Microglia as a Source and Target of Cytokine Activities in the Brain (original) (raw)
Immune responses in the nervous system. Oxford: BIOS Scientific Publishers. Google Scholar
Cytokines and the CNS. Boca Raton: CRC Press. Google Scholar
Psychoneuroimmunology. San Diego: Academic Press. Google Scholar
Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagami M, Nakanishi K, Akira S (1998) Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9: 143–150. ArticlePubMedCAS Google Scholar
Akbar AN, Lord JM, Salmon M (2000) IFN-alpha and IFN-beta: a link between immune memory and chronic inflammation. Immunol Today 21: 337–342. ArticlePubMedCAS Google Scholar
Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O’Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T (2000) Inflammation and Alzheimer’s disease. Neurobiol Aging 21: 383–421. ArticlePubMedCAS Google Scholar
Alheim K, Bartfai T (1998) The interleukin-1 system: receptors, ligands, and ICE in the brain and their involvement in the fever response. Ann N Y Acad Sci 840: 51–58. ArticlePubMedCAS Google Scholar
Aloisi F, Penna G, Cerase J, Menendez IB, Adorini L (1997) IL-12 production by central nervous system microglia is inhibited by astrocytes. J Immunol 159: 1604–1612. PubMedCAS Google Scholar
Aloisi F, Serafini B, Adorini L (2000) Glia-T cell dialogue. J N euroimmunol 107: 111–17. ArticleCAS Google Scholar
Angstwurm K, Freyer D, Dirnagl U, Hanisch UK, Schumann RR, Einhaupl KM, Weber JR (1998) Tumour necrosis factor alpha induces only minor inflammatory changes in the central nervous system, but augments experimental meningitis. Neuroscience 86: 627–634. ArticlePubMedCAS Google Scholar
Antel JP, Becher B, Owens T (1996) Immunotherapy for multiple sclerosis: from theory to practice. Nat Med 2: 1074–1075. ArticlePubMedCAS Google Scholar
Araujo DM, Cotman CW (1993) Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors. Brain Res 600: 49–55. ArticlePubMedCAS Google Scholar
Araujo DM, Cotman CW (1995) Differential effects of interleukin-1 beta and interleukin-2 on glia and hippocampal neurons in culture. Int J Dev Neurosci 13: 201–212. ArticlePubMedCAS Google Scholar
Asensio VC, Campbell IL (1999) Chemokines in the CNS: plurifunctional mediators in diverse states. Trends Neurosci 22: 504–512. ArticlePubMedCAS Google Scholar
Ashkenazi A, Dixit VM (1998) Death receptors: signaling and modulation. Science 281: nos. Google Scholar
Ashkenazi Ashkenazi A, Dixit VM (1999) Apoptosis control by death and decoy receptors. Curr Opin Cell Biol 11: 255–260. ArticlePubMedCAS Google Scholar
Badie B, Schartner J, Vorpahl J, Preston K (2000) Interferon-gamma induces apoptosis and augments the expression of Fas and Fas ligand by microglia in vitro. Exp Neurol 162: 290–296. ArticlePubMedCAS Google Scholar
Balasingam V, Dickson K, Brade A, Yong VW (1996) Astrocyte reactivity in neonatal mice: apparent dependence on the presence of reactive microglia/macrophages. Glia 18: 11–26. ArticlePubMedCAS Google Scholar
Balasingam V, Tejada-Berges T, Wright E, Bouckova R, Yong VW (1994) Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J Neurosci 14: 846–856. PubMedCAS Google Scholar
Balasingam V, Yong VW (1996) Attenuation of astroglial reactivity by interleukin-10. J Neurosci 16: 2945–2955. PubMedCAS Google Scholar
Banks WA, Kastin AJ (1992) The interleukins-1 alpha, -1 beta, and -2 do not acutely disrupt the murine blood-brain barrier. Int J Immunopharmacol 14: 629–636. ArticlePubMedCAS Google Scholar
Banks WA, Kastin AJ, Gutierrez EG (1993) Interleukin-1 alpha in blood has direct access to cortical brain cells. Neurosci Lett 163: 41–44. ArticlePubMedCAS Google Scholar
Banks WA, Kastin AJ, Gutierrez EG (1994) Penetration of interleukin-6 across the murine blood-brain barrier. Neurosci Lett 179: 53–56. ArticlePubMedCAS Google Scholar
Banks WA, Plotkin SR, Kastin AJ (1995) Permeability of the blood-brain barrier to soluble cytokine receptors. Neuroimmunomodulation 2: 161–165. ArticlePubMedCAS Google Scholar
Banks WA, Kastin AJ (1997) Relative contributions of peripheral and central sources to levels of IL-1 alpha in the cerebral cortex of mice: assessment with species-specific enzyme immunoassays. J Neuroimmunol 79: 22–28. ArticlePubMedCAS Google Scholar
Banks WA, Ortiz L, Plotkin SR, Kastin AJ (1991) Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism. J Pharmacol Exp Ther 259: 988–996. PubMedCAS Google Scholar
Bazan JF, Timans JC, Kastelein RA (1996) A newly defined interleukin-1? Nature 379: 591–591. ArticlePubMedCAS Google Scholar
Becher B, Prat A, Antel JP (2000) Brain-immune connection: immuno-regulatory properties of CNS-resident cells. Glia 29: 293–304. ArticlePubMedCAS Google Scholar
Berkenbosch F, de Goeij DE, del Rey AD, Besedovsky HO (1989) Neuroendocrine, sympathetic and metabolic responses induced by interleukin-1. Neuroendocrinology 50: 570–576. ArticlePubMedCAS Google Scholar
Berkenbosch F, van Oers J, del Rey A, Tilders F, Besedovsky H (1987) Corticotropinreleasing factor-producing neurons in the rat activated by interleukin-1. Science 238: 524–526. ArticlePubMedCAS Google Scholar
Besedovsky HO, del Rey A. (1996) Immune-neuro-endocrine interactions: facts and hypotheses. Endocr Rev 17: 64–102. PubMedCAS Google Scholar
Besedovsky HO, del Rey A. (2001) Cytokines as mediators of central and peripheral immune-neuroendocrine interactions. In: Psychoneuroimmunology (Ader R, Felten DL, Cohen N, eds), pp 1–17. San Diego: Academic Press. Google Scholar
Blasi F, Riccio M, Brogi A, Strazza M, Taddei ML, Romagnoli S, Luddi A, D’Angelo R, Santi S, Costantino-Ceccarini E, Melli M (1999) Constitutive expression of interleukin-1 beta (IL-1 beta) in rat oligodendrocytes. Biol Chem 380: 259–264 ArticlePubMedCAS Google Scholar
Blatteis CM (2000) The afferent signalling of fever. J Phvsiol 526 Pt 3. 470 CAS Google Scholar
Blume AJ, Vitek MP (1989) Focusing on IL-1-promotion of beta-amyloid precursor protein synthesis as an early event in Alzheimer’s disease. Neurobiol Aging 10: 412–414 Article Google Scholar
Boehme SA, Lio FM, Maciejewski-Lenoir D, Bacon KB, Conlon PJ (2000) The chemokine fractalkine inhibits Fas-mediated cell death of brain microglia. J Immunol 165: 397–403. PubMedCAS Google Scholar
Boucsein C, Kettenmann H, Nolte C (2000) Electrophysiological properties of microglial cells in normal and pathologic rat brain slices. Eur J Neurosci 12: 2049–2058. ArticlePubMedCAS Google Scholar
Brockhaus J, Ilschner S, Banati RB, Kettenmann H (1993) Membrane properties of ameboid microglial cells in the corpus callosum slice from early postnatal mice. J Neurosci 13: 4412–4421. PubMedCAS Google Scholar
Brogi A, Strazza M, Melli M, Costantino-Ceccarini E (1997) Induction of intracellular ceramide by interleukin-1 beta in oligodendrocvtes. J Cell Biochem 66: 532–541 ArticlePubMedCAS Google Scholar
Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F (2000) Tollip, a new componment of the IL-1 RI pathway, links IRAK to the IL-1 receptor . Nature Cell Biol 2: 346–351 ArticlePubMedCAS Google Scholar
Cacabelos R, Alvarez XA, Fernandez-Novoa L, Franco A, Mangues R, Pellicer A, Nishimura T (1994) Brain interleukin-1 beta in Alzheimer’s disease and vascular dementia. Methods Find Exp Clin Pharmacol 16: 141–151 PubMedCAS Google Scholar
Cammer W, Zhang H (1999) Maturation of oligodendrocytes is more sensitive to TNF alpha than is survival of precursors and immature oligodendrocytes. J Neuroimmunol 97: 37–42. ArticlePubMedCAS Google Scholar
Campbell IL (1998) Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology. Brain Res Brain Res Rev 26: 327–336. ArticlePubMedCAS Google Scholar
Campbell IL, Chiang CS (1995) Cytokine involvement in central nervous system disease. Implications from transgenic mice. Ann N Y Acad Sci 771: 301–312. ArticlePubMedCAS Google Scholar
Campbell IL, Krucker T, Steffensen S, Akwa Y, Powell HC, Lane T, Carr DJ, Gold LH, Henriksen SJ, Siggins GR (1999) Structural and functional neuropathology in transgenic mice with CNS expression of IFN-alpha. Brain Res 835: 46–61. ArticlePubMedCAS Google Scholar
Carlson NG, Wieggel WA, Chen J, Bacchi A, Rogers SW, Gahring LC (1999) Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. J Immunol 163: 3963–3968. PubMedCAS Google Scholar
Carr DJ, Campbell IL (1999) Transgenic expression of interleukin-6 in the central nervous system confers protection against acute herpes simplex virus type-1 infection. J Neurovirol 5: 449–457. ArticlePubMedCAS Google Scholar
Carrie A, Jun L, Bienvenu T, Vinet MC, McDonell N, Couvert P, Zemni R, Cardona A, Van Buggenhout G, Frints S, Hamel B, Moraine C, Ropers HH, Strom T., Howell GR, Whittaker A, Ross MT, Kahn A, Fryns JP, Beldjord C, Marynen P, Chelly J. (1999) A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation. Nature Genetics 23: 25–31. PubMedCAS Google Scholar
Cartmell T, Poole S, Turnbull AV, Rothwell NJ, Luheshi GN (2000) Circulating interleukin-6 mediates the febrile response to localised inflammation in rats. J Physiol 526 Pt 3: 653–661. ArticlePubMedCAS Google Scholar
Cartmell T, Luheshi GN, Rothwell NJ (1999) Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat. J Physiol Lond 518: 585–594. ArticlePubMedCAS Google Scholar
Chao CC, Molitor TW, Hu S (1993) Neuroprotective role of IL-4 against activated microglia. J Immunol 151: 1473–1481. PubMedCAS Google Scholar
Cheng B, Christakos S, Mattson MP (1994) Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. NEU-RON 12: 139–153. ArticleCAS Google Scholar
Conti B, Jahng JW, Tinti C, Son JH, Joh TH (1997) Induction of interferon-gamma inducing factor in the adrenal cortex. J Biol Chem 272: 2035–2037. ArticlePubMedCAS Google Scholar
Conti B, Park LC, Calingasan NY, Kim Y, Kim H, Bae Y, Gibson GE, Joh TH (1999) Cultures of astrocytes and microglia express interleukin 18. Mol Brain Res 67: 46–52. ArticlePubMedCAS Google Scholar
Cooper NR, Bradt BM, O’Barr S, Yu JX (2000b) Focal inflammation in the brain: role in Alzheimer’s disease. Immunol Res 21: 159–165. ArticlePubMedCAS Google Scholar
Cooper NR, Kalaria RN, McGeer PL, Rogers J (2000a) Key issues in Alzheimers disease inflammation. Neurobiol Aging 21: 451–453. ArticlePubMedCAS Google Scholar
Coughlin SR (2000) Thrombin signalling and protease-activated receptors. Nature 407: 258–264. ArticlePubMedCAS Google Scholar
Culhane AC, Hall MD, Rothwell NJ, Luheshi GN (1998) Cloning of rat brain interleukin18 cDNA. Mol Psychiatry 3: 362–366. ArticlePubMedCAS Google Scholar
D’Souza S, Alinauskas K, McCrea E, Goodyer C, Antel JP (1995) Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury. J Neurosci 15: 7293–7300. PubMed Google Scholar
Das S, Potter H (1995) Expression of the Alzheimer amyloid-promoting factor anticnymotrypsin is induced in human astrocytes by IL-1. Neuron 14: 447–456. ArticlePubMedCAS Google Scholar
de Pablo F, de la Rosa EJ (1995) The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like growth factors. Trends Neurosci 18: 143–150. ArticlePubMed Google Scholar
Dickson DW, Lee SC, Mattiace LA, Yen SH, Brosnan C (1993) Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer’s disease. Glia 7: 75–83. ArticlePubMedCAS Google Scholar
Dinarello CA (1997c) Blocking interleukin-1 and tumor necrosis factor in disease. Eur Cytokine Netw 8: 294–296. PubMedCAS Google Scholar
Dinarello CA (1997d) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol 24: S9–S9. PubMedCAS Google Scholar
Dinarello CA (1997b) Role of pro- and anti-inflammatory cytokines during inflammation: experimental and clinical findings. J Biol Regul Homeost Agents 11: 91–103. PubMedCAS Google Scholar
Dinarello CA (1998b) Interleukin-1. In: The cytokine handbook (Thomson A, ed), pp 35–72. San Diego: Academic Press. Google Scholar
Dinarello CA (1998a) Interleukin-1, interleukin-1 receptors and interleukin-1 antagonist. Intern Rev Immunol 16: 457–499. ArticleCAS Google Scholar
Dinarello CA (1999b) IL-18: A TH 1-inducing, proinflammatory cytokine and a new member of the IL-1 family. J Allergy Clin Immunol 103: 11–24. ArticlePubMedCAS Google Scholar
Dinarello CA, Novick D, Puren AJ, Fantuzzi G, Shapiro L, Muhl H, Yoon DY, Reznikov LL, Kim SH, Rubinstein M (1998) Overview of interleukin-18: more than an interferon-gamma inducing factor . J Leukoc Biol 63: 658–664. PubMedCAS Google Scholar
Dirnagl U, Iadecola C, Moskowitz MA (1999) Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22: 391–397. ArticlePubMedCAS Google Scholar
Dore S, Kar S, Zheng WH, Quirion R (2000) Rediscovering good old friend IGF-I in the new millenium: possible usefulness in Alzheimer’s disease and stroke. Pharm Acta Helv 74: 273–280. ArticlePubMedCAS Google Scholar
Draheim HJ, Prinz M, Weber JR, Weiser T, Kettenmann H, Hanisch UK (1999) Induction of K+ channels in mouse brain microglia: cells acquire responsiveness to pneumococcal cell wall components during late development. Neuroscience 89: 1379–1390. ArticlePubMedCAS Google Scholar
Dunn AJ, Wang J, Ando T (1999) Effects of cytokines on cerebral neurotransmission. Comparison with the effects of stress. Adv Exp Med Biol 461: 117–127. ArticlePubMedCAS Google Scholar
Durum S-K, Muegge K (1997) Contemporary immunology: cytokine knockouts. Totowa: Humunan Press . Google Scholar
Eddleston M, Mucke L (1993) Molecular profile of reactive astrocytes—implications for their role in neurologic disease. Neuroscience 54: 15–36. ArticlePubMedCAS Google Scholar
Elkabes S, DiCicco BE, Black IB (1996) Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci 16: 2508–2521. PubMedCAS Google Scholar
Fassbender K, Schneider S, Bertsch T, Schlueter D, Fatar M, Ragoschke A, Kuhl S, Kischka U, Hennerici M (2000) Temporal profile of release of interleukin-1 beta in neurotrauma. Neurosci Lett 284: 135–138. ArticlePubMedCAS Google Scholar
Fassbender K, Mielke O, Bertsch T, Muehlhauser F, Hennerici M, Kurimoto M, Rossol S (1999) Interferon-gamma-inducing factor (IL-18) and interferon-gamma in inflammatory CNS diseases. Neurology 53: 1104–1106. ArticlePubMedCAS Google Scholar
Ferrari D, Chiozzi P, Falzoni S, Hanau S, Di Virgilio F (1997) Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin. J Exp Med 185: 579–582. ArticlePubMedCAS Google Scholar
Freshney NW, Rawlinson L, Guesdon F, Jones E, Cowley S, Hsuan J, Saklatvala J (1994) Interleukin-1 activates a novel protein cascade that results in the phopshorylation of hsp27. Cell 78: 1039–1049. ArticlePubMedCAS Google Scholar
Gabay C, Smith JMF, Eidlen D, Arend WP (1997) Interleukin 1 receptor antagonist (IL-1R a) is an acute-phase protein. J Clin Invest 99: 2930–2940. ArticlePubMedCAS Google Scholar
Gebicke-Haerter PJ, Appel K, Taylor GD, Schobert A, Rich IN, Northofft H, Berger M (1994) Rat microglial interleukin-3. J Neuroimmunol 50: 203–214. ArticlePubMedCAS Google Scholar
Gendelman HE, Tardieu M (1994) Macrophages/microglia and the pathophysiology of CNS injuries in AIDS. J Leukoc Biol 56: 387–388. PubMedCAS Google Scholar
Gillespie MT, Horwood NJ (1998) Interleukin-18: Perspectives on the newest interleukin. Cytokine Growth Factor Rev 9: 109–116. ArticlePubMedCAS Google Scholar
Gingrich MB, Traynelis SF (2000) Serine proteases and brain dam. Trends Neurosci 23: 399–407. ArticlePubMedCAS Google Scholar
Giulian D (1995) Microglia and neuronal dysfunction. In: Neuroglia (Kettenmann H, Ransom BR, eds), pp 671–684. New York: Oxford University Press. Google Scholar
Giulian D, Li J, Leara B, Keenen C (1994b) Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture. Neurochem Int 25: 227–233. ArticlePubMedCAS Google Scholar
Giulian D, Li J, Li X, George J, Rutecki PA (1994a) The impact of microglia-derived cytokines upon gliosis in the CNS. Dey Neurosci 16: 128–136. ArticleCAS Google Scholar
Giulian D, Woodward J, Young DG, Krebs JF, Lachman LB (1988c) Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization. J Neurosci 8: 2485–2490. PubMedCAS Google Scholar
Giulian D, Young DG, Woodward J, Brown DC, Lachman LB (1988b) Interleukin-1 is an astroglial growth factor in the developing brain. J Neurosci 8: 709–714. PubMedCAS Google Scholar
Giulian D, Young DG, Woodward J, Brown DC, Lachman LB (1988a) Interleukin-1 is an astroglial growth factor in the developing brain. J Neurosci 8: 709–714. PubMedCAS Google Scholar
Glabinski AR, Ransohoff RM (1999) Chemokines and chemokine receptors in CNS pathology. J Neurovirol 5: 3–12. ArticlePubMedCAS Google Scholar
Gold LH, Heyser CJ, Roberts AJ, Henriksen SJ, Steffensen SC, Siggms UR, Bellinger RR, Chiang CS, Powell HC, Masliah E, Campbell IL (1996) Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice. Adv Exp Med Biol 402: 199–205. ArticlePubMedCAS Google Scholar
Graeber MB, Lopez-Redondo F, Ikoma E, Ishikawa M, Imai Y, Nakajima K, Kreutzberg GW, Kohsaka S (1998) The microglia/macrophage response in the neonatal rat facial nucleus following axotomy. Brain Res 813: 241–253. ArticlePubMedCAS Google Scholar
Grilli M, Goffi F, Memo M, Spano P (1996) Interleukin-1 beta and glutamate activate me NF-kappaB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures. J Biol Chem 271: 15002–15007. ArticlePubMedCAS Google Scholar
Gu C, Casaccia-Bonnefil P, Srinivasan A, Chao MV (1999) Oligodendrocyte apoptosis mediated by caspase activation. J Neurosci 19: 3043–3049. PubMedCAS Google Scholar
Gutierrez EG, Banks WA, Kastin AJ (1993) Murine tumor necrosis factor alpha is transported from blood to brain in the mouse. J Neuroimmunol 47: 169–176. ArticlePubMedCAS Google Scholar
Gutierrez EG, Banks WA, Kastin AJ (1994) Blood-borne interleukin-1 receptor antagonist crosses the blood-brain barrier. J Neuroimmunol 55: 153–160. ArticlePubMedCAS Google Scholar
Hanisch UK (2001) Effects of interleukin-2 and interferons on the nervous system. in: Rsychoneuroimmunology (Ader R, Felten DL, Cohen N, eds), pp 585–631. San Diego: Academic Press. Google Scholar
Hanisch UK, Lyons SA, Prinz M, Nolte C, Weber JR, Kettenmann H, Kirchhoff F (1997a) Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity. J Biol Chem 272: 28853–28860. ArticlePubMedCAS Google Scholar
Hanisch UK, Neuhaus J, Quirion R, Kettenmann H (1996b) Neurotoxicity induced by interleukin-2: involvement of infiltrating immune cells. Synapse 24: 104–114. ArticlePubMedCAS Google Scholar
Hanisch UK, Neuhaus J, Rowe W, van Rossum D, Moller T, Kettenmann H, Quirion R (1997b) Neurotoxic consequences of central long-term administration of interleukin2 in rats. Neuroscience 79: 799–818. ArticlePubMedCAS Google Scholar
Hanisch UK, Quirion R (1995) Interleukin-2 as a neuroregulatory cytokine. Brain Res Brain Res Rev 21: 246–284. ArticlePubMedCAS Google Scholar
Hanisch UK, Rowe W, Sharma S, Meaney MJ, Quirion R (1994) Hypothalamic-pituitaryadrenal activity during chronic central administration of interleukin-2. Endocrinology 135: 2465–2472. ArticlePubMedCAS Google Scholar
Hanisch UK, Rowe W, van Rossum D, Meaney MJ, Quirion R (1996a) Phasic hyperactivity of the HPA axis resulting from chronic central IL-2 administration. Neuroreport 7: 2883–2888. ArticlePubMedCAS Google Scholar
Hanisch UK, Seto D, Quirion R (1993) Modulation of hippocampal acetylcholine release: a potent central action of interleukin-2. J Neurosci 13: 3368–3374. PubMedCAS Google Scholar
Harrison JK, Jiang Y, Chen S, Xia Y, Maciejewski D, McNamara RK, Streit WJ, Salafranca MN, Adhikari S, Thompson DA, Botti P, Bacon KB, Feng L (1998) Role for neuronally derived fractalkine in mediating interactions between neurons and CX3 CR 1-expressing microglia. Proc Natl Acad Sci U S A 95: 10896–10901. ArticlePubMedCAS Google Scholar
Hartung HP, Jung S, Stoll G, Zielasek J, Schmidt B, Archelos JJ, Toyka KV (1992) Inflammatory mediators in demyelinating disorders of the CNS and PNS. J Neuroimmunol 40: 197–210. ArticlePubMedCAS Google Scholar
Hays SJ (1998) Therapeutic approaches to the treatment of neuroinflammatory diseases. Curr Pharm Des 4: 335–348. PubMedCAS Google Scholar
Hide I, Tanaka M, Inoue A, Nakajima K, Kohsaka S, Inoue K, Nakata Y (2000) Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia. J Neurochem 75: 965–972. ArticlePubMedCAS Google Scholar
Hoffmann JA, Kafatos FC, Janeway CA, Ezekowitz RAB (1999) Phylogenetic perspectives in innate immunity. Science 284: 1313–1318. ArticlePubMedCAS Google Scholar
Hopkins SJ, Rothwell NJ (1995) Cytokines and the nervous system. I: Expression and recognition. Trends Neurosci 18: 83–88. ArticlePubMedCAS Google Scholar
Kanakaraj P, Ngo K, Wu Y, Angulo A, Ghazal P, Harris CA, Siekierka JJ, Peterson PA, Fung-Leung WP (1999) Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice. J Exp Med 189: 1129–1138. ArticlePubMedCAS Google Scholar
Karanth S, McCann SM (1991) Anterior pituitary hormone control by interleukin 2. Proc Natl Acad Sci U S A 88: 2961–2965. ArticlePubMedCAS Google Scholar
Katsuki H, Nakai S, Hirai Y, Akaji K, Kiso Y, Satoh M (1990) Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices. Eur J Pharmacol 181: 323–326. ArticlePubMedCAS Google Scholar
Kita T, Tanaka T, Tanaka N, Kinoshita Y (2000) The role of tumor necrosis factor-alpha in diffuse axonal injury following fluid-percussive brain injury in rats [In Process Citation]. Int J Legal Med 113: 221–228. ArticlePubMedCAS Google Scholar
Kohno K, Kurimoto M (1998) Interleukin 18, a cytokine which resembles IL-1 structurally and IL-12 functionally but exerts its effect independently of both. Clin Immunol Immunopathol 86: 11–15. ArticlePubMedCAS Google Scholar
Kojima H, Takeuchi M, Ohta T, Nishida Y, Arai N, Ikeda M, Ikegami H, Kurimoto M (1998) Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells. Biochem Biophys Res Commun 244: 183–186. ArticlePubMedCAS Google Scholar
Kreutzberg GW (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19: 312–318. ArticlePubMedCAS Google Scholar
Kumar S, McDonnell PC, Lehr R, Tierney L, Tzimas MN, Griswold DE, Capper EA, Talsinger R, Wells GI, Doyle ML, Young PR (2000) Identification and initial characterization of four novel members of the interleukin-1 familiy. J Biol Chem 275: 10308–10314. ArticlePubMedCAS Google Scholar
Lapchak PA, Araujo DM, Beck KD, Finch CE, Johnson SA, Hefti F (1993) BDNF and trkB mRNA expression in the hippocampal formation of aging rats. Neurobiol Aging 14: 121–126. ArticlePubMedCAS Google Scholar
Lapchak PA, Araujo DM, Quirion R, Beaudet A (1991) Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigenlike immunoreactivity) in the rat brain. Neuroscience 44: 173–184. ArticlePubMedCAS Google Scholar
Lee SC, Liu W, Dickson DW, Brosnan CF, Berman JW (1993) Cytokine production by human fetal microglia and astrocytes. J Immunol 150: 2659–2667. PubMedCAS Google Scholar
Licinio JWML (1997) Pathways and mechanism for cytokine signaling of the central nervous system. J Clin Invest 100: 2941–2947. ArticlePubMedCAS Google Scholar
Liu JS, Amaral TD, Brosnan CF, Lee SC (1998) IFNs are critical regulators of IL-1 receptor antagonist and IL-1 expression in human microglia. J Immunol 161: 1989–1996. PubMedCAS Google Scholar
Liu JS, John GR, Sikora A, Lee SC, Brosnan CF (2000) Modulation of interleukin-1beta and tumor necrosis factor alpha signaling by P2 purinergic receptors in human fetal astrocytes. J Neurosci 20: 5292–5299. PubMedCAS Google Scholar
Locati M, Murphy PM (1999) Chemokines and chemokine receptors: biology and clinical relevance in inflammation and AIDS. Annu Rev Med 50: 425–440. ArticlePubMedCAS Google Scholar
Loddick SA, Liu C, Takao T, Hashimoto K, De Souza EB (1998) Interleukin-1 receptors: Cloning studies and role in central nervous system disorders. Brain Res Rev 26: 306–319. ArticlePubMedCAS Google Scholar
Luheshi GN, Gardner JD, Rushforth DA, Loudon AS, Rothwell NJ (1999) Leptin actions on food intake and body temperature are mediated by IL-1. Proc Natl Acad Sci USA 96: 7047–7052. ArticlePubMedCAS Google Scholar
Luk WP, Zhang Y, White TD, Lue FA, Wu C, Jiang CG, Zhang L, Moldofsky H (1999) Adenosine: a mediator of interleukin- 1beta-induced hippocampal synaptic inhibition. T Neurosci 19: 4238–4244. CAS Google Scholar
Luster AD (1998) Chemokines—chemotactic cytokines that mediate inflammation. N Engl J Med 338: 436–445. ArticlePubMedCAS Google Scholar
Maciejewski-Lenoir D, Chen S, Feng L, Maki R, Bacon KB (1999) Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia. J Immunol 163: 1628–1635. PubMedCAS Google Scholar
Madigan MC, Sadun AA, Rao NS, Dugel PU, Tenhula WN, Gill PS (1996) Tumor necrosis factor-alpha (TNF-alpha)-induced optic neuropathy in rabbits. Neurol Res 18: 176–184. PubMedCAS Google Scholar
Maier SF, Goehler LE, Fleshner M, Watkins LR (1998) The role of the vagus nerve in cytokine-to-brain communication. Ann N Y Acad Sci 840: 289–300. ArticlePubMedCAS Google Scholar
Martino G, Furlan R, Brambilla E, Bergami A, Ruffini F, Gironi M, Poliani PL, Grimaldi LM, Comi G (2000) Cytokines and immunity in multiple sclerosis: the dual signal hypothesis. J Neuroimmunol 109: 3–9. ArticlePubMedCAS Google Scholar
Matsumoto S, Tsuji-Takayama K, Aizawa Y, Koide K, Takeuchi M, Ohta T, Kurimoto M (1997) Interleukin-18 activates NF-kappaB in murine T helper type 1 cells. Biochem Biophys Res Commun 234: 454–457. ArticlePubMedCAS Google Scholar
McCann SM, Karanth S, Kamat A, Les DW, Lyson K, Gimeno M, Rettori V (1994b) Induction by cytokines of the pattern of pituitary hormone secretion in infection. Neuroimmunomodulation 1: 2–13. ArticlePubMedCAS Google Scholar
McCann SM, Kimura M, Karanth S, Yu WH, Rettori V (1997b) Nitric oxide controls the hypothalamic-pituitary response to cytokines. Neuroimmunomodulation 4: 98–106. PubMedCAS Google Scholar
McCann SM, Kimura M, Karanth S, Yu WH, Rettori V (1998) Role of nitric oxide in the neuroendocrine responses to cytokines. Ann N Y Acad Sci 840: 174–184. ArticlePubMedCAS Google Scholar
McCann SM, Lyson K, Karanth S, Gimeno M, Belova N, Kamat A, Rettori V (1994a) Role of cytokines in the endocrine system. Ann N Y Acad Sci 741: 50–63. ArticlePubMedCAS Google Scholar
McCann SM, Kimura M, Karanth S, Yu WH, Rettori V (1997a) Nitric oxide controls the hypothalamic-pituitary response to cytokines. Neuroimmunomodulation 4: 98–106. PubMedCAS Google Scholar
McGeer EG, McGeer PL (1999) Brain inflammation in Alzheimer disease and the therapeutic implications. Curr Pharm Des 5: 821–836. PubMedCAS Google Scholar
McGeer PL, McGeer EG, Yasojima K (2000) Alzheimer disease and neuroinflammation. J Neural Transm Suppl 59: 53–57. PubMedCAS Google Scholar
McInnes IB, Gracie JA, Leung BP, Wei XQ, Liew FY (2000) Interleukin 18: a pleiotropic participant in chronic inflammation. Immunol Today 21: 312–315. ArticlePubMedCAS Google Scholar
Mennicken F, Maki R, De Souza EB, Quirion R (1999) Chemokines and chemokine receptors in the CNS: a possible role in neuroinflammation and patterning. Trends Pharmacol Sci 20: 73–78. ArticlePubMedCAS Google Scholar
Merrill JE, Benveniste EN (1996) Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci 19: 331–338. ArticlePubMedCAS Google Scholar
Merrill JE, Scolding NJ (1999) Mechanisms of damage to myelin and oligodendrocytes and their relevance to disease. Neuropathol Appl Neurobiol 25: 435–458. ArticlePubMedCAS Google Scholar
Mertsch K, Hanisch UK, Kettenmann H, Schnitzer J (2001) Characterization of microglial cells and their response to stimulation in an organotypic retinal culture system. J Comp Neurol 431: 217–227. ArticlePubMedCAS Google Scholar
Meucci O, Fatatis A, Simen AA, Miller RJ (2000) Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc Natl Acad Sci U S A 97: 8075–8080. ArticlePubMedCAS Google Scholar
Möller T, Hanisch UK, Ransom BR (2000) Thrombin-induced activation of cultured rodent microglia. J Neurochem 75: 1539–1547. ArticlePubMed Google Scholar
Mrak RE, Griffin WS (2000) Interleukin-1 and the immunogenetics of Alzheimer disease. J Neuropathol Exp Neurol 59: 471–476. PubMedCAS Google Scholar
Mucke L, Eddleston M (1993) Astrocytes in infectious and immune-mediated diseases of the central nervous system. FASEB J 7: 1226–1232. PubMedCAS Google Scholar
Nicoll JA, Mrak RE, Graham DI, Stewart J, Wilcock G, MacGowan S, Esiri MM, Murray LS, Dewar D, Love S, Moss T, Griffin WS (2000) Association of interleukin-1 gene polymorphisms with Alzheimer’s disease. Ann Neurol 47: 365–368. ArticlePubMedCAS Google Scholar
Nishiyori A, Minami M, Ohtani Y, Takami S, Yamamoto J, Kawaguchi N, Kume T, Akaike A, Satoh M (1998) Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia? FEBS Lett 429: 167–172. ArticlePubMedCAS Google Scholar
Norton WT, Aquino DA, Hozumi I, Chiu FC, Brosnan CF (1992) Quantitative aspects of reactive gliosis: a review. Neurochem Res 17: 877–885. ArticlePubMedCAS Google Scholar
O’Connor JJ, Coogan AN (1999) Actions of the pro-inflammatory cytokine IL-1 beta on central synaptic transmission. Exp Physiol 84: 601–614. ArticlePubMed Google Scholar
O’Neill LAJ, Dinarello CA (2000) The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunol Today 21: 206–209 ArticlePubMed Google Scholar
O’Neill LAJ, Greene C (1998) Signal transduction pathways activated by the IL-1 receptor family: Ancient signaling machinery in mamals, insects and plants. J Leukoc Biol 63. 650–657. PubMed Google Scholar
Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, Akita K, Namba M, Tanabe F, Konishi K, Fokuda S, Kurimoto M (1995) Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 379: 88–91. Article Google Scholar
Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams JS, Moore KW, Rennick D, Waal-Malefyt R, Hannum C, Bazan JF, Kastelein RA (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715–725. ArticlePubMedCAS Google Scholar
Otero GC, Merrill JE (1997) Response of human oligodendrocytes to interleukin-2. Brain Behav Immun 11: 24–38. ArticlePubMedCAS Google Scholar
Pan W, Banks WA, Kennedy MK, Gutierrez EG, Kastin AJ (1996) Differential permeability of the BBB in acute EAE: enhanced transport of TNT-alpha. Am J Physiol 271: E636–E642. PubMedCAS Google Scholar
Petitto JM, Huang Z, Raizada MK, Rinker CM, McCarthy DB (1998) Molecular cloning of the cDNA coding sequence of IL-2 receptor-gamma (gamma) from human and murine forebrain: expression in the hippocampus in situ and by brain cells in vitro. Brain Res Mol Brain Res 53: 152–162. ArticlePubMedCAS Google Scholar
Petitto JM, McNamara RK, Gendreau PL, Huang Z, Jackson AJ (1999) Impaired learning and memory and altered hippocampal neurodevelopment resulting from interleukin-2 gene deletion. J Neurosci Res 56: 441–446. ArticlePubMedCAS Google Scholar
Prinz M, Hanisch UK (1999) Murine microglial cells produce and respond to interleukin18. J Neurochem 72: 2215–2218. ArticlePubMedCAS Google Scholar
Prinz M, Hanisch UK, Kettenmann H, Kirchhoff F (1998) Alternative splicing of mouse IL15 is due to the use of an internal splice site in exon 5. Mol Brain Res 63: 155–162. ArticlePubMedCAS Google Scholar
Prinz M, Kann O, Draheim HJ, Schumann RR, Kettenmann H, Weber JR, Hanisch UK (1999) Microglial activation by components of Gram-positive and -negative bacteria: Distinct and common routes to the induction of ion channels and cytokines. J Neuropathol Exp Neurol 58: 1078–1089. ArticlePubMedCAS Google Scholar
Raber J, Sorg O, Horn TF, Yu N, Koob GF, Campbell IL, Bloom FE (1998) Inflammatory cytokines: putative regulators of neuronal and neuro- endocrine function. Brain Res Brain Res Rev 26: 320–326. ArticlePubMedCAS Google Scholar
Raine CS, Bonetti B, Cannella B (1998) Multiple sclerosis: expression of molecules of the tumor necrosis factor ligand and receptor families in relationship to the demyelinated plaque. Rev Neurol (Paris) 154: 577–585 CAS Google Scholar
Raivich G, Bluethmann H, Kreutzberg GW (1996) Signaling molecules and neuroglial activation in the injured central nervous system. Keio J Med 45: 239–247. ArticlePubMedCAS Google Scholar
Raivich G, Bohatschek M, Kloss CU, Werner A, Jones LL, Kreutzberg GW (1999a) Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function. Brain Res Brain Res Rev 30: 77–105. ArticlePubMedCAS Google Scholar
Raivich G, Jones LL, Werner A, Bluthmann H, Doetschmann T, Kreutzberg GW (1999b) Molecular signals for glial activation: pro- and anti-inflammatory cytokines in the injured brain. Acta Neurochir Suppl (Wien) 73: 21–30. CAS Google Scholar
Ren L, Lubrich B, Biber K, Gebicke-Haerter PJ (1999) Differential expression of inflammatory mediators in rat microglia cultured from different brain regions. Brain Res Mol Brain Res 65: 198–205. ArticlePubMedCAS Google Scholar
Renno T, Krakowski M, Piccirillo C, Lin JY, Owens T (1995) TNF-alpha expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. Regulation by Thl cytokines. J Immunol 154: 944–953. CAS Google Scholar
Rogers J, Webster S, Lue LF, Brachova L, Civin WH, Emmerling M, Shivers B, Walker D, McGeer P (1996) Inflammation and Alzheimer’s disease pathogenesis. Neurobiol Aging 17: 681–686. ArticlePubMedCAS Google Scholar
Rostworowski M, Balasingam V, Chabot S, Owens T, Yong VW (1997) Astrogliosis in the neonatal and adult murine brain post-trauma: elevation of inflammatory cytokines and the lack of requirement for endogenous interferon-gamma. J Neurosci 17: 3664–3674. PubMedCAS Google Scholar
Rothwell N, Allan S, Toulmond S (1997) Perspectives Series: Cytokines and the brain. J Clin Invest 100: 2648–2652 ArticlePubMedCAS Google Scholar
Rothwell N, Allan S, Toulmond S (1997) The role of Interleukin 1 in acute neurodegeneration and stroke: Pathophysiological and therapeutic implications. J Clin Invest 100: 2648–2652. ArticlePubMedCAS Google Scholar
Rothwell NJ, Hopkins SJ (1995) Cytokines and the nervous system II: Actions and mechanisms of action. Trends Neurosci 18: 130–136. ArticlePubMedCAS Google Scholar
Rothwell NJ, Luheshi G, Toulmond S (1996) Cytokines and their receptors in the central nervous system: physiology, pharmacology, and pathology. Pharmacol Ther 69: 85–95. ArticlePubMedCAS Google Scholar
Rothwell NJ, Luheshi GN (2000) Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci 23: 618–625. ArticlePubMedCAS Google Scholar
Sanz JM, Di Virgilio F (2000) Kinetics and mechanism of ATP-dependent IL-β release from microglial cells. J Immunol 164: 4893–4898. PubMedCAS Google Scholar
Sawada M, Suzumura A, Hosoya H, Marunouchi T, Nagatsu T (1999) Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia. J Neurochem 72: 1466–1471. ArticlePubMedCAS Google Scholar
Schneider H, Pitossi F, Balschun D, Wagner A, del Rey A, Besedovsky HO (1998) A neuromodulatory role of interleukin-β in the hippocampus. Proc Natl Acad Sci USA 95: 7778–7783. ArticlePubMedCAS Google Scholar
Schubert P, Morino T, Miyazaki H, Ogata T, Nakamura Y, Marchini C, Ferroni S (2000) Cascading glia reactions: a common pathomechanism and its differentiated control by cyclic nucleotide signaling. Ann N Y Acad Sci 903: 24–33. ArticlePubMedCAS Google Scholar
Schwaiger FW, Hager G, Raivich G, Kreutzberg GW (1998) Cellular activation in neuroregeneration. Prog Brain Res 117: 197–210. ArticlePubMedCAS Google Scholar
Seilhean D, Kobayashi K, He Y, Uchihara T, Rosenblum O, Katlama C, Bricaire F, Duyckaerts C, Hauw JJ (1997) Tumor necrosis factor-alpha, microglia and astrocytes in AIDS dementia complex. Acta Neuropathol (Berl) 93: 508–517. ArticleCAS Google Scholar
Selmaj K, Raine CS, Farooq M, Norton WT, Brosnan CF (1991b) Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin. J Immunol 147: 1522–1529. PubMedCAS Google Scholar
Selmaj K, Shafit-Zagardo B, Aquino DA, Farooq M, Raine CS, Norton WT, Brosnan CF (1991a) Tumor necrosis factor-induced proliferation of astrocytes from mature brain is associated with down-regulation of glial fibrillary acidic protein mRNA. J Neurochem 57: 823–830. ArticlePubMedCAS Google Scholar
Selmaj KW, Farooq M, Norton WT, Raine CS, Brosnan CF (1990) Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. J Immunol 144: 129–135. PubMedCAS Google Scholar
Seto D, Kar S, Quirion R (1997) Evidence for direct and indirect mechanisms in the potent modulatory action of interleukin-2 on the release of acetylcholine in rat hippocampal slices. Br T Pharmacol 120: 1151–1157. ArticleCAS Google Scholar
Shadiack AM, Hart RP, Carlson CD, Jonakait GM (1993) Interleukin-1 induces substance P in sympathetic ganglia through the induction of leukemia inhibitory factor (LIF). J Neurosci 13: 2601–2609. PubMedCAS Google Scholar
Shadiack AM, Vaccariello SA, Sun Y, Zigmond RE (1998) Nerve growth factor inhibits sympathetic neurons’ response to an injury cytokine. Proc Natl Acad Sci USA 95: 7727–7730. ArticlePubMedCAS Google Scholar
Sheng JG, Griffin WS, Royston MC, Mrak RE (1998) Distribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer’s disease. Neuropathol Appl Neurobiol 24: 278–283. ArticlePubMedCAS Google Scholar
Sheng JG, Ito K, Skinner RD, Mrak RE, Rovnaghi CR, Van Eldik LJ, Griffin WS (1996) In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol Aging 17: 761–776 ArticlePubMedCAS Google Scholar
Sheng JG, Mrak RE, Griffin WS (1995) Microglial interleukin-1 alpha expression in brain regions in Alzheimer’s disease: correlation with neuritic plaque distribution. Neuropathol Appl Neurobiol 21: 290–301. ArticlePubMedCAS Google Scholar
Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (2000) Four new members expand the interleukin-1 superfamily. J Biol Chem 275: 1169–1175. ArticlePubMedCAS Google Scholar
Smith EM, Cadet P, Stefano GB, Opp MR, Hughes TK, Jr. (1999) IL-10 as a mediator in the HPA axis and brain. J Neuroimmunol 100: 140–148. ArticlePubMedCAS Google Scholar
Smith ME, van-der MK, Somera FP (1998) Macrophage and microglial responses to cytokines in vitro: phagocytic activity, proteolytic enzyme release, and free radical production. J Neurosci Res 54: 68–78. ArticlePubMedCAS Google Scholar
Stalder AK, Pagenstecher A, Yu NC, Kincaid C, Chiang CS, Hobbs MV, Bloom FE, Campbell IL (1997) Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia. J Immunol 159: 1344–1351. PubMedCAS Google Scholar
Sternberg EM (1997) Neural-immune interactions in health and disease. J Clin Invest 100: 2641–2647. ArticlePubMedCAS Google Scholar
Stohwasser R, Giesebrecht J, Kraft R, Müller E-C, Häusler KG, Kettenmann H, Hanisch UK, Kloetzel P-M (2000) Biochemical analysis of proteasomes from microglia: Induction of immunoproteasomes by interferon-gamma and lipopolysaccharide. Glia 29: 355–365. ArticlePubMedCAS Google Scholar
Stoll G, Jander S (1999) The role of microglia and macrophages in the pathophysiology of the CNS. Prog Neurobiol 58: 233–247. ArticlePubMedCAS Google Scholar
Stoll G, Jander S, Schroeter M (1998) Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 56: 149–171. ArticlePubMedCAS Google Scholar
Stoll G, Jander S, Schroeter M (2000) Cytokines in CNS disorders: neurotoxicity versus neuroprotection. J Neural Transm Suppl 59: 81–89. PubMedCAS Google Scholar
Streit WJ (1994) The role of microglia in regeneration. Eur Arch Otorhinolaryngol Suppl S69–570. Google Scholar
Streit WJ (2000) Microglial response to brain injury: a brief synopsis. Toxicol Pathol 28: 28–30. ArticlePubMedCAS Google Scholar
Streit WJ, Hurley SD, McGraw TS, Semple-Rowland SL (2000b) Comparative evaluation of cytokine profiles and reactive gliosis supports a critical role for interleukin-6 in neuron-glia signaling during regeneration. J Neurosci Res 61: 10–20. ArticlePubMedCAS Google Scholar
Streit WJ, Walter SA, Pennel NA (2000a) Reactive microgliosis. Prog Neurobiol 57: 563–581. Article Google Scholar
Suzumura A, Sawada M, Itoh Y, Marunouchi T (1994) Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression. J Neuroimmunol 53: 209–218. ArticlePubMedCAS Google Scholar
Suzumura A, Sawada M, Takayanagi T (1998) Production of interleukin-12 and expression of its receptors by murine microglia. Brain Res 787: 139–142. ArticlePubMedCAS Google Scholar
Szczepanik AM, Funes S, Petko W, Ringheim GE (2001) IL-4, IL-10 and IL-13 modulate Abeta(1–42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line. J Neuroimmunol 113: 49–62 ArticlePubMedCAS Google Scholar
Takahashi S, Kapas L, Fang J, Krueger JM (1999) Somnogenic relationships between tumor necrosis factor and interleukin-1. Am J Physiol 276: R1132 –R1140 Google Scholar
Tan J, Town T, Paris D, Mori T, Suo Z, Crawford F, Mattson MP, Flavell RA, Mullan M (1999) Microglial activation resulting from CD40-CD40L interaction after beta- amyloid stimulation. Science 286: 2352–2355. ArticlePubMedCAS Google Scholar
Thomas WE (1999) Brain macrophages: on the role of pericytes and perivascular cells. Brain Res Brain Res Rev 31: 42–57. ArticlePubMedCAS Google Scholar
Thomassen E, Bird TA, Renshaw BR, Kennedy MK, Sims JE (1998) Binding of interleukin-18 to the interleukin-1 receptor homologous receptor IL-1 Rrp l leads to activation of signaling pathways similar to those used by interleukin-1. J Interferon Cytokine Res 18: 1077–1088. ArticlePubMedCAS Google Scholar
Torres C, Aranguez I, Rubio N (1995) Expression of interferon-gamma receptors on murine oligodendrocytes and its regulation by cytokines and mitogens. Immunology 86: 250–255. PubMedCAS Google Scholar
Tran EH, Prince EN, Owens T (2000) IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines. J Immunol 164: 2759–2768. PubMedCAS Google Scholar
Tringali G, Dello-Russo C, Preziosi P, Navarra P (1998) Hypothalamic interleukin-1 in nhvsiologv and nathology. Toxicol Lett 102: 295–299. ArticlePubMed Google Scholar
Tsuji-Takayama K, Aizawa Y, Okamoto I, Kojima H, Koide K, Takeuchi M, Ikegami H, Ohta T, Kurimoto M (1999) Interleukin-18 induces interferon-gamma production through NF-kappaB and NFAT activation in murine T helper type 1 cells. Cell Immunol 196: 41–50. ArticlePubMedCAS Google Scholar
Tsuji-Takayama K, Matsumoto S, Koide K, Takeuchi M, Ikeda M, Ohta T, Kurimoto M (1997) Interleukin-18 induces activation and association of p56(lck) and MAPK in a murine TH1 clone. Biochem Biophys Res Commun 237: 126–130. ArticlePubMedCAS Google Scholar
Vandenabeele P, Fiers W (1991) Is amyloidogenesis during Alzheimer’s disease due to an IL-1-/IL-6-mediated ‘acute phase response’ in the brain? Immunol Today 12: 217–219. ArticlePubMedCAS Google Scholar
Vilcek J (1998) The cytokines: an overview. In: The cytokine handbook (Thomson A, ed), pp 1–20. San Diego: Academic Press. Google Scholar
Vitkovic L, Bockaert J, Jacque C (2000) “Inflammatory” cytokines: Neuromodulators in normal brain? J Neurochem 74: 457–471. ArticlePubMedCAS Google Scholar
Waguespack PJ, Banks WA, Kastin AJ (1994) Interleukin-2 does not cross the blood-brain barrier by a saturable transport system. Brain Res Bull 34: 103–109. ArticlePubMedCAS Google Scholar
Ware CF, Santee S, Glass A (1998) Tumor necrosis factor-related ligands and receptors. in: The cytokine handbook (Thomson A, ed), pp 549–592. San Diego: Academic Press. Google Scholar
Wei R, Jonakait GM (1999) Neurotrophins and the anti-inflammatory agents interleukin-4 (IL-4), IL-10, IL-11 and transforming growth factor-betal (TGF-betal) down- regulate T cell costimulatory molecules B7 and CD40 on cultured rat microglia. J Neuroimmunol 95: 8–18. ArticlePubMedCAS Google Scholar
Wewers MD, Herzyk DJ (1989) Alveolar macrophages diffter trom blood monocytes human IL-lb release. J Immunol 143: 1635–1641. PubMedCAS Google Scholar
Wheeler, R.D., Culhane AC, Hall MD, Pickering-Brown S, Rothwell N, Luheshi GN (2000) Detection of the interleukin 18 family in rat brain by RT- PCR. Mol Brain Res 77: 290–293. ArticlePubMedCAS Google Scholar
Wildbaum G, Youssef S, Grabie N, Karin N (1998) Neutralizing antibodies to IFN-gammainducing factor prevent experimental autoimmune encephalomyelitis. J Immunol 161: 6368–6374. PubMedCAS Google Scholar
Woodroofe MN, Sarna GS, Wawda M, Hayes GM, Loughlin AJ, Linker A, Curzner ML (1991) Detection of interleukin-1 and interleukin-6 in adult rat brain following mechnical injury by in vivo microdialysis: Evidence of a role for microglia in cytokine production. J Immunol 33: 227–236. CAS Google Scholar
Xia MQ, Hyman BT (1999) Chemokines/chemokine receptors in the central nervous system and Alzheimer’s disease. J Neurovirol 5: 32–41. ArticlePubMedCAS Google Scholar
Xia MQ, Qin SX, Wu LJ, Mackay CR, Hyman BT (1998) Immunohistochemical study the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer’s disease brains. Am J Pathol 153: 31–37. ArticlePubMedCAS Google Scholar
Yang RB, Mark MR, Gray A, Huang A, Xie MH, Zhang M, Goddard A, Wood WI, Gurney AL, Godowski PJ (1998) Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 395: 284–288. ArticlePubMedCAS Google Scholar
Yao J, Keri JE, Taffs RE, Colton CA (1992) Characterization of interleukin-1 production by microglia in culture. Brain Res 591: 88–93. ArticlePubMedCAS Google Scholar
Yates SL, Burgess LH, Kocsis-Angle J, Antal JM, Dority MD, Embury PB, Piotrkowski AM, Brunden KR (2000) Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia. J Neurochem 74: 1017–1025. ArticlePubMedCAS Google Scholar
Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D (1999) Cutting edge: Recognition of gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol 163: 1–5. PubMedCAS Google Scholar
Zhang M., Tracey KJ (1998) Tumor necrosis factor. In: The cytokine handbook (Thomson A, ed), pp 517–548. San Diego: Academic Press. Google Scholar
Zhang GX, Baker CM, Kolson DL, Rostami AM (2000) Chemokines and chemokine receptors in the pathogenesis of multiple sclerosis. Mult Scler 6: 3–13. PubMedCAS Google Scholar
Zujovic V, Benavides J, Vige X, Carter C, Taupin V (2000) Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation. Glia 29: 305–315. ArticlePubMedCAS Google Scholar