Марія Котелюх | Kharkiv National Medical University (original) (raw)
Papers by Марія Котелюх
Zdobutki klìnìčnoï ì eksperimentalʹnoï medicini, Mar 25, 2022
The study of inflammatory and anti-inflammatory processes of combined acute myocardial infarction... more The study of inflammatory and anti-inflammatory processes of combined acute myocardial infarction (AMI) with type 2 diabetes mellitus (DM) is an urgent problem of modern medicine. The aim-to determine the relationship between the fatty acid binding protein 4 (FABP 4), C1q/Tumor necrosis factor related protein 3 (CTRP 3) and echocardiographic parameters in patients with AMI in the presence of type 2 DM. Material and Methods. The study involved examination of 134 patients with AMI. The first group consisted of 60 atients with AMI and the second group comprised 74 patients with AMI and type 2 DM. The control group included 20 healthy individuals. The content of FABP 4 and CTRP 3 was determined by enzyme-linked immunosorbent assay. Results. Group 1 patients were shown to have a relationship between FABP 4 and end-diastolic size (EDS) (r=-0.458, p<0.01), end-systolic size (ESS) (r=-0.460, p<0.01), end-diastolic volume (EDV) (r=-0.452, p<0.01), left atrium (r=-0.487, p<0.01), left ventricular myocardial mass (LVMM) (r=-0.411, p<0.01), LVMM index (r=-0.419, p<0.01) and between CTRP 3 and EDS (r=0.469, p<0.01), EDV (r=0.425, p<0.01), stroke volume (r=0.407, p<0.05), the relative thickness of the posterior wall of the LV (RPWLVT) (r=-0.469, p<0.01). Group 2 patients were found to have a relationship between FABP 4 and ESS (r=-0.452, p<0.01), end-systolic volume (r=-0.482, p<0.01), LVMM (r=-0.424), p<0.01), LVMMI (r=-0.464, p<0.01), LV ejec tion fraction (EF) (r=0.402, p<0.01) and between CTRP 3 and EDS (r=0.402, p<0.01), EDV (r=0.424, p<0.01), LV EF (r=-0.465, p<0.05). Conclusion. In Groups 1 and 2, echocardiographic parameters had reliably low inverse correlations with FABP 4 and low direct correlations with CTRP 3, except for RPWLVT and EF.
Spiritual-intellectual upbringing and teaching of youth in the 21st century, 2021
The article reveals the role of spirituality and morality in performing the professional activity... more The article reveals the role of spirituality and morality in performing the professional activity of a doctor. It is noted that the conditions of the pandemic have changed a person’s attitude to himself, the health of relatives, relationships with other people. A sense of self-preservation and responsibility for another person’s life became a priority
Ischemic heart disease ranks first among cardiovascular disorders and is one of the main causes o... more Ischemic heart disease ranks first among cardiovascular disorders and is one of the main causes of disability and mortality worldwide. The development and course of acute myocardial infarction is known to be accompanied by changes in extracellular matrix. Today the impact of hyperglycemia on intercellular matrix system in patients with acute myocardial infarction and type 2 diabetes still remains disputable. The study demonstrated a statistically significant increase in matrix metalloproteinase-13 in an insufficient increase in the level of tissue inhibitor of metalloproteinase-4 in patients with acute myocardial infarction and type 2 diabetes, indicating an imbalance in intercellular matrix system. The authors defined prognostic characteristics regarding matrix metalloproteinase-13 and tissue inhibitor of metalloproteinase-4 in patients with acute myocardial infarction and type 2 diabetes as for mortality of these patients.
Zdobutki klìnìčnoï ì eksperimentalʹnoï medicini, Mar 25, 2022
The study of inflammatory and anti-inflammatory processes of combined acute myocardial infarction... more The study of inflammatory and anti-inflammatory processes of combined acute myocardial infarction (AMI) with type 2 diabetes mellitus (DM) is an urgent problem of modern medicine. The aim-to determine the relationship between the fatty acid binding protein 4 (FABP 4), C1q/Tumor necrosis factor related protein 3 (CTRP 3) and echocardiographic parameters in patients with AMI in the presence of type 2 DM. Material and Methods. The study involved examination of 134 patients with AMI. The first group consisted of 60 atients with AMI and the second group comprised 74 patients with AMI and type 2 DM. The control group included 20 healthy individuals. The content of FABP 4 and CTRP 3 was determined by enzyme-linked immunosorbent assay. Results. Group 1 patients were shown to have a relationship between FABP 4 and end-diastolic size (EDS) (r=-0.458, p<0.01), end-systolic size (ESS) (r=-0.460, p<0.01), end-diastolic volume (EDV) (r=-0.452, p<0.01), left atrium (r=-0.487, p<0.01), left ventricular myocardial mass (LVMM) (r=-0.411, p<0.01), LVMM index (r=-0.419, p<0.01) and between CTRP 3 and EDS (r=0.469, p<0.01), EDV (r=0.425, p<0.01), stroke volume (r=0.407, p<0.05), the relative thickness of the posterior wall of the LV (RPWLVT) (r=-0.469, p<0.01). Group 2 patients were found to have a relationship between FABP 4 and ESS (r=-0.452, p<0.01), end-systolic volume (r=-0.482, p<0.01), LVMM (r=-0.424), p<0.01), LVMMI (r=-0.464, p<0.01), LV ejec tion fraction (EF) (r=0.402, p<0.01) and between CTRP 3 and EDS (r=0.402, p<0.01), EDV (r=0.424, p<0.01), LV EF (r=-0.465, p<0.05). Conclusion. In Groups 1 and 2, echocardiographic parameters had reliably low inverse correlations with FABP 4 and low direct correlations with CTRP 3, except for RPWLVT and EF.
Spiritual-intellectual upbringing and teaching of youth in the 21st century, 2021
The article reveals the role of spirituality and morality in performing the professional activity... more The article reveals the role of spirituality and morality in performing the professional activity of a doctor. It is noted that the conditions of the pandemic have changed a person’s attitude to himself, the health of relatives, relationships with other people. A sense of self-preservation and responsibility for another person’s life became a priority
Ischemic heart disease ranks first among cardiovascular disorders and is one of the main causes o... more Ischemic heart disease ranks first among cardiovascular disorders and is one of the main causes of disability and mortality worldwide. The development and course of acute myocardial infarction is known to be accompanied by changes in extracellular matrix. Today the impact of hyperglycemia on intercellular matrix system in patients with acute myocardial infarction and type 2 diabetes still remains disputable. The study demonstrated a statistically significant increase in matrix metalloproteinase-13 in an insufficient increase in the level of tissue inhibitor of metalloproteinase-4 in patients with acute myocardial infarction and type 2 diabetes, indicating an imbalance in intercellular matrix system. The authors defined prognostic characteristics regarding matrix metalloproteinase-13 and tissue inhibitor of metalloproteinase-4 in patients with acute myocardial infarction and type 2 diabetes as for mortality of these patients.