Siham Lahsasni | King Saud University (original) (raw)
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Riyadh 11495
Kingdom of Saudi Arabia
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Papers by Siham Lahsasni
Pharmaceutical Chemistry Journal, 2014
ABSTRACT A series of new pyrimidine analogs carrying 1,4-naphthoquinone and uracil moiety were pr... more ABSTRACT A series of new pyrimidine analogs carrying 1,4-naphthoquinone and uracil moiety were prepared as hybrid compounds 1-(3'-chloro-1',4'-dioxo-1',4'-dihydronaphthalen-2'-yl)-5-substitued-1H-pyrimidine-2,4-diones (6 - 9), which might possess biological activity. The structures of new products were confirmed by IR, 1H and 13C NMR, and mass spectroscopy data. All synthesized compounds were also evaluated for their antibacterial activity. The structure - activity relationship for these compounds was studied and the results showed that 1-(3'-chloro-1',4'-dioxo-1',4'-dihydronaphthalen-2'-yl)-5-fluoro-1H-pyrimidine-2,4-dione (9) containing a fluorine atom exhibited in vitro potent antibacterial activity (MIC50 = 1.0 mu g/mL) comparable with that of the clinically useful antibacterial drug gentamicin (MIC50 = 2.0 mu g/mL) against S. aureus and B. subtilis. Compound 9 also exhibited the same antibacterial activity with MIC50 = 1.0 mg/mL compared to gentamicin and ciprofloxacin against P. aeruginosa and with MIC50 = 0.5 mg/mL compared to Gentamicin (MIC50 = 0.5 mg/mL) against E. coli.
Macedonian Journal of Chemistry and Chemical Engineering, 2016
Acta Crystallographica Section E Structure Reports Online, 2012
Zeitschrift für Kristallographie - New Crystal Structures, 2016
Journal of Stored Products Research, 2005
Moisture equilibrium data for adsorption and desorption of water from Gelidium sesquipedale were ... more Moisture equilibrium data for adsorption and desorption of water from Gelidium sesquipedale were investigated at temperatures in the range of 30–50°C and water activity ranging from 0.05 to 0.9. The experimental procedure used was based on the gravimetric static method. The sorption curves of Gelidium sesquipedale decreased with increase in temperature at constant relative humidity. The hysteresis effect was observed.
Journal of Food Process Engineering, 2004
Journal of Food Engineering, 2004
Journal of Food Engineering, 2002
Energy Conversion and Management, 2004
Energy Conversion and Management, 2005
Energy Conversion and Management, 2003
Drying Technology, 2002
The paper deals with sorption isotherms and drying kinetics of Eucalyptus globulus. The sorption ... more The paper deals with sorption isotherms and drying kinetics of Eucalyptus globulus. The sorption isotherms have been determined using a static gravimetric method and then fitted by GAB equation at T = 30, 40, and 50°C over a range of relative humidity from 0.05 to 0.9. The drying kinetics in a solar dryer with an auxiliary heating system are determined.
Arzneimittelforschung, 2011
Acta Crystallographica Section E Structure Reports Online, 2012
Acta Crystallographica Section E Structure Reports Online, 2012
Acta Crystallographica Section E Structure Reports Online, 2012
Pharmaceutical Chemistry Journal
A series of new pyrimidine analogs carrying 1,4-naphthoquinone and uracil moiety were prepared as... more A series of new pyrimidine analogs carrying 1,4-naphthoquinone and uracil moiety were prepared as hybrid compounds 1-(3'-chloro-1',4'-dioxo-1',4'-dihydronaphthalen-2'-yl)-5-substitued-1H-pyrimidine-2,4-diones (6 - 9), which might possess biological activity. The structures of new products were confirmed by IR, 1H and 13C NMR, and mass spectroscopy data. All synthesized compounds were also evaluated for their antibacterial activity. The structure - activity relationship for these compounds was studied and the results showed that 1-(3'-chloro-1',4'-dioxo-1',4'-dihydronaphthalen-2'-yl)-5-fluoro-1H-pyrimidine-2,4-dione (9) containing a fluorine atom exhibited in vitro potent antibacterial activity (MIC50 = 1.0 mu g/mL) comparable with that of the clinically useful antibacterial drug gentamicin (MIC50 = 2.0 mu g/mL) against S. aureus and B. subtilis. Compound 9 also exhibited the same antibacterial activity with MIC50 = 1.0 mg/mL compared t...
Pharmaceutical Chemistry Journal, 2014
ABSTRACT A series of new pyrimidine analogs carrying 1,4-naphthoquinone and uracil moiety were pr... more ABSTRACT A series of new pyrimidine analogs carrying 1,4-naphthoquinone and uracil moiety were prepared as hybrid compounds 1-(3'-chloro-1',4'-dioxo-1',4'-dihydronaphthalen-2'-yl)-5-substitued-1H-pyrimidine-2,4-diones (6 - 9), which might possess biological activity. The structures of new products were confirmed by IR, 1H and 13C NMR, and mass spectroscopy data. All synthesized compounds were also evaluated for their antibacterial activity. The structure - activity relationship for these compounds was studied and the results showed that 1-(3'-chloro-1',4'-dioxo-1',4'-dihydronaphthalen-2'-yl)-5-fluoro-1H-pyrimidine-2,4-dione (9) containing a fluorine atom exhibited in vitro potent antibacterial activity (MIC50 = 1.0 mu g/mL) comparable with that of the clinically useful antibacterial drug gentamicin (MIC50 = 2.0 mu g/mL) against S. aureus and B. subtilis. Compound 9 also exhibited the same antibacterial activity with MIC50 = 1.0 mg/mL compared to gentamicin and ciprofloxacin against P. aeruginosa and with MIC50 = 0.5 mg/mL compared to Gentamicin (MIC50 = 0.5 mg/mL) against E. coli.
Macedonian Journal of Chemistry and Chemical Engineering, 2016
Acta Crystallographica Section E Structure Reports Online, 2012
Zeitschrift für Kristallographie - New Crystal Structures, 2016
Journal of Stored Products Research, 2005
Moisture equilibrium data for adsorption and desorption of water from Gelidium sesquipedale were ... more Moisture equilibrium data for adsorption and desorption of water from Gelidium sesquipedale were investigated at temperatures in the range of 30–50°C and water activity ranging from 0.05 to 0.9. The experimental procedure used was based on the gravimetric static method. The sorption curves of Gelidium sesquipedale decreased with increase in temperature at constant relative humidity. The hysteresis effect was observed.
Journal of Food Process Engineering, 2004
Journal of Food Engineering, 2004
Journal of Food Engineering, 2002
Energy Conversion and Management, 2004
Energy Conversion and Management, 2005
Energy Conversion and Management, 2003
Drying Technology, 2002
The paper deals with sorption isotherms and drying kinetics of Eucalyptus globulus. The sorption ... more The paper deals with sorption isotherms and drying kinetics of Eucalyptus globulus. The sorption isotherms have been determined using a static gravimetric method and then fitted by GAB equation at T = 30, 40, and 50°C over a range of relative humidity from 0.05 to 0.9. The drying kinetics in a solar dryer with an auxiliary heating system are determined.
Arzneimittelforschung, 2011
Acta Crystallographica Section E Structure Reports Online, 2012
Acta Crystallographica Section E Structure Reports Online, 2012
Acta Crystallographica Section E Structure Reports Online, 2012
Pharmaceutical Chemistry Journal
A series of new pyrimidine analogs carrying 1,4-naphthoquinone and uracil moiety were prepared as... more A series of new pyrimidine analogs carrying 1,4-naphthoquinone and uracil moiety were prepared as hybrid compounds 1-(3'-chloro-1',4'-dioxo-1',4'-dihydronaphthalen-2'-yl)-5-substitued-1H-pyrimidine-2,4-diones (6 - 9), which might possess biological activity. The structures of new products were confirmed by IR, 1H and 13C NMR, and mass spectroscopy data. All synthesized compounds were also evaluated for their antibacterial activity. The structure - activity relationship for these compounds was studied and the results showed that 1-(3'-chloro-1',4'-dioxo-1',4'-dihydronaphthalen-2'-yl)-5-fluoro-1H-pyrimidine-2,4-dione (9) containing a fluorine atom exhibited in vitro potent antibacterial activity (MIC50 = 1.0 mu g/mL) comparable with that of the clinically useful antibacterial drug gentamicin (MIC50 = 2.0 mu g/mL) against S. aureus and B. subtilis. Compound 9 also exhibited the same antibacterial activity with MIC50 = 1.0 mg/mL compared t...