Raimon Mathew | Kerala Veterinary and Animal Science University (original) (raw)

Papers by Raimon Mathew

Research paper thumbnail of HAEMOCHROMATOSIS AND ASSOCIATED HEPATOPATHY IN A MULE - A CASE REPORT

Research paper thumbnail of A Study of Occurrence, Gross and Histopathological Characteristics of Canine Cutaneous Neoplasms

The present work was undertaken to study the occurrence along with the gross and histopathologica... more The present work was undertaken to study the occurrence along with the gross and histopathological features of canine cutaneous neoplasms in and around Thrissur. A total of 17 tumour samples were examined during the study. The mean age of the dogs affected with tumours was 6.55±0.59 years. The occurrence was slightly higher in males, but there was no association (p>0.05) between the sex and occurrence of skin tumours. Among the various breeds, Labradors were more affected with these tumours. Grossly, most of the tumours were round to oval in shape with soft to firm consistency and greyish white colour. Histopathological examination confirmed majority of the tumours as benign with more number of epithelial/melanocytic tumours.

Research paper thumbnail of Histological and Immunohistochemical Evaluation of Phosphorylated Mechanistic Target of Rapamycin in Canine Skin Tumours

Journal of comparative pathology, 2021

The mechanistic target of rapamycin (mTOR) plays an important role in cellular functions, includi... more The mechanistic target of rapamycin (mTOR) plays an important role in cellular functions, including growth and metabolism. Recently, mTOR and the activated phosphorylated form of mTOR (p-mTOR) have been reported as potential prognostic markers in many human tumours. However, there are few studies on its activation in canine tumours. We investigated the expression of p-mTOR in 17 canine skin tumours (CSTs), of which 58.8% were epithelial and melanocytic and 41.2% were mesenchymal tumours. Seventy-six per cent of the CSTs had high or moderate expression of p-mTOR. Mean p-mTOR expression in the epithelial and melanocytic tumours (5.7 ± 0.56) was significantly higher (P <0.05) than that of the mesenchymal tumours (3.14 ± 0.55). The age of the animals had no influence on p-mTOR expression. These findings suggest that activation of m-TOR is important in the development of skin tumours in dogs and the study might form the basis for further research on utilizing m-TOR inhibitors as impro...

Research paper thumbnail of Occurrence of osseous metaplasia in association with Avian lymphoid leukosis - A case report

Research paper thumbnail of A Study of Occurrence, Gross and Histopathological Characteristics of Canine Cutaneous Neoplasms

The present work was undertaken to study the occurrence along with the gross and histopathologica... more The present work was undertaken to study the occurrence along with the gross and histopathological features of canine cutaneous neoplasms in and around Thrissur. A total of 17 tumour samples were examined during the study. The mean age of the dogs affected with tumours was 6.55±0.59 years. The occurrence was slightly higher in males, but there was no association (p>0.05) between the sex and occurrence of skin tumours. Among the various breeds, Labradors were more affected with these tumours. Grossly, most of the tumours were round to oval in shape with soft to firm consistency and greyish white colour. Histopathological examination confirmed majority of the tumours as benign with more number of epithelial/melanocytic tumours.

Research paper thumbnail of A case of Ehrlichiosis in a Labrador Retriever

Journal of Indian veterinary association, 2018

Research paper thumbnail of Canine mammary tumours: Histological malignancy grading as a prognostic indicatior

Histopathology is considered as the gold standard for diagnosis of canine mammary tumours (CMTs).... more Histopathology is considered as the gold standard for diagnosis of canine mammary tumours (CMTs). Like human breast cancer, mammary tumour is a common tumour in dogs. Mastectomy is the most commonly adopted approach for treatment of CMTs. Grading of the tumour by histopathology is an effective tool to assess its biological behaviour and aggressiveness. In humans, Elston and Ellis grading method is routinely used to grade breast carcinomas. Present study was aimed at classification and histological malignancy grading of CMTs that were reported in and around Thrissur, Kerala, by using the modified human grading method. The samples included 16 tumours of canine mammary gland. Out of these, 87.5% (n=14) were malignant and 12.5% (n=2) were benign. After grading, it was found that 21.4% (n = 3) of the malignant tumours were of grade I, 57.1% (n = 8) were grade II and 21.4% (n= 3) were grade III tumours. The study revealed that majority of the simple carcinomas (most malignant type) were grade III or II and all the grade III tumours recurred within six months. Hence grading of the tumours was an effective prognostic indicator for planning further line of treatment. This study is first of its kind to classify and grade CMTs common in this area.

Research paper thumbnail of Canine mammary tumours: Histological malignancy grading as a prognostic indicatior

The Pharma Innovation Journal, 2019

Histopathology is considered as the gold standard for diagnosis of canine mammary tumours (CMTs).... more Histopathology is considered as the gold standard for diagnosis of canine mammary tumours (CMTs). Like human breast cancer, mammary tumour is a common tumour in dogs. Mastectomy is the most commonly adopted approach for treatment of CMTs. Grading of the tumour by histopathology is an effective tool to assess its biological behaviour and aggressiveness. In humans, Elston and Ellis grading method is routinely used to grade breast carcinomas. Present study was aimed at classification and histological malignancy grading of CMTs that were reported in and around Thrissur, Kerala, by using the modified human grading method. The samples included 16 tumours of canine mammary gland. Out of these, 87.5% (n=14) were malignant and 12.5% (n=2) were benign. After grading, it was found that 21.4% (n = 3) of the malignant tumours were of grade I, 57.1% (n = 8) were grade II and 21.4% (n= 3) were grade III tumours. The study revealed that majority of the simple carcinomas (most malignant type) were grade III or II and all the grade III tumours recurred within six months. Hence grading of the tumours was an effective prognostic indicator for planning further line of treatment. This study is first of its kind to classify and grade CMTs common in this area.

Research paper thumbnail of HAEMOCHROMATOSIS AND ASSOCIATED HEPATOPATHY IN A MULE - A CASE REPORT

Research paper thumbnail of A Study of Occurrence, Gross and Histopathological Characteristics of Canine Cutaneous Neoplasms

The present work was undertaken to study the occurrence along with the gross and histopathologica... more The present work was undertaken to study the occurrence along with the gross and histopathological features of canine cutaneous neoplasms in and around Thrissur. A total of 17 tumour samples were examined during the study. The mean age of the dogs affected with tumours was 6.55±0.59 years. The occurrence was slightly higher in males, but there was no association (p>0.05) between the sex and occurrence of skin tumours. Among the various breeds, Labradors were more affected with these tumours. Grossly, most of the tumours were round to oval in shape with soft to firm consistency and greyish white colour. Histopathological examination confirmed majority of the tumours as benign with more number of epithelial/melanocytic tumours.

Research paper thumbnail of Histological and Immunohistochemical Evaluation of Phosphorylated Mechanistic Target of Rapamycin in Canine Skin Tumours

Journal of comparative pathology, 2021

The mechanistic target of rapamycin (mTOR) plays an important role in cellular functions, includi... more The mechanistic target of rapamycin (mTOR) plays an important role in cellular functions, including growth and metabolism. Recently, mTOR and the activated phosphorylated form of mTOR (p-mTOR) have been reported as potential prognostic markers in many human tumours. However, there are few studies on its activation in canine tumours. We investigated the expression of p-mTOR in 17 canine skin tumours (CSTs), of which 58.8% were epithelial and melanocytic and 41.2% were mesenchymal tumours. Seventy-six per cent of the CSTs had high or moderate expression of p-mTOR. Mean p-mTOR expression in the epithelial and melanocytic tumours (5.7 ± 0.56) was significantly higher (P <0.05) than that of the mesenchymal tumours (3.14 ± 0.55). The age of the animals had no influence on p-mTOR expression. These findings suggest that activation of m-TOR is important in the development of skin tumours in dogs and the study might form the basis for further research on utilizing m-TOR inhibitors as impro...

Research paper thumbnail of Occurrence of osseous metaplasia in association with Avian lymphoid leukosis - A case report

Research paper thumbnail of A Study of Occurrence, Gross and Histopathological Characteristics of Canine Cutaneous Neoplasms

The present work was undertaken to study the occurrence along with the gross and histopathologica... more The present work was undertaken to study the occurrence along with the gross and histopathological features of canine cutaneous neoplasms in and around Thrissur. A total of 17 tumour samples were examined during the study. The mean age of the dogs affected with tumours was 6.55±0.59 years. The occurrence was slightly higher in males, but there was no association (p>0.05) between the sex and occurrence of skin tumours. Among the various breeds, Labradors were more affected with these tumours. Grossly, most of the tumours were round to oval in shape with soft to firm consistency and greyish white colour. Histopathological examination confirmed majority of the tumours as benign with more number of epithelial/melanocytic tumours.

Research paper thumbnail of A case of Ehrlichiosis in a Labrador Retriever

Journal of Indian veterinary association, 2018

Research paper thumbnail of Canine mammary tumours: Histological malignancy grading as a prognostic indicatior

Histopathology is considered as the gold standard for diagnosis of canine mammary tumours (CMTs).... more Histopathology is considered as the gold standard for diagnosis of canine mammary tumours (CMTs). Like human breast cancer, mammary tumour is a common tumour in dogs. Mastectomy is the most commonly adopted approach for treatment of CMTs. Grading of the tumour by histopathology is an effective tool to assess its biological behaviour and aggressiveness. In humans, Elston and Ellis grading method is routinely used to grade breast carcinomas. Present study was aimed at classification and histological malignancy grading of CMTs that were reported in and around Thrissur, Kerala, by using the modified human grading method. The samples included 16 tumours of canine mammary gland. Out of these, 87.5% (n=14) were malignant and 12.5% (n=2) were benign. After grading, it was found that 21.4% (n = 3) of the malignant tumours were of grade I, 57.1% (n = 8) were grade II and 21.4% (n= 3) were grade III tumours. The study revealed that majority of the simple carcinomas (most malignant type) were grade III or II and all the grade III tumours recurred within six months. Hence grading of the tumours was an effective prognostic indicator for planning further line of treatment. This study is first of its kind to classify and grade CMTs common in this area.

Research paper thumbnail of Canine mammary tumours: Histological malignancy grading as a prognostic indicatior

The Pharma Innovation Journal, 2019

Histopathology is considered as the gold standard for diagnosis of canine mammary tumours (CMTs).... more Histopathology is considered as the gold standard for diagnosis of canine mammary tumours (CMTs). Like human breast cancer, mammary tumour is a common tumour in dogs. Mastectomy is the most commonly adopted approach for treatment of CMTs. Grading of the tumour by histopathology is an effective tool to assess its biological behaviour and aggressiveness. In humans, Elston and Ellis grading method is routinely used to grade breast carcinomas. Present study was aimed at classification and histological malignancy grading of CMTs that were reported in and around Thrissur, Kerala, by using the modified human grading method. The samples included 16 tumours of canine mammary gland. Out of these, 87.5% (n=14) were malignant and 12.5% (n=2) were benign. After grading, it was found that 21.4% (n = 3) of the malignant tumours were of grade I, 57.1% (n = 8) were grade II and 21.4% (n= 3) were grade III tumours. The study revealed that majority of the simple carcinomas (most malignant type) were grade III or II and all the grade III tumours recurred within six months. Hence grading of the tumours was an effective prognostic indicator for planning further line of treatment. This study is first of its kind to classify and grade CMTs common in this area.