Ye Ai | Los Alamos National Laboratory (original) (raw)
Papers by Ye Ai
A low-voltage electroosmotic (EO) micropump based on an anodic aluminum oxide (AAO) nano-porous m... more A low-voltage electroosmotic (EO) micropump based on an anodic aluminum oxide (AAO) nano-porous membrane with platinum electrodes coated on both sides has been designed, fabricated, tested, and analyzed. The maximum flow rate of 0.074 mlmin− 1V− 1cm− 2 for a membrane with porosity of 0.65 was obtained.
Abstract A high-throughput cell electrofusion microfluidic chip has been designed, fabricated on ... more Abstract A high-throughput cell electrofusion microfluidic chip has been designed, fabricated on a silicon-on-insulator wafer and tested for in vitro cell fusion under a low applied voltage. The developed chip consists of six individual straight microchannels with a 40-μm thickness conductive highly doped Si layer as the microchannel wall. In each microchannel, there are 75 pairs of counter protruding microelectrodes, between which the cell electrofusion is performed.
Abstract A conical nanofluidic field effect transistor (FET) refers to a conical nanopore embedde... more Abstract A conical nanofluidic field effect transistor (FET) refers to a conical nanopore embedded with an electrically controllable gate electrode. The surface potential of the nanopore can be effectively regulated by manipulating the gate potential applied to the gate electrode, which in turn controls the ionic current through the nanopore.
When particles in an electrolyte subjected to an external electric field get close to each other,... more When particles in an electrolyte subjected to an external electric field get close to each other, the presence of particles could alter the local electric field and consequently induce mutual dielectrophoretic (DEP) forces on each other.
Electrokinetics has emerged as one of the most promising techniques to transport and manipulate i... more Electrokinetics has emerged as one of the most promising techniques to transport and manipulate ions, fluid and particles in micro/nanofluidic devices. Field effect permits flexible and rapid control of the surface charge property on the channel wall, which in turn offers a more sophisticated control of the electrokinetic transport phenomena in micro/nanofluidics.
Many biocolloids, biological cells and micro-organisms are soft particles, consisted with a rigid... more Many biocolloids, biological cells and micro-organisms are soft particles, consisted with a rigid inner core covered by an ion-permeable porous membrane layer. The electrophoretic motion of a soft spherical nanoparticle in a nanopore filled with an electrolyte solution has been investigated using a continuum mathematical model.
Field effect regulation of DNA nanoparticle translocation through a nanopore using a gate electro... more Field effect regulation of DNA nanoparticle translocation through a nanopore using a gate electrode is investigated using a continuum model, composed of the coupled Poisson− Nernst− Planck equations for the ionic mass transport and the Navier− Stokes equations for the hydrodynamic field. The field effect regulation of the DNA translocation relies on the induced electroosmotic flow (EOF) and the particle− nanopore electrostatic interaction.
Abstract In this entry, we review the current knowledge on DNA–surfactant interactions with a spe... more Abstract In this entry, we review the current knowledge on DNA–surfactant interactions with a special emphasis on single molecule compaction in the dilute regime as well as phase separation, effect of the chain length and headgroup of the surfactants, and DNA secondary structure.
Acoustics has emerged as one of the most promising non-invasive techniques for particle and dropl... more Acoustics has emerged as one of the most promising non-invasive techniques for particle and droplet manipulation in microfluidics. Surface acoustic wave (SAW) based microfluidic devices are developed to manipulate micron-sized particles and discrete droplets. When solid particles are immersed in a standing SAW, the resulting acoustic radiation force acting on the particles can drive the particles into the pressure node, resulting in particle focusing phenomenon.
DC dielectrophoretic (DEP) separation of particles through a constricted microchannel was numeric... more DC dielectrophoretic (DEP) separation of particles through a constricted microchannel was numerically investigated by a verified multiphysics finite element model, composed of the Navier-Stokes equations for the flow field and the Laplace equation for the electric field solved in an arbitrary Lagrangian-Eulerian (ALE) framework. The particle-fluid-electric field interactions are fully taken into account in the present model.
1. Electrophoresis. 2011 Apr;32(9):959. doi: 10.1002/elps.201190027. Electroand liquid phase-sepa... more 1. Electrophoresis. 2011 Apr;32(9):959. doi: 10.1002/elps.201190027. Electroand liquid phase-separations--part I. El Rassi Z. PMID: 21491463 [PubMed - indexed for MEDLINE]. Publication Types: Editorial; Introductory Journal Article. MeSH Terms. Biological Markers; Electrophoresis*; Mass Spectrometry; Proteomics. Substances. Biological Markers.
Abstract This paper presents the design and modeling of a micromachined thermal convective gyrosc... more Abstract This paper presents the design and modeling of a micromachined thermal convective gyroscope with bidirectional jets. Unlike earlier reported thermal convective gyroscopes, the proposed gyroscope comprises two chambers for gas jet deflection. Mathematical analysis was applied to investigate the centrifugal acceleration coupling in both single directional jet detection method and bidirectional jets detection method.
Abstract This paper presents the experimental investigations of droplet movement driven by focuse... more Abstract This paper presents the experimental investigations of droplet movement driven by focused surface acoustic waves (SAWs) generated by a circular-arc interdigital transducer (CIDT). Surface acoustic waves propagating through a droplet in contact with the substrate exerted an acoustic streaming force on the droplet, as demonstrated by numerical modeling in this study. Different from the straight droplet movement driven by a straight interdigital transducer (SIDT), the droplets were focused to the center region of the CIDT.
Numerous applications of micro-/nanofluidics are related to particle transport in micro-/nanoscal... more Numerous applications of micro-/nanofluidics are related to particle transport in micro-/nanoscale channels, and electrokinetics has proved to be one of the most promising tools to manipulate particles in micro/nanofluidics. Therefore, a comprehensive understanding of electrokinetic particle transport in micro-/nanoscale channels is crucial to the development of micro/nano-fluidic devices.
The fundamental study of particle electrophoresis in microchannels is relevant to many applicatio... more The fundamental study of particle electrophoresis in microchannels is relevant to many applications. It has long been accepted that particles move parallel to the applied electric field in a straight uniform microchannel. This paper presents the first experimental demonstration of lateral particle migration in electrophoresis through a rectangular microchannel. This wall-induced dielectrophoresis-resembled motion is driven by the electrical force arising from the non-uniform electric field around the particle.
Abstract Nanopore-based sensing of single molecules is based on a detectable change in the ionic ... more Abstract Nanopore-based sensing of single molecules is based on a detectable change in the ionic current arising from the electrokinetic translocation of individual nanoparticles through a nanopore. In this study, we propose a continuum-based model to investigate the dynamic electrokinetic translocation of a cylindrical nanoparticle through a nanopore and the corresponding ionic current response.
Electrokinetic transport of a cylindrical microparticle in a straight microchannel under direct c... more Electrokinetic transport of a cylindrical microparticle in a straight microchannel under direct current (DC) electric fields is numerically and experimentally investigated. DC dielectrophoresis (DEP) is taken into account in the proposed mathematical model, which is composed of the Navier-Stokes equations for the flow field and the Laplace equation for the electric field solved in an arbitrary Lagrangian-Eulerian (ALE) framework. Cylindrical particles experience an oscillatory motion under low electric fields.
Abstract Contact configuration modification at carbon nanotube (CNT)-metal interface during nanow... more Abstract Contact configuration modification at carbon nanotube (CNT)-metal interface during nanowelding is investigated using molecular dynamics simulation. It is found that the nanowelding could be accomplished at a temperature much lower than the melting point of the metal, during which a side contact structure and core filling nanowires form at the CNT-metal interface. Metal atoms prefer entering into the core to moving along the outer surface of the CNTs.
A low-voltage electroosmotic (EO) micropump based on an anodic aluminum oxide (AAO) nano-porous m... more A low-voltage electroosmotic (EO) micropump based on an anodic aluminum oxide (AAO) nano-porous membrane with platinum electrodes coated on both sides has been designed, fabricated, tested, and analyzed. The maximum flow rate of 0.074 mlmin− 1V− 1cm− 2 for a membrane with porosity of 0.65 was obtained.
Abstract A high-throughput cell electrofusion microfluidic chip has been designed, fabricated on ... more Abstract A high-throughput cell electrofusion microfluidic chip has been designed, fabricated on a silicon-on-insulator wafer and tested for in vitro cell fusion under a low applied voltage. The developed chip consists of six individual straight microchannels with a 40-μm thickness conductive highly doped Si layer as the microchannel wall. In each microchannel, there are 75 pairs of counter protruding microelectrodes, between which the cell electrofusion is performed.
Abstract A conical nanofluidic field effect transistor (FET) refers to a conical nanopore embedde... more Abstract A conical nanofluidic field effect transistor (FET) refers to a conical nanopore embedded with an electrically controllable gate electrode. The surface potential of the nanopore can be effectively regulated by manipulating the gate potential applied to the gate electrode, which in turn controls the ionic current through the nanopore.
When particles in an electrolyte subjected to an external electric field get close to each other,... more When particles in an electrolyte subjected to an external electric field get close to each other, the presence of particles could alter the local electric field and consequently induce mutual dielectrophoretic (DEP) forces on each other.
Electrokinetics has emerged as one of the most promising techniques to transport and manipulate i... more Electrokinetics has emerged as one of the most promising techniques to transport and manipulate ions, fluid and particles in micro/nanofluidic devices. Field effect permits flexible and rapid control of the surface charge property on the channel wall, which in turn offers a more sophisticated control of the electrokinetic transport phenomena in micro/nanofluidics.
Many biocolloids, biological cells and micro-organisms are soft particles, consisted with a rigid... more Many biocolloids, biological cells and micro-organisms are soft particles, consisted with a rigid inner core covered by an ion-permeable porous membrane layer. The electrophoretic motion of a soft spherical nanoparticle in a nanopore filled with an electrolyte solution has been investigated using a continuum mathematical model.
Field effect regulation of DNA nanoparticle translocation through a nanopore using a gate electro... more Field effect regulation of DNA nanoparticle translocation through a nanopore using a gate electrode is investigated using a continuum model, composed of the coupled Poisson− Nernst− Planck equations for the ionic mass transport and the Navier− Stokes equations for the hydrodynamic field. The field effect regulation of the DNA translocation relies on the induced electroosmotic flow (EOF) and the particle− nanopore electrostatic interaction.
Abstract In this entry, we review the current knowledge on DNA–surfactant interactions with a spe... more Abstract In this entry, we review the current knowledge on DNA–surfactant interactions with a special emphasis on single molecule compaction in the dilute regime as well as phase separation, effect of the chain length and headgroup of the surfactants, and DNA secondary structure.
Acoustics has emerged as one of the most promising non-invasive techniques for particle and dropl... more Acoustics has emerged as one of the most promising non-invasive techniques for particle and droplet manipulation in microfluidics. Surface acoustic wave (SAW) based microfluidic devices are developed to manipulate micron-sized particles and discrete droplets. When solid particles are immersed in a standing SAW, the resulting acoustic radiation force acting on the particles can drive the particles into the pressure node, resulting in particle focusing phenomenon.
DC dielectrophoretic (DEP) separation of particles through a constricted microchannel was numeric... more DC dielectrophoretic (DEP) separation of particles through a constricted microchannel was numerically investigated by a verified multiphysics finite element model, composed of the Navier-Stokes equations for the flow field and the Laplace equation for the electric field solved in an arbitrary Lagrangian-Eulerian (ALE) framework. The particle-fluid-electric field interactions are fully taken into account in the present model.
1. Electrophoresis. 2011 Apr;32(9):959. doi: 10.1002/elps.201190027. Electroand liquid phase-sepa... more 1. Electrophoresis. 2011 Apr;32(9):959. doi: 10.1002/elps.201190027. Electroand liquid phase-separations--part I. El Rassi Z. PMID: 21491463 [PubMed - indexed for MEDLINE]. Publication Types: Editorial; Introductory Journal Article. MeSH Terms. Biological Markers; Electrophoresis*; Mass Spectrometry; Proteomics. Substances. Biological Markers.
Abstract This paper presents the design and modeling of a micromachined thermal convective gyrosc... more Abstract This paper presents the design and modeling of a micromachined thermal convective gyroscope with bidirectional jets. Unlike earlier reported thermal convective gyroscopes, the proposed gyroscope comprises two chambers for gas jet deflection. Mathematical analysis was applied to investigate the centrifugal acceleration coupling in both single directional jet detection method and bidirectional jets detection method.
Abstract This paper presents the experimental investigations of droplet movement driven by focuse... more Abstract This paper presents the experimental investigations of droplet movement driven by focused surface acoustic waves (SAWs) generated by a circular-arc interdigital transducer (CIDT). Surface acoustic waves propagating through a droplet in contact with the substrate exerted an acoustic streaming force on the droplet, as demonstrated by numerical modeling in this study. Different from the straight droplet movement driven by a straight interdigital transducer (SIDT), the droplets were focused to the center region of the CIDT.
Numerous applications of micro-/nanofluidics are related to particle transport in micro-/nanoscal... more Numerous applications of micro-/nanofluidics are related to particle transport in micro-/nanoscale channels, and electrokinetics has proved to be one of the most promising tools to manipulate particles in micro/nanofluidics. Therefore, a comprehensive understanding of electrokinetic particle transport in micro-/nanoscale channels is crucial to the development of micro/nano-fluidic devices.
The fundamental study of particle electrophoresis in microchannels is relevant to many applicatio... more The fundamental study of particle electrophoresis in microchannels is relevant to many applications. It has long been accepted that particles move parallel to the applied electric field in a straight uniform microchannel. This paper presents the first experimental demonstration of lateral particle migration in electrophoresis through a rectangular microchannel. This wall-induced dielectrophoresis-resembled motion is driven by the electrical force arising from the non-uniform electric field around the particle.
Abstract Nanopore-based sensing of single molecules is based on a detectable change in the ionic ... more Abstract Nanopore-based sensing of single molecules is based on a detectable change in the ionic current arising from the electrokinetic translocation of individual nanoparticles through a nanopore. In this study, we propose a continuum-based model to investigate the dynamic electrokinetic translocation of a cylindrical nanoparticle through a nanopore and the corresponding ionic current response.
Electrokinetic transport of a cylindrical microparticle in a straight microchannel under direct c... more Electrokinetic transport of a cylindrical microparticle in a straight microchannel under direct current (DC) electric fields is numerically and experimentally investigated. DC dielectrophoresis (DEP) is taken into account in the proposed mathematical model, which is composed of the Navier-Stokes equations for the flow field and the Laplace equation for the electric field solved in an arbitrary Lagrangian-Eulerian (ALE) framework. Cylindrical particles experience an oscillatory motion under low electric fields.
Abstract Contact configuration modification at carbon nanotube (CNT)-metal interface during nanow... more Abstract Contact configuration modification at carbon nanotube (CNT)-metal interface during nanowelding is investigated using molecular dynamics simulation. It is found that the nanowelding could be accomplished at a temperature much lower than the melting point of the metal, during which a side contact structure and core filling nanowires form at the CNT-metal interface. Metal atoms prefer entering into the core to moving along the outer surface of the CNTs.