How to take down the terminator (original) (raw)
Abstract
In bacteria, production of aberrant RNAs and transcription of foreign genes, including those on phages, are readily terminated by a hexameric ATPase, Rho. However, to make necessary transcripts, particularly during stress, bacteria depend on mechanisms to temper Rho activity. Similarly, phages have evolved diverse Rho-inhibitory mechanisms to enable the expression of their own genomes. In recent years, the structural bases of many such anti-termination mechanisms have been elucidated.
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Funding note: Open Access funding enabled and organized by Projekt DEAL.
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Authors and Affiliations
- Institute of Chemistry and Biochemistry, Laboratory of Structural Biochemistry, Freie Universität Berlin, Takustraße 6, D-14195, Berlin, Deutschland
Nelly Said & Markus C. Wahl - Department of Microbiology and Center for RNA Biology, The Ohio State University, 318 West 12th Ave., Columbus, OH, 43210, USA
Irina Artsimovitch - Macromolecular Crystallography, Helmholtz-Zentrum Berlin für Materialien und Energie, Berlin, Deutschland
Markus C. Wahl
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- Nelly Said
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Correspondence to Irina Artsimovitch or Markus C. Wahl.
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Nelly Said 2002–2008 studies of Biochemistry at FU Berlin. 2011–2016 Doctorate at Freie Universität Berlin under supervision of Prof. Dr. M. Wahl, PhD. Since 2016 Postdoc with Prof. Dr. M. Wahl, PhD at FU Berlin.
Irina Artsimovitch 1984–1989 studies of Biochemistry at Moscow State University, Moscow, Russia. 1992-1996 PhD in Microbiology at The University of Tennessee, USA, mentored by Prof. M. Howe, PhD. 1996-2001 Postdoc with Prof. R. Landick, PhD at the University of Wisconsin, USA,. Since 2001, Professor of Microbiology at The Ohio State University.
Markus Wahl 1987–1993 studies of Biochemistry. 1993–1996 PhD at The Ohio State University mentored by Prof. M. Sundaralingam, PhD. 1997–2002 Postdoc with Prof. Dr. R. Huber, FRS, Max-Planck-Institute for Biochemistry, Martinsried. 2002–2008 Group Leader, Max-Planck-Institute for Biophysical Chemistry, Göttingen. 2008 Professor for Macromolecular Crystallography, University Medical Center Göttingen. Since 2009, Professor for Structural Biochemistry, FU Berlin.
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Said, N., Artsimovitch, I. & Wahl, M.C. How to take down the terminator.Biospektrum 30, 490–493 (2024). https://doi.org/10.1007/s12268-024-2283-x
- Published: 11 September 2024
- Issue Date: September 2024
- DOI: https://doi.org/10.1007/s12268-024-2283-x