The Movements of Water and Solutes in the Brains of Mammals (original) (raw)

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In normal animals there seems to be little or no bulk flow across CNS capillaries and through neural tissue. The resistance to volume flow at each of these sites seems to be too great for significant convective transport to take place; yet, during the time course of cerebral edema, relatively large flows of fluid do occur both at the capillaries and through the ECS. Such changes in bulk fluid movement probably involve alterations in the hydraulic conductivity of cerebral blood vessels, the solute reflection coefficients and concentration differences across the blood-brain barrier and the hydraulic conductivity of the tissue ECS (the latter as a result of increases in the size and channel width of the space).

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Authors and Affiliations

  1. Membrane Transport Section, Division of Cancer Treatment, National Cancer Institute and Theoretical Statistics and Mathematics Branch, Bethesda, Md., USA
    J. D. Fenstermacher & C. S. Patlak
  2. Division of Biometry and Epidemiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Md., USA
    J. D. Fenstermacher & C. S. Patlak

Authors

  1. J. D. Fenstermacher
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  2. C. S. Patlak
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Editors and Affiliations

  1. Dept. of Neurology and Neurosurgery, McGill University, 3801 University Street, H3A 2B4, Montreal, Que., Canada
    Hanna M. Pappius Ph. D. (Associate Professor, Associate Neurochemist) & William Feindel M. D., D. Phil., F.R.S.C. (Professor, Director) (Associate Professor, Associate Neurochemist) & (Professor, Director)
  2. Montreal Neurological Institute, 3801 University Street, H3A 2B4, Montreal, Que., Canada
    Hanna M. Pappius Ph. D. (Associate Professor, Associate Neurochemist) & William Feindel M. D., D. Phil., F.R.S.C. (Professor, Director) (Associate Professor, Associate Neurochemist) & (Professor, Director)

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Fenstermacher, J.D., Patlak, C.S. (1976). The Movements of Water and Solutes in the Brains of Mammals. In: Pappius, H.M., Feindel, W. (eds) Dynamics of Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66524-0\_16

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