Reciprocal changes in striatal dopamine and β-phenylethylamine induced by reserpine in the presence of monoamine oxidase inhibitors (original) (raw)

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Summary

Recent studies have demonstrated that selective monoamine oxidase inhibition may induce changes in brain β-phenylethylamine availability following lesions. The present study used this approach to re-assess the possible effects of reserpine on striatal concentrations of β-phenylethylamine and of other amines and selected metabolites. Mice were injected with pargyline (2,200 mg kg−1, 4 h), clorgyline (2 mg kg−1, 2 h) or (−)deprenyl (2 mg kg−1, 2 h) alone or in combination with reserpine (1,10 mg kg−1, 2 h). Increases in β-phenylethylamine accumulation were observed in the presence of both (−)deprenyl or pargyline respectively after reserpine except in the case of combined 200 mg kg−1 of pargyline plus 1 mg kg−1 of reserpine. In this condition, a minimal dopamine decrease was observed (to 80% of the concentration of pargyline-treated controls). Increases in β-phenylethylamine concentration were not observed with reserpine alone (1 or 10 mg kg−1). In the latter condition, the concentrations of β-phenylethylamine remained at control values due to the activity of monoamine oxidase B. Changes in _p_-tyrosine, 5-hydroxytryptamine or tryptophan did not consistently accompany increases in β-phenylethylamine accumulation. Increased β-phenylethylamine accumulation was always accompanied by the decreases in dopamine induced by reserpine in mice with either non-selective (200 mg kkg−1 pargyline) or type B monoamine oxidase inhibition (2 mg kg−1 pargyline or deprenyl). These data suggest that although the changes in β-phenylethylamine accumulation may not be due simply to p-tyrosine availability they are related to dopamine levels in the intact striatum.

Access this article

Log in via an institution

Subscribe and save

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Download references

Author information

Authors and Affiliations

  1. Neuropsychiatric Research Unit, Medical Research Building, University of Saskatchewan, S7N 0WO, Saskatoon, Saskatchewan, Canada
    A. V. Juorio
  2. Department of Psychiatry, Neurochemical Research Unit, MacKenzie Centre, University of Alberta, T6G 2B7, Edmonton, Alberta, Canada
    A. J. Greenshaw
  3. Department of Psychology, University of Saskatchewan, S7N OWO, Saskatoon, Saskatchewan, Canada
    T. B. Wishart

Authors

  1. A. V. Juorio
    You can also search for this author inPubMed Google Scholar
  2. A. J. Greenshaw
    You can also search for this author inPubMed Google Scholar
  3. T. B. Wishart
    You can also search for this author inPubMed Google Scholar

Additional information

Send offprint requests to A. V. Juorio at the above address

Rights and permissions

About this article

Cite this article

Juorio, A.V., Greenshaw, A.J. & Wishart, T.B. Reciprocal changes in striatal dopamine and β-phenylethylamine induced by reserpine in the presence of monoamine oxidase inhibitors.Naunyn-Schmiedeberg's Arch Pharmacol 338, 644–648 (1988). https://doi.org/10.1007/BF00165628

Download citation

Key words