Ryan Naylor | La Trobe University (original) (raw)

Papers by Ryan Naylor

Widening Higher Education Participation, 2016

For over 20 years it has been recognised that a gap has existed between the professional skills p... more For over 20 years it has been recognised that a gap has existed between the professional skills possessed by engineering graduates and the expectations of industry. This gap has gradually been accepted by many academics with new and innovative programs constantly being implemented, but even so, research indicates that this gap still exists and is still significant. So what is going wrong? Are educators not using the correct approaches? Do students need more resources? Are the assessments misaligned? This paper investigates one possible barrier to the development of professional skills; the self-efficacy of students. A study of 50 Masters of Engineering students explores the links between how the students perceive their verbal communication skills, how teaching staff have evaluated these skills and how the students have made use of available resources. The data is derived from presentation assessments, self-reflections and a survey completed by the participants. The paper concludes w...

Voprosy Obrazovaniya/ Educational Studies. Moscow, 2016

European Biophysics Journal, Apr 1, 2008

Alzheimer's disease is the most common form of dementia in the elderly, and is characterised by e... more Alzheimer's disease is the most common form of dementia in the elderly, and is characterised by extracellular amyloid plaques composed of the -amyloid peptide (A ). However, disease progression has been shown to correlate more closely with the level of soluble A oligomers. Recent evidence suggests that these oligomers are covalently crosslinked, possibly due to the interaction of A with redox-active metal ions. These Wndings oVer new avenues for the treatment and prevention of disease, by modulating metal binding or preventing the formation of neurotoxic A oligomers.

Eur Biophys J Biophys Lett, 2008

Alzheimer's disease is the most common form of dementia in the elderly, and is characterised by e... more Alzheimer's disease is the most common form of dementia in the elderly, and is characterised by extracellular amyloid plaques composed of the -amyloid peptide (A ). However, disease progression has been shown to correlate more closely with the level of soluble A oligomers. Recent evidence suggests that these oligomers are covalently crosslinked, possibly due to the interaction of A with redox-active metal ions. These Wndings oVer new avenues for the treatment and prevention of disease, by modulating metal binding or preventing the formation of neurotoxic A oligomers.

Faseb J, 2007

Alzheimer's disease (AD) is the most common form of dementia and is associated with the depositio... more Alzheimer's disease (AD) is the most common form of dementia and is associated with the deposition of the 39-to 43-amino acid ␤-amyloid peptide (A␤) in the brain. C-terminal fragments (CTFs) of amyloid precursor protein (APP) can accumulate in endosomally derived multivesicular bodies (MVBs). These intracellular structures contain intraluminal vesicles that are released from the cell as exosomes when the MVB fuses with the plasma membrane. Here we have investigated the role of exosomes in the processing of APP and show that these vesicles contain APP-CTFs, as well as A␤. In addition, inhibition of ␥-secretase results in a significant increase in the amount of ␣and ␤-secretase cleavage, further increasing the amount of APP-CTFs contained within these exosomes. We identify several key members of the secretase family of proteases (BACE, PS1, PS2, and ADAM10) to be localized in exosomes, suggesting they may be a previously unidentified site of APP cleavage. These results provide further evidence for a novel pathway in which APP fragments are released from cells and have implications for the analysis of APP processing and diagnostics for Alzheimer's disease.-Sharples, R.

Student Equity in Australian Higher Education, 2016

Proceedings of the Australian Conference on Science and Mathematics Education, Sep 23, 2013

In recent years it has become quite common to use a routine research practice within our classroo... more In recent years it has become quite common to use a routine research practice within our classrooms: that of peer review. Involving students in peer review is often regarded as an effective way to help students improve the quality of their assignment work before it is submitted. The peer review process offers many other benefits to students: an opportunity to reflect on their work in the light of the work of others; to observe the quality and scope of other students' work; to critically evaluate a piece of work and construct appropriate and constructive feedback; and to develop critical thinking, higher-order cognitive, negotiation and diplomacy skills. However, one benefit less often acknowledged is the impact that the peer review process can have on students' conceptual learning. In this presentation we will report on two case studies that illustrate how peer review improved the conceptual understanding of students. One was a formal research study that assessed the effect of peer review on the performance of third year zoology students. The other, less formal study, describes students' self-reported conceptual gains in a first year physics subject.

Http Dx Doi Org 10 1080 02602938 2013 860421, 2014

ABSTRACT Involving students in peer review has many pedagogical benefits, but few studies have ex... more ABSTRACT Involving students in peer review has many pedagogical benefits, but few studies have explicitly investigated relationships between the content of peer reviews, student perceptions and assessment outcomes. We conducted a case study of peer review within a third-year undergraduate subject at a research-intensive Australian university, in which we examined: (1) students’ perceptions of the peer review process before and after peer review, (2) content of the peer reviews and what kinds of feedback were adopted and (3) the effect of participation in peer review on performance (grades) in the assessment task. Students overwhelmingly perceived peer review to be beneficial, and the opportunity to participate in peer review resulted in a significant improvement in the quality of work submitted for assessment. Students who benefited most from peer review were those of below-median performance, and the magnitude of benefit was related to the degree to which students engaged with the peer review process. Our study confirms that participation in peer review can lead to important improvements in performance and learning outcomes.

DEC 2008, Is Covalently Crosslinked A beta Responsible for Synaptotoxicity in Alzheimer's Dis... more DEC 2008, Is Covalently Crosslinked A beta Responsible for Synaptotoxicity in Alzheimer's Disease?

The user has requested enhancement of the downloaded file. All in-text references underlined in b... more The user has requested enhancement of the downloaded file. All in-text references underlined in blue are added to the original document and are linked to publications on ResearchGate, letting you access and read them immediately.

In recent years it has become quite common to use a routine research practice within our classroo... more In recent years it has become quite common to use a routine research practice within our classrooms: that of peer review. Involving students in peer review is often regarded as an effective way to help students improve the quality of their assignment work before it is submitted. The peer review process offers many other benefits to students: an opportunity to reflect on their work in the light of the work of others; to observe the quality and scope of other students' work; to critically evaluate a piece of work and construct appropriate and constructive feedback; and to develop critical thinking, higher-order cognitive, negotiation and diplomacy skills. However, one benefit less often acknowledged is the impact that the peer review process can have on students' conceptual learning. In this presentation we will report on two case studies that illustrate how peer review improved the conceptual understanding of students. One was a formal research study that assessed the effect of peer review on the performance of third year zoology students. The other, less formal study, describes students' self-reported conceptual gains in a first year physics subject.

Proceedings of the 5th International Conference on Communities and Technologies - C&T '11, 2011

Augmented reality was used as an innovative way to engage the general public with biomedical and ... more Augmented reality was used as an innovative way to engage the general public with biomedical and healthcare research information. Six research institutes in Melbourne's Parkville precinct were augmented with web-based information, and volunteers tested the usability of both this content and the augmented reality browser. Participants' feedback concerning the usefulness of the biomedical and healthcare information was very positive; over 75% of participants described the application favourably. Participants expressed a range of preferences regarding the types of information presented and its structure. Several participants felt they had learned something new from the application, and commented positively on the locative and mobile context of the technology. A challenge for science communicators is to provide user-friendly, accessible technologies that provide information of a suitable complexity and allow users to access that information according to their personal preferences. User feedback indicated that the application described in this study generally met these requirements, and shows that smart phone based AR has potential for use in science communication and public engagement with science.

Assessment & Evaluation in Higher Education, 2013

ABSTRACT Involving students in peer review has many pedagogical benefits, but few studies have ex... more ABSTRACT Involving students in peer review has many pedagogical benefits, but few studies have explicitly investigated relationships between the content of peer reviews, student perceptions and assessment outcomes. We conducted a case study of peer review within a third-year undergraduate subject at a research-intensive Australian university, in which we examined: (1) students’ perceptions of the peer review process before and after peer review, (2) content of the peer reviews and what kinds of feedback were adopted and (3) the effect of participation in peer review on performance (grades) in the assessment task. Students overwhelmingly perceived peer review to be beneficial, and the opportunity to participate in peer review resulted in a significant improvement in the quality of work submitted for assessment. Students who benefited most from peer review were those of below-median performance, and the magnitude of benefit was related to the degree to which students engaged with the peer review process. Our study confirms that participation in peer review can lead to important improvements in performance and learning outcomes.

The FASEB Journal, 2007

Alzheimer's disease (AD) is the most common form of dementia and is associated with the depositio... more Alzheimer's disease (AD) is the most common form of dementia and is associated with the deposition of the 39-to 43-amino acid ␤-amyloid peptide (A␤) in the brain. C-terminal fragments (CTFs) of amyloid precursor protein (APP) can accumulate in endosomally derived multivesicular bodies (MVBs). These intracellular structures contain intraluminal vesicles that are released from the cell as exosomes when the MVB fuses with the plasma membrane. Here we have investigated the role of exosomes in the processing of APP and show that these vesicles contain APP-CTFs, as well as A␤. In addition, inhibition of ␥-secretase results in a significant increase in the amount of ␣and ␤-secretase cleavage, further increasing the amount of APP-CTFs contained within these exosomes. We identify several key members of the secretase family of proteases (BACE, PS1, PS2, and ADAM10) to be localized in exosomes, suggesting they may be a previously unidentified site of APP cleavage. These results provide further evidence for a novel pathway in which APP fragments are released from cells and have implications for the analysis of APP processing and diagnostics for Alzheimer's disease.-Sharples, R.

Widening Higher Education Participation, 2016

For over 20 years it has been recognised that a gap has existed between the professional skills p... more For over 20 years it has been recognised that a gap has existed between the professional skills possessed by engineering graduates and the expectations of industry. This gap has gradually been accepted by many academics with new and innovative programs constantly being implemented, but even so, research indicates that this gap still exists and is still significant. So what is going wrong? Are educators not using the correct approaches? Do students need more resources? Are the assessments misaligned? This paper investigates one possible barrier to the development of professional skills; the self-efficacy of students. A study of 50 Masters of Engineering students explores the links between how the students perceive their verbal communication skills, how teaching staff have evaluated these skills and how the students have made use of available resources. The data is derived from presentation assessments, self-reflections and a survey completed by the participants. The paper concludes w...

Voprosy Obrazovaniya/ Educational Studies. Moscow, 2016

European Biophysics Journal, Apr 1, 2008

Alzheimer's disease is the most common form of dementia in the elderly, and is characterised by e... more Alzheimer's disease is the most common form of dementia in the elderly, and is characterised by extracellular amyloid plaques composed of the -amyloid peptide (A ). However, disease progression has been shown to correlate more closely with the level of soluble A oligomers. Recent evidence suggests that these oligomers are covalently crosslinked, possibly due to the interaction of A with redox-active metal ions. These Wndings oVer new avenues for the treatment and prevention of disease, by modulating metal binding or preventing the formation of neurotoxic A oligomers.

Eur Biophys J Biophys Lett, 2008

Alzheimer's disease is the most common form of dementia in the elderly, and is characterised by e... more Alzheimer's disease is the most common form of dementia in the elderly, and is characterised by extracellular amyloid plaques composed of the -amyloid peptide (A ). However, disease progression has been shown to correlate more closely with the level of soluble A oligomers. Recent evidence suggests that these oligomers are covalently crosslinked, possibly due to the interaction of A with redox-active metal ions. These Wndings oVer new avenues for the treatment and prevention of disease, by modulating metal binding or preventing the formation of neurotoxic A oligomers.

Faseb J, 2007

Alzheimer's disease (AD) is the most common form of dementia and is associated with the depositio... more Alzheimer's disease (AD) is the most common form of dementia and is associated with the deposition of the 39-to 43-amino acid ␤-amyloid peptide (A␤) in the brain. C-terminal fragments (CTFs) of amyloid precursor protein (APP) can accumulate in endosomally derived multivesicular bodies (MVBs). These intracellular structures contain intraluminal vesicles that are released from the cell as exosomes when the MVB fuses with the plasma membrane. Here we have investigated the role of exosomes in the processing of APP and show that these vesicles contain APP-CTFs, as well as A␤. In addition, inhibition of ␥-secretase results in a significant increase in the amount of ␣and ␤-secretase cleavage, further increasing the amount of APP-CTFs contained within these exosomes. We identify several key members of the secretase family of proteases (BACE, PS1, PS2, and ADAM10) to be localized in exosomes, suggesting they may be a previously unidentified site of APP cleavage. These results provide further evidence for a novel pathway in which APP fragments are released from cells and have implications for the analysis of APP processing and diagnostics for Alzheimer's disease.-Sharples, R.

Student Equity in Australian Higher Education, 2016

Proceedings of the Australian Conference on Science and Mathematics Education, Sep 23, 2013

In recent years it has become quite common to use a routine research practice within our classroo... more In recent years it has become quite common to use a routine research practice within our classrooms: that of peer review. Involving students in peer review is often regarded as an effective way to help students improve the quality of their assignment work before it is submitted. The peer review process offers many other benefits to students: an opportunity to reflect on their work in the light of the work of others; to observe the quality and scope of other students' work; to critically evaluate a piece of work and construct appropriate and constructive feedback; and to develop critical thinking, higher-order cognitive, negotiation and diplomacy skills. However, one benefit less often acknowledged is the impact that the peer review process can have on students' conceptual learning. In this presentation we will report on two case studies that illustrate how peer review improved the conceptual understanding of students. One was a formal research study that assessed the effect of peer review on the performance of third year zoology students. The other, less formal study, describes students' self-reported conceptual gains in a first year physics subject.

Http Dx Doi Org 10 1080 02602938 2013 860421, 2014

ABSTRACT Involving students in peer review has many pedagogical benefits, but few studies have ex... more ABSTRACT Involving students in peer review has many pedagogical benefits, but few studies have explicitly investigated relationships between the content of peer reviews, student perceptions and assessment outcomes. We conducted a case study of peer review within a third-year undergraduate subject at a research-intensive Australian university, in which we examined: (1) students’ perceptions of the peer review process before and after peer review, (2) content of the peer reviews and what kinds of feedback were adopted and (3) the effect of participation in peer review on performance (grades) in the assessment task. Students overwhelmingly perceived peer review to be beneficial, and the opportunity to participate in peer review resulted in a significant improvement in the quality of work submitted for assessment. Students who benefited most from peer review were those of below-median performance, and the magnitude of benefit was related to the degree to which students engaged with the peer review process. Our study confirms that participation in peer review can lead to important improvements in performance and learning outcomes.

DEC 2008, Is Covalently Crosslinked A beta Responsible for Synaptotoxicity in Alzheimer's Dis... more DEC 2008, Is Covalently Crosslinked A beta Responsible for Synaptotoxicity in Alzheimer's Disease?

The user has requested enhancement of the downloaded file. All in-text references underlined in b... more The user has requested enhancement of the downloaded file. All in-text references underlined in blue are added to the original document and are linked to publications on ResearchGate, letting you access and read them immediately.

In recent years it has become quite common to use a routine research practice within our classroo... more In recent years it has become quite common to use a routine research practice within our classrooms: that of peer review. Involving students in peer review is often regarded as an effective way to help students improve the quality of their assignment work before it is submitted. The peer review process offers many other benefits to students: an opportunity to reflect on their work in the light of the work of others; to observe the quality and scope of other students' work; to critically evaluate a piece of work and construct appropriate and constructive feedback; and to develop critical thinking, higher-order cognitive, negotiation and diplomacy skills. However, one benefit less often acknowledged is the impact that the peer review process can have on students' conceptual learning. In this presentation we will report on two case studies that illustrate how peer review improved the conceptual understanding of students. One was a formal research study that assessed the effect of peer review on the performance of third year zoology students. The other, less formal study, describes students' self-reported conceptual gains in a first year physics subject.

Proceedings of the 5th International Conference on Communities and Technologies - C&T '11, 2011

Augmented reality was used as an innovative way to engage the general public with biomedical and ... more Augmented reality was used as an innovative way to engage the general public with biomedical and healthcare research information. Six research institutes in Melbourne's Parkville precinct were augmented with web-based information, and volunteers tested the usability of both this content and the augmented reality browser. Participants' feedback concerning the usefulness of the biomedical and healthcare information was very positive; over 75% of participants described the application favourably. Participants expressed a range of preferences regarding the types of information presented and its structure. Several participants felt they had learned something new from the application, and commented positively on the locative and mobile context of the technology. A challenge for science communicators is to provide user-friendly, accessible technologies that provide information of a suitable complexity and allow users to access that information according to their personal preferences. User feedback indicated that the application described in this study generally met these requirements, and shows that smart phone based AR has potential for use in science communication and public engagement with science.

Assessment & Evaluation in Higher Education, 2013

ABSTRACT Involving students in peer review has many pedagogical benefits, but few studies have ex... more ABSTRACT Involving students in peer review has many pedagogical benefits, but few studies have explicitly investigated relationships between the content of peer reviews, student perceptions and assessment outcomes. We conducted a case study of peer review within a third-year undergraduate subject at a research-intensive Australian university, in which we examined: (1) students’ perceptions of the peer review process before and after peer review, (2) content of the peer reviews and what kinds of feedback were adopted and (3) the effect of participation in peer review on performance (grades) in the assessment task. Students overwhelmingly perceived peer review to be beneficial, and the opportunity to participate in peer review resulted in a significant improvement in the quality of work submitted for assessment. Students who benefited most from peer review were those of below-median performance, and the magnitude of benefit was related to the degree to which students engaged with the peer review process. Our study confirms that participation in peer review can lead to important improvements in performance and learning outcomes.

The FASEB Journal, 2007

Alzheimer's disease (AD) is the most common form of dementia and is associated with the depositio... more Alzheimer's disease (AD) is the most common form of dementia and is associated with the deposition of the 39-to 43-amino acid ␤-amyloid peptide (A␤) in the brain. C-terminal fragments (CTFs) of amyloid precursor protein (APP) can accumulate in endosomally derived multivesicular bodies (MVBs). These intracellular structures contain intraluminal vesicles that are released from the cell as exosomes when the MVB fuses with the plasma membrane. Here we have investigated the role of exosomes in the processing of APP and show that these vesicles contain APP-CTFs, as well as A␤. In addition, inhibition of ␥-secretase results in a significant increase in the amount of ␣and ␤-secretase cleavage, further increasing the amount of APP-CTFs contained within these exosomes. We identify several key members of the secretase family of proteases (BACE, PS1, PS2, and ADAM10) to be localized in exosomes, suggesting they may be a previously unidentified site of APP cleavage. These results provide further evidence for a novel pathway in which APP fragments are released from cells and have implications for the analysis of APP processing and diagnostics for Alzheimer's disease.-Sharples, R.