Localization of Muscle Gene Products in Nuclear Domains: Does this Constitute a Problem for Myoblast Therapy? (original) (raw)

Abstract

A question of major interest in considering myoblast therapy is whether the gene product dystrophin, provided by the introduced myoblasts, can contribute to the function of the myofiber into which the cells fuse. As shown in several papers in this volume, there is now ample evidence that injected myoblasts can fuse with myofibers and produce dystrophin, but the question of whether that dystrophin can restore muscle function still remains. In this regard, a major consideration is whether dystrophin can gain access to distant sites within the myofiber or remains localized in the vicinity of the nucleus that encoded it.

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Authors and Affiliations

  1. Department of Pharmacology, Stanford University School of Medicine, Stanford, CA, USA, 94305
    Helen M. Blau, Grace K. Pavlath, Kevin Rich & Steven G. Webster

Authors

  1. Helen M. Blau
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  2. Grace K. Pavlath
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  3. Kevin Rich
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  4. Steven G. Webster
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Editor information

Editors and Affiliations

  1. University of Rochester, Rochester, New York, USA
    Robert C. Griggs
  2. McGill University, Montreal, Quebec, Canada
    George Karpati

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© 1990 Plenum Press, New York

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Blau, H.M., Pavlath, G.K., Rich, K., Webster, S.G. (1990). Localization of Muscle Gene Products in Nuclear Domains: Does this Constitute a Problem for Myoblast Therapy?. In: Griggs, R.C., Karpati, G. (eds) Myoblast Transfer Therapy. Advances in Experimental Medicine and Biology, vol 280. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5865-7\_19

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