Reham Jasser | King Saud University (original) (raw)

Papers by Reham Jasser

Cureus, Dec 7, 2023

Background: Patients with excessive gingival display (EGD) are treated with lip repositioning sur... more Background: Patients with excessive gingival display (EGD) are treated with lip repositioning surgeries (LRS). This study used a questionnaire to analyze and evaluate how patients who received LRS with modified and traditional techniques perceived their own oral and facial esthetics at various timelines after their surgeries. Methods: An orofacial esthetic questionnaire (OEQ) was used in this cross-sectional study. The participants were patients who underwent LRS for the treatment of their EGD. They were divided into control (n=100) and test (n=100) groups. For the control group, LRS were performed using traditional/conventional techniques, and for the test group, LRS were performed using a modified approach. An OEQ was used to record responses. The scale comprised eight questions targeted to capture participating patients' perceptions about their own oral and facial esthetics at four timelines (baseline and one-month, six-month, and one-year follow-up). Patients responded to each question on a 10-point Likert scale (0: very dissatisfied, 10: very satisfied). Data was analyzed by independent samples T-tests using Statistical Package for the Social Sciences (SPSS) version 21.0 software (IBM SPSS Statistics, Armonk, NY). Results: Seven (3.5%) out of the total (N=200) patients were unable to take part in the study's OEQ. At oneyear follow-up, the mean and standard deviation (SD) for the test group's gingival display (GD) were 2.48±0.86 mm and 3.77±1.76 mm, respectively, and comparisons revealed that the test group's GD was significantly lower (p=0.000) than the control group. Results from the participant responses to OEQ using the Likert scale at one-year follow-up revealed significant differences between the control and test groups for all questions, except question 5 (p=0.06), as the shape of the teeth will not be affected by LRS. Patients in the test group who underwent LRS with a modified approach have a high level of satisfaction (satisfaction score: >9). Patients in the control group scored their satisfaction less favorably, with certain questions (question 3) receiving scores as low as 0.31. Perception of oral and facial esthetics was significantly higher for the test group at different time points. At one-year follow-up, the mean difference was 4.46, which was the greatest (p=0.000). Conclusions: EGD improved significantly at one year with the modified lip repositioning technique. The satisfaction level of patients with outcomes of the modified lip repositioning was significantly higher as compared to the satisfaction level of patients who underwent the conventional technique.

The International Journal of Periodontics & Restorative Dentistry, 2021

Clinical Case Reports and Reviews, 2016

The purpose of this review is to present several techniques available for augmenting and regenera... more The purpose of this review is to present several techniques available for augmenting and regenerating the deficient alveolar bone mainly for implant placement and restoring the lost bone for functional and esthetic purposes. These include, but are not limited to, the use of barrier membranes for guided bone regeneration, particulate grafting materials, block grafting techniques, distraction osteogenesis, ridge split techniques, the current applications of growth factors to accelerate the rate of bone formation, and enhance the quality of bone formed especially in severe defects, and finally, to discuss the combination staged approach of these techniques.

BMC Oral Health, 2021

Aim To compare changes in clinical periodontal parameters (gingival consistency, colour, BOP, PI,... more Aim To compare changes in clinical periodontal parameters (gingival consistency, colour, BOP, PI, PD) and changes of salivary inflammatory biomarkers (IL-1 β, IL-6, MMP-8, TNF- α and TIMP-1 between conventional, electronic cigarette smokers and non-smokers after peri-implant treatment. Methods Study participants were grouped into three groups (i) Conventional cigarette smokers (ii) Electronic cigarette smokers and (iii) non-smokers respectively. A total of 60 adult patients aged (40–56 years) with 60 implants with active per-impantitis was included.Clinical and Biological parameters were evaluated before surgical treatment at baseline, one, six and twelve month post treatment. Pearson’s chi-square test was used to compare the distribution of the categorical while Two-way repeated analysis of variance was used to compare the mean values of quantitative outcome variables among all study groups across the 4 time points. Results A total of 60 subjects (60 implants) were selected and cla...

Pakistan Journal of Medical and Health Sciences

Stem cells are undifferentiated cells that have significant potential to regenerate missing tissu... more Stem cells are undifferentiated cells that have significant potential to regenerate missing tissues and living structures. Exosomes are a specific subgroup of extracellular vesicles that are recognized as important mediators of intercellular communication in the process of regeneration. They contribute to various pathways of physiological and pathological processes. Given the ability of exosomes to carry molecular cargos and transfer bioactive components, exosome-based disease diagnosis and therapeutics have been extensively studied over the past few decades. The present review highlights the emerging applications of exosomes as therapeutic agents in craniofacial and dental regenerative processes. In addition, the current challenges and future perspectives of exosomes in dental clinical applications are discussed. Keywords: dentistry, stem cells, exosome, regeneration, periodontal.

Journal of Dentistry, Oral Disorders & Therapy

include coronally advanced flap [3], laterally advanced flap [4], double papilla flap [5]. Others... more include coronally advanced flap [3], laterally advanced flap [4], double papilla flap [5]. Others include autogenous grafts such as sub-epithelial connective tissue graft [6], free gingival graft [2], and the use of non-autologous substitutes including; acellular dermal matrix [7], Enamel Matrix Derivatives (EMD), Living Cellular Construct (LCC), and guided tissue regeneration [8]. The choice of surgical modality and material of choice is based on different factors such as degree of recession, location, width of keratinized tissue, gingival tissue biotype, esthetic demands, and patient's preference. CTG has been considered the golden standard for the treatment of GR due to its significant outcomes in complete RC, attachment gain, keratinized tissue gain, and overall long-term treatment stability [9,10]. On the other hand, the need for a second surgical site to harvest the CTG is a main disadvantage due to the increased risk of bleeding, pain, and swelling that leads to the need for other RC alternatives [10]. As a result, approaches have been proposed and showed approximately similar results to CTG based treatment and considered an alternative depending on the clinician's and patient's choices; these include: Guided Tissue Regeneration (GTR), Acellular Dermal Matrix Graft (ADMT), and biological materials e.g. Platelet Rich Fibrin (PRF), Platelet Rich Plasma (PRP), Enamel Matrix Derivatives (EMD), among others [10,11]. Platelet Rich Fibrin (PRF) is an autologous cicatricial matrix of fibrin that holds platelets, growth factors and cells within, and is capable of slow releasing them during its natural resorption. PRF membrane is prepared through the centrifugation of autologous blood in the absence of anticoagulants, which result in fibrin clot formation between the Platelet Poor Plasma (PPP) layer at the top and the red blood cells layer at the bottom of the centrifuge tube [12]. That clot is then pressed to release the serum and in turn forms a membrane [13]. A number of growth factors have been identified within the PRF membrane, which are Platelet-Derived Growth Factor (PDGF), Transforming Growth Factor-β1 (TGF-β1), Vascular Endothelial Growth Factor (VEGF), Epidermal Growth Factor (EGF), and Insulin-Like Growth factor-1 [14]. PRF preparation and application is safe, simple, and cost effective. It improves wound healing through the slow

The Saudi Dental Journal, 2022

An esthetic smile is a common cosmetic concern in the dental field. Excessive gingival display (E... more An esthetic smile is a common cosmetic concern in the dental field. Excessive gingival display (EGD), also called gummy smile (GS), is one of the main complaints related to an unsatisfying dental smile; it is said to be present when the gingival display exceeds 4 mm. The dental smile is achieved by a harmonious relationship between the size, shape, arrangement, and color of the anterior teeth; lip framework; and gingival contour. Altered passive eruption (AEP) is characterized by short square-shaped teeth occuring when the gingiva covers the crown of the teeth excessively. Altered passive eruption is one of the causes of GS along with maxillary lip length, bony maxillary excess, hyperactive upper lip, anterior dentoalveolar extrusion, and vertical maxillary excess. There are various options for periodontal management of EGD, such as surgical or laser gingivectomy, esthetic crown lengthening, forced eruption, lip repositioning surgery, use of Botox, or a combination of these. The aim...

Background: β-TCP is a synthetic grafting material (alloplasts)that can be used as allografts an... more Background: β-TCP is a synthetic grafting material (alloplasts)that can be used as allografts and xenografts in peridontal periodontal infra-bony defect. However, it is important to compare this material outcomes in such treatments when comparted to others Therefore, the aim of this review is to evaluate the effectiveness of β-TCP in the regeneration of periodontal infra-bony defect. Methods: Three electronic databases (Cochrane, Pubmed, Embase) were searched up to March 2020. The inclusion criteria consist of regeneration of periodontal infra-bony defect via implementation of β-TCP in combination with other bone graft materials. Outcomes consisted of pocket depth reduction, clinical attachment level gain and bone fill. Results: Five studies were included according to inclusion criteria. β-TCP found to be superior than debridement alone while it shown comparable result to other bone grafts materials in term of pocket depth reduction, clinical attachment level gain and bone fill. th...

Sleep and Breathing, 2015

The aim of this study is to evaluate the association between periodontal disease and obstructive ... more The aim of this study is to evaluate the association between periodontal disease and obstructive sleep apnea (OSA). Methods Electronic search using PubMed, Cumulative Index to Nursing and Allied Health (CINAHL), Cochrane Central Trial Registry, Cochrane Database of Systematic Reviews, Scopus, and Embase was carried out for randomized controlled trials, longitudinal, cohort, case-control, and epidemiological studies on humans, published until October 2014. Manual searches were also performed. The participants considered were adult subjects with OSA and chronic periodontitis. The authors reviewed all articles and extracted data using a customized data abstraction sheet. Methodological quality assessment was carried out using the Newcastle-Ottawa Quality Assessment Scale. Results Six studies met the inclusion criteria set for this review. They evaluated the association between periodontal disease and OSA and the efficacy of periodontal interventions on OSA occurrence and severity. The periodontal disease outcome measures included clinical attachment loss, periodontal pocket depth, oral hygiene indices, radiographic alveolar bone loss, and salivary cytokines. Meta-analysis of four studies revealed a statistically significant association between periodontal disease and OSA (pooled odds ratio=1.65, 95 % confidence interval (CI)=1.11, 2.46, P=0.01). There is insufficient evidence on the efficacy of periodontal disease interventions. Conclusions There is some evidence to a plausible association between periodontal disease and OSA. Evidence on the efficacy of periodontal disease interventions is insufficient. The causal-effect relationship of periodontal disease and OSA is debatable. Further research with case-control studies is warranted.

Tissue Engineering and Regenerative Medicine, 2017

Platelet-rich fibrin (PRF) has been used in regenerative medicine and dentistry. Recently, its us... more Platelet-rich fibrin (PRF) has been used in regenerative medicine and dentistry. Recently, its use has been advocated for regenerative periodontics and wound healing. The randomized control trials have assessed the regenerative efficacy of the PRF for restoring intrabony periodontal defects. The objectives are to critically analyze and appraise the currently available literature, focusing on the use of PRF in regenerating periodontal bone defects. An electronic search was conducted (PubMed/MEDLINE, Google Scholar, ISI-WOS). Various combinations of following keywords were used: 'platelet-rich fibrin', 'intrabony', 'periodontal', 'bone defect' and 'guided tissue regeneration'. A secondary search was conducted by analyzing the reference lists of the articles obtained in initial search. The final search resulted in 13 randomized controlled trials being included. In majority of studies, PRF resulted in better clinical/radiographic outcomes than open flap debridement and augmented therapeutic effects of bone grafts. The combination of bovine bone substitutes and PRF resulted in better performance compared to alone. Similarly better outcomes were observed while using PRF in combination with nanohydroxyapatite, metformin and demineralized freeze-dried bone allograft. It can be concluded that PRF produces better outcomes than open flap debridement alone and augments the regenerative effects of bone substitutes.

Journal of Research in Medical and Dental Science, 2020

Introduction: The development of the healthcare industry has laid significant attention towards t... more Introduction: The development of the healthcare industry has laid significant attention towards the provision of patient centered care for satisfactory treatment outcomes. Aim: This study aims to assess the practice of patient-centered care among dentists in Saudi Arabia, while analyzing the influence of gender and years of experience on their ability to conduct proper patient-centered care among their patients. Materials and methods: Cross-sectional study was conducted among dentists practicing in Riyadh, Saudi Arabia. Questionnaires, consisting of Patient-Practitioner Orientation Scale (PPOS) and demographic details, were electronically mailed to 272 study participants for data collection. Independent sample t-test and one-way analysis of variance followed by the post-hoc test was undertaken. Results: Findings indicated females as more patient-centered than males, with a total PPOS scores (3.11± 0.57 vs. 3.06± 0.50), p=0.037 and in the sharing subscale (3.24 ± 0.78) vs. (3.13 ± 0....

BMC Oral Health

Background Beta-tricalcium phosphate in regenerative surgery has shown promising results in terms... more Background Beta-tricalcium phosphate in regenerative surgery has shown promising results in terms of bone gain and new vital bone formation; however, several studies have contradicted this finding. The aim of this study was to evaluate the effectiveness of beta-tricalcium phosphate compared to other grafting materials in the regeneration of periodontal infra-bony defects. Methods Electronic database (Cochrane, MEDLINE, PubMed, Embase, Science Citation Index Expanded) and manual searches for related data were performed up until March 2020. The outcomes were pocket depth reduction, clinical attachment level gain, and amount of bone fill. Results Five studies were selected based on the inclusion criteria. Bone regeneration with beta-tricalcium phosphate was observed to be superior to that with debridement alone but showed comparable results to other bone graft materials in terms of pocket depth reduction, clinical attachment level gain, and bone fill. Regenerative procedures for period...

Photodiagnosis and Photodynamic Therapy

Scientific Reports

Risk indicators of peri-implantitis is still contradictory and somehow unclear in present literat... more Risk indicators of peri-implantitis is still contradictory and somehow unclear in present literature therefore efforts should be done for better understanding of the exact etiology of peri-implant disease progression. The present study aimed to assess risk indicators associated with peri-implantitis by observing the changes in several periodontal parameters after implant placement. This cross-sectional study included 213 female and 271 male patients aged 26–87 years, who received 484 titanium implants (Straumann, Switzerland) at King Saud University’s Dental College, Saudi Arabia. Patients were called for dental visits. During these visits; full clinical and radiographic assessment of implants were done. The periodontal pocket depth (PPD) was greater around implants placed at grafted sites than non-grafted sites and around bone-level implants than tissue-level implants. The plaque index (PI) was associated with poor oral hygiene. There was a strong association between graft (yes/no)...

Journal of Multidisciplinary Healthcare

The risk of acquiring coronavirus disease 2019 (COVID-19) among dental professionals is high beca... more The risk of acquiring coronavirus disease 2019 (COVID-19) among dental professionals is high because they are exposed to aerosol production and body fluids during dental procedures. Therefore, the aim of the study was to determine the level of awareness among the dental students regarding COVID-19. Materials and Methods: An online cross-sectional questionnaire with three sections (knowledge, attitudes, practice) was completed by 412 postgraduate and undergraduate dental students and interns from King Saud University in Saudi Arabia. Results: The overall mean survey score was 9.56±1.19 out of 15. A mean score of 2.31 ±0.32 was recorded for level of knowledge among the dental professionals that indicated a fair level of knowledge among the participants. Similarly, a mean score of 6.5±0.45 was recorded for attitude of dental professionals towards COVID-19 that indicated a moderate level of attitude. "Novel COVID-19 virus transmits through droplets," and "masks should be worn most of the time to prevent infection spread," had the lowest correct answer rates. The practice had a low mean score of 0.81±0.22. The results depicted statistically significant differences in knowledge, with postgraduate students having the highest mean scores, followed by interns and undergraduate students. Conclusion: Despite attaining fair scores on knowledge and attitudes, the low practice scores highlight the need for urgent strategies to prevent infection among dental students, including mandatory crash courses and hands-on protection measures.

International Journal of Molecular Sciences

Several investigators have reported about the intricate molecular mechanism underlying periodonta... more Several investigators have reported about the intricate molecular mechanism underlying periodontal diseases (PD). Nevertheless, the role of specific genes, cells, or cellular mechanisms involved in the pathogenesis of periodontitis are still unclear. Although periodontitis is one of the most prevalent oral diseases globally, there are no pre-diagnostic markers or therapeutic targets available for such inflammatory lesions. A pivotal role is played by pro- and anti-inflammatory markers in modulating pathophysiological and physiological processes in repairing damaged tissues. In addition, effects on osteoimmunology is ever evolving due to the ongoing research in understanding the molecular mechanism lying beneath periodontal diseases. The aim of the current review is to deliver an evidence-based update on the molecular mechanism of periodontitis with a particular focus on recent developments. Reports regarding the molecular mechanism of these diseases have revealed unforeseen results ...