Saudi population. The aim of the study was to establish the relative frequency of the various histological types of OTs. design and settings: A retrospective study of 188 cases of OTs using the histopathology archives of the College of Dentistry, King Saud University. Methods: The histopathology archives of the College of Dentistry, King Saud University were reviewed from January 1984 to December 2010 for OTs. The age and gender of the patients, tumor site, and histopathologic typing were analyzed. results: A total of 188 (4.3%) patients met the criteria for being classified as an OT. Odontogenic keratocystic tumor (36.7%) was the most commonly diagnosed, followed by ameloblastoma (25.0%), odontoma (14.9%), and odontogenic myxoma (6.4%). Two cases of malignant OTs (1.1%) are found. The male-to-female ratio was 1.4:1. The most frequently affected area was the posterior mandible (48.9%), followed by the anterior maxilla (22.9%). conclusion: This is a relatively large series of OTs revealing aspects of similarities and differences with those of previous studies of populations in Africa, Asia, and the Americas. The findings of the present study may be useful as a guide for clinicians who need to make clinical judgments prior to biopsy about the most probable diagnosis. Published cases of OTs have been found to vary depending on the affected population. 4,5 In Saudi Arabia, a few case reports are avaialbe. 6,7 The aim of the present study was to establish the relative frequency of the various histological types of OTs over a period of 27 years using the histopathology archives of the of the College of Dentistry, King Saud University. The latest WHO classification criteria were applied and the results were compared with previously reported cases of OTs from other populations. Methods This study was conducted in compliance with the "Ethical Principles for Medical Research Involving Human Subjects" statement of the Helsinki Declaration and was approved by the Committee of Ethics in Research of the College of Dentistry Research Center original article odontogenic tuMorS Ann Saudi Med 2015 March-April www.annsaudimed.net

Research paper thumbnail of Insights into Epigenetics Mechanisms in Oral Squamous Cell Carcinoma

Saudi Journal of Oral and Dental Research

Oral squamous cell carcinoma (OSCC) is one of the most common oral cancers accounting for 96% of ... more Oral squamous cell carcinoma (OSCC) is one of the most common oral cancers accounting for 96% of all head and neck cancers. Beside the different endogenous and environmental risk factors, epigenetics play an important role in causing OSCC. Epigenetics shed light on the presence of inherited changes in the phenotype of a gene with the absence of an alteration in the DNA sequence. The epigenetic modifications can result in the emersion of cancer, autoimmune diseases, aging and other diseases. Under several circumstances, DNA undergoes methylation. This methylation might be related to normal development or serious diseases like cancer. DNA methylation is a heritable biochemical modification occurs predominantly by transferal of a methyl group to C-5 position of the cytosine ring (CpGs) which may cause epigenetic disturbances. This review aims toward investigating the genetics in literature to help in diagnosing OSCC with new modalities that are less invasive compared to histopathology. Studied genes including ECAD, DAPK, MGMT and P53 has different methylation frequencies in relation to OSCC which may be related to their significant role in early diagnosis and prognosis. Since genetics has a major role in OSCC, we searched most recently reported genes and technologies seeking early detection and treatment of OSCC results in a better prognosis and more conservative treatment.