Tosin Olarinmoye | Lagos State University, Lagos, Nigeria (original) (raw)
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Papers by Tosin Olarinmoye
Academic Journals, Feb 28, 2008
Information on the occurrence of pharmaceuticals in the environment of Nigeria is limited, only a... more Information on the occurrence of pharmaceuticals in the environment of Nigeria is limited, only a single publication previously on pharmaceutical occurrence in the environment of Nigeria, which measured general estrogen levels in Enugu, South-East Nigeria. In order to establish a first overview, surface water samples from six locations as well as ten sewage sludge samples from waste water treatment plants were analysed for a range of different pharmaceuticals, including antibiotics, estrogens, and lipid-lowering drugs. The results of this monitoring campaign were evaluated in comparison to published measured environmental concentrations in Africa and worldwide. In surface water samples, 12 of 37 pharmaceutical substances were detected at concentrations ranging from Limits of Detection (LOD) up to 8.84 µg/l. Four of these pharmaceuticals were found at concentrations exceeding ecotoxicological predicted no-effect concentrations (PNEC). In industrial, domestic, and hospital sewage slud...
African Journal of Aquatic Science, 2008
A'snapshot'evaluation of the he... more A'snapshot'evaluation of the health status of feral populations of the brackish water catfish, Chrysichthys nigrodigitatus, was carried out in 2006 at four locations in the Lagos lagoon complex, with varying levels of anthropogenic impacts, using a modified Health ...
AFRICAN JOURNAL OF BIOTECHNOLOGY, 2011
Several toxicological studies into the effects of aquatic pollutants on the liver of teleost fish... more Several toxicological studies into the effects of aquatic pollutants on the liver of teleost fish exist in literature. The focus on the liver in these studies is predicated on its central nature in the scheme of biotransformation and excretion of xenobiotics following exposure in polluted water bodies. As a consequence of the latter primary role of the liver in these processes it is regarded as a predilective site for the sub lethal effects of xenobiotics on the organism usually detectable at histological level. Hepatic histopathology recorded in livers from feral populations of the brackish water catfish Chrysichthys nigrodigitatus from locations on the Lagos lagoon complex with significant anthropogenic inputs from denizen populations and industries are presented. Liver sections from sixty specimens from two locations on the Lagos lagoon complex (Badagry lagoon: 6 0 24'N, 2 0 56'E; and Lagos lagoon: 6 0 29'N, 3 0 22'E) were analysed. Observed pathologies included hydropic degeneration (58%), portal / sinusoidal congestion (33%), hepatic necrosis (26%), hemosiderosis (12%) and foci of cellular alterations (FCA's). No obvious oncologic features were observed; the presence of the hydropic Vacuolation lesion was taken as prelude to the development of neoplasms and discussed as such.
Information on the occurrence of pharmaceuticals in the environment of Nigeria is limited, only a... more Information on the occurrence of pharmaceuticals in the environment of Nigeria is limited, only a single publication previously on pharmaceutical occurrence in the environment of Nigeria, which measured general estrogen levels in Enugu, SouthEast Nigeria. In order to establish a first overview, surface water samples from six locations as well as ten sewage sludge samples from waste water treatment plants were analysed for a range of different pharmaceuticals, including antibiotics, estrogens, and lipid-lowering drugs. The results of this monitoring campaign were evaluated in comparison to published measured environmental concentrations in Africa and worldwide. In surface water samples, 12 of 37 pharmaceutical substances were detected at concentrations ranging from Limits of Detection (LOD) up to 8.84 µg/l. Four of these pharmaceuticals were found at concentrations exceeding ecotoxicological predicted no-effect concentrations (PNEC). In industrial, domestic, and hospital sewage sludge, nine different pharmaceutical substances were detected with the NSAID diclofenac present in all samples at concentrations of up to 1100 µg/kg dry weight, exceeding the highest measured concentration of 560 µg/ kg reported in sludge samples worldwide. This study proves the presence of several pharmaceuticals at relevant concentrations in the environmental matrices studied. Further, more comprehensive monitoring campaigns, especially in locations with high population density and low dilution of treated or untreated waste water in receiving streams are recommended.
A ‘snapshot’ evaluation of the health status of feral populations of the brackish water catfish, ... more A ‘snapshot’ evaluation of the health status of feral populations of the brackish water catfish, Chrysichthys nigrodigitatus, was
carried out in 2006 at four locations in the Lagos lagoon complex, with varying levels of anthropogenic impacts, using a modified
Health Assessment Index (HAI) protocol. Fish health was assessed using condition-related indices including condition factor
and a modified Health Assessment Index (HAI). Condition indices provided relatively simple and rapid indications of how well
fish were coping in their environment. The HAI score varied across the four sample sites. The highest individual mean value was
76.57 at Badagry Lagoon, followed by a score of 49.87 at Ologe and 48.16 at Epe, while the lowest was 29.67 in the Lagos Lagoon.
This investigation did not reveal widespread pathognomonic, truly specific, responses to contaminant exposure, but showed the
existence of differences in the health status of fish populations in four different lagoons within the Lagos lagoon complex.
Several toxicological studies into the effects of aquatic pollutants on the liver of teleost fish... more Several toxicological studies into the effects of aquatic pollutants on the liver of teleost fish exist in
literature. The focus on the liver in these studies is predicated on its central nature in the scheme of
biotransformation and excretion of xenobiotics following exposure in polluted water bodies. As a
consequence of the latter primary role of the liver in these processes it is regarded as a predilective
site for the sub lethal effects of xenobiotics on the organism usually detectable at histological level.
Hepatic histopathology recorded in livers from feral populations of the brackish water catfish
Chrysichthys nigrodigitatus from locations on the Lagos lagoon complex with significant
anthropogenic inputs from denizen populations and industries are presented. Liver sections from sixty
specimens from two locations on the Lagos lagoon complex (Badagry lagoon: 6°24’N, 2°56’E; and
Lagos lagoon: 6°29’N, 3°22’E) were analysed. Observed pathologies included hydropic degeneration
(58%), portal / sinusoidal congestion (33%), hepatic necrosis (26%), hemosiderosis (12%) and foci of
cellular alterations (FCA’s). No obvious oncologic features were observed; the presence of the
hydropic Vacuolation lesion was taken as prelude to the development of neoplasms and discussed as
such.
Key words: Liver, pathology, fish, toxicology, water quality.
Academic Journals, Feb 28, 2008
Information on the occurrence of pharmaceuticals in the environment of Nigeria is limited, only a... more Information on the occurrence of pharmaceuticals in the environment of Nigeria is limited, only a single publication previously on pharmaceutical occurrence in the environment of Nigeria, which measured general estrogen levels in Enugu, South-East Nigeria. In order to establish a first overview, surface water samples from six locations as well as ten sewage sludge samples from waste water treatment plants were analysed for a range of different pharmaceuticals, including antibiotics, estrogens, and lipid-lowering drugs. The results of this monitoring campaign were evaluated in comparison to published measured environmental concentrations in Africa and worldwide. In surface water samples, 12 of 37 pharmaceutical substances were detected at concentrations ranging from Limits of Detection (LOD) up to 8.84 µg/l. Four of these pharmaceuticals were found at concentrations exceeding ecotoxicological predicted no-effect concentrations (PNEC). In industrial, domestic, and hospital sewage slud...
African Journal of Aquatic Science, 2008
A'snapshot'evaluation of the he... more A'snapshot'evaluation of the health status of feral populations of the brackish water catfish, Chrysichthys nigrodigitatus, was carried out in 2006 at four locations in the Lagos lagoon complex, with varying levels of anthropogenic impacts, using a modified Health ...
AFRICAN JOURNAL OF BIOTECHNOLOGY, 2011
Several toxicological studies into the effects of aquatic pollutants on the liver of teleost fish... more Several toxicological studies into the effects of aquatic pollutants on the liver of teleost fish exist in literature. The focus on the liver in these studies is predicated on its central nature in the scheme of biotransformation and excretion of xenobiotics following exposure in polluted water bodies. As a consequence of the latter primary role of the liver in these processes it is regarded as a predilective site for the sub lethal effects of xenobiotics on the organism usually detectable at histological level. Hepatic histopathology recorded in livers from feral populations of the brackish water catfish Chrysichthys nigrodigitatus from locations on the Lagos lagoon complex with significant anthropogenic inputs from denizen populations and industries are presented. Liver sections from sixty specimens from two locations on the Lagos lagoon complex (Badagry lagoon: 6 0 24'N, 2 0 56'E; and Lagos lagoon: 6 0 29'N, 3 0 22'E) were analysed. Observed pathologies included hydropic degeneration (58%), portal / sinusoidal congestion (33%), hepatic necrosis (26%), hemosiderosis (12%) and foci of cellular alterations (FCA's). No obvious oncologic features were observed; the presence of the hydropic Vacuolation lesion was taken as prelude to the development of neoplasms and discussed as such.
Information on the occurrence of pharmaceuticals in the environment of Nigeria is limited, only a... more Information on the occurrence of pharmaceuticals in the environment of Nigeria is limited, only a single publication previously on pharmaceutical occurrence in the environment of Nigeria, which measured general estrogen levels in Enugu, SouthEast Nigeria. In order to establish a first overview, surface water samples from six locations as well as ten sewage sludge samples from waste water treatment plants were analysed for a range of different pharmaceuticals, including antibiotics, estrogens, and lipid-lowering drugs. The results of this monitoring campaign were evaluated in comparison to published measured environmental concentrations in Africa and worldwide. In surface water samples, 12 of 37 pharmaceutical substances were detected at concentrations ranging from Limits of Detection (LOD) up to 8.84 µg/l. Four of these pharmaceuticals were found at concentrations exceeding ecotoxicological predicted no-effect concentrations (PNEC). In industrial, domestic, and hospital sewage sludge, nine different pharmaceutical substances were detected with the NSAID diclofenac present in all samples at concentrations of up to 1100 µg/kg dry weight, exceeding the highest measured concentration of 560 µg/ kg reported in sludge samples worldwide. This study proves the presence of several pharmaceuticals at relevant concentrations in the environmental matrices studied. Further, more comprehensive monitoring campaigns, especially in locations with high population density and low dilution of treated or untreated waste water in receiving streams are recommended.
A ‘snapshot’ evaluation of the health status of feral populations of the brackish water catfish, ... more A ‘snapshot’ evaluation of the health status of feral populations of the brackish water catfish, Chrysichthys nigrodigitatus, was
carried out in 2006 at four locations in the Lagos lagoon complex, with varying levels of anthropogenic impacts, using a modified
Health Assessment Index (HAI) protocol. Fish health was assessed using condition-related indices including condition factor
and a modified Health Assessment Index (HAI). Condition indices provided relatively simple and rapid indications of how well
fish were coping in their environment. The HAI score varied across the four sample sites. The highest individual mean value was
76.57 at Badagry Lagoon, followed by a score of 49.87 at Ologe and 48.16 at Epe, while the lowest was 29.67 in the Lagos Lagoon.
This investigation did not reveal widespread pathognomonic, truly specific, responses to contaminant exposure, but showed the
existence of differences in the health status of fish populations in four different lagoons within the Lagos lagoon complex.
Several toxicological studies into the effects of aquatic pollutants on the liver of teleost fish... more Several toxicological studies into the effects of aquatic pollutants on the liver of teleost fish exist in
literature. The focus on the liver in these studies is predicated on its central nature in the scheme of
biotransformation and excretion of xenobiotics following exposure in polluted water bodies. As a
consequence of the latter primary role of the liver in these processes it is regarded as a predilective
site for the sub lethal effects of xenobiotics on the organism usually detectable at histological level.
Hepatic histopathology recorded in livers from feral populations of the brackish water catfish
Chrysichthys nigrodigitatus from locations on the Lagos lagoon complex with significant
anthropogenic inputs from denizen populations and industries are presented. Liver sections from sixty
specimens from two locations on the Lagos lagoon complex (Badagry lagoon: 6°24’N, 2°56’E; and
Lagos lagoon: 6°29’N, 3°22’E) were analysed. Observed pathologies included hydropic degeneration
(58%), portal / sinusoidal congestion (33%), hepatic necrosis (26%), hemosiderosis (12%) and foci of
cellular alterations (FCA’s). No obvious oncologic features were observed; the presence of the
hydropic Vacuolation lesion was taken as prelude to the development of neoplasms and discussed as
such.
Key words: Liver, pathology, fish, toxicology, water quality.