Gloria Aguayo | Luxembourg Institute of Health (original) (raw)
Papers by Gloria Aguayo
BMJ Open, 2023
ABSTRACT Introduction Type 1 diabetes (T1D) requires continuous management to obtain a good metab... more ABSTRACT
Introduction Type 1 diabetes (T1D) requires continuous management to obtain a good metabolic control and prevent acute complications. This often affects psychological well-being. People with T1D frequently report diabetes distress (DD). Psychological issues can negatively affect metabolic control and well-being. New technologies can improve quality of life, reduce the treatment burden and improve glycaemic control. Voice
technology may serve as an innovative and inexpensive remote monitoring device to evaluate psychological well-being. Tailoring digital health interventions according to the ability and interest of their intended ‘end-users’ increases the acceptability of the intervention itself. PsyVoice
explores the perspectives and needs of people with T1D on voice-based
digital health interventions to manage DD. Methods and analysis PsyVoice is a mixed-methods study with qualitative and quantitative data sources. For the qualitative part, the researchers will invite 20 people with a T1D or caregivers of children with T1D to participate in in-depth semi-structured
interviews. They will be invited as well to answer three questionnaires to assess socio-demographics, diabetes management, e-Health
literacy and diabetes distress. Information from questionnaires
will be integrated with themes developed in the qualitative
analysis of the interviews. People with T1D will be invited
to participate in the protocol and give feedback on interview guides, questionnaires, information sheets and informed consent.
Ethics and dissemination PsyVoice received ethical approval from Luxembourg’s National Research Ethics Committee. Participants will receive information about the purpose, risks and strategies to ensure the confidentiality and anonymity of the study. The results of PsyVoice will
guide the selection and development of voice-based technological interventions for managing DD. The outcome will be disseminated to academic and non-academic stakeholders through peer-reviewed
open-access journals and a lay public report. Trial registration number This study is registered on ClinicalTrials. gov with the number NCT05517772.
Rev Chil Pediatr, Jun 1, 1990
Rev Med Chile, Apr 1, 1998
BACKGROUND: The evolution of ulcerative colitis in pregnancy is far from clear. While some author... more BACKGROUND: The evolution of ulcerative colitis in pregnancy is far from clear. While some authors state that the disease aggravates during this period, others do not share this opinion. AIM: To assess the evolution of ulcerative colitis in pregnancy. PATIENTS AND METHODS: A paired case-control design was used in which 15 women, with diagnosed ulcerative colitis at the moment of becoming pregnant, were followed for 12 months and the activity of the disease was compared with that of the 12 months preceding the pregnancy. The activity of the disease in the period preceding the pregnancy was gathered retrospectively from the patient's charts. RESULTS: The mean age of the first ulcerative colitis crisis was 24 years. It was moderate in 49% and severe in 35% of women. During pregnancy 55% of women did not have a crisis, compared with 26.7% during the period preceding pregnancy (relative risk of not having a crisis during pregnancy of 1.7). During both periods, seven women had digestive complications, whereas extra digestive complications were not observed in 60% of patients during pregnancy and 11.8% of patients during the preceding period. Perinatal results were similar to those of the general population. CONCLUSIONS: In our group of patients the evolution of ulcerative colitis was better during pregnancy, reflected by a lower number of crisis.
Revue d'Épidémiologie et de Santé Publique, 2014
Bulletin de la Société des sciences médicales du Grand-Duché de Luxembourg, 2012
Excessive food intake has been linked to many factors including taste preference and the presence... more Excessive food intake has been linked to many factors including taste preference and the presence of psychopathology. The purpose of this study was to investigate the association between sweet and salty taste preference and psychopathology in patients with severe obesity. A consecutive series of patients applying for bariatric surgery was recruited for the study. Taste preference was self-reported. Psychopathology was assessed using the revised version of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). 190 patients were included in the study. In comparison with patients who had salty taste preference, patients with sweet taste preference had significantly higher elevations on the depression (OD: 4.090, p = 0.010) and the hysteria (OD: 2.951, p = 0.026) clinical scales of the MMPI-2. The results suggest the presence of an association between taste preference and psychopathology. The findings may be of interest for clinicians who are involved in the treatment of obesity. I...
Revista médica de Chile, 1998
Total parenteral nutrition (TPN) has been traditionally used as an adjunctive therapy in severe u... more Total parenteral nutrition (TPN) has been traditionally used as an adjunctive therapy in severe ulcerative colitis patients. We performed a prospective study to ascertain the safety, nutritional efficiency, tolerance and costs of total enteral nutrition in this situation. After 48 hours of intensive medical treatment, severe ulcerative colitis patients initiated enteral feeding with a polymeric formula. The formula concentration and volume were increased daily. 17 patients (7 women, 10 men; age 36.8 +/- 12.8 years) with a mean clinical activity score of 15.6 +/- 1.5 were included. In 14 patients (82.4%) enteral nutrition was well tolerated, attaining in 11 of them more than 80% of the caloric requirements by day 4. In 3 cases we observed vomiting and bloating. Prealbumin levels improved significantly from 11.1 +/- 3.4 mg/dl to 22.7 +/- 6.8 mg/dl (p = 0.002) at the end of enteral nutrition (11.8 +/- 4.7 days). Albumin and other nutritional parameters did not change. Total enteral nut...
Revista chilena de pediatría
The incidence of bronchopulmonary dysplasia (BPD) was retrospectively studied in all ventilated n... more The incidence of bronchopulmonary dysplasia (BPD) was retrospectively studied in all ventilated newborns at a neonatal intensive care unit of a university based hospital at Santiago, Chile along a 5 years period (1983-1987). BPD incidence among the whole sample of newborn infants requiring artificial ventilation was analysed according to birth weight (BW) and compared with that of newborns surviving after 28 days of life. The possible association of BPD with hyaline membrane disease (HMD), ductus arteriosus (DA) and pulmonary air leak (PAL) was studied. The total number of ventilated newborns was 200, incidence of BPD was 9.5% (19/200) and lethality for BPD was 5.2% (1/19). The incidence of BPD increased progressively with decreasing BW, reaching 37.5% in infants less than 1,000 g (p less than 0.001 chi 2). Among 28 day survivors incidence of BPD in the same BW group increased to 75% (p less than 0.05). These findings support the idea that the incidence of BPD increases with improve...
Revista chilena de pediatría, 1990
Journal of CyberTherapy …, 2012
... Antoine Pelissolo1, Mohammed Zaoui2, Gloria Aguayo3, Sai Nan Yao4, Sylvain Roche5, Rene Ecoch... more ... Antoine Pelissolo1, Mohammed Zaoui2, Gloria Aguayo3, Sai Nan Yao4, Sylvain Roche5, Rene Ecochard5, François Gueyffier6, Charles Pull3, Alain Berthoz2, Roland Jouvent1 and Jean Cottraux4 ... North, M., North, S., & Coble, J. (1996). ...
Gut, 1980
A survey has been made of pregnancy occurring in patients who were attending the Ulcerative Colit... more A survey has been made of pregnancy occurring in patients who were attending the Ulcerative Colitis Clinic at Oxford during the 20-year period, 1960-79 inclusive. There were 256 married women of child-bearing age who attended during this period. Of these, 100 were excluded from the survey for various reasons, such as that they had completed their family before the onset of the ulcerative colitis, had already had an hysterectomy, or had a proctocolectomy before their first pregnancy. Of the remaining 156 patients, nine could not be traced. Full details were obtained from 147 patients, virtually all of whom were interviewed. The fertility of these patients was normal.
Rev. méd. …, 1998
Resumo: Backgrounds and aims: Total parenteral nutrition (TPN) has been traditionally used as an ... more Resumo: Backgrounds and aims: Total parenteral nutrition (TPN) has been traditionally used as an adjunctive therapy in severe ulcerative colitis patients. We performed a prospective study to ascertain the safety, nutritional efficiency, tolerance and costs of total ...
Current Opinion in Psychiatry, 2011
To examine techniques that have been used to assess various aspects of body-image perception and ... more To examine techniques that have been used to assess various aspects of body-image perception and body-image attitudes in obesity. It summarizes findings from previous review articles and reports on new research findings that have been published between August 2007 and August 2010. Body-image perception and attitudes in obesity have been assessed using questionnaires, figural drawing scales and computer morphing or adjustment programs. Most of these techniques have been developed to assess body image in eating disorders and as such are not specific to the assessment of body image in obesity. Body-image perception and body-image attitudes are commonly assessed in research studies on obesity. However, currently available assessment instruments have not been developed specifically for use in obese populations and not all have been validated in these populations. Researchers should be careful in selecting assessment instruments that are appropriate for use in obesity.
Curr Opin Psychiatry, 2011
PURPOSE OF REVIEW: To examine techniques that have been used to assess various aspects of body-im... more PURPOSE OF REVIEW: To examine techniques that have been used to assess various aspects of body-image perception and body-image attitudes in obesity. It summarizes findings from previous review articles and reports on new research findings that have been published between August 2007 and August 2010. RECENT FINDINGS: Body-image perception and attitudes in obesity have been assessed using questionnaires, figural drawing scales and computer morphing or adjustment programs. Most of these techniques have been developed to assess body image in eating disorders and as such are not specific to the assessment of body image in obesity. SUMMARY: Body-image perception and body-image attitudes are commonly assessed in research studies on obesity. However, currently available assessment instruments have not been developed specifically for use in obese populations and not all have been validated in these populations. Researchers should be careful in selecting assessment instruments that are appropriate for use in obesity.
Bull Soc Sci Med Grand Duche Luxemb, 2012
Objective: Excessive food intake has been linked to many factors including taste preference and t... more Objective: Excessive food intake has been linked to many factors including taste preference and the presence of psychopathology. The purpose of this study was to investigate the association between sweet and salty taste preference and psychopathology in patients with severe obesity. Methods: A consecutive series of patients applying for bariatric surgery was recruited for the study. Taste preference was self-reported. Psychopathology was assessed using the revised version of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). 190 patients were included in the study. Results: In comparison with patients who had salty taste preference, patients with sweet taste preference had significantly higher elevations on the depression (OD: 4.090, p=0.010) and the hysteria (OD: 2.951, p=0.026) clinical scales of the MMPI-2. Conclusion: The results suggest the presence of an association between taste preference and psychopathology. The findings may be of interest for clinicians who are involved in the treatment of obesity. In particular, they may wish to pay increased attention to patients with sweet taste preference or who have a strong attraction for both sweet and salty foods, in order to detect psychopathology and to adapt the treatment.
Journal of CyberTherapy and Rehabilitation, 2012
Our objective was to compare the effects of Virtual reality exposure therapy (VrEt), cognitive be... more Our objective was to compare the effects of Virtual reality exposure therapy (VrEt), cognitive behavior therapy (cBt), and a waitlist control condition in patients with panic disorder with agoraphobia (PdA). ninety two outpatients were initially randomized in three arms, 29 treated with VrEt, 31 with cBt, and 32 assigned to the waitlist. At the end of a 12-week period, the patients assigned to the waitlist were re-randomized in VrEt or cBt groups. no between-group significant differences appeared at the end of the first phase, however a lower responder rate was observed in the waitlist group. After the second randomization, response rates were not different in the VrEt and cBt groups (respectively 38.7% and 48.5%; p=0.46). during the 9-month follow-up period, the response rates remained stable without differences between groups. thus, VrEt seems to be an effective treatment for PdA with short-term and long-term therapeutic results equivalent to those obtained with cBt.
Trials, 2018
Background: In attempting to achieve optimal metabolic control, the day-today management is chall... more Background: In attempting to achieve optimal metabolic control, the day-today management is challenging for a child with type 1 diabetes (T1D) and his family and can have a major negative impact on their quality of life. Augmenting an insulin pump with glucose sensor information leads to improved outcomes: decreased haemoglobin A1c levels, increased time in glucose target and less hypoglycaemia. Fear of nocturnal hypoglycaemia remains pervasive amongst parents, leading to chronic sleep interruption and lack of sleep for the parents and their children. The QUEST study, an open-label, single-centre randomized crossover study, aims to evaluate the impact on time in target, in hypoglycaemia and hyperglycaemia and the effect on sleep and quality of life in children with T1D, comparing a sensor-augmented pump (SAP) with predictive low glucose suspend and alerts to the use of the same insulin pump with a flash glucose measurement (FGM) device not interacting with the pump. Methods/design: Subjects meeting the inclusion criteria are randomized to treatment with the SAP or treatment with an insulin pump and independent FGM for 5 weeks. Following a 3-week washout period, the subjects cross over to the other study arm for 5 weeks. During the week before and in the last week of treatment, the subjects and one of their caregivers wear a sleep monitor in order to obtain sleep data. The primary endpoint is the between-arm difference in percentage of time in glucose target during the final 6 days of each treatment arm, measured by a blinded continuous glucose measurement (CGM). Additional endpoints include comparison of quantity and quality of sleep as well as quality of life perception of the subjects and one of their caregivers in the two different treatment arms. Recruitment started in February 2017. A total of 36 patients are planned to be randomized. The study recruitment was completed in April 2018.
BMC Med Res Methodol, 2019
Background: It is challenging to manage data collection as planned and creation of opportunities ... more Background: It is challenging to manage data collection as planned and creation of opportunities to adapt during the course of enrolment may be needed. This paper aims to summarize the different sampling strategies adopted in the second wave of Observation of Cardiovascular Risk Factors (ORISCAV-LUX, 2016-17), with a focus on population coverage and sample representativeness. Methods: Data from the first nationwide cross-sectional, population-based ORISCAV-LUX survey, 2007-08 and from the newly complementary sample recruited via different pathways, nine years later were analysed. First, we compare the socio-demographic characteristics and health profiles between baseline participants and non-participants to the second wave. Then, we describe the distribution of subjects across different strategy-specific samples and performed a comparison of the overall ORISCAV-LUX2 sample to the national population according to stratification criteria. Results: For the baseline sample (1209 subjects), the participants (660) were younger than the non-participants (549), with a significant difference in average ages (44 vs 45.8 years; P = 0.019). There was a significant difference in terms of education level (P < 0.0001), 218 (33%) participants having university qualification vs. 95 (18%) non-participants. The participants seemed having better health perception (p < 0.0001); 455 (70.3%) self-reported good or very good health perception compared to 312 (58.2%) non-participants. The prevalence of obesity (P < 0.0001), hypertension (P < 0.0001), diabetes (P = 0.007), and mean values of related biomarkers were significantly higher among the non-participants. The overall sample (1558 participants) was mainly composed of randomly selected subjects, including 660 from the baseline sample and 455 from other health examination survey sample and 269 from civil registry sample (constituting in total 88.8%), against only 174 volunteers (11.2%), with significantly different characteristics and health status. The ORISCAV-LUX2 sample was representative of national population for geographical district, but not for sex and age; the younger (25-34 years) and older (65-79 years) being underrepresented, whereas middle-aged adults being over-represented, with significant sex-specific difference (p < 0.0001). Conclusion: This study represents a careful first-stage analysis of the ORISCAV-LUX2 sample, based on available information on participants and non-participants. The ORISCAV-LUX datasets represents a relevant tool for epidemiological research and a basis for health monitoring and evidence-based prevention of cardiometabolic risk in Luxembourg.
Background: We propose a general approach to the analysis of multivariate health outcome data whe... more Background: We propose a general approach to the analysis of multivariate health outcome data where geo-coding at different spatial scales is available. We propose multiscale joint models which address the links between individual outcomes and also allow for correlation between areas. The models are highly novel in that they exploit survey data to provide multiscale estimates of the prevalences in small areas for a range of disease outcomes. Results The models incorporate both disease specific, and common disease spatially structured components. The multiple scales envisaged is where individual survey data is used to model regional prevalences or risks at an aggregate scale. This approach involves the use of survey weights as predictors within our Bayesian multivariate models. Missingness has to be addressed within these models and we use predictive inference which exploits the correlation between diseases to provide estimates of missing prevalances. The Case study we examine is from the National Health Survey of Chile where geocoding to Province level is available. In that survey, diabetes, Hypertension, obesity and elevated low-density cholesterol (LDL) are available but differential missingness requires that aggregation of estimates and also the assumption of smoothed sampling weights at the aggregate level. Conclusions: The methodology proposed is highly novel and flexibly handles multiple disease outcomes at individual and aggregated levels (i.e., multiscale joint models). The missingness mechanism adopted provides realistic estimates for inclusion in the aggregate model at Provincia level. The spatial structure of four diseases within Provincias has marked spatial differentiation, with diabetes and hypertension strongly clustered in central Provincias and obesity and LDL more clustered in the southern areas.
BMJ Open, 2023
ABSTRACT Introduction Type 1 diabetes (T1D) requires continuous management to obtain a good metab... more ABSTRACT
Introduction Type 1 diabetes (T1D) requires continuous management to obtain a good metabolic control and prevent acute complications. This often affects psychological well-being. People with T1D frequently report diabetes distress (DD). Psychological issues can negatively affect metabolic control and well-being. New technologies can improve quality of life, reduce the treatment burden and improve glycaemic control. Voice
technology may serve as an innovative and inexpensive remote monitoring device to evaluate psychological well-being. Tailoring digital health interventions according to the ability and interest of their intended ‘end-users’ increases the acceptability of the intervention itself. PsyVoice
explores the perspectives and needs of people with T1D on voice-based
digital health interventions to manage DD. Methods and analysis PsyVoice is a mixed-methods study with qualitative and quantitative data sources. For the qualitative part, the researchers will invite 20 people with a T1D or caregivers of children with T1D to participate in in-depth semi-structured
interviews. They will be invited as well to answer three questionnaires to assess socio-demographics, diabetes management, e-Health
literacy and diabetes distress. Information from questionnaires
will be integrated with themes developed in the qualitative
analysis of the interviews. People with T1D will be invited
to participate in the protocol and give feedback on interview guides, questionnaires, information sheets and informed consent.
Ethics and dissemination PsyVoice received ethical approval from Luxembourg’s National Research Ethics Committee. Participants will receive information about the purpose, risks and strategies to ensure the confidentiality and anonymity of the study. The results of PsyVoice will
guide the selection and development of voice-based technological interventions for managing DD. The outcome will be disseminated to academic and non-academic stakeholders through peer-reviewed
open-access journals and a lay public report. Trial registration number This study is registered on ClinicalTrials. gov with the number NCT05517772.
Rev Chil Pediatr, Jun 1, 1990
Rev Med Chile, Apr 1, 1998
BACKGROUND: The evolution of ulcerative colitis in pregnancy is far from clear. While some author... more BACKGROUND: The evolution of ulcerative colitis in pregnancy is far from clear. While some authors state that the disease aggravates during this period, others do not share this opinion. AIM: To assess the evolution of ulcerative colitis in pregnancy. PATIENTS AND METHODS: A paired case-control design was used in which 15 women, with diagnosed ulcerative colitis at the moment of becoming pregnant, were followed for 12 months and the activity of the disease was compared with that of the 12 months preceding the pregnancy. The activity of the disease in the period preceding the pregnancy was gathered retrospectively from the patient's charts. RESULTS: The mean age of the first ulcerative colitis crisis was 24 years. It was moderate in 49% and severe in 35% of women. During pregnancy 55% of women did not have a crisis, compared with 26.7% during the period preceding pregnancy (relative risk of not having a crisis during pregnancy of 1.7). During both periods, seven women had digestive complications, whereas extra digestive complications were not observed in 60% of patients during pregnancy and 11.8% of patients during the preceding period. Perinatal results were similar to those of the general population. CONCLUSIONS: In our group of patients the evolution of ulcerative colitis was better during pregnancy, reflected by a lower number of crisis.
Revue d'Épidémiologie et de Santé Publique, 2014
Bulletin de la Société des sciences médicales du Grand-Duché de Luxembourg, 2012
Excessive food intake has been linked to many factors including taste preference and the presence... more Excessive food intake has been linked to many factors including taste preference and the presence of psychopathology. The purpose of this study was to investigate the association between sweet and salty taste preference and psychopathology in patients with severe obesity. A consecutive series of patients applying for bariatric surgery was recruited for the study. Taste preference was self-reported. Psychopathology was assessed using the revised version of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). 190 patients were included in the study. In comparison with patients who had salty taste preference, patients with sweet taste preference had significantly higher elevations on the depression (OD: 4.090, p = 0.010) and the hysteria (OD: 2.951, p = 0.026) clinical scales of the MMPI-2. The results suggest the presence of an association between taste preference and psychopathology. The findings may be of interest for clinicians who are involved in the treatment of obesity. I...
Revista médica de Chile, 1998
Total parenteral nutrition (TPN) has been traditionally used as an adjunctive therapy in severe u... more Total parenteral nutrition (TPN) has been traditionally used as an adjunctive therapy in severe ulcerative colitis patients. We performed a prospective study to ascertain the safety, nutritional efficiency, tolerance and costs of total enteral nutrition in this situation. After 48 hours of intensive medical treatment, severe ulcerative colitis patients initiated enteral feeding with a polymeric formula. The formula concentration and volume were increased daily. 17 patients (7 women, 10 men; age 36.8 +/- 12.8 years) with a mean clinical activity score of 15.6 +/- 1.5 were included. In 14 patients (82.4%) enteral nutrition was well tolerated, attaining in 11 of them more than 80% of the caloric requirements by day 4. In 3 cases we observed vomiting and bloating. Prealbumin levels improved significantly from 11.1 +/- 3.4 mg/dl to 22.7 +/- 6.8 mg/dl (p = 0.002) at the end of enteral nutrition (11.8 +/- 4.7 days). Albumin and other nutritional parameters did not change. Total enteral nut...
Revista chilena de pediatría
The incidence of bronchopulmonary dysplasia (BPD) was retrospectively studied in all ventilated n... more The incidence of bronchopulmonary dysplasia (BPD) was retrospectively studied in all ventilated newborns at a neonatal intensive care unit of a university based hospital at Santiago, Chile along a 5 years period (1983-1987). BPD incidence among the whole sample of newborn infants requiring artificial ventilation was analysed according to birth weight (BW) and compared with that of newborns surviving after 28 days of life. The possible association of BPD with hyaline membrane disease (HMD), ductus arteriosus (DA) and pulmonary air leak (PAL) was studied. The total number of ventilated newborns was 200, incidence of BPD was 9.5% (19/200) and lethality for BPD was 5.2% (1/19). The incidence of BPD increased progressively with decreasing BW, reaching 37.5% in infants less than 1,000 g (p less than 0.001 chi 2). Among 28 day survivors incidence of BPD in the same BW group increased to 75% (p less than 0.05). These findings support the idea that the incidence of BPD increases with improve...
Revista chilena de pediatría, 1990
Journal of CyberTherapy …, 2012
... Antoine Pelissolo1, Mohammed Zaoui2, Gloria Aguayo3, Sai Nan Yao4, Sylvain Roche5, Rene Ecoch... more ... Antoine Pelissolo1, Mohammed Zaoui2, Gloria Aguayo3, Sai Nan Yao4, Sylvain Roche5, Rene Ecochard5, François Gueyffier6, Charles Pull3, Alain Berthoz2, Roland Jouvent1 and Jean Cottraux4 ... North, M., North, S., & Coble, J. (1996). ...
Gut, 1980
A survey has been made of pregnancy occurring in patients who were attending the Ulcerative Colit... more A survey has been made of pregnancy occurring in patients who were attending the Ulcerative Colitis Clinic at Oxford during the 20-year period, 1960-79 inclusive. There were 256 married women of child-bearing age who attended during this period. Of these, 100 were excluded from the survey for various reasons, such as that they had completed their family before the onset of the ulcerative colitis, had already had an hysterectomy, or had a proctocolectomy before their first pregnancy. Of the remaining 156 patients, nine could not be traced. Full details were obtained from 147 patients, virtually all of whom were interviewed. The fertility of these patients was normal.
Rev. méd. …, 1998
Resumo: Backgrounds and aims: Total parenteral nutrition (TPN) has been traditionally used as an ... more Resumo: Backgrounds and aims: Total parenteral nutrition (TPN) has been traditionally used as an adjunctive therapy in severe ulcerative colitis patients. We performed a prospective study to ascertain the safety, nutritional efficiency, tolerance and costs of total ...
Current Opinion in Psychiatry, 2011
To examine techniques that have been used to assess various aspects of body-image perception and ... more To examine techniques that have been used to assess various aspects of body-image perception and body-image attitudes in obesity. It summarizes findings from previous review articles and reports on new research findings that have been published between August 2007 and August 2010. Body-image perception and attitudes in obesity have been assessed using questionnaires, figural drawing scales and computer morphing or adjustment programs. Most of these techniques have been developed to assess body image in eating disorders and as such are not specific to the assessment of body image in obesity. Body-image perception and body-image attitudes are commonly assessed in research studies on obesity. However, currently available assessment instruments have not been developed specifically for use in obese populations and not all have been validated in these populations. Researchers should be careful in selecting assessment instruments that are appropriate for use in obesity.
Curr Opin Psychiatry, 2011
PURPOSE OF REVIEW: To examine techniques that have been used to assess various aspects of body-im... more PURPOSE OF REVIEW: To examine techniques that have been used to assess various aspects of body-image perception and body-image attitudes in obesity. It summarizes findings from previous review articles and reports on new research findings that have been published between August 2007 and August 2010. RECENT FINDINGS: Body-image perception and attitudes in obesity have been assessed using questionnaires, figural drawing scales and computer morphing or adjustment programs. Most of these techniques have been developed to assess body image in eating disorders and as such are not specific to the assessment of body image in obesity. SUMMARY: Body-image perception and body-image attitudes are commonly assessed in research studies on obesity. However, currently available assessment instruments have not been developed specifically for use in obese populations and not all have been validated in these populations. Researchers should be careful in selecting assessment instruments that are appropriate for use in obesity.
Bull Soc Sci Med Grand Duche Luxemb, 2012
Objective: Excessive food intake has been linked to many factors including taste preference and t... more Objective: Excessive food intake has been linked to many factors including taste preference and the presence of psychopathology. The purpose of this study was to investigate the association between sweet and salty taste preference and psychopathology in patients with severe obesity. Methods: A consecutive series of patients applying for bariatric surgery was recruited for the study. Taste preference was self-reported. Psychopathology was assessed using the revised version of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). 190 patients were included in the study. Results: In comparison with patients who had salty taste preference, patients with sweet taste preference had significantly higher elevations on the depression (OD: 4.090, p=0.010) and the hysteria (OD: 2.951, p=0.026) clinical scales of the MMPI-2. Conclusion: The results suggest the presence of an association between taste preference and psychopathology. The findings may be of interest for clinicians who are involved in the treatment of obesity. In particular, they may wish to pay increased attention to patients with sweet taste preference or who have a strong attraction for both sweet and salty foods, in order to detect psychopathology and to adapt the treatment.
Journal of CyberTherapy and Rehabilitation, 2012
Our objective was to compare the effects of Virtual reality exposure therapy (VrEt), cognitive be... more Our objective was to compare the effects of Virtual reality exposure therapy (VrEt), cognitive behavior therapy (cBt), and a waitlist control condition in patients with panic disorder with agoraphobia (PdA). ninety two outpatients were initially randomized in three arms, 29 treated with VrEt, 31 with cBt, and 32 assigned to the waitlist. At the end of a 12-week period, the patients assigned to the waitlist were re-randomized in VrEt or cBt groups. no between-group significant differences appeared at the end of the first phase, however a lower responder rate was observed in the waitlist group. After the second randomization, response rates were not different in the VrEt and cBt groups (respectively 38.7% and 48.5%; p=0.46). during the 9-month follow-up period, the response rates remained stable without differences between groups. thus, VrEt seems to be an effective treatment for PdA with short-term and long-term therapeutic results equivalent to those obtained with cBt.
Trials, 2018
Background: In attempting to achieve optimal metabolic control, the day-today management is chall... more Background: In attempting to achieve optimal metabolic control, the day-today management is challenging for a child with type 1 diabetes (T1D) and his family and can have a major negative impact on their quality of life. Augmenting an insulin pump with glucose sensor information leads to improved outcomes: decreased haemoglobin A1c levels, increased time in glucose target and less hypoglycaemia. Fear of nocturnal hypoglycaemia remains pervasive amongst parents, leading to chronic sleep interruption and lack of sleep for the parents and their children. The QUEST study, an open-label, single-centre randomized crossover study, aims to evaluate the impact on time in target, in hypoglycaemia and hyperglycaemia and the effect on sleep and quality of life in children with T1D, comparing a sensor-augmented pump (SAP) with predictive low glucose suspend and alerts to the use of the same insulin pump with a flash glucose measurement (FGM) device not interacting with the pump. Methods/design: Subjects meeting the inclusion criteria are randomized to treatment with the SAP or treatment with an insulin pump and independent FGM for 5 weeks. Following a 3-week washout period, the subjects cross over to the other study arm for 5 weeks. During the week before and in the last week of treatment, the subjects and one of their caregivers wear a sleep monitor in order to obtain sleep data. The primary endpoint is the between-arm difference in percentage of time in glucose target during the final 6 days of each treatment arm, measured by a blinded continuous glucose measurement (CGM). Additional endpoints include comparison of quantity and quality of sleep as well as quality of life perception of the subjects and one of their caregivers in the two different treatment arms. Recruitment started in February 2017. A total of 36 patients are planned to be randomized. The study recruitment was completed in April 2018.
BMC Med Res Methodol, 2019
Background: It is challenging to manage data collection as planned and creation of opportunities ... more Background: It is challenging to manage data collection as planned and creation of opportunities to adapt during the course of enrolment may be needed. This paper aims to summarize the different sampling strategies adopted in the second wave of Observation of Cardiovascular Risk Factors (ORISCAV-LUX, 2016-17), with a focus on population coverage and sample representativeness. Methods: Data from the first nationwide cross-sectional, population-based ORISCAV-LUX survey, 2007-08 and from the newly complementary sample recruited via different pathways, nine years later were analysed. First, we compare the socio-demographic characteristics and health profiles between baseline participants and non-participants to the second wave. Then, we describe the distribution of subjects across different strategy-specific samples and performed a comparison of the overall ORISCAV-LUX2 sample to the national population according to stratification criteria. Results: For the baseline sample (1209 subjects), the participants (660) were younger than the non-participants (549), with a significant difference in average ages (44 vs 45.8 years; P = 0.019). There was a significant difference in terms of education level (P < 0.0001), 218 (33%) participants having university qualification vs. 95 (18%) non-participants. The participants seemed having better health perception (p < 0.0001); 455 (70.3%) self-reported good or very good health perception compared to 312 (58.2%) non-participants. The prevalence of obesity (P < 0.0001), hypertension (P < 0.0001), diabetes (P = 0.007), and mean values of related biomarkers were significantly higher among the non-participants. The overall sample (1558 participants) was mainly composed of randomly selected subjects, including 660 from the baseline sample and 455 from other health examination survey sample and 269 from civil registry sample (constituting in total 88.8%), against only 174 volunteers (11.2%), with significantly different characteristics and health status. The ORISCAV-LUX2 sample was representative of national population for geographical district, but not for sex and age; the younger (25-34 years) and older (65-79 years) being underrepresented, whereas middle-aged adults being over-represented, with significant sex-specific difference (p < 0.0001). Conclusion: This study represents a careful first-stage analysis of the ORISCAV-LUX2 sample, based on available information on participants and non-participants. The ORISCAV-LUX datasets represents a relevant tool for epidemiological research and a basis for health monitoring and evidence-based prevention of cardiometabolic risk in Luxembourg.
Background: We propose a general approach to the analysis of multivariate health outcome data whe... more Background: We propose a general approach to the analysis of multivariate health outcome data where geo-coding at different spatial scales is available. We propose multiscale joint models which address the links between individual outcomes and also allow for correlation between areas. The models are highly novel in that they exploit survey data to provide multiscale estimates of the prevalences in small areas for a range of disease outcomes. Results The models incorporate both disease specific, and common disease spatially structured components. The multiple scales envisaged is where individual survey data is used to model regional prevalences or risks at an aggregate scale. This approach involves the use of survey weights as predictors within our Bayesian multivariate models. Missingness has to be addressed within these models and we use predictive inference which exploits the correlation between diseases to provide estimates of missing prevalances. The Case study we examine is from the National Health Survey of Chile where geocoding to Province level is available. In that survey, diabetes, Hypertension, obesity and elevated low-density cholesterol (LDL) are available but differential missingness requires that aggregation of estimates and also the assumption of smoothed sampling weights at the aggregate level. Conclusions: The methodology proposed is highly novel and flexibly handles multiple disease outcomes at individual and aggregated levels (i.e., multiscale joint models). The missingness mechanism adopted provides realistic estimates for inclusion in the aggregate model at Provincia level. The spatial structure of four diseases within Provincias has marked spatial differentiation, with diabetes and hypertension strongly clustered in central Provincias and obesity and LDL more clustered in the southern areas.