Stefan Braese | Karlsruhe Institute of Technology (KIT) (original) (raw)
Papers by Stefan Braese
Biophysical Journal, Feb 1, 2016
Nachrichten Aus Der Chemie, 2013
Beuerle F, Krueger A, Lehmann M, et al. Organic Chemistry 2012. Nachrichten aus der Chemie . 2013... more Beuerle F, Krueger A, Lehmann M, et al. Organic Chemistry 2012. Nachrichten aus der Chemie . 2013;61(3):265-297
Chemical Science, 2020
Correction for ‘Metal complexes as a promising source for new antibiotics’ by Angelo Frei et al.,... more Correction for ‘Metal complexes as a promising source for new antibiotics’ by Angelo Frei et al., Chem. Sci., 2020, 11, 2627–2639.
There are currently fewer than ten antifungal drugs in clinical development, but new fungal strai... more There are currently fewer than ten antifungal drugs in clinical development, but new fungal strains, which are resistant to most current antifungals are spreading rapidly across the world. To prevent a second resistance crisis, new classes of antifungal drugs are urgently needed. Metal complexes have proven to be promising candidates for novel antibiotics, but so far, few compounds have been explored for their potential application as antifungal agents. In this work we report the evaluation of 1039 metal-containing compounds that were screened by the Community for Open Antimicrobial Drug Discovery (CO-ADD). We show that 20.9% of all metal compounds tested have antimicrobial activity against two representative Candida and Cryptococcus strains, compared with only 1.1% of the >300,000 purely organic molecules tested through CO-ADD. We identified 90 metal compounds (8.7%) that show antifungal activity while not displaying any cytotoxicity against mammalian cell lines or haemolytic pr...
Journal of chemical research, Nov 24, 2020
ChemInform, Aug 11, 2011
The core structural unit of marmycins is prepared by vinylogous aldol—aza-Michael reaction of o-a... more The core structural unit of marmycins is prepared by vinylogous aldol—aza-Michael reaction of o-aminobenzaldehydes (I) with prenal (II).
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ChemInform, Jan 2, 2014
ABSTRACT
Biophysical Journal, Feb 1, 2016
Nachrichten Aus Der Chemie, 2013
Beuerle F, Krueger A, Lehmann M, et al. Organic Chemistry 2012. Nachrichten aus der Chemie . 2013... more Beuerle F, Krueger A, Lehmann M, et al. Organic Chemistry 2012. Nachrichten aus der Chemie . 2013;61(3):265-297
Chemical Science, 2020
Correction for ‘Metal complexes as a promising source for new antibiotics’ by Angelo Frei et al.,... more Correction for ‘Metal complexes as a promising source for new antibiotics’ by Angelo Frei et al., Chem. Sci., 2020, 11, 2627–2639.
There are currently fewer than ten antifungal drugs in clinical development, but new fungal strai... more There are currently fewer than ten antifungal drugs in clinical development, but new fungal strains, which are resistant to most current antifungals are spreading rapidly across the world. To prevent a second resistance crisis, new classes of antifungal drugs are urgently needed. Metal complexes have proven to be promising candidates for novel antibiotics, but so far, few compounds have been explored for their potential application as antifungal agents. In this work we report the evaluation of 1039 metal-containing compounds that were screened by the Community for Open Antimicrobial Drug Discovery (CO-ADD). We show that 20.9% of all metal compounds tested have antimicrobial activity against two representative Candida and Cryptococcus strains, compared with only 1.1% of the >300,000 purely organic molecules tested through CO-ADD. We identified 90 metal compounds (8.7%) that show antifungal activity while not displaying any cytotoxicity against mammalian cell lines or haemolytic pr...
Journal of chemical research, Nov 24, 2020
ChemInform, Aug 11, 2011
The core structural unit of marmycins is prepared by vinylogous aldol—aza-Michael reaction of o-a... more The core structural unit of marmycins is prepared by vinylogous aldol—aza-Michael reaction of o-aminobenzaldehydes (I) with prenal (II).
ChemInform, Jan 2, 2014
ABSTRACT