Arun Holden | University of Leeds (original) (raw)

Papers by Arun Holden

Philosophical transactions, Jun 15, 1994

Briefings in Bioinformatics, 2001

arXiv (Cornell University), Apr 13, 2017

International Journal of Bifurcation and Chaos, May 1, 2006

Springer eBooks, 2003

Electrophysiology and immunocytochemistry have been used to map the detailed properties of cells ... more Electrophysiology and immunocytochemistry have been used to map the detailed properties of cells cross the pacemaker of the heart, the sinoatrial node. The electrical activities and expressions of various proteins across the sinoatrial node change smoothly with distance and so can be modelled by a gradient in parameter values. Experimental data have been integrated into computational models of the SA node at cellular and tissue levels and mechanisms underlying initiation and propagation of pacemaker activity of the heart identified.

Scientific Reports, 2018

Aberrant uterine myometrial activities in humans are major health issues. However, the cellular a... more Aberrant uterine myometrial activities in humans are major health issues. However, the cellular and tissue mechanism(s) that maintain the uterine myometrium at rest during gestation, and that initiate and maintain long-lasting uterine contractions during delivery are incompletely understood. In this study we construct a computational model for describing the electrical activity (simple and complex action potentials), intracellular calcium dynamics and mechanical contractions of isolated uterine myocytes from the pregnant rat. The model reproduces variant types of action potentials – from spikes with a smooth plateau, to spikes with an oscillatory plateau, to bursts of spikes – that are seen during late gestation under different physiological conditions. The effects of the hormones oestradiol (via reductions in calcium and potassium selective channel conductance), oxytocin (via an increase in intracellular calcium release) and the tocolytic nifedipine (via a block of L-type calcium c...

American Journal of Physiology-Heart and Circulatory Physiology, 2000

Mathematical models of the action potential in the periphery and center of the rabbit sinoatrial ... more Mathematical models of the action potential in the periphery and center of the rabbit sinoatrial (SA) node have been developed on the basis of published experimental data. Simulated action potentials are consistent with those recorded experimentally: the model-generated peripheral action potential has a more negative takeoff potential, faster upstroke, more positive peak value, prominent phase 1 repolarization, greater amplitude, shorter duration, and more negative maximum diastolic potential than the model-generated central action potential. In addition, the model peripheral cell shows faster pacemaking. The models behave qualitatively the same as tissue from the periphery and center of the SA node in response to block of tetrodotoxin-sensitive Na+current, L- and T-type Ca2+ currents, 4-aminopyridine-sensitive transient outward current, rapid and slow delayed rectifying K+ currents, and hyperpolarization-activated current. A one-dimensional model of a string of SA node tissue, inco...

Cardiac virtual tissues are biophysically, histologically and anatomically detailed computational... more Cardiac virtual tissues are biophysically, histologically and anatomically detailed computational models that are sufficiently well validated to be used as a predictive tool, are currently used in basic research, and are beginning to be applied to clinical problems. Virtual cardiac cells and tissues are stiff, high order ordinary and partial differential equations. While 1- and 2-D tissues can be run

Frontiers in Physiology, 2012

Lecture Notes in Computer Science, 2005

Studies in Multidisciplinarity, 2005

... 21 Towards understanding the physical basis of re-entrant cardiac arrhythmias Oleg V. Aslanid... more ... 21 Towards understanding the physical basis of re-entrant cardiac arrhythmias Oleg V. Aslanidi a, Vadim N. Biktashev b, Irina V. Biktasheva c, Richard H. Clayton a and Arun V. Holden a aCardiovascular Research Institute, University of ... Nicol, M., Melbourne, I., Ashwin, P., 2001. ...